pentetic acid
acetic acid, 2,2',2'',2'''-[[(carboxymethyl)imino]bis(2, 1-ethanediylnitrilo)]tetrakis-
 
Notes:
an iron chelating agent with properties like edetic acid. dtpa has also been used as a chelator for other metals, such as plutonium.
  • Charkit Chemical
    • Charkit Chemical Corporation
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      Since 1982, Charkit has been committed to expanding the markets we serve and our roster of products and services continues to grow with us. Personal care ingredients now include a substantial array of luxury and exotic components. Substantial inroads have been made in the nutraceutical and resins markets, with a growing roster of versatile and unique ingredients. And we continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions.
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    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
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      D0504 Diethylenetriaminepentaacetic Acid >98.0%(T)
       
Synonyms   Articles   Notes   Search
2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid (Click)
CAS Number: 67-43-6Picture of molecule
Other: 13407-13-1
ECHA EINECS - REACH Pre-Reg: 200-652-8
FDA UNII: 7A314HQM0I
Nikkaji Web: J2.813D
Beilstein Number: 1810219
MDL: MFCD00004289
XlogP3-AA: -8.50 (est)
Molecular Weight: 393.35031000
Formula: C14 H23 N3 O10
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: chelating agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
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US Patents: Search
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PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: white crystalline solid (est)
Assay: 90.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 721.00 to  722.00 °C. @ 760.00 mm Hg (est)
Flash Point: 734.00 °F. TCC ( 389.90 °C. ) (est)
logP (o/w): -1.361 (est)
Soluble in:
 water, 4800 mg/L @ 25 °C (exp)
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Organoleptic Properties:
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: chelating agents
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Suppliers:
Charkit Chemical
DISSOLVINE DZ
Dow Chemical
VERSENEX DTPA Acid Chelating Agent
Santa Cruz Biotechnology
For experimental / research use only.
Diethylenetriaminepentaacetic acid ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Diethylenetriaminepentaacetic acid ≥98% (titration)
Strem Chemicals
For experimental / research use only.
Diethylenetriaminepentaacetic acid, 98.5% DTPA (USP)
TCI AMERICA
For experimental / research use only.
Diethylenetriaminepentaacetic Acid >98.0%(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50  587 mg/kg
LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: AGGRESSION
Toxicology Letters. Vol. 32, Pg. 37, 1986.

intraperitoneal-mouse LD50  543 mg/kg
Archives of Toxicology. Vol. 57, Pg. 212, 1985.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: chelating agents
Recommendation for pentetic acid usage levels up to:
 not for fragrance use.
 
Recommendation for pentetic acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 67-43-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3053
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
Chemidplus: 0000067436
RTECS: MB8205000 for cas# 67-43-6
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References:
 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 67-43-6
Pubchem (cid): 3053
Pubchem (sid): 134970715
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): D05422
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2922.49.4050
Household Products: Search
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
pentetate calcium trisodium injection contains the sodium salt of calcium diethylenetriaminepentaacetate. pentetate calcium trisodium
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 chelating agents 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 acetic acid, ((carboxymethylimino)bis(ethylenenitrilo))tetra-
 acetic acid, [(carboxymethylimino)bis(ethylenenitrilo)]tetra-
 acetic acid, {2,2',2'',2'''-[[(carboxymethyl)imino]bis(2,} 1-ethanediylnitrilo)\]tetrakis-
 acetic acid, 2,2',2'',2'''-(((carboxymethyl)imino)bis(2,1-ethanediylnitrilo))tetrakis-
 acetic acid, 2,2',2'',2'''-[[(carboxymethyl)imino]bis(2, 1-ethanediylnitrilo)]tetrakis-
3-(benzyloxy)-1-methyl-4-((2-thioxo-1,3-thiazolidin-3-yl)carbonyl)-2(1H)-pyridinone
N-carboxymethyl iminobis(ethylene nitrilo)tetra(acetic acid)
N,N-bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine
N,N-bis(2-(bis(carboxymethyl)amino)ethyl)glycine
N,N-bis(2-[bis(carboxymethyl)amino]ethyl)glycine
2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
N,N-bis[2-[bis(carboxymethyl)amino]ethyl]glycine
2-{[2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)ethyl](carboxymethyl)amino}acetic acid
2-(bis{2-[bis(carboxymethyl)amino]ethyl}amino)acetic acid
N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine
(((carboxymethyl)imino)bis(ethylenenitrilo))tetraacetic acid
[[(carboxymethyl)imino]bis(1,2-ethanediylnitrilo)tetraacetic acid]
[[(carboxymethyl)imino]bis(ethylenenitrilo)]tetraacetic acid
(carboxymethylimino)bis(ethylenenitrilo)tetraacetic acid
N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid)
 diethylene triamine pentaacetic acid
 diethylenetriamine pentaacetic acid
 diethylenetriamine-N,N,N',N'',N''-pentaacetic acid
(diethylenetriamine)pentaacetic acid
 diethylenetriaminepentaacetic Acid
1,1,4,7,7-diethylenetriaminepentaacetic acid
N,N,N',N'',N''-diethylenetriaminepentaacetic acid
 diethylenetriaminepentaaceticacid
 diethylenetriaminepentacetic acid
(diethylenetrinitrilo)pentaacetic acid
 DTPA
 glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-
 glycine, N,N-bis[2-[bis (carboxymethyl)amino]ethyl]-
 penthanil
3,6,9-triazaundecanedioic acid, 3,6,9-tris(carboxymethyl)-
 versenex DTPA
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Immobilization of His-tagged kinase JAK2 onto the surface of a plasmon resonance gold disc modified with different copper (II) complexes.
