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dextro-(-)-tagatose (mixture of anomers)
D-lyxo-hex-2-ulose

Supplier Sponsors

Name:(3S,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-one
CAS Number: 87-81-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-772-3
FDA UNII: T7A20Y888Y
Nikkaji Web:J9.874D
Beilstein Number:1724555
MDL:MFCD00134449
XlogP3-AA:-3.20 (est)
Molecular Weight:180.15684000
Formula:C6 H12 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:sweeteners, texturizers, stabalizers, humectants, formulation aids
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 352 D-Tagatose View - notice PDF
GRN 78 D-Tagatose View - notice PDF
JECFA Food Additive: D-Tagatose
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 133.00 to 137.00 °C. @ 760.00 mm Hg
Boiling Point: 551.74 °C. @ 760.00 mm Hg (est)
Flash Point: 575.00 °F. TCC ( 301.50 °C. ) (est)
logP (o/w): -1.029 (est)
Soluble in:
 water, 160 g/100 ml @ 20C (exp)
 alcohol, very slightly
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
D-Tagatose
Glentham Life Sciences
D-(-)-Tagatose
Santa Cruz Biotechnology
For experimental / research use only.
D-(-)-Tagatose
Sigma-Aldrich: Sigma
For experimental / research use only.
D-(-)-Tagatose ≥98.5%
TCI AMERICA
For experimental / research use only.
D-Tagatose >98.0%(HPLC)
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
sweeteners, texturizers, stabalizers, humectants, formulation aids
Recommendation for dextro-(-)-tagatose (mixture of anomers) usage levels up to:
 not for fragrance use.
 
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Outcome of a public consultation on a draft scientific opinion on the energy conversion factor of D-tagatose for labelling purposes
View page or View pdf

Scientific Opinion on the energy conversion factor of d-tagatose for labelling purposes
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :92092
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(3S,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-one
Chemidplus:0000087810
RTECS:WW1100000 for cas# 87-81-0
 
References:
 (3S,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):92092
Pubchem (sid):135047785
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):D09007
HMDB (The Human Metabolome Database):HMDB03418
FooDB:FDB001109
Export Tariff Code:2940.00.6000
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
D(-)-fructose
 lyxo-2-hexulose
D-lyxo-hex-2-ulose
(3S,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-one
alpha-dextro-tagatose
D-tagatose
D-(-)-tagatose
dextro-tagatose
keto-D-tagatose
D-(-)-tagatose (mixture of anomers)
 tagatose, D-
 

Articles:

Info:EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed:Engineering of Alicyclobacillus hesperidum L-Arabinose Isomerase for Improved Catalytic Activity and Reduced pH Optimum Using Random and Site-Directed Mutagenesis.
J-Stage:Characterization of an L-Arabinose Isomerase from Bacillus thermoglucosidasius for D-Tagatose Production
PubMed:Chemical improvement of chitosan-modified beads for the immobilization of Enterococcus faecium DBFIQ E36 L-arabinose isomerase through multipoint covalent attachment approach.
PubMed:Synthesis and Physicochemical Characterization of D-Tagatose-1-Phosphate: The Substrate of the Tagatose-1-Phosphate Kinase in the Phosphotransferase System-Mediated D-Tagatose Catabolic Pathway of Bacillus licheniformis.
PubMed:Enantioselective oxidation of galactitol 1-phosphate by galactitol-1-phosphate 5-dehydrogenase from Escherichia coli.
PubMed:Cloning, expression and purification of d-tagatose 3-epimerase gene from Escherichia coli JM109.
PubMed:Production of l-allose and d-talose from l-psicose and d-tagatose by l-ribose isomerase.
PubMed:Potent inhibitory effects of D-tagatose on the acid production and water-insoluble glucan synthesis of Streptococcus mutans GS5 in the presence of sucrose.
PubMed:A separation-integrated cascade reaction to overcome thermodynamic limitations in rare-sugar synthesis.
PubMed:Essentiality of tetramer formation of Cellulomonas parahominis L-ribose isomerase involved in novel L-ribose metabolic pathway.
PubMed:Directed divergent evolution of a thermostable D-tagatose epimerase towards improved activity for two hexose substrates.
