EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cyanoguanidine
dicyandiamide

Supplier Sponsors

Name:2-cyanoguanidine
CAS Number: 461-58-5Picture of molecule3D/inchi
Other(deleted CASRN):125148-58-5
ECHA EINECS - REACH Pre-Reg:207-312-8
FDA UNII: M9B1R0C16H
Nikkaji Web:J3.635H
Beilstein Number:605637
MDL:MFCD00008066
XlogP3:-1.20 (est)
Molecular Weight:84.08188000
Formula:C2 H4 N4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Contact Materials:dicyandiamide
FDA Mainterm (IAUFC):461-58-5 ; CYANOGUANIDINE
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 211.00 °C. @ 760.00 mm Hg
Boiling Point: 229.00 to 230.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.068000 mmHg @ 25.00 °C. (est)
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -1.150
Soluble in:
 water, 4.13E+04 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Dicyandiamide
Charkit Chemical
DICYANDIAMIDE
Covalent Chemical
Cyanoguanidine
Glentham Life Sciences
Dicyandiamide
Kowa Amerian Corporation
Dicyanimide
Odor: characteristic
Use: Dicyanimide is used in the production of laboratory chemicals and manufacture of other substances. This high purity product has a high melting point. It is used extensively as a counterion of organic and inorganic salts, and also as a reactant for the synthesis of various covalent organic structures.
Santa Cruz Biotechnology
For experimental / research use only.
Cyanoguanidine
Sigma-Aldrich: Aldrich
For experimental / research use only.
Dicyandiamide 99%
Silver Fern Chemical
Dicyandiamide
Odor: characteristic
Use: Dicyandiamide (DICY) is produced from the polymerization of cyanamide in the presence of a base. It is typically pure white crystals, stable when dry and soluble in liquid ammonia. It is partly soluble in hot water. Dicyandiamide is non-flammable.
TCI AMERICA
For experimental / research use only.
Dicyandiamide >98.0%(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 > 4000 mg/kg
Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 329, 1952.

oral-mouse LD50 > 10000 mg/kg
Toksikologicheskii Vestnik. Vol. (4), Pg. 39, 1998.

intraperitoneal-rabbit LD50 > 3000 mg/kg
Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 329, 1952.

oral-rat LD > 500 mg/kg
National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 17, 1953.

unreported-rat LDLo 600 mg/kg
Biochemical Pharmacology. Vol. 14, Pg. 1325, 1965.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for cyanoguanidine usage levels up to:
 not for fragrance use.
 
Recommendation for cyanoguanidine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):461-58-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10005
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2-cyanoguanidine
Chemidplus:0000461585
RTECS:461-58-5
 
References:
 2-cyanoguanidine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:461-58-5
Pubchem (cid):10005
Pubchem (sid):134973308
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEMBL:View
KEGG (GenomeNet):C00154
HMDB (The Human Metabolome Database):HMDB01338
FooDB:FDB022562
Export Tariff Code:2926.20.0000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grades: 99% pure; technical. •commercial cyanoguanidine: cyanoguanidine = 99.3%; water = 0.01%; melamine = 0.7%; thiourea = 200 ppm; heavy metals = 10 ppm.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-cyanoguanidine
 dicyandiamide
 hexadecanoyl CoA
 palmitoyl CoA
 palmitoyl coenzyme A
 palmitoyl-(carbonyl-14C)-coenzyme A
 palmitoyl-CoA
 palmityl-CoA
 

Articles:

PubMed:Determination of dicyandiamide in infant formula by stable isotope dilution hydrophilic interaction liquid chromatography with tandem mass spectrometry.
PubMed:Microwave-assisted extraction and determination of dicyandiamide residue in infant formula samples by liquid chromatography-tandem mass spectrometry.
PubMed:Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
PubMed:Preparation and reactivity towards hydrazines of bis(cyanamide) and bis(cyanoguanidine) complexes of the iron triad.
PubMed:Preparation and characterization of a novel nano-absorbent based on multi-cyanoguanidine modified magnetic chitosan and its highly effective recovery for Hg(II) in aqueous phase.
PubMed:Application of nanoring amino-functionalized magnetic polymer dispersive micro-solid-phase extraction and ultra fast liquid chromatography-tandem mass spectrometry in dicyandiamide residue analysis of powdered milk.
PubMed:Simultaneous analysis of metformin and cyanoguanidine by capillary zone electrophoresis and its application in a stability study.
