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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 264.12 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.003000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 236.00 °F. TCC ( 113.50 °C. ) (est)
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| logP (o/w): | -1.075 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for dextro-aspartic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for dextro-aspartic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acide D-aspartique | | (R)-2- | amino-succinic acid | | (2R)-2- | aminobutanedioic acid | | (R)-2- | aminobutanedioic acid | | (2R)-2- | aminosuccinic acid | | (R)-2- | aminosuccinic acid | | D- | aminosuccinic acid | | D- | asparaginsaeure | | D- | aspartatic acid | | (-)- | aspartic acid | | (R)- | aspartic acid | | D- | aspartic acid | | D-(-)- | aspartic acid | | | aspartic acid D- | | | aspartic acid, D- | | D- | asparticacid |
Articles:
| PubMed:Evaluation of enantiomeric purity of magnesium-l-aspartate dihydrate. |
| J-Stage:Enzymatic Assay for D-Aspartic Acid Using D-Aspartate Oxidase and Oxaloacetate Decarboxylase |
| PubMed:Repeated ketamine administration alters N-methyl-d-aspartic acid receptor subunit gene expression: Implication of genetic vulnerability for ketamine abuse and ketamine psychosis in humans. |
| PubMed:IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. |
| PubMed:Cisplatin induces neuronal activation and increases central AMPA and NMDA receptor subunit gene expression in mice. |
| PubMed:Spinal muscular atrophy: an update on therapeutic progress. |
| PubMed:The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. |
| PubMed:Differential effects of serotonin-specific and excitotoxic lesions of OFC on conditioned reinforcer devaluation and extinction in rats. |
| PubMed:Racemization of the aspartic acid residue of amyloid-β peptide by a radical reaction. |
| PubMed:Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine. |
| PubMed:Microinjection of NMDA-type glutamate receptor agonist NMDA and antagonist D-AP-5 into the central nucleus of the amygdale alters water intake rather than food intake. |
| PubMed:Medical management of frontotemporal dementias: the importance of the caregiver in symptom assessment and guidance of treatment strategies. |
| PubMed:The discriminative stimulus effects of midazolam are resistant to modulation by morphine, amphetamine, dizocilpine, and γ-butyrolactone in rhesus monkeys. |
| PubMed:Visible wavelength spectrophotometric assays of L-aspartate and D-aspartate using hyperthermophilic enzyme systems. |
| PubMed:The effects of repeated social defeat on long-term depressive-like behavior and short-term histone modifications in the hippocampus in male Sprague-Dawley rats. |
| PubMed:The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. |
| PubMed:Magnesium for treatment-resistant depression: a review and hypothesis. |
| PubMed:Cholinesterase inhibitor and N-methyl-D-aspartic acid receptor antagonist use in older adults with end-stage dementia: a survey of hospice medical directors. |
| PubMed:Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: cellular organization and neurotransmitters. |
| PubMed:Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. |
| PubMed:D-Aspartic acid induced oxidative stress and mitochondrial dysfunctions in testis of prepubertal rats. |
| PubMed:Enantiomer separation of imidazo-quinazoline-dione derivatives on quinine carbamate-based chiral stationary phase in normal phase mode. |
| PubMed:Oxidative alterations induced by D-aspartic acid in prepubertal rat testis in vitro: a mechanistic study. |
| PubMed:Rats with hippocampal lesion show impaired learning and memory in the ziggurat task: a new task to evaluate spatial behavior. |
| PubMed:Specific blockade of morphine- and cocaine-induced reinforcing effects in conditioned place preference by nitrous oxide in mice. |
| PubMed:Relationships among mercury, selenium, and neurochemical parameters in common loons (Gavia immer) and bald eagles (Haliaeetus leucocephalus). |
| PubMed:Orexin-induced feeding requires NMDA receptor activation in the perifornical region of the lateral hypothalamus. |
| PubMed:The influence of manufacture on the free D-amino acid content of Cheddar cheese. |
| PubMed:D-amino acid formation in sterilized alkali-treated olives. |
| PubMed:Paenidase, a novel D-aspartyl endopeptidase from Paenibacillus sp. B38: purification and substrate specificity. |
| PubMed:A new method of age estimation based on the changes in human non-collagenous proteins from dentin. |
| PubMed:Origins of lateral hypothalamic afferents associated with N-methyl-d-aspartic acid-elicited eating studied using reverse microdialysis of NMDA and Fluorogold. |
| PubMed:First evidence on induced topological changes in supercoiled DNA by an aluminium D-aspartate complex. |
| PubMed:Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds. |
| PubMed:Regional differences in feeding and other behaviors elicited by N-methyl-D-aspartic acid in the rodent hypothalamus: a reverse microdialysis mapping study. |
| PubMed:Reverse microdialysis of N-methyl-D-aspartic acid into the lateral hypothalamus of rats: effects on feeding and other behaviors. |
| PubMed:Physiological studies on umami taste. |
| PubMed:Glutamatergic control of food intake in pigeons: effects of central injections of glutamate, NMDA, and AMPA receptor agonists and antagonists. |
