EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

flavone
2-phenyl-1,4-benzopyrone

Supplier Sponsors

Name:2-phenylchromen-4-one
CAS Number: 525-82-6Picture of molecule3D/inchi
Other(deleted CASRN):11091-19-3
ECHA EINECS - REACH Pre-Reg:208-383-8
FDA UNII: S2V45N7G3B
Nikkaji Web:J53.111A
Beilstein Number:0157598
MDL:MFCD00006825
XlogP3:3.60 (est)
Molecular Weight:222.24310000
Formula:C15 H10 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 97.00 to 100.00 °C. @ 760.00 mm Hg
Boiling Point: 367.00 to 368.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000014 mmHg @ 25.00 °C. (est)
Flash Point: 340.00 °F. TCC ( 171.10 °C. ) (est)
logP (o/w): 3.560
Soluble in:
 alcohol
 water, 30.52 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
ExtraSynthese
For experimental / research use only.
Flavone (HPLC) ≥95%
Penta International
FLAVONE
Santa Cruz Biotechnology
For experimental / research use only.
Flavone
Sigma-Aldrich: Aldrich
For experimental / research use only.
Flavone
TCI AMERICA
For experimental / research use only.
Flavone >98.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 2500 mg/kg
Journal of Heterocyclic Chemistry. Vol. 21, Pg. 193, 1984.

intraperitoneal-mouse LD50 380 mg/kg
Farmaco, Edizione Scientifica. Vol. 13, Pg. 561, 1958.

Dermal Toxicity:
subcutaneous-mouse LD > 400 mg/kg
Antibiotics and Chemotherapy Vol. 3, Pg. 603, 1953.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for flavone usage levels up to:
 not for fragrance use.
 
Recommendation for flavone flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):525-82-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10680
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2-phenylchromen-4-one
Chemidplus:0000525826
RTECS:DJ3100630 for cas# 525-82-6
 
References:
 2-phenylchromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):10680
Pubchem (sid):134978180
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C10043
HMDB (The Human Metabolome Database):HMDB03075
FooDB:FDB006784
Export Tariff Code:2932.99.9090
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 dill plant
Search Trop Picture
 guava pineapple guava
Search Trop Picture
 pomegranate fruit
Search Trop Picture
 rosemary leaf
Search Trop Picture
 
Synonyms:
 asmacoril
4H-1-benzopyran-4-one, 2-phenyl-
 chromocor
 cromaril
 cromarile
2-phenyl-1,4-benzopyrone
2-phenyl-4-benzopyron
2-phenyl-4-chromone
2-phenyl-4H-1-benzopyran-4-one
2-phenyl-4H-benzopyran-4-one
2-phenyl-4H-chromen-4-on
2-phenyl-4H-chromen-4-one
2-phenyl-chromen-4-one
2-phenyl-g-benzopyrone
2-phenyl-gamma-benzopyrone
2-phenylbenzopyran-4-one
2-phenylchromen-4-one
2-phenylchromone
 

Articles:

PubMed:Comprehensive Phenolic Profiling of Cyclopia genistoides (L.) Vent. by LC-DAD-MS and -MS/MS Reveals Novel Xanthone and Benzophenone Constituents.
PubMed:Rapid screening of low molecular weight phenols from persimmon (Diospyros kaki) pulp using liquid chromatography-UV/Vis-electrospray mass spectrometry analysis.
PubMed:Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium).
PubMed:The occurrence, fate and biological activities of C-glycosyl flavonoids in the human diet.
PubMed:Characteristics of an Organic Solvent-Tolerant β-Fructofuranosidase from Arthrobacter arilaitensis NJEM01 and Efficient Synthesis of Prebiotic Kestose.
PubMed:Using an FFQ to assess intakes of dietary flavonols and flavones among female adolescents in the Suihua area of northern China.
PubMed:Phytochemicals and antioxidant activities of Rhus tripartitum (Ucria) fruits depending on locality and different stages of maturity.
PubMed:Stimulation of Osteogenic Activity in Human Osteoblast Cells by Edible Uraria crinita.
PubMed:Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells.
PubMed:Characterization of natural aryl hydrocarbon receptor agonists from cassia seed and rosemary.
PubMed:Metabolite profiling of polyphenols in peels of Citrus limetta Risso by combination of preparative high-speed countercurrent chromatography and LC-ESI-MS/MS.
PubMed:Differences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagens.
PubMed:Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats.
PubMed:Antitumor effects of the flavone chalcone: inhibition of invasion and migration through the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS cells.
PubMed:Antiviral activity of polymethoxylated flavones from "Guangchenpi", the edible and medicinal pericarps of citrus reticulata 'Chachi'.
PubMed:Soluble Phenolic Compounds in Fresh and Ensiled Orchard Grass ( Dactylis glomerata L.), a Common Species in Permanent Pastures with Potential as a Biomass Feedstock.
PubMed:Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women.
PubMed:α-Glucosidase inhibition by luteolin: kinetics, interaction and molecular docking.
PubMed:First evidence of C- and O-glycosyl flavone in blood orange (Citrus sinensis (L.) Osbeck) juice and their influence on antioxidant properties.
PubMed:Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts.
PubMed:Wheat straw biomass: a resource for high-value chemicals.
PubMed:Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation.
PubMed:Antioxidant activity of phenolics in leaves of three red pepper (Capsicum annuum) cultivars.
PubMed:Characterisation of phenolic compounds in wild fruits from Northeastern Portugal.
PubMed:Bioactive compounds present in the Mediterranean sofrito.
PubMed:Phenolic content of strawberry spreads during processing and storage.
PubMed:Bioconversion of flavones during fermentation in milk containing Scutellaria baicalensis extract by Lactobacillus brevis.
PubMed:Fuzhuanins A and B: the B-ring fission lactones of flavan-3-ols from Fuzhuan brick-tea.
PubMed:Caecal absorption of vitexin-2-O-xyloside and its aglycone apigenin, in the rat.
PubMed:[Biologically active substances of plant origin. Flavonols and flavones: prevalence, dietary sourses and consumption].
PubMed:Effects of food formulation and thermal processing on flavones in celery and chamomile.
PubMed:Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats.
PubMed:Enrichment and antioxidant properties of flavone C-glycosides from trollflowers using macroporous resin.
PubMed:Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity.
PubMed:Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity.
PubMed:Tea and non-tea flavonol intakes in relation to atherosclerotic vascular disease mortality in older women.
PubMed:Flavonoids from the capitula of Eriocaulon australe.
PubMed:Identification of a nitric oxide generation-stimulative principle in Scutellariae radix.
PubMed:Identification of phenolic constituents in red chicory salads (Cichorium intybus) by high-performance liquid chromatography with diode array detection and electrospray ionisation tandem mass spectrometry.
PubMed:Winter wheat hull (husk) is a valuable source for tricin, a potential selective cytotoxic agent.
PubMed:Structural characterization of lignin isolated from coconut (Cocos nucifera) coir fibers.
PubMed:Identification of flavone glucuronide isomers by metal complexation and tandem mass spectrometry: regioselectivity of uridine 5'-diphosphate-glucuronosyltransferase isozymes in the biotransformation of flavones.
PubMed:Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer-considerations concerning related efficacy and safety.
PubMed:Stabilization of anthocyanin and skullcap flavone complexes--investigations with computer simulation and experimental methods.
PubMed:Food ingredient extracts of Cyclopia subternata (Honeybush): variation in phenolic composition and antioxidant capacity.
PubMed:Rapid resolution liquid chromatography-electrospray ionisation tandem mass spectrometry method for identification of chemical constituents in Citri Reticulatae Pericarpium.
PubMed:Phenolic Compounds from Halimodendron halodendron (Pall.) Voss and Their Antimicrobial and Antioxidant Activities.
PubMed:Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae.
PubMed:The risk of lung cancer related to dietary intake of flavonoids.
PubMed:Flavone potently stimulates an apical transporter for flavonoids in human intestinal Caco-2 cells.
PubMed:Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women.
PubMed:Evaluation of flavonoid contents and antioxidant capacity of the aerial parts of common and tartary buckwheat plants.
PubMed:Identification of 5,7,3',4'-tetramethoxyflavone metabolites in rat urine by the isotope-labeling method and ultrahigh-performance liquid chromatography-electrospray ionization-mass spectrometry.
PubMed:Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.
PubMed:Structural characterization of wheat straw lignin as revealed by analytical pyrolysis, 2D-NMR, and reductive cleavage methods.
PubMed:Habitual flavonoid intakes are positively associated with bone mineral density in women.
PubMed:A new lignan with anti-tumour activity from Polygonum perfoliatum L.
PubMed:Pretreatment with the total flavone glycosides of Flos Abelmoschus manihot and hyperoside prevents glomerular podocyte apoptosis in streptozotocin-induced diabetic nephropathy.
PubMed:Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii.
PubMed:Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells.
PubMed:Re-examination of chromogenic quantitative assays for determining flavonoid content.
PubMed:Flavone deglycosylation increases their anti-inflammatory activity and absorption.
PubMed:Characterization of phenolic compounds in flowers of wild medicinal plants from Northeastern Portugal.
PubMed:Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing.
PubMed:Endogenous enzymes, heat, and pH affect flavone profiles in parsley (Petroselinum crispum var. neapolitanum) and celery (Apium graveolens) during juice processing.
PubMed:Phenolic compounds and anti-oxidant capacity of twelve morphologically heterogeneous bamboo species.
PubMed:Antioxidant and cytotoxic activities of ethanolic extracts and isolated fractions of species of the genus Phellinus Quél. (Aphyllophoromycetideae).
PubMed:Apigenin-induced suicidal erythrocyte death.
PubMed:Corn mint (Mentha arvensis) extract diminishes acute Chlamydia pneumoniae infection in vitro and in vivo.
PubMed:In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31.
PubMed:Flavonoids in tropical citrus species.
PubMed:Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships.
PubMed:Noncovalent interaction of dietary polyphenols with common human plasma proteins.
PubMed:Liquid chromatography-tandem mass spectrometry analysis allows the simultaneous characterization of C-glycosyl and O-glycosyl flavonoids in stingless bee honeys.
PubMed:Electrooxidation of flavonoids at platinum electrode studied by cyclic voltammetry.
PubMed:Phenylethanoid glycosides as major antioxidants in Lippia multiflora herbal infusion and their stability during steam pasteurisation of plant material.
PubMed:Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.
PubMed:Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells.
PubMed:Brazilian red propolis: unreported substances, antioxidant and antimicrobial activities.
PubMed:Natural flavone kaempferol suppresses chemokines expression in human monocyte THP-1 cells through MAPK pathways.
PubMed:Isolation of cholinesterase-inhibiting flavonoids from Morus lhou.
PubMed:ZnO-ZnS QDs interfacial heterostructure for drug and food delivery application: enhancement of the binding affinities of flavonoid aglycones to bovine serum albumin.
PubMed:Approach to the study of C-glycosyl flavones acylated with aliphatic and aromatic acids from Spergularia rubra by high-performance liquid chromatography-photodiode array detection/electrospray ionization multi-stage mass spectrometry.
PubMed:Identification of proanthocyanidin dimers and trimers, flavone C-Glycosides, and antioxidants in Ficus deltoidea , a malaysian herbal tea.
PubMed:Habitual intake of flavonoid subclasses and incident hypertension in adults.
PubMed:Differential expression of flavonoid biosynthesis genes and accumulation of phenolic compounds in common buckwheat (Fagopyrum esculentum).
PubMed:Dietary flavonol and flavone intakes and their major food sources in Chinese adults.
PubMed:Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells.
PubMed:Methylated chrysin, a dimethoxy flavone, partially suppresses the development of liver preneoplastic lesions induced by N-nitrosodiethylamine in rats.
PubMed:Potent modification of inducible CYP1A1 expression by flavonoids.
PubMed:Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms.
PubMed:Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species.
PubMed:Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice.
PubMed:Reproducibility and relative validity of a food frequency questionnaire to assess intake of dietary flavonol and flavone in Chinese university campus population.
PubMed:Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation.
PubMed:Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose.
PubMed:Mixture effects of dietary flavonoids on steroid hormone synthesis in the human adrenocortical H295R cell line.
PubMed:Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK).
PubMed:The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines.
PubMed:Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn).
PubMed:Flavone induces changes in intermediary metabolism that prevent microadenoma formation in colonic tissue of carcinogen-treated mice.
PubMed:Effect of flavonoids on 2'-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen.