PubMed:Hydrothermal formation of N-doped (BiO)2CO3 honeycomb-like microspheres photocatalysts with bismuth citrate and dicyandiamide as precursors.
PubMed:Slow delivery of a nitrification inhibitor (dicyandiamide) to soil using a biodegradable hydrogel of chitosan.
PubMed:Effects of nitrogen application rate and a nitrification inhibitor dicyandiamide on ammonia oxidizers and N2O emissions in a grazed pasture soil.
PubMed:[Determination of dicyandiamide in dairy products by high performance liquid chromatography].
PubMed:A general quantitative pH sensor developed with dicyandiamide N-doped high quantum yield graphene quantum dots.
PubMed:Application of biuret, dicyandiamide, or urea as a cathode buffer layer toward the efficiency enhancement of polymer solar cells.
PubMed:[Effects and influence factors of dicyandiamide (DCD) application in agricultural ecosystem].
PubMed:Effects of nitrogen application rate and a nitrification inhibitor dicyandiamide on methanotroph abundance and methane uptake in a grazed pasture soil.
PubMed:Synthesis and dual histamine H₁ and H₂ receptor antagonist activity of cyanoguanidine derivatives.
PubMed:Effect of phosphogypsum and dicyandiamide as additives on NH3, N20 and CH4 emissions during composting.
PubMed:[Determination of dicyandiamide, melamine and cyanuric acid in milk and milk powder by ultra performance liquid chromatography-tandem mass spectrometry].
PubMed:Novel chelating resin with cyanoguanidine group: useful recyclable materials for Hg(II) removal in aqueous environment.
PubMed:Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine.
PubMed:Benzamide synthesis by direct electrophilic aromatic substitution with cyanoguanidine.
PubMed:Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer.
PubMed:[Mitigation of nitrous oxide emissions in vegetable system by treating soil with dicyandiamide, a nitrification inhibitor].
PubMed:Development and validation of an analytical method for metformin hydrochloride and its related compound (1-cyanoguanidine) in tablet formulations by HPLC-UV.
PubMed:Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors.
PubMed:Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists.
PubMed:Different routes for amination of platinum(II)-bound cyanoguanidine.
PubMed:Effect of timing of joint application of hydroquinone and dicyandiamide on nitrous oxide emission from irrigated lowland rice paddy field.
PubMed:Dynamics of changes in methanogenesis and associated microflora in a flooded alluvial soil following repeated application of dicyandiamide, a nitrification inhibitor.
PubMed:Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain.
PubMed:Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists.
PubMed:Attenuation of N2O emission rates from agricultural soil at different dicyandiamide concentrations.
PubMed:[Subchronic oral toxicity study of cyanoguanidine in F344 rats].
PubMed:Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine.
PubMed:Protease inhibitors, part 13: Specific, weakly basic thrombin inhibitors incorporating sulfonyl dicyandiamide moieties in their structure.
PubMed:Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.
PubMed:Nitrous oxide and greenhouse gas emissions from grazed pastures as affected by use of nitrification inhibitor and restricted grazing regime.
PubMed:Reorientational dynamics and solid-phase transformation of ammonium dicyanamide into dicyandiamide: a (2)H solid-state NMR study.
PubMed:Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.
PubMed:Lack of carcinogenicity of cyanoguanidine in F344 rats.
PubMed:Dicyandiamide and 3,4-dimethyl pyrazole phosphate decrease N2O emissions from grassland but dicyandiamide produces deleterious effects in clover.
PubMed:Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor.
PubMed:Cardioselective anti-ischemic ATP-sensitive potassium channel openers. 3. Structure-activity studies on benzopyranyl cyanoguanidines: modification of the cyanoguanidine portion.
PubMed:Novel potassium-channel openers: preparation and pharmacological evaluation of racemic and optically active N-(6-amino-3-pyridyl)-N'-bicycloalkyl-N"-cyanoguanidine derivatives.
PubMed:Pyridazinones. 2. Synthesis and antisecretory and antiulcer activities of thiourea and 2-cyanoguanidine derivatives.
PubMed:Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguanidine CHS 828.
PubMed:Bis(cyanoguanidine)silver(I) nitrate-cyanoguanidine (1/1).
PubMed:Pyridazinones. 3. Synthesis, antisecretory, and antiulcer activities of 2-cyanoguanidine derivatives.
PubMed:Synthesis of spherical macroporous epoxy-dicyandiamide chelating resin and properties of concentration and separation of trace metal ions from samples.