PubMed:Protein purification, crystallization and preliminary X-ray diffraction analysis of L-arabinose isomerase from Lactobacillus fermentum CGMCC2921.
PubMed:Highly efficient production of rare sugars D-psicose and L-tagatose by two engineered D-tagatose epimerases.
PubMed:Salipiger nanhaiensis sp. nov., a bacterium isolated from deep sea water.
PubMed:Effects of Three Low-Doses of D-Tagatose on Glycemic Control Over Six Months in Subjects with Mild Type 2 Diabetes Mellitus Under Control with Diet and Exercise.
PubMed:Production of rare sugars from common sugars in subcritical aqueous ethanol.
PubMed:Production and application of a rare disaccharide using sucrose phosphorylase from Leuconostoc mesenteroides.
PubMed:Effect of D-psicose used as sucrose replacer on the characteristics of meringue.
PubMed:D-sorbose inhibits disaccharidase activity and demonstrates suppressive action on postprandial blood levels of glucose and insulin in the rat.
PubMed:L-Arabinose isomerase and its use for biotechnological production of rare sugars.
PubMed:Enzymatic production of three 6-deoxy-aldohexoses from L-rhamnose.
PubMed:Structure of D-tagatose 3-epimerase-like protein from Methanocaldococcus jannaschii.
PubMed:Efficient production of D-tagatose using a food-grade surface display system.
PubMed:Characterization of a F280N variant of L-arabinose isomerase from Geobacillus thermodenitrificans identified as a D-galactose isomerase.
PubMed:Cloning and characterization of a galactitol 2-dehydrogenase from Rhizobium legumenosarum and its application in D-tagatose production.
PubMed:Coexpression of β-D-galactosidase and L-arabinose isomerase in the production of D-tagatose: a functional sweetener.
PubMed:L-Arabinose isomerase and D-xylose isomerase from Lactobacillus reuteri: characterization, coexpression in the food grade host Lactobacillus plantarum, and application in the conversion of D-galactose and D-glucose.
PubMed:Crystallization and preliminary X-ray crystallographic analysis of L-arabinose isomerase from thermophilic Geobacillus kaustophilus.
PubMed:Biosynthesis of rare hexoses using microorganisms and related enzymes.
PubMed:Structural insight into L-ribulose 3-epimerase from Mesorhizobium loti.
PubMed:Fecal metabonomic study of a polysaccharide, MDG-1 from Ophiopogon japonicus on diabetic mice based on gas chromatography/time-of-flight mass spectrometry (GC TOF/MS).
PubMed:Function of aspartic acid residues in optimum pH control of L-arabinose isomerase from Lactobacillus fermentum.
PubMed:Characterization of a metal-dependent D-psicose 3-epimerase from a novel strain, Desmospora sp. 8437.
PubMed:DDDAS Design of Drug Interventions for the Treatment of Dyslipidemia in ApoE(-/-) Mice.
PubMed:Crystal structure and substrate specificity of D-galactose-6-phosphate isomerase complexed with substrates.
PubMed:Structural features of sugars that trigger or support conidial germination in the filamentous fungus Aspergillus niger.
PubMed:Enzymatic conversion of D-galactose to D-tagatose: cloning, overexpression and characterization of L-arabinose isomerase from Pediococcus pentosaceus PC-5.
PubMed:[The use of low-calorie sweeteners].
PubMed:Systematic optimization of interface interactions increases the thermostability of a multimeric enzyme.
PubMed:An uncharacterized member of the ribokinase family in Thermococcus kodakarensis exhibits myo-inositol kinase activity.
PubMed:A D-psicose 3-epimerase with neutral pH optimum from Clostridium bolteae for D-psicose production: cloning, expression, purification, and characterization.
PubMed:A pathway closely related to the (D)-tagatose pathway of gram-negative enterobacteria identified in the gram-positive bacterium Bacillus licheniformis.
PubMed:Characterization of an L-arabinose isomerase from Bacillus thermoglucosidasius for D-tagatose production.
PubMed:Adaptive evolution of the Streptococcus pyogenes regulatory aldolase LacD.1.
PubMed:The Effect of D-Tagatose on Fructose Absorption in a Rat Model.