PubMed:Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract.
PubMed:Flavone C-glycosides from seeds of fenugreek, Trigonella foenum-graecum L.
PubMed:Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells.
PubMed:Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm.
PubMed:Analysis of the residues of 20 organochlorine pesticides in Herba epimedii, a Chinese herbal medicine, by solid-phase extraction with gas chromatography/negative chemical ionization-mass spectrometry.
PubMed:Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A.
PubMed:Antibacterial and antifungal properties of acetonic extract of Feijoa sellowiana fruits and its effect on Helicobacter pylori growth.
PubMed:Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application.
PubMed:Dietary flavonoids activate the constitutive androstane receptor (CAR).
PubMed:Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study.
PubMed:Phenolic substance characterization and chemical and cell-based antioxidant activities of 11 lentils grown in the northern United States.
PubMed:Regulation of phase II enzymes by genistein and daidzein in male and female Swiss Webster mice.
PubMed:Plant chemical defence: a partner control mechanism stabilising plant--seed-eating pollinator mutualisms.
PubMed:Inhibitory effect of flavonoids on 26S proteasome activity.
PubMed:Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro.
PubMed:Antioxidant activity of the dihydrochalcones Aspalathin and Nothofagin and their corresponding flavones in relation to other Rooibos ( Aspalathus linearis ) Flavonoids, Epigallocatechin Gallate, and Trolox.
PubMed:From functional food to medicinal product: systematic approach in analysis of polyphenolics from propolis and wine.
PubMed:Quantitation of chafurosides A and B in tea leaves and isolation of prechafurosides A and B from oolong tea leaves.
PubMed:Evaluation of the antioxidant activity of non-transformed and transformed pineapple: a comparative study.
PubMed:Distribution and major sources of flavonoid intakes in the middle-aged Japanese women.
PubMed:Identification and assessment of antioxidant capacity of phytochemicals from kiwi fruits.
PubMed:New acylated flavone and cyanogenic glycosides from Linum grandiflorum.
PubMed:Tyrosinase inhibitory polyphenols from roots of Morus lhou.
PubMed:[Study of alcohol-soluble lignin in cognac spirits].
PubMed:Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.
PubMed:Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography.
PubMed:Higher dietary flavone, flavonol, and catechin intakes are associated with less of an increase in BMI over time in women: a longitudinal analysis from the Netherlands Cohort Study.
PubMed:Induction of cytochromes P450 in small intestine by chemopreventive compounds.
PubMed:On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection.
PubMed:Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation.
PubMed:Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3',4',3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays.
PubMed:Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.
PubMed:Stress-induced biosynthesis of dicaffeoylquinic acids in globe artichoke.
PubMed:Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats.
PubMed:Dietary flavonoid sources in Australian adults.
PubMed:Development of a potential reference material for evaluating antioxidant activity.
PubMed:Fate and impact on microorganisms of rice allelochemicals in paddy soil.
PubMed:Enhanced electrochemiluminescence of Ru(bpy)3(2+) by flavone compounds.
PubMed:Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus.
PubMed:The influence of diet composition on phase I and II biotransformation enzyme induction.
PubMed:Online identification of chlorogenic acids, sesquiterpene lactones, and flavonoids in the Brazilian arnica Lychnophora ericoides Mart. (Asteraceae) leaves by HPLC-DAD-MS and HPLC-DAD-MS/MS and a validated HPLC-DAD method for their simultaneous analysis.
PubMed:Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells.
PubMed:Proteome response in HT-29 human colorectal cancer cells to two apoptosis-inducing compounds with different mode of action.
PubMed:Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities.
PubMed:Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages.
PubMed:Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells.
PubMed:[Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].
PubMed:Efficient synthesis of polyoxygenated flavones from naturally occurring flavanones.
PubMed:How heating affects extra virgin olive oil quality indexes and chemical composition.
PubMed:Permeability profile estimation of flavonoids and other phenolic compounds by biopartitioning micellar capillary chromatography.
PubMed:Dietary flavonoid apigenin is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal.
PubMed:A new flavone glycoside from the fruits of Luffa cylindrica.
PubMed:Activity and allelopathy of soil of flavone o-glycosides from rice.
PubMed:Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids.
PubMed:Inhibition of inducible nitric oxide synthase expression by an acetonic extract from Feijoa sellowiana Berg. fruits.
PubMed:Isozyme- and gender-specific induction of glutathione S-transferases by flavonoids.
PubMed:Dietary intakes of flavonols and flavones and coronary heart disease in US women.