| PubMed:Racemization kinetics of aspartic acid in fish material under different conditions of moisture, pH, and oxygen pressure. |
| PubMed:Changes of amino acid composition and lysinoalanine formation in alkali-pickled duck eggs. |
| PubMed:Aspartate dehydrogenase in vitamin B12-producing Klebsiella pneumoniae IFO 13541. |
| PubMed:Effect of NMDA lesion of the medial preoptic neurons on sleep and other functions. |
| PubMed:Specific changes in food intake elicited by blockade or activation of glutamate receptors in the nucleus accumbens shell. |
| PubMed:Modulation of the discriminative stimulus and rate-altering effects of cocaine by competitive and noncompetitive N-methyl-D-aspartate antagonists. |
| PubMed:Changes in glutamate receptors, c-fos mRNA expression and activator protein-1 (AP-1) DNA binding activity in the brain of phenobarbital-dependent and -withdrawn rats. |
| PubMed:Evaluation of D-amino acid levels in rat by gas chromatography-selected ion monitoring mass spectrometry: no evidence for subacute toxicity of orally fed D-proline and D-aspartic acid. |
| PubMed:Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat. |
| PubMed:NMDA-induced lesions of the nucleus accumbens or the ventral pallidum increase the rewarding efficacy of food to deprived rats. |
| PubMed:Schedule-controlled behavioral effects of the selective 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic acid antagonist LY293558 in pigeons. |
| PubMed:LY226936 administered orally and centrally to obese Zucker rats suppresses food intake and body weight gain. |
| PubMed:The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating. |
| PubMed:Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats. |
| PubMed:Central mechanisms subserving the impaired growth hormone secretion induced by persistent blockade of NMDA receptors in immature male rats. |
| PubMed:Excitotoxic lesions of the paraventricular hypothalamus: metabolic and cardiac effects. |
| PubMed:Delay of puberty and impairment of growth in female rats given a non competitive antagonist of NMDA receptors. |
| PubMed:Increased response of cerebellar cGMP to kainate but not NMDA or quisqualate following barbital withdrawal from dependent rats. |
| PubMed:Aggravation by morphine and D-aspartic acid of pyelonephritis induced by i.v. inoculation of Staphylococcus aureus in rats. |
| PubMed:Some N-acyl-D-amino acid derivatives having antibotulinal properties. |
| PubMed:The inhibition by morphine and D-aspartic acid of antibody production against Salmonella typhimurium antigen in rats: its antagonism by L-aspartic acid. |
| PubMed:Continuously infused 2-amino-7-phosphonoheptanoic acid antagonizes N-methyl-D-aspartate-induced elevations of cyclic GMP in vivo in multiple brain areas and chemically-induced seizure activity. |
| PubMed:Racemization of aspartic acid and phenylalanine in the sweetener aspartame at 100 degrees C. |
| PubMed:Antagonistic effect of L-aspartic acid on decrease in body weight, and food and fluid intake, and naloxone reversible rectal temperature depression caused by D-aspartic acid. |
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the d-isomer of aspartic acid. D-Aspartic acid is the D-isomer of aspartic acid. Since its discovery in invertebrates, free D-aspartate (D-Asp) has been identified in a variety of organisms, including microorganisms, plants, and lower animals, mammals and humans. D-Asp in mammalian tissues is present in specific cells, indicating the existence of specific molecular components that regulate D-Asp levels and localization in tissues. In the rat adrenal medulla, D-Asp is closely associated with adrenaline-cells (A-cells), which account for approximately 80% of the total number of chromaffin cells in the tissue, and which make and store adrenaline. D-Asp appears to be absent from noradrenaline-cells (NA-cells), which comprise approximately 20% of the total number of chromaffin cells in the adrenal medulla, and which make and store noradrenaline. D-aspartate oxidase (EC 1.4.3.1, D-AspO), which catalyzes oxidative deamination of D-Asp, appears to be present only in NA-cells, suggesting that the lack of D-Asp in these cells is due to D-Asp oxidase-mediated metabolism of D-Asp. In the rat adrenal cortex, the distribution of D-Asp changes during development. It has been suggested that developmental changes in the localization of D-Asp reflects the participation of D-Asp in the development and maturation of steroidogenesis in rat adrenal cortical cells. D-Asp is involved in steroid hormone synthesis and secretion in mammals as well. D-Asp is synthesized intracellularly, most likely by Asp racemase (EC 5.1.1.13). Endogenous D-Asp apparently has two different intracellular localization patterns: cytoplasmic and vesicular. D-Asp release can occur through three distinct pathways: 1) spontaneous, continuous release of cytoplasmic D-Asp, which is not associated with a specific stimulus; 2) release of cytoplasmic D-Asp via a volume-sensitive organic anion channel that connects the cytoplasm and extracellular space; 3) exocytotic discharge of vesicular D-Asp. D-Asp can be released via a mechanism that involves the L-Glu transporter. D-Asp is thus apparently in dynamic flux at the cellular level to carry out its physiological function(s) in mammals. (PMID: 16755369) [HMDB]
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3D/inchi