PubMed:Ammonia and nitrous oxide emissions from two acidic soils of Nova Scotia fertilised with liquid hog manure mixed with or without dicyandiamide.
PubMed:[Effects of elemental sulphur and dicyandiamide on mitigating NO3- -N leaching loss from vegetable soil].
PubMed:Transformation of ammonium dicyanamide into dicyandiamide in the solid.
PubMed:Effects of ascorbic acid deficiency on methyl mercury dicyandiamide toxicosis in guinea pigs.
PubMed:[Pathomorphological changes in the skin and internal organs in white rats as a result of repeated administration of dicyandiamide and lubricants containing dicyandiamide (experimental-morphological study)].
PubMed:Methane emission from a simulated rice field ecosystem as influenced by hydroquinone and dicyandiamide.
PubMed:DICYANDIAMIDE: POSSIBLE ROLE IN PEPTIDE SYNTHESIS DURING CHEMICAL EVOLUTION.
PubMed:Quantitative structure-activity relationship by CoMFA for cyclic urea and nonpeptide-cyclic cyanoguanidine derivatives on wild type and mutant HIV-1 protease.
PubMed:A pharmacophore model for sulphonyl-urea (-cyanoguanidine) compounds with dual action, thromboxane receptor antagonists and thromboxane synthase inhibitors.
PubMed:Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells.
PubMed:Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties.
PubMed:Temporal effects of the novel antitumour pyridyl cyanoguanidine (CHS 828) on human lymphoma cells.
PubMed:Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity.
PubMed:[Synthesis and combined H1-/H2 antagonist activity of mepyramine, pheniramine and cyclizine derivatives with cyanoguanidine, urea and nitroethenediamine partial structures].
PubMed:Cardioprotective effects of the cyanoguanidine potassium channel opener P-1075.
PubMed:Effects of pinacidil and other cyanoguanidine derivatives on guinea-pig isolated trachea, aorta and pulmonary artery.
PubMed:Antitumoural effects of the pyridyl cyanoguanidine CHS 828 on three different types of neuroendocrine tumours xenografted to nude mice.
PubMed:Multiparametric evaluation of apoptosis: effects of standard cytotoxic agents and the cyanoguanidine CHS 828.
PubMed:Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075.
PubMed:The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro--from cytotoxic synergy to complete inhibition of apoptosis.
PubMed:A novel anti-ischemic ATP-sensitive potassium channel (K(ATP)) opener without vasorelaxation: N-(6-aminobenzopyranyl)-N'-benzyl-N' '-cyanoguanidine analogue.
PubMed:A hollow fiber model for in vitro studies of cytotoxic compounds: activity of the cyanoguanidine CHS 828.
PubMed:Cyanoguanidine CHS 828 induces programmed cell death with apoptotic features in human breast cancer cells in vitro.
PubMed:Inhibitors of farnesyl protein transferase. Synthesis and biological activity of amide and cyanoguanidine derivatives containing a 5,11-dihydro[1]benzthiepin, benzoxepin, and benzazepin [4,3-b]pyridine ring system.
PubMed:Synthesis and pharmacological evaluation of N-(6-functionalized-amino-3-pyridyl)-N'-bicycloalkyl-N''-cyanoguanidine s as antihypertensive agents.
PubMed:The effects of methyl-mercury-dicyandiamide on the peripheral nerves and spinal cord of rats.
PubMed:2,4-DIAMINOPYRIMIDINES FROM DICYANDIAMIDE. 3. REACTION WITH MONOCYCLIC KETONES.
PubMed:Accumulation and retention of mercury in the mouse. III. An autoradiographic comparison of methylmercuric dicyandiamide with inorganic mercury.
PubMed:The effect of alkylaryl-sulphonate and soap on the percutaneous resorption in guinea-pigs of mercuric chloride and methyl mercury dicyandiamide.
PubMed:Resorption of mercuric chloride and methyl mercury dicyandiamide in guinea-pigs through normal skin and through skin pretreated with acetone, alkylaryl-sulphonate and soap.
PubMed:[Condensation products between dicyandiamide and alkyl fatty acids in presence of phosphorus oxychloride].
PubMed:Response model analysis for cross-fostering studies: prenatal versus postnatal effects on offspring exposed to methylmercury dicyandiamide.
PubMed:Methylmercury dicyandiamide: retardation of detour learning in chicks hatched from injected eggs.