PubMed:The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes.
PubMed:Metabolism of flavone C-glucosides and p-coumaric acid from antioxidant of bamboo leaves (AOB) in rats.
PubMed:Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo.
PubMed:Pathway engineering for healthy phytochemicals leading to the production of novel flavonoids in tomato fruit.
PubMed:Novel transgenic rice overexpressing anthocyanidin synthase accumulates a mixture of flavonoids leading to an increased antioxidant potential.
PubMed:TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers.
PubMed:Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
PubMed:An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers.
PubMed:Total antioxidant activity and fiber content of select Florida-grown tropical fruits.
PubMed:[Chemical constituents of C-glycosylflavones from Mimosa pudica].
PubMed:Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China.
PubMed:Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.
PubMed:Fourier transform infrared spectroscopic analysis of the polymethoxylated flavone content of orange oil residues.
PubMed:Thermal degradation kinetics of isoflavone aglycones from soy and red clover.
PubMed:Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis.
PubMed:Bioavailability of apigenin from apiin-rich parsley in humans.
PubMed:Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major byproduct of essential oil extraction.
PubMed:Flavone C-glycosides from leaves of Oxalis triangularis.
PubMed:Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells.
PubMed:Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid.
PubMed:Determination of flavonoids in citrus juices by micro-HPLC-ESI/MS.
PubMed:Extraction and identification of natural antioxidant from Sideritis euboea (mountain tea).
PubMed:Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives.
PubMed:Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids.
PubMed:Flavone initiates a hierarchical activation of the caspase-cascade in colon cancer cells.
PubMed:Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells.
PubMed:Human gut microbial degradation of flavonoids: structure-function relationships.
PubMed:Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products.
PubMed:Determination of flavone C-glucosides in antioxidant of bamboo leaves (AOB) fortified foods by reversed-phase high-performance liquid chromatography with ultraviolet diode array detection.
PubMed:Acacetin induces apoptosis in human gastric carcinoma cells accompanied by activation of caspase cascades and production of reactive oxygen species.
PubMed:Fractionation of orange peel phenols in ultrafiltered molasses and mass balance studies of their antioxidant levels.
PubMed:Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells.
PubMed:Three new furostanol saponins from the leaves of Lycianthes synanthera ("Chomte"), an edible Mesoamerican plant.
PubMed:Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry.
PubMed:Secondary metabolites from the leaves of Feijoa sellowiana Berg.
PubMed:Estimated phytochemical content of the dietary approaches to stop hypertension (DASH) diet is higher than in the Control Study Diet.
PubMed:Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship.
PubMed:Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells.
PubMed:Natural products for dental caries prevention.
PubMed:Direct liquid chromatography-mass spectrometry method for the detection of glutathione S-transferase isozymes and investigation of their expression in response to dietary flavone.
PubMed:Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway.
PubMed:Pleiotropic molecular effects of the pro-apoptotic dietary constituent flavone in human colon cancer cells identified by protein and mRNA expression profiling.
PubMed:Antioxidant properties of phenolic compounds from Pelargonium reniforme.
PubMed:The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects.
PubMed:Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.
PubMed:Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation.
PubMed:Effect of flavonoids on feeding preference and development of the crucifer pest Mamestra configurata Walker.
PubMed:Purification and characterization of an isoflavone-conjugates-hydrolyzing beta-glucosidase from endophytic bacterium.
PubMed:Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.
PubMed:Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution.
PubMed:Early and late apoptosis events in human transformed and non-transformed colonocytes are independent on intracellular acidification.
PubMed:Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.
PubMed:Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis.
PubMed:Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha.
PubMed:Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents.
PubMed:Phenolic constituents and antioxidant properties of Xanthosoma violaceum leaves.
PubMed:Clinical pharmacology of flavopiridol following a 72-hour continuous infusion.
PubMed:Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.
PubMed:Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc.
PubMed:Flavonoid structure affects the inhibition of lipid peroxidation in Caco-2 intestinal cells at physiological concentrations.
PubMed:Flavonoid intake and the risk of cardiovascular disease in women.
PubMed:Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars.
