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epichlorohydrin
1-chloro-2,3-epoxypropane

Supplier Sponsors

CAS Number: 106-89-8Picture of molecule3D/inchi
Other(deleted CASRN):109351-74-8
ECHA EINECS - REACH Pre-Reg:203-439-8
FDA UNII: 08OOR508C0
Nikkaji Web:J4.037A
Beilstein Number:0079785
MDL:MFCD00005132
XlogP3-AA:0.50 (est)
Molecular Weight:92.52405000
Formula:C3 H5 Cl O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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DG SANTE Food Contact Materials:epichlorohydrin
FDA Mainterm (IAUFC):106-89-8 ; EPICHLOROHYDRIN
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.18100 to 1.18400 @ 20.00 °C.
Pounds per Gallon - (est).: 9.839 to 9.864
Refractive Index:1.43600 to 1.44000 @ 20.00 °C.
Flash Point: 93.00 °F. TCC ( 33.89 °C. )
Soluble in:
 water, 6.59E+04 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Covalent Chemical
Epichlorohydrin
Shiva Chemicals and Pharmaceuticals
Epichlorohydrin
Sigma-Aldrich: Aldrich
For experimental / research use only.
epiChlorohydrin ≥99%
TCI AMERICA
For experimental / research use only.
epiChlorohydrin >99.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-guinea pig LD50 118 mg/kg
Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972.

oral-guinea pig LD50 280 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 46, 1968.

intraperitoneal-mouse LD50 170 mg/kg
Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972.

oral-mouse LD50 195 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 46, 1968.

intraperitoneal-rabbit LD50 160 mg/kg
Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972.

oral-rabbit LD50 345 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 46, 1968.

intraperitoneal-rat LD50 113 mg/kg
Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972.

intravenous-rat LD50 154 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 41, 1974.

oral-rat LD50 90 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 63, 1948.

Dermal Toxicity:
skin-mouse LD50 250 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 64, 1982.

subcutaneous-mouse LDLo 250 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BEHAVIORAL: MUSCLE WEAKNESS
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 2, Pg. 28, 1961.

skin-rabbit LD50 515 mg/kg
Personal Communication from M.A. Wolf, Dow Chemical Co., Midland, MI 48640, Jan. 18, 1977Vol. 18JAN1977

subcutaneous-rat LD50 150 mg/kg
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 28, Pg. 505, 1967.

skin-rat LDLo 1000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER
University of California, Berkeley, Publications in Pharmacology. Vol. 2, Pg. 69, 1941.

Inhalation Toxicity:
inhalation-human TCLo 20 ppm
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
"Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968Vol. -, Pg. 108, 1968.

inhalation-human TCLo 40 ppm/2H
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 240, 1969.

inhalation-mouse LCLo 72000 mg/m3/9M
Journal of Biomedical Materials Research. Vol. 8, Pg. 11, 1974.

inhalation-rat LC50 250 ppm/8H
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 41, 1974.

 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for epichlorohydrin usage levels up to:
 not for fragrance use.
 
Recommendation for epichlorohydrin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):106-89-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7835
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(chloromethyl)oxirane
Chemidplus:0000106898
EPA/NOAA CAMEO:hazardous materials
RTECS:106-89-8
 
References:
 2-(chloromethyl)oxirane
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:106-89-8
Pubchem (cid):7835
Pubchem (sid):134972083
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C14449
HMDB (The Human Metabolome Database):HMDB34232
FooDB:FDB012543
Export Tariff Code:2910.30.0000
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
1-chloro-2,3-epoxypropane
2-(chloromethyl)oxirane
1,2-epoxy-3-chloropropane
 glycidyl chloride
 propane, 1-chloro-2,3-epoxy-
 
 
Notes:
Used for cross-linking dextrose units in food starch
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