PubMed:Cumulative effects of methylmercury dicyandiamide given orally to rats.
PubMed:Distribution and excretion of mercury in rats intoxicated with methylmercury dicyandiamide.
PubMed:IR determination of trace quantities of dicyandiamide and cyanamide in guanidine sulfate.
PubMed:Mercury residues in chicken eggs and tissues from a flock exposed to methylmercury dicyandiamide.
PubMed:Effect of dicyandiamide on puffing activity and morphology of salivary gland chromosomes of Drosophila melanogaster.
PubMed:Studies on the metabolism of mercuric chloride and methyl mercury dicyandiamide; experiments on rats given subcutaneous injections with radioactive mercury (Hg203).
PubMed:[The characterization of some purine and pyrimidine derivatives by determination of the melting-point of their eutectics with dicyandiamide].
PubMed:Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.
PubMed:CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo.
PubMed:EB1627: a soluble prodrug of the potent anticancer cyanoguanidine CHS828.
PubMed:[H2-antagonistic activity of the impromidine analog, cyanoguanidine. 37. H2 antihistaminics].
PubMed:Triazine-Based, Graphitic Carbon Nitride: a Two-Dimensional Semiconductor.
PubMed:Cobalt-embedded nitrogen-rich carbon nanotubes efficiently catalyze hydrogen evolution reaction at all pH values.
PubMed:Mitigating nitrous oxide emissions from corn cropping systems in the Midwestern U.S.: potential and data gaps.
PubMed:Polymeric carbon nitride/mesoporous silica composites as catalyst support for Au and Pt nanoparticles.
PubMed:Graphene/graphene-tube nanocomposites templated from cage-containing metal-organic frameworks for oxygen reduction in Li-O₂ batteries.
PubMed:Significantly enhancing supercapacitive performance of nitrogen-doped graphene nanosheet electrodes by phosphoric acid activation.
PubMed:The effect of urease and nitrification inhibitors on ammonia and nitrous oxide emissions from simulated urine patches in pastoral system: a two-year study.
PubMed:Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship.
PubMed:Responses of the terrestrial ammonia-oxidizing archaeon Ca. Nitrososphaera viennensis and the ammonia-oxidizing bacterium Nitrosospira multiformis to nitrification inhibitors.
PubMed:Simultaneous detection of multiple adulterants in dry milk using macro-scale Raman chemical imaging.
PubMed:A comparison of the efficacy of organic and mixed-organic polymers with polyaluminium chloride in chemically assisted primary sedimentation (CAPS).
PubMed:Rapid detection of economic adulterants in fresh milk by liquid chromatography-tandem mass spectrometry.
PubMed:Polycondensation of boron- and nitrogen-codoped holey graphene monoliths from molecules: carbocatalysts for selective oxidation.
PubMed:Triazine-based carbon nitrides for visible-light-driven hydrogen evolution.
PubMed:Formation and characterization of melam, melam hydrate, and a melam-melem adduct.
PubMed:Synthesis and photocatalytic activity of poly(triazine imide).
PubMed:Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.
PubMed:[Effects of nitrogen regulators on fertilizer nitrogen transformation in meadow cinnamon soil and on pakchoi growth].
PubMed:Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups.
PubMed:Metal-free photocatalytic graphitic carbon nitride on p-type chalcopyrite as a composite photocathode for light-induced hydrogen evolution.
PubMed:Ammonia-oxidizing archaea have more important role than ammonia-oxidizing bacteria in ammonia oxidation of strongly acidic soils.
PubMed:Tunable optical transition in polymeric carbon nitrides synthesized via bulk thermal condensation.
PubMed:Methanol[1-(methoxymethanimidoyl)-2-(pyridin-2-ylmethyl)guanidine]bis(perchlorato)copper(II).
PubMed:Determination of impurities in medical products containing metformin hydrochloride.
PubMed:[Comparative assessment of nephroprotective properties of potassium and calcium channel modulators in experimental renal injury].
PubMed:[Effects of nitrification inhibitors DCD and DMPP on cinnamon soil' s gross nitrogen mineralization and nitrification rates].
PubMed:A liquid chromatography-tandem mass spectrometry method for the detection of economically motivated adulteration in protein-containing foods.
PubMed:Metal-free activation of H2O2 by g-C3N4 under visible light irradiation for the degradation of organic pollutants.
PubMed:Structure-activity relationship analysis of cytotoxic cyanoguanidines: selection of CHS 828 as candidate drug.
PubMed:Alkoxy-1,3,5-triazapentadien(e/ato) copper(II) complexes: template formation and applications for the preparation of pyrimidines and as catalysts for oxidation of alcohols to carbonyl products.
PubMed:Synthesis and histamine H(3) and H(4) receptor activity of conformationally restricted cyanoguanidines related to UR-PI376.
PubMed:[Effects of different fertilization modes on vegetable growth, fertilizer nitrogen utilization, and nitrogen loss from vegetable field].
PubMed:Direct synthesis of nanoporous carbon nitride fibers using Al-based porous coordination polymers (Al-PCPs).
PubMed:[Biochemical mechanisms of the cardioprotective effect of the K(ATP) channels opener flocalin (medicinal form) in ischemia-reperfusion of myocardium].
PubMed:[Influence of flocalin on development of apoptosis and necrosis at anoxia-reoxygenation of culture rats neonatal cardiomyocytes].
PubMed:[The influence of activation of the ATP-sensitive potassium channels by flocalin on the function of the cardiovascular system].
PubMed:[New fluorine-containing openers of ATP-sensitive potassium channels flokalin and tioflokalin inhibit calcium-induced mitochondrial pore opening in rat hearts].
PubMed:Thiourea isosteres as anion receptors and transmembrane transporters.
PubMed:Effects of fluorine-containing opener of ATP-sensitive potassium channels, pinacidil-derivative flocalin, on cardiac voltage-gated sodium and calcium channels.
PubMed:Poly(triazine imide) with intercalation of lithium and chloride ions [(C3N3)2(NH(x)Li(1-x))3⋅LiCl]: a crystalline 2D carbon nitride network.
PubMed:Synthesis of transition metal-modified carbon nitride polymers for selective hydrocarbon oxidation.
PubMed:Complexes of copper(II) with 3-(ortho-substituted phenylhydrazo)pentane-2,4-diones: syntheses, properties and catalytic activity for cyclohexane oxidation.
PubMed:Discriminating Hodgdon Pyrodex(®) and Triple Seven(®) using gas chromatography-mass spectrometry.
PubMed:[The changes of metabolism in myocardium at ischemia-reperfusion and activating of the ATP-sensitive potassium channels].
PubMed:Ammonia-oxidizing bacteria and archaea grow under contrasting soil nitrogen conditions.
PubMed:Effect of cattle slurry pre-treatment by separation and addition of nitrification inhibitors on gaseous emissions and N dynamics: a laboratory study.
PubMed:Syntheses, structures, and magnetic properties of tetramanganese(III) and hexamanganese(III) complexes containing derivative of biguanidate ligand: ferromagnetic interaction via imino nitrogen.
PubMed:Sarcolemmal cardiac K(ATP) channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin.
PubMed:[Effect of medical form of flocalin on the course of myocardial reperfusion injury].
PubMed:Effect of intensification of pastoral farming on greenhouse gas emissions in New Zealand.
PubMed:Modulatory action of potassium channel openers on field potential and histamine release from rat peritoneal mast cells.
PubMed:The use of microelectrode array (MEA) to study the protective effects of potassium channel openers on metabolically compromised HL-1 cardiomyocytes.
PubMed:[Effect of a new activator of adenosine triphosphate-sensitive potassium channels flocalin on the glucose level in blood].
PubMed:[The vasodilation effects of flokalin, a fluorine-containing K(ATP) channel opener].
PubMed:Use of fourier transform infrared spectroscopy to follow the heterocumulene aided thermal dehydration of phthalic and naphthalic acids.
PubMed:[HPLC determination of metformin hydrochloride-related substances].
PubMed:Biodegradability of end-groups of the biocide polyhexamethylene biguanide (PHMB) assessed using model compounds.
PubMed:Dihydropyridine neuropeptide Y Y1 receptor antagonists 2. bioisosteric urea replacements.
PubMed:The effect of nitrogen form on rhizosphere soil pH and zinc phytoextraction by Thlaspi caerulescens.
PubMed:[Cardioprotective effects of fluorine-containing activator of adenosine triphosphate-dependent potassium channels flokalin].
PubMed:[Cardioprotective effects of flokalin in experiments in vivo: influence on hemodynamic and myocardial lesions in ischemia-reperfusion].
PubMed:[Cardioprotective effects of activation of ATP-sensitive potassium channels in experiments in vivo: influence on blood biochemical parameters following ischemia-reperfusion of the myocardium].
PubMed:Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists.
PubMed:Effects of cultivation on N2O emission and seasonal quantitative variations of related microbes in a temperate grassland soil.
PubMed:Aerobic treatment of a concentrated urea wastewater with simultaneous stripping of ammonia.
PubMed:The infrared spectra of nitriles and related compounds frozen in Ar and H2O.
PubMed:Climate change mitigation for agriculture: water quality benefits and costs.
PubMed:Influences of Chemical Fertilizers and a Nitrification Inhibitor on Greenhouse Gas Fluxes in a Corn (Zea mays L.) Field in Indonesia.
PubMed:Ionothermal synthesis of crystalline, condensed, graphitic carbon nitride.
PubMed:Efficient and beta-stereoselective synthesis of 4(5)-methyl-5(4)-(5-amino-5-deoxy-beta-D-ribofuranosyl)imidazole and related compounds exhibiting antiulcer activity.
PubMed:Bioavailability and anticonvulsant activity of 2-cyanoguanidinophenytoin, a structural analogue of phenytoin.
PubMed:A possible mechanism of action of a new potassium channel opener, AL0671, on lipid metabolism in obese Zucker rats.
PubMed:[Isohistamine and homologs as components of H2-antagonists. 22. H2-antihistaminics].
PubMed:Lack of effect of pinacidil on theophylline pharmacokinetics and metabolism in man.
PubMed:Microsomally-mediated denitrosation of nitrosoguanidinium compounds.
PubMed:Synthesis and antifilarial activity of N-[4-[[4-alkoxy-3-[(dialkylamino)methyl]phenyl]amino]- 2-pyrimidinyl]-N'-phenylguanidines.
PubMed:Novel P2X7 receptor antagonists ease the pain.
PubMed:[Effects of 3,5-dimethylpyrazole phosphate (DMPZP) on soil nitrification].
PubMed:Fourier transform Raman spectral measurements of powdered quaternary mixtures of organic compounds Exceptional pure component spectral reconstruction using band-target entropy minimization (BTEM).
PubMed:[Soil biological activities at maize seedling stage under application of slow/controlled release nitrogen fertilizers].
PubMed:[Effects of nitrification inhibitors on nitrate content in soil and pakchoi and on pakchoi yield].
PubMed:Effects of slow-release urea fertilizers on urease activity, microbial biomass, and nematode communities in an aquic brown soil.
PubMed:[Effects of urease and nitrification inhibitors on alleviating the oxidation and leaching of soil urea's hydrolyzed product ammonium].
PubMed:Melem (2,5,8-triamino-tri-s-triazine), an important intermediate during condensation of melamine rings to graphitic carbon nitride: synthesis, structure determination by X-ray powder diffractometry, solid-state NMR, and theoretical studies.
PubMed:Medicinal and aromatic plant materials as nitrification inhibitors for augmenting yield and nitrogen uptake of Japanese mint (Mentha arvensis L. Var. Piperascens).
PubMed:Methane and nitrous oxide emissions from an irrigated rice of North India.
PubMed:[Response of N transformation related soil enzyme activities to inhibitor applications].
PubMed:Direct conversion of aldehydes to amides, tetrazoles, and triazines in aqueous media by one-pot tandem reactions.
PubMed:Emission of nitrous oxide from rice-wheat systems of Indo-Gangetic plains of India.
PubMed:Suppression of nitrification and N2O emission by karanjin--a nitrification inhibitor prepared from karanja (Pongamia glabra Vent.).
PubMed:Dehydrogenation processes and molecular clusters in mass spectra of organometallic and coordination compounds
PubMed:Carbonic anhydrase activators - part 21. Novel activators of isozymes I, II and IV incorporating carboxamido and ureido histamine moieties.
PubMed:Substrate-directed formation of small biocatalysts under prebiotic conditions.
PubMed:Differential inhibition by allylsulfide of nitrification and methane oxidation in freshwater sediment.
PubMed:Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities.
PubMed:Alternative bases in the RNA world: the prebiotic synthesis of urazole and its ribosides.
PubMed:An ethologist's approach to behavioural toxicology.
PubMed:Radiation chemistry of an aqueous solution of glycine: compounds of interest to chemical evolution studies.
PubMed:Prolonged retention of methyl mercury by mallard drakes.
PubMed:Prebiotic condensation reactions in an aqueous medium: a review of condensing agents.
