dimethyl pyrocarbonate
dicarbonic acid, dimethyl ester

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  Product(s):
  4525-33-1 dimethyl dicarbonate 95%

CAS Number: 4525-33-1 3D/inchi ECHA EINECS - REACH Pre-Reg: 224-859-8 FDA UNII: 1AY9229ZMG Nikkaji Web: J205.896K Beilstein Number: 0956715 MDL: MFCD00008419 XlogP3-AA: 0.70 (est) Molecular Weight: 134.08782000 Formula: C4 H6 O5 NMR Predictor: Predict (works with chrome, Edge or firefox) Category:antimicrobial agents   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Perfumer and Flavorist: Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   FDA/DG SANTE Petitions, Reviews, Notices: EU SANCO Dimethyl dicarbonate View - review FCN 35 Dimethyl dicarbonate View - notice FCN 483 Dimethyl dicarbonate View - notice JECFA Food Additive: Dimethyl Dicarbonate GSFA Codex: Dimethyl dicarbonate (242) DG SANTE Food Additives: dimethyl dicarbonate FDA Mainterm (SATF): 4525-33-1 ; DIMETHYL DICARBONATE FDA Regulation: FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart B--Food Preservatives Sec. 172.133 Dimethyl dicarbonate.   Physical Properties: Appearance: colorless clear liquid (est) Assay: 99.80 to 100.00 Food Chemicals Codex Listed: No Specific Gravity: 1.25000 @ 25.00 °C. Boiling Point: 45.00 to 46.00 °C. @ 5.00 mm Hg Vapor Pressure: 1.399000 mmHg @ 25.00 °C. (est) Flash Point: 176.00 °F. TCC ( 80.00 °C. ) logP (o/w): 0.082 (est) Soluble in:   water, dec.   toluene   water, 4.771e+005 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. dimethyl dicarbonate 95% EMD Millipore For experimental / research use only. Dimethyl Pyrocarbonate sds Santa Cruz Biotechnology For experimental / research use only. Dimethyl dicarbonate Sigma-Aldrich: Sigma For experimental / research use only. Dimethyl Pyrocarbonate for histidine methylation sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: oral-rat LD50 260 mg/kg Weisheng Dulixue Zazhi. Journal of Health Toxicology. Vol. 6, Pg. 104, 1992. oral-mouse LD50 589 mg/kg Weisheng Dulixue Zazhi. Journal of Health Toxicology. Vol. 6, Pg. 104, 1992. Dermal Toxicity: Not determined Inhalation Toxicity: inhalation-rat LC50 711 mg/m3/4H BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: DYSPNEA National Technical Information Service. Vol. OTS0545284   Safety in Use Information: Category: antimicrobial agents Recommendation for dimethyl pyrocarbonate usage levels up to:   not for fragrance use.   Recommendation for dimethyl pyrocarbonate flavor usage levels up to:   not for flavor use.   Safety References: European Food Safety Authority (EFSA) reference(s): Scientific opinion on the re-evaluation of dimethyl dicarbonate (DMDC, E 242) as a food additive View page or View pdf EPI System: View AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA Substance Registry Services (TSCA):4525-33-1 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :3086 National Institute of Allergy and Infectious Diseases:Data WISER:UN 2927 WGK Germany:3 methoxycarbonyl methyl carbonate Chemidplus:0004525331 RTECS:HT0362500 for cas# 4525-33-1   References:   methoxycarbonyl methyl carbonate NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 4525-33-1 Pubchem (cid): 3086 Pubchem (sid): 135020470   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements FDA Substances Added to Food (formerly EAFUS): View HMDB (The Human Metabolome Database): HMDB32872 FooDB: FDB010852 Export Tariff Code: 2920.90.5000 FDA Listing of Food Additive Status: View ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms:   carbonic acid, methoxycarbonyl methyl ester   dicarbonic acid dimethyl ester   dicarbonic acid, dimethyl ester   dimethyl dicarbonate   dimethyl oxydiformate   dimethyldicarbonate   DMPC   formic acid, oxydi-, dimethyl ester   methoxycarbonyl methyl carbonate   pyrocarbonic acid dimethyl ester   velcorin   Articles:   None found yet. Try the PubMed Search.

Notes: Yeast inhibitor and preservative for alcoholic beverages esp. low alcohol wines Dimethyl dicarbonate or DMDC is a colourless liquid with a sharp odour. Its primary use is as a beverage preservative and or processing aid or sterilant (INS No. 242), and acts by inhibiting the enzymes acetate kinase and L-glutamic acid decarboxylase. It has also been proposed that methoxycarbonylation of the histidine part of the enzymes alcohol dehydrogenase and glyceraldehyde 3-phosphate dehydrogenase by DMDC inhibits these essential enzymes also. Once it has been added to beverages, the efficacy of the chemical is provided by the following reactions: