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cytochalasin H
(11)cytochalasa-6(12),13,19-trien-1-one, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18S,19E,21R)-

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CAS Number: 53760-19-3Picture of molecule3D/inchi
FDA UNII: Search
Beilstein Number:1632647
MDL:MFCD00010539
XlogP3-AA:3.40 (est)
Molecular Weight:493.64383000
Formula:C30 H39 N O5
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 676.49 °C. @ 760.00 mm Hg (est)
Flash Point: 685.00 °F. TCC ( 362.90 °C. ) (est)
logP (o/w): 4.758 (est)
Soluble in:
 water, 0.018 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Cytochalasin H
Glentham Life Sciences
Cytochalasin H
Santa Cruz Biotechnology
For experimental / research use only.
Cytochalasin H >95%
Sigma-Aldrich: Sigma
For experimental / research use only.
Cytochalasin H from Phomopsis sp.
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-chicken LD50 12500 ug/kg
Canadian Journal of Microbiology. Vol. 22, Pg. 1137, 1976.

intraperitoneal-mammal (species unspecified) LD50 2341 ug/kg
BEHAVIORAL: ATAXIA SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Indian Drugs. Vol. 15, Pg. 76, 1978.

intravenous-mouse LD50 2 mg/kg
"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 2, Pg. 439, 1980.

unreported-mouse LDLo 2 mg/kg
Japanese Journal of Experimental Medicine. Vol. 48, Pg. 105, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for cytochalasin H usage levels up to:
 not for fragrance use.
 
Recommendation for cytochalasin H flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6434468
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0053760193
RTECS:HA5306000 for cas# 53760-19-3
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6434468
Pubchem (sid):135002757
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.79.1000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
(11)cytochalasa-6(12),13,19-trien-1-one, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18S,19E,21R)-
 kodocytochalasin-1
 paspalin
 

Articles:

PubMed:Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis.
PubMed:Cytochalasin H, an active anti-angiogenic constituent of the ethanol extract of Gleditsia sinensis thorns.
PubMed:Polar auxin transport in relation to long-distance transport of nutrients in the Charales.
PubMed:A novel phytotoxic nonenolide from Phomopsis sp. HCCB03520.
PubMed:Ep-oxy-cytochalasin H methanol solvate.
PubMed:Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa.
PubMed:Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines.
PubMed:1H and 13C NMR assignments of three nitrogen containing compounds from the mangrove endophytic fungus (ZZF08).
PubMed:Changes in secondary metabolism during stromatal ontogeny of Hypoxylon fragiforme.
PubMed:Effects of cytochalasin H, a potent inhibitor of cytoskeletal reorganisation, on platelet function.
PubMed:New botrydial sesquiterpenoids from Hymenoscyphus epiphyllus.
PubMed:Endocytosis of GPI-anchored proteins in human lymphocytes: role of glycolipid-based domains, actin cytoskeleton, and protein kinases.
PubMed:L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. II. Isolation and structure.
PubMed:L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. I. The producing organism and its fermentation.
PubMed:Effects of cytochalasin H on chick embryo explants cultured in vitro.
PubMed:Effect of cytochalasins B & H on isoelectric focusing of chick embryonic neural retina cells.
PubMed:Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro.
PubMed:Inhibitory effect of cytochalasin H on cell reaggregation of the fresh water sponge, Ephydatia meyeni Carter.
PubMed:The actions of various cytochalasins on mouse adrenal tumor cells in relation to trophic stimulation of steroidogenesis.
PubMed:Ultrastructural changes in the embryonic cells of the frog Microhyla ornata after cytochalasin H treatment.
PubMed:Effects of cytochalasin H on human lymphocyte cultures.
PubMed:Effects of cytochalasin H on the morphogenetic movements of the embryos of Microhyla ornata.
PubMed:Effects of cytochalasin H on the embryonic endodermal cells of Microhyla ornata.
PubMed:Structure of a new [11]cytochalasin, cytochalasin H or kodo-cytochalasin-1.
PubMed:Toxicity and plant growth regulator effects of cytochalasin H isolated from Phomopsis sp.
 
Notes:
None found
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