pentetic acid
acetic acid, 2,2',2'',2'''-[[(carboxymethyl)imino]bis(2, 1-ethanediylnitrilo)]tetrakis-
an iron chelating agent with properties like edetic acid. dtpa has also been used as a chelator for other metals, such as plutonium.
  • Charkit Chemical
    • Charkit Chemical Corporation
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      D0504 Diethylenetriaminepentaacetic Acid >98.0%(T)
Synonyms   Articles   Notes   Search
2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid (Click)
CAS Number: 67-43-6Picture of molecule
Other: 13407-13-1
ECHA EINECS - REACH Pre-Reg: 200-652-8
Nikkaji Web: J2.813D
Beilstein Number: 1810219
MDL: MFCD00004289
XlogP3-AA: -8.50 (est)
Molecular Weight: 393.35031000
Formula: C14 H23 N3 O10
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: chelating agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: white crystalline solid (est)
Assay: 90.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 721.00 to  722.00 °C. @ 760.00 mm Hg (est)
Flash Point: 734.00 °F. TCC ( 389.90 °C. ) (est)
logP (o/w): -1.361 (est)
Soluble in:
 water, 4800 mg/L @ 25 °C (exp)
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Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: chelating agents
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BOC Sciences
For experimental / research use only.
DTPA (Pentetic Acid) > 95%
Odor: characteristic
Use: Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.
Charkit Chemical
Dow Chemical
VERSENEX DTPA Acid Chelating Agent
Santa Cruz Biotechnology
For experimental / research use only.
Diethylenetriaminepentaacetic acid ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Diethylenetriaminepentaacetic acid ≥98% (titration)
Strem Chemicals
For experimental / research use only.
Diethylenetriaminepentaacetic acid, 98.5% DTPA (USP)
For experimental / research use only.
Diethylenetriaminepentaacetic Acid >98.0%(T)
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50  587 mg/kg
Toxicology Letters. Vol. 32, Pg. 37, 1986.

intraperitoneal-mouse LD50  543 mg/kg
Archives of Toxicology. Vol. 57, Pg. 212, 1985.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: chelating agents
Recommendation for pentetic acid usage levels up to:
 not for fragrance use.
Recommendation for pentetic acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 67-43-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3053
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
Chemidplus: 0000067436
RTECS: MB8205000 for cas# 67-43-6
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 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 67-43-6
Pubchem (cid): 3053
Pubchem (sid): 134970715
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): D05422
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2922.49.4050
Household Products: Search
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
pentetate calcium trisodium injection contains the sodium salt of calcium diethylenetriaminepentaacetate. pentetate calcium trisodium
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Potential Blenders and core components note
None Found
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Potential Uses:
 chelating agents 
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Occurrence (nature, food, other): note
 not found in nature
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 acetic acid, ((carboxymethylimino)bis(ethylenenitrilo))tetra-
 acetic acid, [(carboxymethylimino)bis(ethylenenitrilo)]tetra-
 acetic acid, {2,2',2'',2'''-[[(carboxymethyl)imino]bis(2,} 1-ethanediylnitrilo)\]tetrakis-
 acetic acid, 2,2',2'',2'''-(((carboxymethyl)imino)bis(2,1-ethanediylnitrilo))tetrakis-
 acetic acid, 2,2',2'',2'''-[[(carboxymethyl)imino]bis(2, 1-ethanediylnitrilo)]tetrakis-
N-carboxymethyl iminobis(ethylene nitrilo)tetra(acetic acid)
2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
2-{[2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)ethyl](carboxymethyl)amino}acetic acid
2-(bis{2-[bis(carboxymethyl)amino]ethyl}amino)acetic acid
(((carboxymethyl)imino)bis(ethylenenitrilo))tetraacetic acid
[[(carboxymethyl)imino]bis(1,2-ethanediylnitrilo)tetraacetic acid]
[[(carboxymethyl)imino]bis(ethylenenitrilo)]tetraacetic acid
(carboxymethylimino)bis(ethylenenitrilo)tetraacetic acid
N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid)
 diethylene triamine pentaacetic acid
 diethylenetriamine pentaacetic acid
 diethylenetriamine-N,N,N',N'',N''-pentaacetic acid
(diethylenetriamine)pentaacetic acid
 diethylenetriaminepentaacetic Acid
1,1,4,7,7-diethylenetriaminepentaacetic acid
N,N,N',N'',N''-diethylenetriaminepentaacetic acid
 diethylenetriaminepentacetic acid
(diethylenetrinitrilo)pentaacetic acid
 glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-
 glycine, N,N-bis[2-[bis (carboxymethyl)amino]ethyl]-
3,6,9-triazaundecanedioic acid, 3,6,9-tris(carboxymethyl)-
 versenex DTPA
Synonyms   Articles   Notes   Search   Top
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PubMed: Cholesterol-diethylenetriaminepentaacetate complexed with thulium ions integrated into bicelles to increase their magnetic alignability.
PubMed: Oriented immobilization of His-tagged protein on a redox active thiol derivative of DPTA-Cu(II) layer deposited on a gold electrode--the base of electrochemical biosensors.
PubMed: Effect of inorganic and organic copper fertilizers on copper nutrition in Spinacia oleracea and on labile copper in soil.
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PubMed: PET imaging of tumor angiogenesis in mice with VEGF-A-targeted (86)Y-CHX-A″-DTPA-bevacizumab.
PubMed: Novel type of bicellar disks from a mixture of DMPC and DMPE-DTPA with complexed lanthanides.
PubMed: Mycorrhizal colonization and grain Cd concentration of field-grown durum wheat in response to tillage, preceding crop and phosphorus fertilization.
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PubMed: Meal-induced acceleration of tablet transit through the human small intestine.
