EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

DL-2-amino-3-hydroxybutanoic acid

Supplier Sponsors

Name:2-amino-3-hydroxybutanoic acid
CAS Number: 80-68-2Picture of molecule3D/inchi
Other(deleted CASRN):1187422-62-3
ECHA EINECS - REACH Pre-Reg:201-300-6
Nikkaji Web:J1.252A
Beilstein Number:1721647
XlogP3:-2.90 (est)
Molecular Weight:119.12033000
Formula:C4 H9 N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
EFSA/JECFA Comments:
Register name to be changed to DL-threonine (racemate) (EFSA, 2006b)
Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
DG SANTE Food Flavourings:17.021 DL-threonine
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 230.00 to 244.00 °C. @ 760.00 mm Hg
Boiling Point: 345.80 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000003 mmHg @ 25.00 °C. (est)
Flash Point: 325.00 °F. TCC ( 162.78 °C. )
logP (o/w): -1.136 (est)
Soluble in:
 water, 2.79e+005 mg/L @ 25 °C (est)
 water, 2.01E+05 mg/L @ 25 °C (exp)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
hair conditioning
hair straightening agents
hair waving agents
BOC Sciences
For experimental / research use only.
H-DL-Thr-OH 99%
Glentham Life Sciences
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Sigma-Aldrich: Sigma
For experimental / research use only.
DL-Threonine ≥90% (TLC)
For experimental / research use only.
DL-Threonine >98.0%(T)
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
flavoring agents
Recommendation for dextro,laevo-threonine usage levels up to:
 not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 49000 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): --
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): --
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): --
Chewing gum (05.3): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): --
Bakery wares (07.0): --
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): --
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 150.00000-
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): --
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): --
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Amino acids from chemical group 34 Flavouring Group Evaluation 26, Revision 1 - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 79, (FGE.79)[1] - Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) structurally related to amino acids from chemical group 34 evaluated by EFSA in FGE.26Rev1 (2008)
View page or View pdf

Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):80-68-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :205
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2-amino-3-hydroxybutanoic acid
 2-amino-3-hydroxybutanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:80-68-2
Pubchem (cid):205
Pubchem (sid):135025753
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.49.4050
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
 antistatic agents
Occurrence (nature, food, other):note
 found in nature
2-amino-3-hydroxybutanoic acid
dextro,laevo-2-amino-3-hydroxybutanoic acid
DL-2-amino-3-hydroxybutanoic acid
(±)-2-amino-3-hydroxybutyric acid
 threonine, DL-


PubMed:Improving the electro-transformation efficiency of Corynebacterium glutamicum by weakening its cell wall and increasing the cytoplasmic membrane fluidity.
J-Stage:Effects of Dietary Low Level of Threonine and Lysine on the Accumulation of Intramuscular Fat in Porcine Muscle
PubMed:HeartWare Ventricular Assist Device Placement in a Patient With Corrected Dextro-Transposition of Great Arteries: A Case Report and Its Clinical Challenges.
PubMed:Plasmid transformation of Weissella paramesenteroides DX by electroporation.
PubMed:Prevalence, correlates and management of type 2 diabetes mellitus in Lebanon: findings from a national population-based study.
PubMed:Assessing the chiral switch: approval and use of single-enantiomer drugs, 2001 to 2011.
PubMed:Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.
PubMed:Dexmethylphenidate extended-release capsules for attention deficit hyperactivity disorder.
PubMed:Identification and estimation of the levo isomer in raw materials and finished products containing atropine and/or hyoscyamine.
PubMed:[Judicious use of anorectics].
PubMed:Blood-brain transport of triiodothyronine is reduced in aged rats.
PubMed:Reduction of food intake by manipulation of central serotonin. Current experimental results.
PubMed:Improved electroporation efficiency of intact Lactococcus lactis subsp. lactis cells grown in defined media.
PubMed:Oral self-administration of N-allylnormetazocine (SKF-10,047) stereoisomers in rhesus monkeys: substitution during phencyclidine self-administration and withdrawal.
PubMed:Medial hypothalamic serotonin: effects on deprivation and norepinephrine-induced eating.
PubMed:Effects of LY150720 (picenadol), a novel mixed-action opioid, on schedule-controlled responding in the squirrel monkey.
PubMed:[Chemical and nutritional evaluation of triticale (Secale sp.) cultivated in Chile].
PubMed:Discriminative stimulus properties of ketamine stereoisomers in phencyclidine-trained rats.
PubMed:[Studies on the methionine-threonine imbalance in chicks].
PubMed:The effects of anorexic doses of dextro-amphetamine on the ventromedial-hypothalamic hyperphagic rat.
PubMed:d-Amphetamine-chlorpromazine antagonism in a food reinforced operant.
None found
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy