cytochalasin J, 56144-22-0

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CODE123351 CODE123351
Product(s):
56144-22-0 Cytochalasin J >95% by HPLC
One of a family of potent mycotoxins produced by a range of fungi; the deacetyl analogue of cytochalasin H and exhibits similar, though less potent, antibacterial, antifungal, nematocidal and antitumour activities.

CAS Number:	56144-22-0	3D/inchi
FDA UNII:	Search
XlogP3-AA:	2.80 (est)
Molecular Weight:	451.60669000
Formula:	C28 H37 N O4
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:natural substances and extractives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	679.51 °C. @ 760.00 mm Hg (est)
Flash Point:	689.00 °F. TCC ( 364.80 °C. ) (est)
logP (o/w):	4.628 (est)
Soluble in:
	water, 0.2406 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

BOC Sciences

For experimental / research use only.

Cytochalasin J >95% by HPLC

Odor: characteristic

Use: One of a family of potent mycotoxins produced by a range of fungi; the deacetyl analogue of cytochalasin H and exhibits similar, though less potent, antibacterial, antifungal, nematocidal and antitumour activities.

Santa Cruz Biotechnology

For experimental / research use only.

Cytochalasin J >95%

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 5 mg/kg "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 2, Pg. 440, 1980.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
natural substances and extractives
Recommendation for cytochalasin J usage levels up to:
	not for fragrance use.

Recommendation for cytochalasin J flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :6434519

National Institute of Allergy and Infectious Diseases:Data

Chemidplus:0056144220

RTECS:HA5306500 for cas# 56144-22-0

References:

NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	6434519
Pubchem (sid):	135003594

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
Export Tariff Code:	2933.79.1000
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

found in nature

Synonyms:

(3S,3aR,4S,6aR,7E,13E,15R)-3-	benzyl-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-1-one
	kodocytochalasin 2
	paspalin P

Articles:

PubMed:Induction of apoptosis against cancer cell lines by four ascomycetes (endophytes) from Malaysian rainforest.

PubMed:Both actin and myosin inhibitors affect spindle architecture in PtK1 cells: does an actomyosin system contribute to mitotic spindle forces by regulating attachment and movements of chromosomes in mammalian cells?

PubMed:Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa.

PubMed:Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells.

PubMed:Localization of myosin II to chromosome arms and spindle fibers in PtK1 cells: a possible role for an actomyosin system in mitosis.

PubMed:Direct block of cloned hKv1.5 channel by cytochalasins, actin-disrupting agents.

PubMed:Redistribution of motor proteins by Cytochalasin J treatment.

PubMed:The effect of cytochalasin J on kinetochore structure in PtK1 cells is mitotic cycle dependent.

PubMed:Cytochalasin J treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in PtK1 cells.

PubMed:Cytochalasin J affects chromosome congression and spindle microtubule organization in PtK1 cells.

Notes:

None found

cytochalasin J (3S,3aR,4S,6aR,7E,13E,15R)-3-benzyl-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-1-one

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Articles:

cytochalasin J
(3S,3aR,4S,6aR,7E,13E,15R)-3-benzyl-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-1-one