EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ethoxyacetic acid
acetic acid, ethoxy-

Supplier Sponsors

CAS Number: 627-03-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:210-978-2
FDA UNII: 467VW095BX
Nikkaji Web:J1.694B
Beilstein Number:1743037
MDL:MFCD00004310
Molecular Weight:104.10536000
Formula:C4 H8 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.09700 to 1.10300 @ 20.00 °C.
Pounds per Gallon - (est).: 9.139 to 9.189
Refractive Index:1.41700 to 1.42000 @ 20.00 °C.
Flash Point: 208.00 °F. TCC ( 97.78 °C. )
Soluble in:
 water, 4.081e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Ethoxyacetic acid
Santa Cruz Biotechnology
For experimental / research use only.
Ethoxyacetic Acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
Ethoxyacetic Acid 98%
sds
TCI AMERICA
For experimental / research use only.
Ethoxyacetic Acid >98.0%(GC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for ethoxyacetic acid usage levels up to:
 not for fragrance use.
 
Recommendation for ethoxyacetic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):627-03-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :12301
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-ethoxyacetic acid
Chemidplus:0000627032
EPA/NOAA CAMEO:hazardous materials
RTECS:AH3600000 for cas# 627-03-2
 
References:
 2-ethoxyacetic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:627-03-2
Pubchem (cid):12301
Pubchem (cas):627-03-2
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB31212
FooDB:FDB003235
Export Tariff Code:2918.99.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 perilla leaf
Search Trop Picture
 
Synonyms:
 acetic acid, ethoxy-
2-ethoxyacetic acid
 

Articles:

