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edetate disodium dihydrate
ethylenediaminetetraacetic acid disodium salt

Supplier Sponsors

Name:disodium 2-[carboxymethyl-[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate dihydrate
CAS Number: 6381-92-6Picture of molecule3D/inchi
Beilstein Number:3900609
Molecular Weight:336.20871856
Formula:C10 H14 N2 Na2 O8 · 2H2O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antioxidants and preservatives for fragrance and flavor
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 363 Calcium disodium ethylenediaminetetraacetic acid (EDTA) and disodium EDTA View - notice PDF
FEMA Number:4520 ethylenediaminetetraacetic acid disodium salt
FDA:No longer provide for the use of these seven synthetic flavoring substances
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 248.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor Description:odorless
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
None found
American International Chemical, LLC.
Disodium EDTA
BOC Sciences
For experimental / research use only.
EDTA disodium salt dihydrate ACS
Charkit Chemical
Connect Chemicals
Ethylenediaminetetraacetic acid disodium salt (EDTA 2Na)
Odor: characteristic
Use: EDTA Na2 (ethylenediaminetetracetic acid disodium) is a chelating agent, used to sequester and decrease the reactivity of metal ions that may be present in many industrial and personal care products.
ECSA Chemicals
ECSA Chemicals
ECSA Chemicals
ECSA Chemicals
ECSA Chemicals
EMD Millipore
For experimental / research use only.
EDTA, Disodium Salt, Dihydrate, Molecular Biology Grade
Glentham Life Sciences
EDTA disodium salt dihydrate
Indis NV
For experimental / research use only.
Edetate Disodium Dihydrate
Jiangyin Healthway
New functional food ingredients
Jiangyin Healthway
Kraft Chemical
Disodium EDTA
Disodium EDTA Dihydrate
98.5 % min.
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
EDTA, Disodium Salt, Dihydrate ≥99%
Shiva Chemicals and Pharmaceuticals
EDTA disodium salt
Sigma-Aldrich: Sigma
For experimental / research use only.
Edetate disodium meets USP testing specifications
For experimental / research use only.
Disodium Dihydrogen Ethylenediaminetetraacetate Dihydrate [for Biochemical Research] >99.0%(T)
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
antioxidants and preservatives for fragrance and flavor
Recommendation for edetate disodium dihydrate usage levels up to:
 not for fragrance use.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
Click here to view publication 24
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 100.00000120.00000
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8759
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
disodium 2-[carboxymethyl-[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate dihydrate
RTECS:AH4375000 for cas# 6381-92-6
 disodium 2-[carboxymethyl-[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate dihydrate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):8759
Pubchem (sid):134974234
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
KEGG (GenomeNet):D03945
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.49.4950
FDA Listing of Food Additive Status:View
•the cosmetic-grade material contains a minimum of 99.0% tetrasodium edta as na4edta.2h2o •anhydrous or dihydrate.
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 acetic acid, (ethylenedinitrilo)tetra-, disodium salt
 disodium 2-[carboxymethyl-[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate dihydrate
 disodium 2,2'-({2-[bis(carboxymethyl)amino]ethyl}imino)diacetate
 disodium 2,2'-{ethane-1,2-diylbis[(carboxymethyl)imino]}diacetate
 disodium EDTA dihydrate
 disodium EDTA FCC
 disodium EDTA technical
 disodium EDTA USP FCC
 edetate disodium dihydrate USP
 edta disodium salt dihydrate ACS
 ethylene diamine tetraacetic acid disodium salt dihydrate
 ethylenediaminetetraacetic acid disodium salt
 ethylenediaminetetraacetic acid disodium salt dihydrate


PubMed:Chronic Toxic Metal Exposure and Cardiovascular Disease: Mechanisms of Risk and Emerging Role of Chelation Therapy.
PubMed:Multiclass method for the quantification of 92 veterinary antimicrobial drugs in livestock excreta, wastewater, and surface water by liquid chromatography with tandem mass spectrometry.
PubMed:Residual antibacterial activity of canine hair treated with topical antimicrobial sprays against Staphylococcus pseudintermedius inĀ vitro.
PubMed:Heavy Metals, Cardiovascular Disease, andĀ the Unexpected Benefits of Chelation Therapy.