PubMed:The crystal structure of galactitol-1-phosphate 5-dehydrogenase from Escherichia coli K12 provides insights into its anomalous behavior on IMAC processes.
PubMed:A method for the production of D-tagatose using a recombinant Pichia pastoris strain secreting β-D-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp. 22c.
PubMed:[Screening of food-grade microorganisms for biotransformation of D-tagatose and cloning and expression of L-arabinose isomerase].
PubMed:D-Tagatose production in the presence of borate by resting Lactococcus lactis cells harboring Bifidobacterium longum L-arabinose isomerase.
PubMed:Analyses of intestinal commensal Escherichia coli strains from wild boars suggest adaptation to conventional pig production conditions.
PubMed:Bifidobacterium longum L-arabinose isomerase--overexpression in Lactococcus lactis, purification, and characterization.
PubMed:Overexpression of D-psicose 3-epimerase from Ruminococcus sp. in Escherichia coli and its potential application in D-psicose production.
PubMed:Recent advances on applications and biotechnological production of D-psicose.
PubMed:Probing the general time scale question of boronic acid binding with sugars in aqueous solution at physiological pH.
PubMed:Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars.
PubMed:Production of D-tagatose, a functional sweetener, utilizing alginate immobilized Lactobacillus fermentum CGMCC2921 cells.
PubMed:Creation of metal-independent hyperthermophilic L-arabinose isomerase by homologous recombination.
PubMed:The acid-tolerant L-arabinose isomerase from the mesophilic Shewanella sp. ANA-3 is highly active at low temperatures.
PubMed:Bioconversion of D-galactose to D-tagatose: continuous packed bed reaction with an immobilized thermostable L-arabinose isomerase and efficient purification by selective microbial degradation.
PubMed:Bacterial L-arabinose isomerases: industrial application for D-tagatose production.
PubMed:Identification and characterization of a novel L-arabinose isomerase from Anoxybacillus flavithermus useful in D-tagatose production.
PubMed:Crystal structures of LacD from Staphylococcus aureus and LacD.1 from Streptococcus pyogenes: insights into substrate specificity and virulence gene regulation.
PubMed:Dietary supplementation with d-tagatose in subjects with type 2 diabetes leads to weight loss and raises high-density lipoprotein cholesterol.
PubMed:Production of D-tagatose, a low caloric sweetener during milk fermentation using L-arabinose isomerase.
PubMed:Isolation and characterization of lactic acid bacteria strains with ornithine producing capacity from natural sea salt.
PubMed:Novel activity of UDP-galactose-4-epimerase for free monosaccharide and activity improvement by active site-saturation mutagenesis.
PubMed:The acid tolerant L-arabinose isomerase from the food grade Lactobacillus sakei 23K is an attractive D-tagatose producer.
PubMed:Development of D-allose sensor on the basis of three strategic enzyme reactions.
PubMed:Thermostable L-arabinose isomerase from Bacillus stearothermophilus IAM 11001 for D-tagatose production: gene cloning, purification and characterisation.
PubMed:Thermostable variants of pyranose 2-oxidase showing altered substrate selectivity for glucose and galactose.
PubMed:Phenotype MicroArray in the metabolic characterisation of Salmonella serotypes Agona, Enteritidis, Give, Hvittingfoss, Infantis, Newport and Typhimurium.
PubMed:1,5-Anhydro-D-fructose: biocatalytic and chemical synthetic methods for the preparation, transformation and derivatization.
PubMed:An L-arabinose isomerase from Acidothermus cellulolytics ATCC 43068: cloning, expression, purification, and characterization.
PubMed:[Catalytic reaction mechanisms of the enzymes producing rare sugars based on X-ray structures].
PubMed:Roles of Ile66 and Ala107 of D-psicose 3-epimerase from Agrobacterium tumefaciens in binding O6 of its substrate, D-fructose.
PubMed:Probing active-site residues of pyranose 2-oxidase from Trametes multicolor by semi-rational protein design.
PubMed:Synthesis of 4-O-glycosylated 1,5-anhydro-D-fructose and of 1,5-anhydro-D-tagatose from a common intermediate 2,3-O-isopropylidene-D-fructose.
PubMed:Rational design of Bacillus stearothermophilus US100 L-arabinose isomerase: potential applications for D-tagatose production.
PubMed:Structure of a D-tagatose 3-epimerase-related protein from the hyperthermophilic bacterium Thermotoga maritima.
PubMed:Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase.
PubMed:Characterization of D-tagatose-3-epimerase from Rhodobacter sphaeroides that converts D-fructose into D-psicose.
PubMed:α-d-Tagatopyran-ose.
PubMed:Effect of diets containing sucrose vs. D-tagatose in hypercholesterolemic mice.
PubMed:Novel substrates of a ribose-5-phosphate isomerase from Clostridium thermocellum.
PubMed:Biotechnological applications of acetic acid bacteria.
PubMed:Tagatose production with pH control in a stirred tank reactor containing immobilized L-arabinose rom Thermotoga neapolitana.
PubMed:Removal and prevention of dental plaque with d-tagatose.
PubMed:Humectancies of d-tagatose and d-sorbitol.
PubMed:Differential selectivity of the Escherichia coli cell membrane shifts the equilibrium for the enzyme-catalyzed isomerization of galactose to tagatose.
PubMed:Development of an amperometric flow analysis sensor for specific detection of D-psicose.
PubMed:Highly enantioselective direct syn- and anti-aldol reactions of dihydroxyacetones catalyzed by chiral primary amine catalysts.
PubMed:Characterization of pyranose dehydrogenase from Agaricus meleagris and its application in the C-2 specific conversion of D-galactose.
PubMed:Cloning, expression, and transcription analysis of L-arabinose isomerase gene from Mycobacterium smegmatis SMDU.
PubMed:Characterization of an l-arabinose isomerase from the Lactobacillus plantarum NC8 strain showing pronounced stability at acidic pH.
PubMed:Crystal structures of D-tagatose 3-epimerase from Pseudomonas cichorii and its complexes with D-tagatose and D-fructose.
PubMed:High production of D-tagatose by the addition of boric acid.
PubMed:Tagatose: properties, applications, and biotechnological processes.
PubMed:Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism.
PubMed:Purification, crystallization and preliminary X-ray diffraction studies of D-tagatose 3-epimerase from Pseudomonas cichorii.
PubMed:Production of D-tagatose at high temperatures using immobilized Escherichia coli cells expressing L-arabinose isomerase from Thermotoga neapolitana.
PubMed:The concomitant crystallization of two polymorphs of 1-deoxy-alpha-D-tagatose.
PubMed:Novel substrate specificity of D-arabinose isomerase from Klebsiella pneumoniae and its application to production of D-altrose from D-psicose.
PubMed:Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia.
PubMed:Inclusion body anatomy and functioning of chaperone-mediated in vivo inclusion body disassembly during high-level recombinant protein production in Escherichia coli.
PubMed:Crystal structure of D-psicose 3-epimerase from Agrobacterium tumefaciens and its complex with true substrate D-fructose: a pivotal role of metal in catalysis, an active site for the non-phosphorylated substrate, and its conformational changes.
PubMed:Stereoselectivity of fructose-1,6-bisphosphate aldolase in Thermus caldophilus.
PubMed:Characterization of a mutated Geobacillus stearothermophilus L-arabinose isomerase that increases the production rate of D-tagatose.
PubMed:Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production.
PubMed:Efficient biosynthesis of D-allose from D-psicose by cross-linked recombinant L-rhamnose isomerase: separation of product by ethanol crystallization.
PubMed:Bioconversion of D-psicose to D-tagatose and D-talitol by Mucoraceae fungi.
PubMed:Izumoring: a strategy for bioproduction of all hexoses.
PubMed:Dihydroxyacetone variants in the organocatalytic construction of carbohydrates: mimicking tagatose and fuculose aldolases.
PubMed:Synthesis of 1,4-anhydro-D-fructose and 1,4-anhydro-D-tagatose.
PubMed:Increase in D-tagatose production rate by site-directed mutagenesis of L-arabinose isomerase from Geobacillus thermodenitrificans.
PubMed:Characterization of an Agrobacterium tumefaciens D-psicose 3-epimerase that converts D-fructose to D-psicose.