PubMed:Effects of methylmercury on approach and avoidance behavior of mallard ducklings.
PubMed:Cyanamide Formation under Primitive Earth Conditions.
PubMed:Ammonia and Nitrous Acid from Nitrogenous Amendments Kill the Microsclerotia of Verticillium dahliae.
PubMed:Microwave-assisted one-pot tandem reactions for direct conversion of primary alcohols and aldehydes to triazines and tetrazoles in aqueous media.
PubMed:The structure and synthetic capabilities of a catalytic peptide formed by substrate-directed mechanism--implications to prebiotic catalysis.
PubMed:Mitigating nitrous oxide and methane emissions from soil in rice-wheat system of the Indo-Gangetic plain with nitrification and urease inhibitors.
PubMed:Antimycobacterial activity of 3,4-dichlorophenyl-ureas, N,N-diphenyl-ureas and related derivatives.
PubMed:Interactions between organic flocculant PAN-DCD and dyes.
PubMed:Creatine as nutritional supplementation and medicinal product.
PubMed:Is there a rationale for the use of creatine either as nutritional supplementation or drug administration in humans participating in a sport?
PubMed:Biodegradability of fluorinated surfactants under aerobic and anaerobic conditions.
PubMed:Early change and adaptation in the social behaviour or rats given methyl mercury in the diet.
PubMed:Comparison of game-farm and wild-strain mallard ducks in accumulation of methylmercury.
PubMed:Time dependent effects produced in chicks after prenatal injection of methylmercury.
PubMed:Brain lesions in mallard ducklings from parents fed methylmercury.
PubMed:Volatility of fungicidal mercury compounds on wheat seeds.
PubMed:[Cardioprotective effects of flokalin: relative role of activation of sarcolemmal and mitochondrial adenosine triphosphate-dependent potassium channels].
PubMed:Synthesis and analgesic activity evaluation of some agmatine derivatives.
PubMed:Molecular structure, bioavailability and bioactivity of [Cu(o-phen)2(cnge)](NO3)2.2H2O and [Cu(o-phen)(cnge)(H2O)(NO3)2] complexes.
PubMed:Neuroprotective effect of KR-31378, a novel potassium channel activator, on spinal cord ischemic injury in rabbits.
PubMed:Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators.
PubMed:Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor.
PubMed:Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.
PubMed:Design, synthesis, and biological evaluation of thio-containing compounds with serum HDL-cholesterol-elevating properties.
PubMed:Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
PubMed:Interactions between the new cytotoxic drug CHS 828 and amiloride and mitomycin C in a human tumour cell line and in tumour cells from patients.
PubMed:Activity of CHS 828 in primary cultures of human hematological and solid tumors in vitro.
PubMed:Guanidino-containing drugs in cancer chemotherapy: biochemical and clinical pharmacology.
PubMed:Determination of drug effect on tumour cells, host animal toxicity and drug pharmacokinetics in a hollow-fibre model in rats.
PubMed:Early stimulation of acidification rate by novel cytotoxic pyridyl cyanoguanidines in human tumor cells: comparison with m-iodobenzylguanidine.
PubMed:Exaggerated impact of ATP-sensitive K(+) channels on afferent arteriolar diameter in diabetes mellitus.
PubMed:Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
PubMed:Combined histamine H1/H2 receptor antagonists: part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures.
PubMed:Evidence that BKCa channel activation contributes to K+ channel opener induced relaxation of the porcine coronary artery.
PubMed:Synthesis and histamine H2-receptor antagonist activity of 4-(1-pyrazolyl)butanamides, guanidinopyrazoles, and related compounds.
PubMed:Comparative effects of the potassium channel openers cromakalim and pinacidil and the cromakalim analog U-89232 on isolated vascular and cardiac tissue.
PubMed:Electrophysiologic effects of a potassium channel activator (pinacidil) on repolarization parameters in healthy volunteers: a surface ECG study.
PubMed:Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.
PubMed:[Theoretical conformation study of tiotidine and nizatidine, two strong histamine H2-receptor antagonists].
PubMed:Pinacidil. Preclinical investigations.
PubMed:Pinacidil: history, basic pharmacology, and therapeutic implications.
PubMed:Effect of pinacidil on blood pressure, plasma catecholamines and plasma renin activity in essential hypertension.
PubMed:Inhibitory effects of 2-guanidinebenzimidazole and 1-phenylbiguanide on gastric acid secretion in rats.