PubMed:Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989-2014(1).
PubMed:Massive intravenous manganese overdose due to compounding error: minimal role for hemodialysis.
PubMed:Chelation therapy to treat atherosclerosis, particularly in diabetes: is it time to reconsider?
PubMed:Do Taiwanese people have greater heavy metal levels than those of Western countries?
PubMed:Physicochemical properties of skim milk powders prepared with the addition of mineral chelators.
PubMed:Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients.
PubMed:Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn.
PubMed:Development of a stable low-dose aglycosylated antibody formulation to minimize protein loss during intravenous administration.
PubMed:A case of systemic contact dermatitis secondary to edetate disodium.
PubMed:Development and Optimization of Gastro-Retentive Controlled-Release Tablet of Calcium-Disodium Edentate and its In Vivo Gamma Scintigraphic Evaluation.
PubMed:Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films.
PubMed:In vitro activity of gentamicin, vancomycin or amikacin combined with EDTA or l-arginine as lock therapy against a wide spectrum of biofilm-forming clinical strains isolated from catheter-related infections.
PubMed:Orodispersible films in individualized pharmacotherapy: The development of a formulation for pharmacy preparations.
PubMed:Chelation therapy and cardiovascular disease: connecting scientific silos to benefit cardiac patients.
PubMed:Determination of phosphorus and potassium in commercial inorganic fertilizers by inductively coupled plasma-optical emission spectrometry: single-laboratory validation.
PubMed:Quality-of-life outcomes with a disodium EDTA chelation regimen for coronary disease: results from the trial to assess chelation therapy randomized trial.
PubMed:Ethylenediaminetetraacetic acid in endodontics.
PubMed:Characterization of phenoloxidase from the sea cucumber Apostichopus japonicus.
PubMed:Evaluation of the impact of tromethamine edetate disodium dihydrate on antimicrobial susceptibility of Pseudomonas aeruginosa in biofilm in vitro.
PubMed:A TACTful reappraisal of chelation therapy in cardiovascular disease.
PubMed:Is lead chelation therapy effective for chronic kidney disease? A meta-analysis.
PubMed:Ferrous-activated persulfate oxidation of arsenic(III) and diuron in aquatic system.
PubMed:Microarray-based gene expression profiling of peripheral blood mononuclear cells in dairy cows with experimental hypocalcemia and milk fever.
PubMed:Preparation of ultrathin, robust protein microcapsules through template-mediated interfacial reaction between amine and catechol groups.
PubMed:Comparison of the effects of ophthalmic solutions on human corneal epithelial cells using fluorescent dyes.
PubMed:Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial.
PubMed:Flow injection chemiluminescence determination of naphazoline hydrochloride in pharmaceuticals.
PubMed:Antimicrobial activity of a new preservative for multiuse ophthalmic solutions.
PubMed:Near-infrared electrogenerated chemiluminescence of ultrasmall Ag2Se quantum dots for the detection of dopamine.
PubMed:Does calcium disodium EDTA slow CKD progression?
PubMed:A review of a family of ultra-rapid-acting insulins: formulation development.
PubMed:Ultra-rapid absorption of recombinant human insulin induced by zinc chelation and surface charge masking.
PubMed:Mineral concentrations of plasma and liver after injection with a trace mineral complex differ among Angus and Simmental cattle.
PubMed:The challenges of developing a generic extraction procedure to analyze multi-class veterinary drug residues in milk and honey using ultra-high pressure liquid chromatography quadrupole time-of-flight mass spectrometry.
PubMed:Validation of a quantitative HPLC method for bacitracin and bacitracin zinc using EDTA as a mobile-phase modifier.
PubMed:Effect of injectable trace minerals on the humoral immune response to multivalent vaccine administration in beef calves.
PubMed:Design of the Trial to Assess Chelation Therapy (TACT).
PubMed:The Ability of PAS, Acetylsalicylic Acid and Calcium Disodium EDTA to Protect Against the Toxic Effects of Manganese on Mitochondrial Respiration in Gill of Crassostrea virginica.
PubMed:A validated reverse phase HPLC method for the determination of disodium EDTA in meropenem drug substance with UV-detection using precolumn derivatization technique.
