ethyl paraben
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    • Penta International Corporation
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      Product(s):
      05-40400 ETHYL-p-HYDROXYBENZOATE, Kosher
      05-40405 ETHYL-P-HYDROXYBENZOATE NF GRADE, Kosher
       
 
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ethyl 4-hydroxybenzoate (Click)
CAS Number: 120-47-8
ECHA EC Number:204-399-4
FDA UNII:14255EXE39
Beilstein Number:1101972
MDL:MFCD00002353
XlogP3:2.50 (est)
Molecular Weight:166.17630000
Formula:C9 H10 O3
BioActivity Summary:listing
NMR Predictor:Predict
Category:antioxidants and preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents:Search
PubMed: Search
NCBI: Search
 FDA/EU SANCO Petitions, Reviews, Notices:
EU SANCO Ethyl-p-hydroxybenzoate View-review
JECFA Food Additive: Ethyl p-Hydroxybenzoate
GSFA Codex: Ethyl para-hydroxybenzoate (214).
Flavis Number:09.367 (Old)
EU SANCO Food Flavourings:09.367  ethyl 4-hydroxybenzoate

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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed:No
Melting Point: 118.00 °C. @ 760.00 mm Hg
Boiling Point: 298.00 °C. @ 760.00 mm Hg
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Organoleptic Properties:
Odor Strength:low
Odor Description:
at 100.00 %. 
mild phenolic
  
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Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
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Suppliers:
Acme-Hardesty
Ethyl Paraben
Odor: characteristic
Use: Antimicrobial Preservative Used in Cosmetics and Personal Care.
Coompo
Ethylparaben from Plants ≥96%
For experimental / research use only.
ExtraSynthese
Ethyl-4-hydroxybenzoate (HPLC) ≥99%
For experimental / research use only.
Foodchem International
Ethyl Paraben
HallStar
CoSept(tm) E
Odor: characteristic
Use: CoSept E provides the good performance against Gram positive bacteria exhibited by all the parabens and has the same limitations regarding pH range (acidic only), system compatibility (avoid high levels of ethoxylates) and water solubility (limited). Ethylparaben has been used in combination with Propylparaben in oral preparations for controlling fermentative action. It can be used alone, but is generally used at 0.10 to 0.25% levels with other CoSepts as the antifungal portion of the preservative system.
Inoue Perfumery
ETHYL 4-HYDROXY BENZOATE
Kraft Chemical
Ethyl Paraben
Nanjing Jiancheng Chemical
Ethylparaben(Nipagin A)
Odor: characteristic
Use: Ethylparaben is mainly used as antiseptics in cosmetics, food and medicine. It is also can be used as feed preservatives and antiseptic for bacteria.
Penta International
ETHYL-P-HYDROXYBENZOATE NF GRADE, Kosher
Penta International
ETHYL-p-HYDROXYBENZOATE, Kosher
Santa Cruz Biotechnology
Ethyl Paraben
For experimental / research use only.
Sigma-Aldrich: Aldrich
Ethyl 4-hydroxybenzoate ReagentPlus®, 99%
For experimental / research use only.
TRI-K Industries
Trisept E
Zhejiang Taizhou TU-POLY
Ethylparaben
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Safety Information:
Oral/Parenteral Toxicity:
  oral-rabbit LD50  5000 mg/kg
(Sabalitschka & Neufeld-Crzellitzer,1954)

oral-rat LD  > 200 mg/kg
Acta Obstetrica et Gynaecologica Japonica, English Edition. Vol. 22, Pg. 94, 1975.

gavage-rat LD50  [sex: F] 4300 mg/kg
(CTFA, 1980b)

oral-mouse LD50  8000 mg/kg
(Sokol, 1952)

oral-mouse LD50  6008 mg/kg
(Sado, 1973)

oral-dog LD50  5000 mg/kg
(Sabalitschka & Neufeld-Crzellitzer, 1954)

oral-dog LD50  5000 mg/kg
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974.

oral-guinea pig LD50  2000 mg/kg
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974.

intraperitoneal-mouse LD50  520 mg/kg
Drug Standards. Vol. 20, Pg. 89, 1952.

oral-mouse LD50  3000 mg/kg
Bromatologia i Chemia Toksykologiczna. Vol. 14, Pg. 301, 1981.

oral-rabbit LD50  5000 mg/kg
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974.

Dermal Toxicity:
  Not determined
Inhalation Toxicity:
  Not determined
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Safety in Use Information:
Category:antioxidants and preservatives
Maximised Survey-derived Daily Intakes (MSDI-EU):10.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI):3900 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class:I
Recommendation for ethyl paraben usage levels up to:
 not for fragrance use.
Recommendation for ethyl paraben flavor usage levels up to:
 not for flavor use.
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.0000025.00000
Edible ices, including sherbet and sorbet (03.0): 10.0000050.00000
Processed fruit (04.1): 7.0000035.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000025.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 20.00000100.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
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Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
page or pdf
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
page or pdf
Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
page or pdf
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
page or pdf
Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009)
page or pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
page or pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
page or pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 4 (FGE.20Rev4): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
page or pdf
EPI System:View
Chemicalize.org:Calculate predicted properties
ECHA Data Sheet:View
Daily Med:search
NLM Hazardous Substances Data Bank:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):120-47-8
EPA ACToR:Toxicology Data
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:1
 ethyl 4-hydroxybenzoate
DTP/NCI:8510
Chemidplus:0000120478
RTECS:DH2190000 for cas# 120-47-8
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References:
 ethyl 4-hydroxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:120-47-8
Pubchem (cid):8434
Pubchem (sid):134975046
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Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
Metabolomics Database:Search
Export Tariff Code:2918.29.8000
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ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
•trade names: aseptoform e, bobomold oe, easeptol, ethyl butex, ethyl parasept, mycoten, napagin a, nipagina a, nipazin a, sobrol a, solbrol a, and tegosept e. •esters are usually sold in form which contains free phenolic groupparaben esters
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Potential Blenders and core components note
None Found
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Potential Uses:
 preservatives 
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Natural Occurrence in: note
 not found in nature
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Synonyms:
 benzoic acid, 4-hydroxy-, ethyl ester
4-carbethoxyphenol
p-carbethoxyphenol
para-carbethoxyphenol
 ethyl 4-hydroxybenzoate
 ethyl p-hydroxybenzoate
 ethyl para-hydroxybenzoate
 ethyl-4-hydroxybenzoate
 ethyl-p-hydroxybenzoate
 ethyl-para-hydroxybenzoate
 ethylparaben
4-hydroxy-benzoic acid ethyl ester
4-hydroxybenzoic acid ethyl ester
p-hydroxybenzoic acid ethyl ester
para-hydroxybenzoic acid ethyl ester
4-hydroxybenzoic acid ethylester
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click on the picture(s) below to
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Picture of molecule
Soluble in:
 alcohol
 water, 1894 mg/L @ 25 °C (est)
 water, 885 mg/L @ 25 °C (exp)
Insoluble in:
 water
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