PubMed:Cloning, purification and biochemical characterization of metallic-ions independent and thermoactive l-arabinose isomerase from the Bacillus stearothermophilus US100 strain.
PubMed:A novel enzymatic approach to the massproduction of L-galactose from L-sorbose.
PubMed:Izumoring: a novel and complete strategy for bioproduction of rare sugars.
PubMed:Direct production of D-arabinose from D-xylose by a coupling reaction using D-xylose isomerase, D-tagatose 3-epimerase and D-arabinose isomerase.
PubMed:A novel bioconversion of L-fructose to L-glucose by Klebsiella pneumoniae.
PubMed:Chitosan productivity enhancement in Rhizopus oryzae YPF-61A by D-psicose.
PubMed:Direct production of allitol from D-fructose by a coupling reaction using D-tagatose 3-epimerase, ribitol dehydrogenase and formate dehydrogenase.
PubMed:Mass production of D-psicose from d-fructose by a continuous bioreactor system using immobilized D-tagatose 3-epimerase.
PubMed:Evaluation of certain food additives.
PubMed:Purification and characterization of an L-arabinose isomerase from an isolated strain of Geobacillus thermodenitrificans producing D-tagatose.
PubMed:Alternansucrase acceptor reactions with D-tagatose and L-glucose.
PubMed:Distinct metal dependence for catalytic and structural functions in the L-arabinose isomerases from the mesophilic Bacillus halodurans and the thermophilic Geobacillus stearothermophilus.
PubMed:Evaluation of certain food additives and contaminants.
PubMed:The genes and enzymes for the catabolism of galactitol, D-tagatose, and related carbohydrates in Klebsiella oxytoca M5a1 and other enteric bacteria display convergent evolution.
PubMed:Current studies on biological tagatose production using L-arabinose isomerase: a review and future perspective.
PubMed:Autodisplay of active sorbitol dehydrogenase (SDH) yields a whole cell biocatalyst for the synthesis of rare sugars.
PubMed:Enzymatic conversion of D-galactose to D-tagatose: heterologous expression and characterisation of a thermostable L-arabinose isomerase from Thermoanaerobacter mathranii.
PubMed:Characterization of a thermostable L-arabinose (D-galactose) isomerase from the hyperthermophilic eubacterium Thermotoga maritima.
PubMed:Continuous D-tagatose production by immobilized thermostable L-arabinose isomerase in a packed-bed bioreactor.
PubMed:Production of tagatose by a recombinant thermostable L-arabinose isomerase from Thermus sp. IM6501.
PubMed:Food labeling: health claims; D-tagatose and dental caries. Final rule.
PubMed:A feasible enzymatic process for D-tagatose production by an immobilized thermostable L-arabinose isomerase in a packed-bed bioreactor.
PubMed:Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution.
PubMed:Fluorogenic stereochemical probes for transaldolases.
PubMed:Evaluation of certain food additives and contaminants.
PubMed:Lactobacillus pantheris sp. nov., isolated from faeces of a jaguar.
PubMed:Cloning, expression and characterization of L-arabinose isomerase from Thermotoga neapolitana: bioconversion of D-galactose to D-tagatose using the enzyme.
PubMed:Mitsuokella jalaludinii sp. nov., from the rumens of cattle in Malaysia.
PubMed:Bioproduction strategies for rare hexose sugars.
PubMed:Glycerol-3-phosphate-induced catabolite repression in Escherichia coli.
PubMed:Base catalysed isomerisation of aldoses of the arabino and lyxo series in the presence of aluminate.
PubMed:Two class II D-tagatose-bisphosphate aldolases from enteric bacteria.
PubMed:L-glucitol catabolism in Stenotrophomonas maltophilia Ac.
PubMed:Evaluation of certain food additives and contaminants.
PubMed:Effect of oral D-tagatose on liver volume and hepatic glycogen accumulation in healthy male volunteers.
PubMed:D-tagatose, a novel hexose: acute effects on carbohydrate tolerance in subjects with and without type 2 diabetes.
PubMed:High production of D-tagatose, a potential sugar substitute, using immobilized L-arabinose isomerase.
PubMed:Small-bowel absorption of D-tagatose and related effects on carbohydrate digestibility: an ileostomy study.
