EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

dimethyl amine
methanamine, N-methyl-

Supplier Sponsors

CAS Number: 124-40-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-697-4
FDA UNII: ARQ8157E0Q
Nikkaji Web:J2.933E
Beilstein Number:0605257
MDL:MFCD00008288
CoE Number:10473
XlogP3-AA:-0.20 (est)
Molecular Weight:45.08479000
Formula:C2 H7 N
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:food-contact surface of paper and paperboard
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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NCBI:Search
FDA Mainterm (SATF):124-40-3 ; DIMETHYLAMINE
FDA Regulation:
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart A--Polymer Substances and Polymer Adjuvants for Food Treatment
Sec. 173.20 Ion-exchange membranes.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.
 
Physical Properties:
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 6.00 to 7.00 °C. @ 760.00 mm Hg
Boiling Point: 6.80 °C. @ 760.00 mm Hg
Vapor Pressure:1520.280029 mmHg @ 25.00 °C. (est)
Flash Point: -69.00 °F. TCC ( -56.10 °C. ) (est)
logP (o/w): -0.380
Soluble in:
 water, 1630000 mg/L @ 40C
 water, 1e+006 mg/L @ 25 °C (est)
 water, 1.63E+06 mg/L @ 40C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses:
 
Suppliers:
BASF
Dimethylamine
Eastman Chemical
Dimethylamine anhydrous
Odor: characteristic
Use: DMA is a versatile building block that is used in a wide variety of applications. We produces a range of high volume DMA based molecules like DMF and DMAC, DMAE, DMA-based dithiocarbamates,
EMD Millipore
For experimental / research use only.
Dimethylamine
OQEMA
Dimethylamine
Penta International
DIMETHYLAMINE 40% AQUEOUS SOLUTION
Sigma-Aldrich: Aldrich
For experimental / research use only.
Dimethylamine anhydrous, ≥99%
Silver Fern Chemical
Dimethylamine
Odor: characteristic
Use: DMA is used as an acid-gas absorbent, a solvent for antioxidants, a flotation agent, a gasoline stabilizer, and as a reagent for magnesium. It is also used in dyes, textiles, rubbers, electroplating, pesticide, and cleaning compounds.
Taminco (Eastman)
dimethylamine
TCI AMERICA
For experimental / research use only.
Dimethylamine (ca. 10% in Tetrahydrofuran, ca. 2mol/L)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 698 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS
Hygiene and Sanitation Vol. 32(6), Pg. 329, 1967.

oral-rabbit LD50 240 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: EXCITEMENT
Hygiene and Sanitation Vol. 32(6), Pg. 329, 1967.

oral-mouse LD50 316 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Hygiene and Sanitation Vol. 32(6), Pg. 329, 1967.

oral-guinea pig LD50 240 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: EXCITEMENT
Hygiene and Sanitation Vol. 32(6), Pg. 329, 1967.

intraperitoneal-mouse LD50 736 mg/kg
Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.

intravenous-rabbit LDLo 4000 mg/kg
"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 509, 1989.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-rat LC50 4540 ppm/6H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
American Industrial Hygiene Association Journal. Vol. 43, Pg. 411, 1982.

inhalation-mouse LC50 4725 ppm/2H
American Industrial Hygiene Association Journal. Vol. 43, Pg. 411, 1982.

inhalation-mammal (species unspecified) LC50 3700 mg/m3
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.

 
Safety in Use Information:
Category:
food-contact surface of paper and paperboard
Recommendation for dimethyl amine usage levels up to:
 not for fragrance use.
 
Recommendation for dimethyl amine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):124-40-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :674
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
N-methylmethanamine
Chemidplus:0000124403
EPA/NOAA CAMEO:hazardous materials
RTECS:124-40-3
 
References:
 N-methylmethanamine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:124-40-3
Pubchem (cid):674
Pubchem (sid):134975214
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C00543
HMDB (The Human Metabolome Database):HMDB00087
FooDB:FDB012589
Export Tariff Code:2921.19.6190
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grades: technical (anhydrous; 25% and 40% aq soln); 99%. •40% and 60% solutions •it is usually marketed in compressed liquid form in tubes or as a 33% aq soln
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 banana fruit
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 barley seed
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 cabbage leaf
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 celery stem
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 corn seed
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 dragonwort
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 grape fruit juice
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 rice seed
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 soybean seed
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Synonyms:
 dimethylamine
N,N-dimethylamine
 methanamine, N-methyl-
N-methyl methanamine
N-methylmethanamine
 
 
Notes:
Aminating agent in the manuf. of ion-exchange resins for food processing Dimethylamine (DMA) is an organic secondary amine. It is a colorless, liquefied and flammable gas with an ammonia and fish-like odor. Dimethylamine is abundantly present in human urine. Main sources of urinary DMA have been reported to include trimethylamine N-oxide, a common food component, and asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthesis. ADMA is excreted in the urine in part unmetabolized and in part after hydrolysis to DMA by dimethylarginine dimethylaminohydrolase (DDAH). Statistically significant increases in urinary DMA have been found in individuals after the consumption of fish and seafoods. The highest values were obtained for individuals that consumed coley, squid and whiting with cod, haddock, sardine, skate and swordfish (PMID: 18282650). As a pure chemical substance Dimethylamine is used as dehairing agent in tanning, in dyes, in rubber accelerators, in soaps and cleaning compounds and as an agricultural fungicide. In the body, DMA also undergoes nitrosation under weak acid conditions to give dimethlynitrosamine.; Dimethylamine is a precursor to several industrially significant compounds. It reacts with carbon disulfide to give dimethyldithiocarbamate, a precursor to a family of chemicals widely used in the vulcanization of rubber. The solvents dimethylformamide and dimethylacetamide are derived from dimethylamine. It is raw material for the production of many agrichemicals and pharmaceuticals, such as dimefox and diphenhydramine, respectively. The chemical weapon tabun is derived from dimethylamine. The surfactant lauryl dimethylamine oxide is found in soaps and cleaning compounds. Unsymmetrical dimethylhydrazine, a rocket fuel, is prepared from dimethylamine.; Dimethylamine is an organic compound with the formula (CH3)2NH. This secondary amine is a colorless, flammable liquified gas with an ammonia- or fish-like odor. Dimethylamine is generally encountered as a solution in water at concentrations up to around 40%. In 2005, an estimated 270,000 tons were produced.; The molecule consists of a nitrogen atom with two methyl substituents and one proton. Dimethylamine is a base and the pKa of the ammonium salt CH3-NH2+-CH3 is 10.73, a value above methylamine (10.64) and trimethylamine (9.79). Dimethylamine reacts with acids to form salts, such as dimethylamine hydrochloride, an odorless white solid with a melting point of 171.5 C. Dimethylamine is produced by catalytic reaction of methanol and ammonia at elevated temperatures and high pressure:
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