PubMed:Synthetically directed self-assembly and enhanced surface-enhanced Raman scattering property of twinned crystalline Ag/Ag homojunction nanoparticles.
PubMed:Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse.
PubMed:Structural restoration of nematodes and acanthocephalans fixed in high percentage alcohol using DESS solution and rehydration.
PubMed:Study on the racemization of synephrine by off-column chiral high-performance liquid chromatography.
PubMed:Characterization of biofilm formation by Riemerella anatipestifer.
PubMed:Chemical stability of amitriptyline hydrochloride in oral liquid dosage forms.
PubMed:Effect of EDTA and methionine on preventing loss of viscosity of cellulose-based topical gel.
PubMed:Stability of aseptically prepared tazocin solutions in polyvinyl chloride bags.
PubMed:In pediatric fatality, edetate disodium was no accident.
PubMed:Effectiveness of treatment of calcific tendinitis of the shoulder by disodium EDTA.
PubMed:Fluorimetric determination of the levels of urinary neopterin and serum thiobarbituric acid reactive substances in the nonagenarians.
PubMed:Pediatric fatality secondary to EDTA chelation.
PubMed:Why the NIH Trial to Assess Chelation Therapy (TACT) should be abandoned.
PubMed:Long-term outcome of repeated lead chelation therapy in progressive non-diabetic chronic kidney diseases.
PubMed:Dialyzability of minerals in corn masa gruel (atole) fortified with different iron compounds: effects of ascorbic acid, disodium EDTA, and phytic acid.
PubMed:Reversal of lead-induced neuronal apoptosis by chelation treatment in rats: role of reactive oxygen species and intracellular Ca(2+).
PubMed:Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.
PubMed:Does the presence of unwanted dermal fibroblasts limit the usefulness of autologous epidermal keratinocyte grafts?
PubMed:Low-level environmental exposure to lead and progressive chronic kidney diseases.
PubMed:Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005.
PubMed:In vitro efficacy of a buffered chelating solution as an antimicrobial potentiator for antifungal drugs against fungal pathogens obtained from horses with mycotic keratitis.
PubMed:Deaths associated with hypocalcemia from chelation therapy--Texas, Pennsylvania, and Oregon, 2003-2005.
PubMed:Effect of oral calcium disodium EDTA on iron absorption in a human model of iron overdose.
PubMed:Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy.
PubMed:"Nanobacterium sanguineum"--is it a new life-form in search of human ailment or commensal: overview of its transmissibility and chemical means of intervention.
PubMed:Urothelial injury to the rabbit bladder caused by calcium dissolving agents including two new citrate solutions.
PubMed:[Effect of blood purification materials and anticoagulants on the contact activity of factor XI].
PubMed:Enantioselective LC analysis of synephrine in natural products on a protein-based chiral stationary phase.
PubMed:[Stability study of an aqueous formulation of captopril at 1 mg/ml].
PubMed:[An examination method for chemiluminescence of whole-blood leucocytes].
PubMed:Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats.
PubMed:Transepithelial electrical resistance is not a reliable measurement of the Caco-2 monolayer integrity in Transwell.
PubMed:The poor bioavailability of elemental iron in corn masa flour is not affected by disodium EDTA.
PubMed:Reduced need for corneal epithelial debridement during vitreo-retinal surgery using two different viscous surface lubricants.
PubMed:Does EDTA-infusion affect calcium homeostatis leading to increased resistance to challenge?
PubMed:Iron bioavailability in corn-masa tortillas is improved by the addition of disodium EDTA.
PubMed:Direct suppressive effect of acute metabolic and respiratory alkalosis on parathyroid hormone secretion in the dog.
PubMed:Technology of eye drops containing aloe (Aloe arborescens Mill.--Liliaceae) and eye drops containing both aloe and neomycin sulphate.
PubMed:Effects of calcium disodium EDTA and meso-2,3-dimercaptosuccinic acid on tissue concentrations of lead for use in treatment of calves with experimentally induced lead toxicosis.
PubMed:Pathways and kinetics of deslorelin degradation in an airway epithelial cell line (Calu-1).
PubMed:Comparative effectiveness of Tiron (4,5-dihydroxy benzene 1,3-disulphonic acid disodium salt) and CaNa2EDTA with time after beryllium poisoning.