PubMed:Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine.
PubMed:Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines.
PubMed:Hydrolytic degradation of 2,6-dichlorobenzylthiopseudourea hydrochloride.
PubMed:In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.
PubMed:Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes.
PubMed:Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity.
PubMed:Cytotoxic effect in vivo and in vitro of CHS 828 on human myeloma cell lines.
PubMed:Activation of p53 protein in normal and in tumor cells by a novel anticancer agent CHS 828.
PubMed:[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.
PubMed:Synthesis and biological activity of 3,3-diamino-sulfonylacrylonitriles as novel inhibitors of glucose induced insulin secretion from beta cells.
PubMed:Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione (A-184209) as a novelK(ATP) channel inhibitor.
PubMed:A Phase I study of CHS 828 in patients with solid tumor malignancy.
PubMed:In vitro activity of the novel cytotoxic agent CHS 828 in childhood acute leukemia.
PubMed:The stereoenantiomers of a pinacidil analog open or close cloned ATP-sensitive K+ channels.
PubMed:Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: arginine substitution.
PubMed:CHS 828 inhibits neuroblastoma growth in mice alone and in combination with antiangiogenic drugs.
PubMed:In vivo activity of CHS 828 on hollow-fibre cultures of primary human tumour cells from patients.
PubMed:Nicorandil analogues containing NO-donor furoxans and related furazans.
PubMed:Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation.
PubMed:Relaxant activity in rat aorta and trachea, conversion to a muscarinic receptor antagonist and structure-activity relationships of new K(ATP) activating 6-varied benzopyrans.
PubMed:BM 144: an original thromboxane A2 receptor antagonist derived from torasemide.
PubMed:Combined histamine H1/H2 receptor antagonists: part I. Pharmacological hybrids with pheniramine- and roxatidine-like substructures.
PubMed:Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.
PubMed:Pharmacological characterization of novel cyanoguanidines as vascular KATP channel blockers.
PubMed:Cimetidine and other H2-receptor antagonists as inhibitors of human E3 aldehyde dehydrogenase.
PubMed:Denitrosation of 1,3-dimethyl-2-cyano-1-nitrosoguanidine in rat primary hepatocyte cultures.
PubMed:Effects of 2-guanidine-4-methylquinazoline on gastric acid secretion in rats.
PubMed:Similarities in bioanalogous structural transformation patterns among various bioactive compound series.
PubMed:Cardioselective antiischemic ATP-sensitive potassium channel openers. 2. Structure-activity studies on benzopyranylcyanoguanidines: modification of the benzopyran ring.
PubMed:Dilating effect of perivascularly applied potassium channel openers cromakalim and pinacidil in rat and cat pial arteries in situ.
PubMed:ATP-sensitive K+ channel opener acts as a potent Cl- channel inhibitor in vascular smooth muscle cells.
PubMed:Theoretical studies on the histamine H2 receptor: molecular mechanism of action of antagonists.
PubMed:Mutagenicity assay with Salmonella typhimurium revealing biotransformation of antiphytoviral substances by cell-free plant extract.
PubMed:Oxmetidine in the short term treatment of active duodenal ulcer. A review and commentary.
PubMed:Chemistry of aminoiminomethanesulfinic and -sulfonic acids related to the toxicity of thioureas.
PubMed:Zwitterionic analogues of cimetidine as H2 receptor antagonists.
PubMed:Dipole moment in relation to H2 receptor histamine antagonist activity for cimetidine analogues.
PubMed:N2-1H-benzimidazol-2-yl-N4-phenyl-2,4-pyrimidinediamines and N2-1H-benzimidazol-2-yl-5,6,7,8-tetrahydro-N4-phenyl-2,4-quinazolinediamines as potential antifilarial agents.
PubMed:Prolonged WBC depression after cimetidine in a patient with chronic myelogenous leukemia.
PubMed:Pharmacodynamic basis for the interaction of cimetidine with the bone marrow stem cells (CFUS).
PubMed:Enzymic denitrosation of 1,3-dimethyl-2-cyano-1-nitrosoguanidine in rat liver cytosol and the fate of the immediate product S-nitrosoglutathione.
PubMed:[Effect of adenosine triphosphate-sensitve potassium channel activator flokalin on the isolated heart functions].
PubMed:Rat, mouse and hamster isozyme specificity in the glutathione transferase-mediated denitrosation of nitrosoguanidinium compounds.
 
Notes:
A fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis. [HMDB]
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