PubMed: Voltammetric detection of S100B protein using His-tagged receptor domains for advanced glycation end products (RAGE) immobilized onto a gold electrode surface.
PubMed: Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential.
PubMed: Cholesterol-diethylenetriaminepentaacetate complexed with thulium ions integrated into bicelles to increase their magnetic alignability.
PubMed: Oriented immobilization of His-tagged protein on a redox active thiol derivative of DPTA-Cu(II) layer deposited on a gold electrode--the base of electrochemical biosensors.
PubMed: Effect of inorganic and organic copper fertilizers on copper nutrition in Spinacia oleracea and on labile copper in soil.
PubMed: Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions.
PubMed: Preparation and characterization of artificial antigens for cadmium and lead.
PubMed: Pretreatment with citrulline improves gut barrier after intestinal obstruction in mice.
PubMed: Phytoavailability, human risk assessment and transfer characteristics of cadmium and zinc contamination from urban gardens in Kano, Nigeria.
PubMed: A phase 2 study of (99m)Tc-tilmanocept in the detection of sentinel lymph nodes in melanoma and breast cancer.
PubMed: Preparation, biological evaluation, and pharmacokinetics of the human anti-HER1 monoclonal antibody panitumumab labeled with 86Y for quantitative PET of carcinoma.
PubMed: PET imaging of tumor angiogenesis in mice with VEGF-A-targeted (86)Y-CHX-A″-DTPA-bevacizumab.
PubMed: Novel type of bicellar disks from a mixture of DMPC and DMPE-DTPA with complexed lanthanides.
PubMed: Mycorrhizal colonization and grain Cd concentration of field-grown durum wheat in response to tillage, preceding crop and phosphorus fertilization.
PubMed: Magnetic field alignable domains in phospholipid vesicle membranes containing lanthanides.
PubMed: Meal-induced acceleration of tablet transit through the human small intestine.
PubMed: Characterization of monoclonal antibodies for lead-chelate complexes: applications in antibody-based assays.
PubMed: Influence of soil type on the mobility and bioavailability of chelated zinc.
PubMed: Metal contamination in urban soils of coastal Tuscany (Italy).
PubMed: Evaluation of extractants for estimation of the phytoavailable trace metals in soils.
PubMed: Transfer characteristics of cadmium and lead from soil to the edible parts of six vegetable species in southeastern China.
PubMed: Effect of cadmium on microbial activity and a ryegrass crop in two semiarid soils.
PubMed: Role of reactive oxygen species in zinc deficiency-induced hepatic stellate cell activation.
PubMed: Browning and decomposed products of model orange juice.
PubMed: Effect of DTPA on the nephrotoxicity induced by uranium in the rat.
PubMed: Effects of zinc complexes on the distribution of zinc in calcareous soil and zinc uptake by maize.
PubMed: Relationships between chromium biomagnification ratio, accumulation factor, and mycorrhizae in plants growing on tannery effluent-polluted soil.
PubMed: Mimicking rubella virus particles by using recombinant envelope glycoproteins and liposomes.
PubMed: Evaluation of pylorus-preserving pancreatoduodenectomy with the Imanaga reconstruction by hepatobiliary and gastrointestinal dual scintigraphy.
PubMed: Radioimmunotherapy of relapsed non-Hodgkin's lymphoma with zevalin, a 90Y-labeled anti-CD20 monoclonal antibody.
PubMed: Evaluation of esophageal bile reflux after total gastrectomy by gastrointestinal and hepatobiliary dual scintigraphy.
PubMed: Inhibition of pink color development in cooked, uncured turkey breast through ingredient incorporation.
PubMed: Indium-111 satumomab pendetide: the first FDA-approved monoclonal antibody for tumor imaging.
PubMed: Chelation of extracellular zinc inhibits proliferation in 3T3 cells independent of insulin-like growth factor-I receptor expression.
PubMed: Gastric emptying in children.
PubMed: Restricted Zn2+ availability affects the antizyme-dependent ornithine decarboxylase degradation pathway in isolated primary cultured rat hepatocytes.
PubMed: Safety and medico-legal implications of intra-articular gadolinium use.
PubMed: Lipid peroxidation in linoleic acid micelles caused by H2O2 in the presence of myoglobin.
PubMed: Effect of bethanechol or erythromycin on gastric emptying in horses.
PubMed: Comparative acute and chronic toxicity of diethylenetriamine pentaacetic acid (DTPA) and ferric-complexed DTPA to Daphnia carinata.
PubMed: Inhibition of renal uptake of indium-111-DTPA-octreotide in vivo.
PubMed: The relationship between gut hormone secretion and gastric emptying in different phases of the migrating motor complex.
PubMed: Functional characteristics of canine pylorus in health, with pyloroplasty, and after pyloric reconstruction.
PubMed: Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes.
PubMed: Relationships between gastric emptying, intragastric meal distribution and blood glucose concentrations in diabetes mellitus.
PubMed: Use of genetically engineered lipid-tagged antibody to generate functional europium chelate-loaded liposomes. Application in fluoroimmunoassay.
PubMed: Toxicity of DTPA to Daphnia carinata as modified by oxygen stress and food limitation.
PubMed: Somatostatin receptor imaging of neuroendocrine tumors with indium-111 pentetreotide (Octreoscan).
PubMed: Scintigraphic assessment of the intragastric distribution and gastric emptying of an encapsulated drug: the effect of feeding and of a proton pump inhibitor.
PubMed: Approval from the Food and Drug Administration for unapproved use of an approved drug or device.
PubMed: First peptide agent enters clinical arena.
PubMed: Delayed gastric emptying of both the liquid and solid components of a meal in chronic liver disease.
PubMed: Inter- and intrasubject variability of solid and liquid gastric emptying parameters. A scintigraphic study in healthy subjects and diabetic patients.
PubMed: Effects of erythromycin on gastric emptying, alcohol absorption and small intestinal transit in normal subjects.
PubMed: Serial nonenhancing magnetic resonance imaging scans of high grade glioblastoma multiforme.
PubMed: Scintigraphic quantitation of gastrointestinal motor activity and transport: oesophagus and stomach.
PubMed: Physical properties of starch meals in vivo and in vitro and their influence on gastric emptying and oral glucose tolerance test.
PubMed: Relationships between oesophageal transit and solid and liquid gastric emptying in diabetes mellitus.
PubMed: A model of gastric emptying in cats shows solid emptying is promoted by MK-329: a CCK antagonist.
PubMed: Safety considerations in MR imaging.
PubMed: Hepatobiliary and gastrointestinal imaging after pancreaticoduodenectomy--a comparative study on Billroth I and Billroth II reconstructions.
PubMed: Gadopentetate dimeglumine: observations on the clinical research process.
PubMed: Effects of liquid versus solid diet on colonic transit in humans. Evaluation by standard colonic transit scintigraphy.
PubMed: Time-resolved fluoroimmunoassay of aflatoxins.
PubMed: [Standardization of the method of gastric emptying analysis].
PubMed: Opening of the blood-brain barrier by intravenous contrast media in euvolemic and dehydrated rabbits.
PubMed: [Gastroesophageal reflux after esophageal surgery--evaluations based on esophageal transit scintigram].
PubMed: Gastrointestinal scintigraphy with 99mTc-DTPA labeled tablets in fed and fasting subjects.
PubMed: Biphasic nature of gastric emptying.
PubMed: [A study of hepato-biliary and alimentary scintigrams using a triple tracer method].
PubMed: Radionuclide studies on gastric evacuatory function in health and in the duodenal ulcer disease. I. Types of solid meal distribution within the stomach and their relation to gastric emptying.
PubMed: Emptying of the terminal ileum in intact humans. Influence of meal residue and ileal motility.
PubMed: Human brain infarcts: Gd-DTPA-enhanced MR imaging.
PubMed: Gastric emptying disorders.
PubMed: Reduction of 85Sr, 137Cs, 131I and 141Ce retention in rats by simultaneous oral administration of calcium alginate, ferrihexacyanoferrate(II), KI and Zn-DTPA.
PubMed: Gastric emptying measurements: delayed and complex emptying patterns without appropriate correction.
PubMed: Estimation of gastric residence time of the Heidelberg capsule in humans: effect of varying food composition.
PubMed: Disorders of gastric emptying and the application of radionuclide techniques.
PubMed: Intestinal transit of solid and liquid components of a meal in health.
PubMed: Abnormalities of esophageal and gastric emptying in progressive systemic sclerosis.
PubMed: Gastric emptying of solid radiopaque markers: studies in healthy subjects and diabetic patients.
PubMed: Influence of meal weight and caloric content on gastric emptying of meals in man.
PubMed: [Studies on the gastric emptying related to the types of stomach forms in healthy subjects].
PubMed: Technical factors in gastric emptying studies.
PubMed: Validation of corrections for errors in collimation during measurement of gastric emptying of nuclide-labeled meals.
PubMed: Some factors influencing the uptake of plutonium-239 by pea plants.
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