PubMed:Effects of oral D-tagatose, a stereoisomer of D-fructose, on liver metabolism in man as examined by 31P-magnetic resonance spectroscopy.
PubMed:The acute effect of D-tagatose on food intake in human subjects.
PubMed:D-tagatose, a stereoisomer of D-fructose, increases blood uric acid concentration.
PubMed:In vitro fermentation pattern of D-tagatose is affected by adaptation of the microbiota from the gastrointestinal tract of pigs.
PubMed:Exploring substrate binding and discrimination in fructose1, 6-bisphosphate and tagatose 1,6-bisphosphate aldolases.
PubMed:Bioconversion of D-galactose into D-tagatose by expression of L-arabinose isomerase.
PubMed:D-tagatose--a novel low-calorie bulk sweetener with prebiotic properties.
PubMed:Effect of L-glucose and D-tagatose on bacterial growth in media and a cooked cured ham product.
PubMed:Characteristics and significance of D-tagatose-induced liver enlargement in rats: An interpretative review.
PubMed:Comparative gastrointestinal tolerance of sucrose, lactitol, or D-tagatose in chocolate.
PubMed:Human gastrointestinal tolerance to D-tagatose.
PubMed:Human tolerance to a single, high dose of D-tagatose.
PubMed:Effects of acute and repeated oral doses of D-tagatose on plasma uric acid in normal and diabetic humans.
PubMed:Disposition of D-[U-14C]tagatose in the rat.
PubMed:L-Sorbose but not D-tagatose induces hemolysis of dog erythrocytes in vitro.
PubMed:Genotoxicity tests on D-tagatose.
PubMed:Developmental toxicity study of D-tagatose in rats.
PubMed:Effect of D-tagatose on liver weight and glycogen content of rats.
PubMed:90-Day oral toxicity study of D-tagatose in rats.
PubMed:D-tagatose has low small intestinal digestibility but high large intestinal fermentability in pigs.
PubMed:Biodiversity of Lactococcus garvieae strains isolated from fish in Europe, Asia, and Australia.
PubMed:A convenient enzymatic procedure for the production of aldose-free D-tagatose.
PubMed:D-Tagatose, a stereoisomer of D-fructose, increases hydrogen production in humans without affecting 24-hour energy expenditure or respiratory exchange ratio.
PubMed:Antioxidant and cytoprotective properties of D-tagatose in cultured murine hepatocytes.
PubMed:Fructose and tagatose protect against oxidative cell injury by iron chelation.
PubMed:Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism.
PubMed:D-tagatose is a bulk sweetener with zero energy determined in rats.
PubMed:Sugar substitutes: their energy values, bulk characteristics, and potential health benefits.
PubMed:New syntheses of D-tagatose and of 1,5-anhydro-D-tagatose from D-galactose derivatives.
PubMed:Polyol metabolism of Rhodobacter sphaeroides: biochemical characterization of a short-chain sorbitol dehydrogenase.
PubMed:Characterization and identification of Vagococcus fluvialis strains isolated from domestic animals.
PubMed:Glycation of myofibrillar proteins and ATPase activity after incubation with eleven sugars.
PubMed:Investigation of sucrose synthase from rice for the synthesis of various nucleotide sugars and saccharides.
PubMed:Physiological characterization and identification of Listeria species.
PubMed:Presence of fructokinase in pancreatic islets.
PubMed:The use of biochemical markers, serotype and fimbriation in the detection of Escherichia coli clones.
PubMed:Carbohydrate substrate specificity of bacterial and plant pyrophosphate-dependent phosphofructokinases.
PubMed:The sugar phosphate specificity of rat hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
PubMed:Production of d-Tagatose from Dulcitol by Arthrobacter globiformis.
PubMed:Selection of Galactose-Fermenting Streptococcus thermophilus in Lactose-Limited Chemostat Cultures.
PubMed:Plasmid linkage of the D-tagatose 6-phosphate pathway in Streptococcus lactis: effect on lactose and galactose metabolism.
PubMed:D-tagatose 1,6-diphosphate aldolase from lactic streptococci: purification, properties, and use in measuring intracellular tagatose 1,6-diphosphate.
