EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

dehydroascorbic acid
oxidized vitamin C

Supplier Sponsors

CAS Number: 490-83-5Picture of molecule3D/inchi
Other(deleted CASRN):19455-06-2
ECHA EINECS - REACH Pre-Reg:207-720-6
FDA UNII: Y2Z3ZTP9UM
MDL:MFCD00066467
XlogP3-AA:-1.00 (est)
Molecular Weight:174.10902000
Formula:C6 H6 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 389.25 °C. @ 760.00 mm Hg (est)
Flash Point: 338.00 °F. TCC ( 170.00 °C. ) (est)
logP (o/w): -1.702 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
L-Dehydro ascorbic acid
Santa Cruz Biotechnology
For experimental / research use only.
L-Dehydro Ascorbic Acid 99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Dehydroascorbic Acid
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for dehydroascorbic acid usage levels up to:
 not for fragrance use.
 
Recommendation for dehydroascorbic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10280
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(5R)-5-(1,2-dihydroxyethyl)oxolane-2,3,4-trione
Chemidplus:0000490835
 
References:
 (5R)-5-(1,2-dihydroxyethyl)oxolane-2,3,4-trione
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):10280
Pubchem (sid):134976465
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C00425
HMDB (The Human Metabolome Database):HMDB01264
FooDB:FDB021459
Export Tariff Code:2936.27.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 apple plant
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 banana fruit
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 black gram sprout
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 buckthorn sea buckthorn fruit
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 cabbage shoot
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 cassava root
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 celery shoot
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 leek wild leek plant
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 pea seed
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 pepper bell pepper fruit
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 spinach leaf
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 tomatillo fruit
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Synonyms:
oxidized ascorbic acid
L-ascorbic acid, dehydro-
L-dehydro ascorbic acid
 dehydro-L-ascorbic acid
L-dehydroascorbic acid
 DHAA
(5R)-5-(1,2-dihydroxyethyl)oxolane-2,3,4-trione
(5R)-5-(1,2-dihydroxyethyl)tetrahydrofuran-2,3,4-trione
L-threo-2,3-hexodiulosonic acid, gamma-lactone
oxidized vitamin C
 
 
Notes:
the reversibly oxidized form of ascorbic acid. it is the lactone of 2,3-diketogulonic acid and has antiscorbutic activity in man on oral ingestion. Widespread in plants, as oxidn. prod. of Ascorbic acid BWR05-S. Formed reversibly in vivo from ascorbic acid and shows similar vitamin function Dehydroascorbic acid (DHA) is an oxidized form of ascorbic acid. It is actively imported into the endoplasmic reticulum of cells and generates the oxidative potential found there. Protein disulfide isomerases are known to reduce DHA back to ascorbic acid, oxidizing their disulfide bonds in the process. Therefore L-dehydroascorbic acid is a vitamin C compound much like L-ascorbic acid. Oxidized forms of esterified ascorbic acids can be numbered at C(5) or C(6) atoms and the (free) chemical radical semi-dehydroascorbate or semidehydro ascorbic acid (SDA) to the group of dehydroascorbic acids.; Dehydroascorbic acid is the oxidized form of vitamin C. Reduced Vitamin C concentrations in the brain exceed those in blood by 10 fold. Dehydroascorbic acid readily enters the brain and is retained in the brain tissue in the form of ascorbic acid (ascorbic acid is not able to cross the blood-brain barrier).; Therefore, transport of dehydroascorbic acid by the Glucose Transporter 1 (GLUT1, Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. GLUT1 is a major glucose transporter in the mammalian blood-brain barrier. It is present at high levels in primate erythrocytes and brain endothelial cells.) is a mechanism by which the brain acquires vitamin C. (OMIM 138140); Vitamin C does not pass from the blood stream into the brain, although the brain is one of the organs which has the greatest concentration of vitamin C. Instead it is dehydroascorbate that is transported through the blood-brain barrier via GLUT1 transporters, and then converted to vitamin C. Some research has suggested that administration of dehydroascorbic acid may confer protection from neuronal injury following an ischemic stroke.
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