PubMed: Characterization of monoclonal antibodies for lead-chelate complexes: applications in antibody-based assays.
PubMed: Influence of soil type on the mobility and bioavailability of chelated zinc.
PubMed: Metal contamination in urban soils of coastal Tuscany (Italy).
PubMed: Evaluation of extractants for estimation of the phytoavailable trace metals in soils.
PubMed: Transfer characteristics of cadmium and lead from soil to the edible parts of six vegetable species in southeastern China.
PubMed: Effect of cadmium on microbial activity and a ryegrass crop in two semiarid soils.
PubMed: Role of reactive oxygen species in zinc deficiency-induced hepatic stellate cell activation.
PubMed: Browning and decomposed products of model orange juice.
PubMed: Effect of DTPA on the nephrotoxicity induced by uranium in the rat.
PubMed: Effects of zinc complexes on the distribution of zinc in calcareous soil and zinc uptake by maize.
PubMed: Relationships between chromium biomagnification ratio, accumulation factor, and mycorrhizae in plants growing on tannery effluent-polluted soil.
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PubMed: Chelation of extracellular zinc inhibits proliferation in 3T3 cells independent of insulin-like growth factor-I receptor expression.
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PubMed: Lipid peroxidation in linoleic acid micelles caused by H2O2 in the presence of myoglobin.
PubMed: Effect of bethanechol or erythromycin on gastric emptying in horses.
PubMed: Comparative acute and chronic toxicity of diethylenetriamine pentaacetic acid (DTPA) and ferric-complexed DTPA to Daphnia carinata.
PubMed: Inhibition of renal uptake of indium-111-DTPA-octreotide in vivo.
PubMed: The relationship between gut hormone secretion and gastric emptying in different phases of the migrating motor complex.
PubMed: Functional characteristics of canine pylorus in health, with pyloroplasty, and after pyloric reconstruction.
PubMed: Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes.
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PubMed: Use of genetically engineered lipid-tagged antibody to generate functional europium chelate-loaded liposomes. Application in fluoroimmunoassay.
PubMed: Toxicity of DTPA to Daphnia carinata as modified by oxygen stress and food limitation.
PubMed: Somatostatin receptor imaging of neuroendocrine tumors with indium-111 pentetreotide (Octreoscan).
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PubMed: First peptide agent enters clinical arena.
PubMed: Delayed gastric emptying of both the liquid and solid components of a meal in chronic liver disease.
PubMed: Inter- and intrasubject variability of solid and liquid gastric emptying parameters. A scintigraphic study in healthy subjects and diabetic patients.
PubMed: Effects of erythromycin on gastric emptying, alcohol absorption and small intestinal transit in normal subjects.
PubMed: Serial nonenhancing magnetic resonance imaging scans of high grade glioblastoma multiforme.
PubMed: Scintigraphic quantitation of gastrointestinal motor activity and transport: oesophagus and stomach.
PubMed: Physical properties of starch meals in vivo and in vitro and their influence on gastric emptying and oral glucose tolerance test.
PubMed: Relationships between oesophageal transit and solid and liquid gastric emptying in diabetes mellitus.
PubMed: A model of gastric emptying in cats shows solid emptying is promoted by MK-329: a CCK antagonist.
PubMed: Safety considerations in MR imaging.
PubMed: Hepatobiliary and gastrointestinal imaging after pancreaticoduodenectomy--a comparative study on Billroth I and Billroth II reconstructions.
PubMed: Gadopentetate dimeglumine: observations on the clinical research process.
PubMed: Effects of liquid versus solid diet on colonic transit in humans. Evaluation by standard colonic transit scintigraphy.
PubMed: Time-resolved fluoroimmunoassay of aflatoxins.
PubMed: [Standardization of the method of gastric emptying analysis].
PubMed: Opening of the blood-brain barrier by intravenous contrast media in euvolemic and dehydrated rabbits.
PubMed: [Gastroesophageal reflux after esophageal surgery--evaluations based on esophageal transit scintigram].
PubMed: Gastrointestinal scintigraphy with 99mTc-DTPA labeled tablets in fed and fasting subjects.
PubMed: Biphasic nature of gastric emptying.
PubMed: [A study of hepato-biliary and alimentary scintigrams using a triple tracer method].
PubMed: Radionuclide studies on gastric evacuatory function in health and in the duodenal ulcer disease. I. Types of solid meal distribution within the stomach and their relation to gastric emptying.
PubMed: Emptying of the terminal ileum in intact humans. Influence of meal residue and ileal motility.
PubMed: Human brain infarcts: Gd-DTPA-enhanced MR imaging.
PubMed: Gastric emptying disorders.
PubMed: Reduction of 85Sr, 137Cs, 131I and 141Ce retention in rats by simultaneous oral administration of calcium alginate, ferrihexacyanoferrate(II), KI and Zn-DTPA.
PubMed: Gastric emptying measurements: delayed and complex emptying patterns without appropriate correction.
PubMed: Estimation of gastric residence time of the Heidelberg capsule in humans: effect of varying food composition.
PubMed: Disorders of gastric emptying and the application of radionuclide techniques.
PubMed: Intestinal transit of solid and liquid components of a meal in health.
PubMed: Abnormalities of esophageal and gastric emptying in progressive systemic sclerosis.
PubMed: Gastric emptying of solid radiopaque markers: studies in healthy subjects and diabetic patients.
PubMed: Influence of meal weight and caloric content on gastric emptying of meals in man.
PubMed: [Studies on the gastric emptying related to the types of stomach forms in healthy subjects].
PubMed: Technical factors in gastric emptying studies.
PubMed: Validation of corrections for errors in collimation during measurement of gastric emptying of nuclide-labeled meals.
PubMed: Some factors influencing the uptake of plutonium-239 by pea plants.
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