PubMed:Environmental lead exposure and progression of chronic renal diseases in patients without diabetes.
PubMed:Management of an ingested lead foreign body in an Amazon parrot.
PubMed:Stabilization and preformulation of anticancer drug--SarCNU.
PubMed:Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA.
PubMed:[Effect of sodium chloride treatment on remineralization of human root dentine caries in vitro].
PubMed:[Anemia secondary to lead poisoning. Our experience with 12 cases].
PubMed:Calcium, carbonic anhydrase and gastric acid secretion.
PubMed:Total selenium concentration in various waters of Turkey.
PubMed:Trace element homeostasis during continuous sedation with propofol containing EDTA versus other sedatives in critically ill patients.
PubMed:The course of selected bone resorption marker concentrations in response to short-term hypocalcemia experimentally induced with disodium EDTA infusions in dairy cows.
PubMed:Beryllium-induced toxicity and its prevention by treatment with chelating agents.
PubMed:Affinity purification of DNA and RNA from environmental samples with peptide nucleic acid clamps.
PubMed:Quantitative liquid chromatographic-tandem mass spectrometric determination of reserpine in FVB/N mouse plasma using a "chelating" agent (disodium EDTA) for releasing protein-bound analytes during 96-well liquid-liquid extraction.
PubMed:Influence of combined therapeutic potential of meso 2,3-dimercaptosuccinic acid and calcium disodium edetate on lead-induced testicular alterations in rats.
PubMed:Antibacterial activity of anesthetic solutions and preservatives: an in vitro comparative study.
PubMed:Laryngospasm and paradoxical bronchoconstriction after repeated doses of beta 2-agonists containing edetate disodium.
PubMed:An unusual cause of recurrent abdominal pain.
PubMed:Mobilization of lead from bone in end-stage renal failure patients with secondary hyperparathyroidism.
PubMed:Cyclosporine transfer from low- and high-density lipoproteins is partially influenced by lipid transfer protein I triglyceride transfer activity.
PubMed:An improved kit formulation of a dopamine transporter imaging agent: [Tc-99m]TRODAT-1.
PubMed:Rapid and simple determination of oxytetracycline in chicken products.
PubMed:Unexpected outcome after two consecutive infusions of disodium EDTA in dairy cows.
PubMed:Ocular tolerance of preservatives on the murine cornea.
PubMed:Adsorption of benzalkonium chloride by filter membranes: mechanisms and effect of formulation and processing parameters.
PubMed:The influence of radiographic contrast media on some granulocyte functions.
PubMed:Circular dichroism and UV melting studies on formation of an intramolecular triplex containing parallel T*A:T and G*G:C triplets: netropsin complexation with the triplex.
PubMed:Quantitative evaluation of newly formed bone in the alveolar wall surrounding the root during the initial stage of experimental tooth movement in the rat.
PubMed:Procedure for the sample preparation and handling for the determination of amino acids, monoamines and metabolites from microdissected brain regions of the rat.
PubMed:Spectroscopic investigation of an intramolecular DNA triplex containing both G.G:C and T.A:T triads and its complex with netropsin.
PubMed:Stability of vancomycin in an extemporaneously compounded ophthalmic solution.
PubMed:Recovery from lead induced biochemical and immunological alterations following combined treatment with DMSA and calcium disodium EDTA in rats.
PubMed:Preservatives in nebulizer solutions: risks without benefit.
PubMed:Effects of ingredients on stability of captopril in extemporaneously prepared oral liquids.
PubMed:Effect of medium composition, agitation and the presence of EDTA on the antimicrobial activity of cryptolepine.
PubMed:Assay of chlortetracycline in animal feeds by liquid chromatography with fluorescence detection.
PubMed:Kinetics of inactivation of green crab (Scylla Serrata) alkaline phosphatase during removal of zinc ions by ethylenediaminetetraacetic acid disodium.
PubMed:Metal excretion and magnesium retention in patients with intermittent claudication treated with intravenous disodium EDTA.
PubMed:The tensile behavior of demineralized bovine cortical bone.
PubMed:Transport of drugs across the Xenopus pulmonary membrane and their absorption enhancement by various absorption enhancers.
PubMed:Molecular insights into the anticoagulant-induced spontaneous activation of platelets in whole blood-various anticoagulants are not equal.
PubMed:Catalase against met-Hb excess during oximetries of dilute Hb-A samples.
PubMed:Confirmation of PM typing protocols for consistent and reliable results.
PubMed:Determination of dopexamine hydrochloride in human blood by high-performance liquid chromatography with electrochemical detection.
PubMed:Therapeutic efficacy of combined meso 2,3-dimercaptosuccinic acid and calcium disodium edetate treatment during acute lead intoxication in rats.
PubMed:An evaluation of a pre-scaling gel (SofScale) on the ease of supragingival calculus removal.
PubMed:Dose-dependent effects of zinc supplementation during chelation of lead in rats.
PubMed:Effects of intravenous EDTA treatment on serum parathyroid hormone (1-84) and biochemical markers of bone turnover.
PubMed:Purification and properties of a diisopropyl-fluorophosphatase from squid Todarodes pacificus steenstrup.
PubMed:Declining blood lead levels and cognitive changes in moderately lead-poisoned children.
PubMed:Stability of hydralazine hydrochloride syrup compounded from tablets.
PubMed:Comparison of phosphoprotein isolated from mature and immature human tooth roots.
PubMed:Morphologic and physiologic effects of artificial tear formulations on corneal epithelial derived cells.
PubMed:Depletion of essential elements by calcium disodium EDTA treatment in the dog.
PubMed:Elevated lead burden in Chinese patients without occupational lead exposure.
PubMed:Disappearance of immune deposits with EDTA chelation therapy in a case of IgA nephropathy.
PubMed:Nisin treatment for inactivation of Salmonella species and other gram-negative bacteria.
PubMed:Determination of melatonin and monoamines in rat pineal using reversed-phase ion-interaction chromatography with fluorescence detection.
PubMed:Current options for the treatment of systemic scleroderma.
PubMed:Simultaneous high-performance liquid chromatographic analysis of carbidopa, levodopa and 3-O-methyldopa in plasma and carbidopa, levodopa and dopamine in urine using electrochemical detection.
PubMed:Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats.
PubMed:Effects of supplemental protein on acid-base status and calcium metabolism of nonlactating Jersey cows.
PubMed:Endothelin-1 and -3 induce the release of tissue-type plasminogen activator and von Willebrand factor from endothelial cells.
PubMed:Survival of Acanthamoeba in contact lens rinse solutions.
PubMed:Technical aspects of quantification of aluminum.
PubMed:Acute hypocalcemia enhances prolactin levels: a study before and after oophorectomy.
PubMed:Phosphoprotein extraction from the dentine/cementum complex of human tooth roots.
PubMed:Using unstimulated urinary lead excretion to assess the need for chelation in the treatment of lead poisoning.
PubMed:Determination of 2-methyl derivatives of tamoxifen in cell culture medium using high-performance liquid chromatography and electrochemical detection.
PubMed:Chelation of lead during co-exposure to ethanol.
PubMed:Urothelial injury from ethylenediaminetetraacetic acid used as an irrigant in the urinary tract.
PubMed:An ion-pair reversed-phase HPLC-fluorimetric system for ultratrace determination of aluminium with salicylaldehydebenzoylhydrazone.
PubMed:Increase in red blood cell aggregability following experimental occlusion of the middle cerebral artery in cats.
PubMed:Body burdens of lead in hypertensive nephropathy.
PubMed:Macrophages possess both neutral and acidic protease activities toward low density lipoproteins.
PubMed:Human-parathormone assay for use in dogs: validation, sample handling studies, and parathyroid function testing.
PubMed:Retention of radiolead by human erythrocytes in vitro.
PubMed:Clotting of whole human blood induces cysteinyl-leukotriene formation.
PubMed:Liquid-chromatographic assay for free and transthyretin-bound retinol-binding protein in serum from normal humans.
PubMed:Pigment gallstone dissolution in vitro. Solubilization of brown bilirubinate and black polybilirubinate stone material by buffered solvents containing ethylenediaminetetraacetic acid, bile salts, and reducing thiols.
PubMed:Human serum and plasma protein binding of enoximone and its sulfoxide metabolite.
PubMed:Inhibitory effect of disodium EDTA upon the growth of Staphylococcus epidermidis in vitro: relation to infection prophylaxis of Hickman catheters.
PubMed:Monoconjugated bilirubin is a major component of hemolysis-induced gallstones in mice.
PubMed:Effects of hypocalcaemia on abomasal motility.
PubMed:Regulation of aortic CuZn-superoxide dismutase with copper. Caeruloplasmin and albumin re-activate and transfer copper to the enzyme in culture.
PubMed:Mobilization and redistribution of lead over the course of calcium disodium ethylenediamine tetraacetate chelation therapy.
PubMed:The toxicology and composition of bovine tissues after parenteral administration of high levels of copper salts.
PubMed:Determination of calcium and magnesium in limestone and dolomite by enthalpimetric flow-injection analysis.
PubMed:Effect of tetrasodium EDTA on enzymatic determinations of urinary oxalate.
PubMed:Hypernickelemia following coronary arteriography, caused by nickel in the radiographic contrast medium.
PubMed:Determination of rubidium, strontium and barium in barite by atomic-absorption spectrometry after dissolution in disodium ethylenediaminetetra-acetate.
PubMed:Differentiation and interaction of secretory immunoglobulin A and a calcium-dependent parotid agglutinin for several bacterial strains.
PubMed:Clinical experience with the testing of serum proteinase activity by cathepsin B-like sensitive amino acid derivatives of 7-amino-4-methylcoumarine.
PubMed:Lead, zinc and copper decorporation during calcium disodium ethylenediamine tetraacetate treatment of lead-poisoned children.
PubMed:High-performance liquid chromatographic, stability indicating assay for disodium EDTA in ophthalmic preparations.
PubMed:Reaffirmation of the validity of enzymatic cleavage of lithocholic acid from N-epsilon-lithocholyl-L-lysine and N-alpha-CBZ-N-epsilon-lithocholyl-L-lysine.
PubMed:Massive cerebral calcifications associated with increased renal phosphate reabsorption.
PubMed:Stability of ascorbate in urine: relevance to analyses for ascorbate and oxalate.
PubMed:Calcium chelators increase airway responsiveness.
PubMed:Chelation treatment of atherosclerosis.
PubMed:Determination of methyl paraoxon in dog plasma by reversed-phase high-performance liquid chromatography.
PubMed:Chelation therapy of atherosclerosis.
PubMed:Radioisotopic studies concerning the efficacy of standard washing procedures for the cleansing of hair before zinc analysis.
PubMed:Lead poisoning in a West Bank Arab Village.
PubMed:Occult lead intoxication in patients with gout and kidney disease.
PubMed:Altered parathyroid set point to calcium in familial hypocalciuric hypercalcaemia.
PubMed:A radioautographic study of the incorporation of iron 55 by the ameloblasts in the zone of maturation of rat incisors.
PubMed:A new radioimmunoassay for the midregion of canine parathyroid hormone.
PubMed:Effects of growth hormone replacement therapy on 1,25-dihydroxyvitamin D and calcium metabolism.
PubMed:Effects of disodium EDTA and calcium infusion on prolactin and thyrotropin responses to thyrotropin-releasing hormone in healthy man.
PubMed:Complexation of procainamide with dextrose.
PubMed:Edetate disodium-mediated chloramphenicol resistance in Pseudomonas cepacia.
PubMed:Diagnostic significance of edetate disodium calcium testing in children with increased lead absorption.
PubMed:Bioavailability of nickel in man: effects of foods and chemically-defined dietary constituents on the absorption of inorganic nickel.
PubMed:Stability-indicating high-performance liquid chromatographic analysis of lidocaine hydrochloride and lidocaine hydrochloride with epinephrine injectable solutions.
PubMed:Alterations in integrity of goldfish membrane induced by edetate disodium.
PubMed:Temperature-dependent effect of edetate disodium on neomycin stability.
PubMed:[Formulation studies of the wetting solutions for hard contact lenses. 1. Microbiological studies].
PubMed:Chelatable lead body burden (by calcium-disodium EDTA) and blood lead concentration in man.
