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ellipticine
6H-pyrido(4,3-b)carbazole, 5,11-dimethyl-

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Name:5,11-dimethyl-6H-pyrido[4,3-b]carbazole
CAS Number: 519-23-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-264-0
FDA UNII: 117VLW7484
Nikkaji Web:J6.591I
Beilstein Number:0221300
MDL:MFCD00010524
XlogP3:4.80 (est)
Molecular Weight:246.31258000
Formula:C17 H14 N2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 313.00 °C. @ 760.00 mm Hg
Boiling Point: 495.40 °C. @ 760.00 mm Hg (est)
Flash Point: 441.00 °F. TCC ( 227.10 °C. ) (est)
logP (o/w): 4.800
Soluble in:
 water, 0.1532 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Ellipticine 0.98
Odor: characteristic
Use: Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Ellipticine is also a natural product, isolated in 1959 from the Australian evergreen tree of the Apocynaceae family.
EMD Millipore
For experimental / research use only.
Ellipticine
sds
ExtraSynthese
For experimental / research use only.
Ellipticine
Santa Cruz Biotechnology
For experimental / research use only.
Ellipticine ≥98%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 150 mg/kg
Biomedicine. Vol. 21, Pg. 101, 1974.

intravenous-mouse LD50 19500 ug/kg
"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 555, 1989.

oral-mouse LD50 178 mg/kg
"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 555, 1989.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for ellipticine usage levels up to:
 not for fragrance use.
 
Recommendation for ellipticine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3213
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
5,11-dimethyl-6H-pyrido[4,3-b]carbazole
Chemidplus:0000519233
RTECS:UU8825000 for cas# 519-23-3
 
References:
 5,11-dimethyl-6H-pyrido[4,3-b]carbazole
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3213
Pubchem (sid):135025341
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C09154
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.90.8000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 celiptium
 CP 5
5,11-dimethyl-6H-pyrido(4,3-b)carbazole
 elliptisine
6H-pyrido(4,3-b)carbazole, 5,11-dimethyl-
 tcmdc-125546
 

Articles:

PubMed:Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).
PubMed:A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.
PubMed:Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors.
PubMed:EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs.
PubMed:Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment: CYP-dependent activation of food and environmental mutagens.
PubMed:Major involvement of rabbit liver cytochrome P4501A in thiabendazole 5-hydroxylation.
PubMed:Metabolic activation of the food mutagen 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]indole (Trp-P-1) in endothelial cells of cytochrome P-450-induced mice.
PubMed:Metabolic activation of the food mutagen Trp-P-1 in endothelial cells of heart and kidney in cytochrome P450-induced mice.
PubMed:In vitro metabolism of teratogens by differentiating rat embryo cells.
 
Notes:
None found
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