PubMed:Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study.
PubMed:Identification and quantification of acidosis inducing metabolites in cases of alcohols intoxication by GC-MS for emergency toxicology.
PubMed:Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether.
PubMed:Urinary glycol ether metabolites in women and time to pregnancy: the PELAGIE cohort.
PubMed:Hematological effects of exposure to mixtures of selected ethylene glycol alkyl ethers in rats.
PubMed:Urinary biomarkers of exposure to glycol ethers and chlorinated solvents during pregnancy: determinants of exposure and comparison with indirect methods of exposure assessment.
PubMed:Chemical class-specific gene expression changes in the zebrafish embryo after exposure to glycol ether alkoxy acids and 1,2,4-triazole antifungals.
PubMed:Occurrence of emerging organic contaminants in a tropical urban catchment in Singapore.
PubMed:Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies.
PubMed:Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites.
PubMed:Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds.
PubMed:NP1EC degradation pathways under oxic and microxic conditions.
PubMed:Reproductive toxicity of ethylene glycol monoethyl ether in Aldh2 knockout mice.
PubMed:The alkoxyacetic acids as calcium and magnesium chelating agents in vitro.
PubMed:Inhibitory effect of ethylene glycol monoethyl ether on rat sperm motion.
PubMed:Gas chromatography analysis of urinary alkoxyacetic acids as biomarkers of exposure to aliphatic alkyl ethers.
PubMed:Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling.
PubMed:Health effects of exposure to ethylene glycol monoethyl ether in female workers.
PubMed:Determination of urinary metabolites of alkyl cellosolves by solid phase extraction and GC/FID.
PubMed:Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate.
PubMed:Percutaneous penetration and metabolism of 2-ethoxyethanol.
PubMed:A toxicokinetic study of inhaled ethylene glycol ethyl ether acetate and validation of a physiologically based pharmacokinetic model for rat and human.
PubMed:Evaluation of exposure to ethylene glycol monoethyl ether acetates and their possible haematological effects on shipyard painters.
PubMed:Improved method to measure urinary alkoxyacetic acids.
PubMed:Rat model for renal effects of 2-alkoxyalcohols and their acetates.
PubMed:Elimination of methoxyacetic acid and ethoxyacetic acid in rat.
PubMed:Decreased formation of ethoxyacetic acid from ethylene glycol monoethyl ether and reduced atrophy of testes in male rats upon combined administration with toluene and xylene.
PubMed:Urinary NAG and GAG as biomarkers of renal effects in exposure to 2-alkoxyalcohols and their acetates.
PubMed:Gender difference in the elimination of 2-methoxyethanol, methoxyacetic acid and ethoxyacetic acid in rat.
PubMed:Biomonitoring of technical grade 1-alkoxy-2-propanol acetates by analysing urinary 2-alkoxypropionic acids.
PubMed:Reproductive toxicology. Ethoxyacetic acid.
PubMed:Dermal absorption of vaporous and liquid 2-methoxyethanol and 2-ethoxyethanol in volunteers.
PubMed:Urinary alkoxyacetic acids and renal effects of exposure to ethylene glycol ethers.
PubMed:Bacterial degradation of glycol ethers.
PubMed:Role of biomarkers of exposure in the assessment of health risks.
PubMed:Mutagenicity of ethylene glycol ethers and of their metabolites in Salmonella typhimurium his-.
PubMed:Occupational exposure to organic solvents during paint stripping and painting operations in the aeronautical industry.
PubMed:Effect of dose on the disposition of 2-ethoxyethanol after inhalation by F344/N rats.
PubMed:Determination of urinary alkoxyacetic acids by a rapid and simple method for biological monitoring of workers exposed to glycol ethers and their acetates.
PubMed:Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers.
PubMed:Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case-control study.
PubMed:Applications of biological monitoring in occupational health practice: practical application of urinary 2-ethoxyacetic acid to assess exposure to 2-ethoxyethyl acetate in large format silk-screening operations.
PubMed:Comparative immunosuppression of various glycol ethers orally administered to Fischer 344 rats.
PubMed:Metabolism and disposition of diethylene glycol in rat and dog.
PubMed:Disposition of three glycol ethers administered in drinking water to male F344/N rats.
PubMed:Occupational chronic exposure to organic solvents. XIII. Glycolether exposure during the production of varnishes.
PubMed:Semen quality in workers exposed to 2-ethoxyethanol.
PubMed:Structure-activity relationships for the in vitro hematotoxicity of N-alkoxyacetic acids, the toxic metabolites of glycol ethers.
PubMed:Analysis of ethylene glycol ether metabolites in urine by extractive alkylation and electron-capture gas chromatography.
PubMed:An improved method for the determination in urine of alkoxyacetic acids.
PubMed:Comparative urinary excretion of ethoxyacetic acid in man and rat after single low doses of ethylene glycol monoethyl ether.
PubMed:The biological exposure index: its use in assessing chemical exposures in the workplace.
PubMed:Ethoxyacetic acid: a metabolite of ethylene glycol monoethyl ether acetate in man.
PubMed:Field study of the urinary excretion of ethoxyacetic acid during repeated daily exposure to the ethyl ether of ethylene glycol and the ethyl ether of ethylene glycol acetate.
PubMed:Comparison of the in vivo and in vitro testicular effects produced by methoxy-, ethoxy- and N-butoxy acetic acids in the rat.
PubMed:Urinary excretion of ethoxyacetic acid after experimental human exposure to ethylene glycol monoethyl ether.
PubMed:Methoxyacetic acid and ethoxyacetic acid inhibit mitochondrial function in vitro.
PubMed:In vivo and in vitro evaluations of spermatotoxicity induced by 2-ethoxyethanol treatment.
PubMed:Gas chromatographic determination of methoxyacetic and ethoxyacetic acid in urine.
PubMed:The teratogenic potential of alkoxy acids in post-implantation rat embryo culture: structure-activity relationships.
PubMed:Studies on the toxicity of some glycol ethers and alkoxyacetic acids in primary testicular cell cultures.
PubMed:Analyses of ethylene glycol monoalkyl ethers and their proposed metabolites in blood and urine.
PubMed:Testicular toxicity produced by ethylene glycol monomethyl and monoethyl ethers in the rat.
PubMed:Metabolism and excretion of 2-ethoxyethanol in the adult male rat.
PubMed:Ethoxyacetic acid and N-ethoxyacetylglycine: metabolites of ethoxyethanol (ethylcellosolve) in rats.
 
Notes:
Component of perilla leaf extract (Perilla frutescens)
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