PubMed:Urinary cyclic 3',5'-adenosine monophosphate responses to exogenous and endogenous parathyroid hormone in familial benign hypercalcemia and primary hyperparathyroidism.
PubMed:Isotachophoretic determination of ethylenediaminetetraacetate in salad dressing, mayonnaise, and margarine.
PubMed:Enzyme inhibitors for renin assay in rat plasma.
PubMed:Effect of edetate disodium on goldfish membrane.
PubMed:Polarographic determination of edetate disodium in eyewash and ophthalmic decongestant solutions.
PubMed:Acute lead poisoning with hemolysis and liver toxicity after ingestion of red lead.
PubMed:Effect of acute ethanol loading on parathyroid gland secretion in the rat.
PubMed:Pseudomonas cepacia resistance to antibacterials.
PubMed:Evidence for the local occurrence of angiotensin II in rat kidney and its modulation by dietary sodium intake and converting enzyme blockade.
PubMed:Impaired parathyroid response to induced hypocalcemia in thalassemia major.
PubMed:Adenoviral meningoencephalitis in a patient with lead toxicity.
PubMed:Comparison of interlaboratory results for blood lead with results from a definitive method.
PubMed:Isolation of lysosomes from brain tissue. A separation method by means of alteration of mitochondrial and synaptosomal sedimentation properties.
PubMed:Detection and treatment of occupational lead nephropathy.
PubMed:Enhancement of the viscosity of mucin by serum albumin.
PubMed:Effect of parathyroid hormone on plasma prolactin in man.
PubMed:Paper chromatographic determination of chlortetracycline.
PubMed:Possible differences in alpha-adrenoceptors in rabbit ileum and spleen.
PubMed:The effect of disodium EDTA on the fructolytic activity of bull semen.
PubMed:Factors influencing decomposition rate of amitriptyline hydrochloride in aqueous solution.
PubMed:Quantitative high-pressure liquid chromatographic determination of thimerosal in pharmaceutical formulations.
PubMed:Purification and characterization of human liver-specific membrane lipoprotein (LSP).
PubMed:Influence of zinc-ligand mixtures on serum zinc levels in rats.
PubMed:Effects of zinc sulfate on Pseudomonas aeruginosa infections and protease in rabbit corneas.
PubMed:Therapeutic effects of heparin on Pseudomonas-induced corneal ulceration.
PubMed:Effect of edetate disodium and reduced glutathione on absorption of acetazolamide from GI tract of rats.
PubMed:Electron microscope study of effect of benzalkonium chloride and edetate disodium on cell envelope of Pseudomonas aeruginosa.
PubMed:Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure.
PubMed:Studies on the stability of injectable solutions of some phenothiazines. Part 2: Effect of chelating agents and antioxidants.
PubMed:[Treatment of saturnism with a low dose of calcium disodium EDTA].
PubMed:Biochemical responses to provocative chelation by edetate disodium calcium.
PubMed:High-yield method for dispersing simian kidneys for cell cultures.
PubMed:Effects of disodium EDTA on the cardiovascular responses to prostaglandin E1.
PubMed:An objective evaluation of the treatment of systemic scleroderma with disodium EDTA, pyridoxine and reserpine.
PubMed:Myocardial contractile force in the treatment of ouabain intoxication with disodium EDTA, potassium chloride, and magnesium sulfate.
PubMed:The treatment of systemic sclerosis with disodium edta, pyridoxine and reserpine.
PubMed:The treatment of coronary artery disease with disodium EDTA. A reappraisal.
PubMed:Systemic sclerosis. Fourteen cases treated with chelation (disodium EDTA) and/or pyridoxine, with comments on the possible role of altered tryptophan metabolism in pathogenesis.
PubMed:[Analysis of the effects of disodium-EDTA, a calciam chelator, on the properties of serotonin in the dog in vivo. 3].
PubMed:[Our experience with the prevention and therapy of lead poisoning with calcium disodium EDTA].
PubMed:The effect of disodium EDTA on digitalis intoxication.
PubMed:The diagnostic and therapeutic use of edathamil calcium disodium (EDTA, versene) in excessive inorganic lead absorption.
PubMed:Chelation in contrast roentgenography with special reference to lead disodium edta.
PubMed:Calcium disodium EDTA in transfusion hemosiderosis.
None found
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