EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

dextro-glucurolactone
beta-D-anhydroglucuronate

Supplier Sponsors

CAS Number: 32449-92-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:251-053-3
FDA UNII:XE4Y3016M9
Nikkaji Web:J3.805I
Beilstein Number:0083595
MDL:MFCD00135622
XlogP3-AA:-1.80 (est)
Molecular Weight:176.12496000
Formula:C6 H8 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 174.00 to 178.00 °C. @ 760.00 mm Hg
Boiling Point: 403.00 to 404.00 °C. @ 760.00 mm Hg
Flash Point: 346.00 °F. TCC ( 174.44 °C. )
logP (o/w): -3.457 (est)
Soluble in:
 alcohol
 water, 257000 mg/L @ 21C (exp)
 
Organoleptic Properties:
Odor Type: mentholic
Odor Strength:low
mentholic
Odor Description:at 100.00 %. very mild mentholic
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Aceto
Glucuronolactone
BOC Sciences
For experimental / research use only.
D-Glucurono-3,6-lactone
Carbosynth
For experimental / research use only.
D-Glucuronolactone
Charkit Chemical
GLUCURONOLACTONE, D-
EMD Millipore
For experimental / research use only.
D-(+)-Glucurolactone
Foodchem International
D-Glucurolactone
Prinova
D-Glucurolactone 99% min. CP
Santa Cruz Biotechnology
For experimental / research use only.
D-Glucurono-3,6-lactone ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
D-(+)-Glucuronic acid gamma-lactone ≥99%
TCI AMERICA
For experimental / research use only.
D-Glucurono-6,3-lactone >99.0%(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 10700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-rat LD50 3200 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-rabbit LD50 940 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

oral-mouse LD50 > 20000 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-mouse LD50 4568 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intraperitoneal-mouse LD50 5797 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-dog LD50 940 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

Dermal Toxicity:
subcutaneous-rat LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-rabbit LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-mouse LD50 8210 ul/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-cat LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-dog LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for dextro-glucurolactone usage levels up to:
 not for fragrance use.
 
Recommendation for dextro-glucurolactone flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks
View page or View pdf

Gathering consumption data on specific consumer groups of energy drinks
View page or View pdf

Scientific Opinion on the safety of caffeine
View page or View pdf

EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):32449-92-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :92283
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde
Chemidplus:0032449926
RTECS:LZ8930000 for cas# 32449-92-6
 
References:
 (2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:32449-92-6
Pubchem (cid):92283
Pubchem (sid):135048564
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C02670
HMDB (The Human Metabolome Database):HMDB06355
FooDB:FDB023903
Export Tariff Code:2932.29.5050
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 skin conditioning
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
beta-D-anhydroglucuronate
beta-dextro-anhydroglucuronate
 dicurone
(2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde
(2R)-[(2S,3R,4S)-3,4-dihydroxy-5-oxotetrahydrofuran-2-yl](hydroxy)acetaldehyde
 glucofuranurono-6,3-lactone
D-glucurolactone
D-glucuronic acid lactone
D-glucurono-3,6-lactone
D-glucurono-6,3-lactone
dextro-glucurono-6,3-lactone
D-glucurono-gamma-lactone
dextro-glucurono-gamma-lactone
D-glucuronolactone
 
 
Notes:
D-glucurono-6,3-lactone participates in ascorbate and aldarate metabolism. D-glucurono-6,3-lactone is produced by the reaction between D-glucaric acid and the enzyme, aldehyde dehydrogenase (NAD+) [EC: 1.2.1.3]. [HMDB]
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