PubMed:D-Tagatose-1,6-bisphosphate aldolase (class I) from Staphylococcus aureus.
PubMed:Accumulation of D-tagatose by D-galactose-grown mycobacteria.
PubMed:D-Tagatose-1,6-bisphosphate aldolase (class II) from Klebsiella pneumoniae.
PubMed:D-Tagatose-6-phosphate kinase from Staphylococcus aureus.
PubMed:A novel enzyme, tagatose kinase, from Mycobacterium butyricum.
PubMed:The specificity of induction of alpha-galactosidase from Saccharomyces carlsbergensis.
PubMed:Galactose fermentation by Streptococcus lactis and Streptococcus cremoris: pathways, products, and regulation.
PubMed:Lactose and D-galactose metabolism in Staphylococcus aureus. IV. Isolation and properties of a class I D-ketohexose-1,6-diphosphate aldolase that catalyzes the cleavage of D-tagatose 1,6-diphosphate.
PubMed:Lactose and D-galactose metabolism in Staphylococcus aureus. II. Isomerization of D-galactose 6-phosphate to D-tagatose 6-phosphate by a specific D-galactose-6-phosphate isomerase.
PubMed:Lactose and D-galactose metabolism in Staphylococcus aureus. III. Purification and properties of D-tagatose-6-phosphate kinase.
PubMed:Synthesis of glycogen from fructose in the presence of elevated levels of glycogen phosphorylase a in rat hepatocytes.
PubMed:Characters of Lactobacillus coryniformis, isolated from an Iraqi cheese.
PubMed:Detection and characterization of sorbitol dehydrogenase from apple callus tissue.
PubMed:[Kinetic properties of the fructose influx across the brush border of the rat jejunum. Effects of a diet rich in fructose].
PubMed:Bovine liver fructokinase: purification and kinetic properties.
PubMed:The fructose 6-phosphate site of phosphofructokinase. Epimeric specificity.
PubMed:Deoxyfluoroketohexoses: 4-deoxy-4-fluoro-D-sorbose and -tagatose and 5-deoxy-5-fluoro-L-sorbose.
PubMed:Gluconeogenesis from D-tagatose by isolated rat and hamster liver cells.
PubMed:Genetic evidence for the physiological significance of the D-tagatose 6-phosphate pathway of lactose and D-galactose degradation in staphylococcus aureus.
PubMed:Lactose and D-galactose metabolism in group N streptococci: presence of enzymes for both the D-galactose 1-phosphate and D-tagatose 6-phosphate pathways.
PubMed:Phosphoric esters of biological importance; the synthesis and biological activity of D-tagatose-6-phosphate.
PubMed:Composition of the gum of Sterculia setigera; occurrence of D-tagatose in nature.
 
Notes:
GRAS status for use as a sweetener, humectant, texturiser or stabiliser in food, esp. low calorie products D-Tagatose, a rare natural hexoketose, is an isomer of d-galactose. D-Tagatose occurs naturally in Sterculia setigera gum, and it is also found in small quantities in various foods such as sterilized and powdered cow's milk, hot cocoa, and a variety of cheeses, yogurts, and other dairy products. It can be synthesized from D-galactose by isomerization under alkaline conditions in the presence of calcium. D-Tagatose have numerous health benefits, including promotion of weight loss, no glycemic effect, anti-plaque, non-cariogenic, anti-halitosis, prebiotic, and anti-biofilm properties, organ transplants, enhancement of flavor, improvement of pregnancy and fetal development, treatment of obesity, and reduction in symptoms associated with type 2 diabetes, hyperglycemia, anemia, and hemophilia. (PMID: 17492284); Oral tagatose significantly blunts the rise in plasma glucose seen after oral glucose in patients with diabetes mellitus in a dose-dependent manner without significantly affecting insulin levels. The minimal elevation of plasma tagatose levels in normal patients and the adverse gastrointestinal effects seen following larger doses of tagatose support poor absorption of this hexose and suggest that tagatose may act by attenuating glucose absorption in the intestine.; Tagatose is a functional sweetener. It is a naturally occurring monosaccharide, specifically a hexose. It is often found in dairy products, and is very similar in texture to sucrose (table sugar) and is 92% as sweet, but with only 38% of the calories.
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