PubMed:Flavone C-glycoside, phenolic acid, and nitrogen contents in leaves of barley subject to organic fertilization treatments.
PubMed:Insect antifeedant activity of flavones and chromones against Spodoptera litura.
PubMed:Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats.
PubMed:Flavonol and flavone intakes in US health professionals.
PubMed:Antiproliferative activities of citrus flavonoids against six human cancer cell lines.
PubMed:Flavonoid oxidation by the radical generator AIBN: a unified mechanism for quercetin radical scavenging.
PubMed:Alfalfa (Medicago sativa L.) flavonoids. 2. Tricin and chrysoeriol glycosides from aerial parts.
PubMed:Inhibitory effects of naturally occurring compounds on aflatoxin B(1) biotransformation.
PubMed:Dietary agents in cancer prevention: flavonoids and isoflavonoids.
PubMed:Immunotoxicity of a standardized citrus polymethoxylated flavone extract.
PubMed:Quantitative study of fruit flavonoids in citrus hybrids of King (C. nobilis) and Mukaku Kishu (C. kinokuni).
PubMed:Selection of hybrids and edible citrus species with a high content in the diosmin functional compound. Modulating effect of plant growth regulators on contents.
PubMed:Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study.
PubMed:Effects of simple aromatic compounds and flavonoids on Ca2+ fluxes in rat pituitary GH(4)C(1) cells.
PubMed:Inhibition of beta-carotene-15,15'-dioxygenase activity by dietary flavonoids.
PubMed:Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus.
PubMed:A new flavone O-glycoside and other constituents from wheat leaves (Triticum aestivum L.).
PubMed:Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells.
PubMed:Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages.
PubMed:Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds.
PubMed:Identification of flavone C-glycosides including a new flavonoid chromophore from barley leaves (Hordeum vulgare L.) by improved NMR techniques.
PubMed:High content of dopamine, a strong antioxidant, in Cavendish banana.
PubMed:Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects.
PubMed:Structure-activity relationship of polyphenols on inhibition of chemical mediator release from rat peritoneal exudate cells.
PubMed:Differential effect of flavonoids on inhibition of secretion and accumulation of secretory granules in rat basophilic leukemia cells.
PubMed:Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slices.
PubMed:Transepithelial transport and accumulation of flavone in human intestinal Caco-2 cells.
PubMed:Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.
PubMed:Isolation of a novel NAD(P)H-quinone oxidoreductase from the cyanobacterium Synechocystis PCC6803.
PubMed:[Flavonols, flavone and anthocyanins as natural antioxidants of food and their possible role in the prevention of chronic diseases].
PubMed:Flavonoid deactivation of ferrylmyoglobin in relation to ease of oxidation as determined by cyclic voltammetry.
PubMed:The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure-activity relationship study.
PubMed:Effects of co-administration of butylated hydroxytoluene, butylated hydroxyanisole and flavonoids on the activation of mutagens and drug-metabolizing enzymes in mice.
PubMed:The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies.
PubMed:Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds.
PubMed:Orange juice classification with a biologically based neural network.
PubMed:Interaction of 5,7-dihydroxy-4'-methoxyflavone with a multisubunit protein, carmin: thermodynamics and kinetics of interaction.
PubMed:Rapid HPLC analysis of dietary phytoestrogens from legumes and from human urine.
PubMed:Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes.
PubMed:Antimutagenic effect of plant flavonoids in the Salmonella assay system.
PubMed:Flavonoid inhibition of aromatase enzyme activity in human preadipocytes.
PubMed:Determination of flavone C-glycosides in tea.
PubMed:Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food.
PubMed:Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344 Rats (Feed Studies).
PubMed:Laboratory colonization has not reduced constitutive or induced polysubstrate monooxygenase activity in velvetbean caterpillars.
PubMed:Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids.
PubMed:Biotransformation of the Pentahydroxy Flavone Quercetin by Rhizobium loti and Bradyrhizobium Strains (Lotus).
PubMed:Inhibition of ethoxyresorufin deethylase activity by natural flavonoids in human and rat liver microsomes.
PubMed:Benzanthrone: a new substrate for hepatic microsomal cytochrome P-450.
PubMed:Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of plant flavonoids.
PubMed:Detoxification of isothiocyanate allelochemicals by glutathione transferase in three lepidopterous species.
PubMed:Comparison of the effects of feeding quercetin or flavone on hepatic and intestinal drug-metabolizing enzymes of the rat.
PubMed:Flavones in citrus exhibit antiadhesive action on platelets.
PubMed:Comparison of the effects of various flavonoids on ethoxycoumarin deethylase activity of rat intestinal and hepatic microsomes.
PubMed:A factor in food which impairs Na+-K+-ATPase in vitro.
 
Notes:
Flavones (flavus = yellow), are a class of flavonoids based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one). (Wikipedia)
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