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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.81300 to 0.82000 @ 20.00 °C.
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| Pounds per Gallon - (est).: | 6.773 to 6.831
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| Refractive Index: | 1.41900 to 1.42200 @ 20.00 °C.
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| Boiling Point: | 50.50 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 299.800000 mmHg @ 25.00 °C. (est) |
| Flash Point: | -14.00 °F. TCC ( -25.56 °C. )
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| logP (o/w): | 0.070 |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 445 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. OTS0573763
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for cyclopropyl amine usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for cyclopropyl amine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | aminocyclopropane | | | cyclopropanamine | | | cyclopropylamine |
Articles:
| US Patents:8,075,937 - Alkyldienamides exhibiting taste and sensory effect in flavor compositions |
| PubMed:Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A. |
| PubMed:Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A. |
| PubMed:Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors. |
| PubMed:Experimental and theoretical investigation on the outer valence electronic structure of cyclopropylamine by (e, 2e) electron momentum spectroscopy. |
| PubMed:Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates. |
| PubMed:Highly stereoselective synthesis of (borylmethyl)cyclopropylamines by copper-catalyzed aminoboration of methylenecyclopropanes. |
| PubMed:Reprogramming fibroblasts to neural-precursor-like cells by structured overexpression of pallial patterning genes. |
| PubMed:Cell-intrinsic regulation of murine dendritic cell function and survival by prereceptor amplification of glucocorticoid. |
| PubMed:Formal substitution of bromocyclopropanes with nitrogen nucleophiles. |
| PubMed:Nazarov reactions of vinyl cyclopropylamines: an approach to the imino-Nazarov problem. |
| PubMed:Highly enantioselective synthesis of cyclopropylamine derivatives via Ru(II)-pheox-catalyzed direct asymmetric cyclopropanation of vinylcarbamates. |
| PubMed:KDM1 is a novel therapeutic target for the treatment of gliomas. |
| PubMed:trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family. |
| PubMed:The GPR88 receptor agonist 2-PCCA does not alter the behavioral effects of methamphetamine in rats. |
| PubMed:Simple and sensitive stability-indicating ion chromatography method for the determination of cyclopropylamine in nevirapine and moxifloxacin hydrochloride drug substances. |
| PubMed:Electrochemical cleavage of sulfonamides: an efficient and tunable strategy to prevent β-fragmentation and epimerization. |
| PubMed:Predicting biological functions of compounds based on chemical-chemical interactions. |
| PubMed:Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase. |
| PubMed:Intermolecular [3+2] cycloaddition of cyclopropylamines with olefins by visible-light photocatalysis. |
| PubMed:A generalized graph-theoretical matrix of heterosystems and its application to the VMV procedure. |
| PubMed:Oligodeoxynucleotides inhibit Toll-like receptor 3 mediated cytotoxicity and CXCL8 release in keratinocytes. |
| PubMed:Stereoselective preparation of β,γ-methano-GABA derivatives. |
| PubMed:Scalable synthesis of (1-cyclopropyl)cyclopropylamine hydrochloride. |
| PubMed:Administration route and carrier dependent effects on vaccine efficacy: implications for vaccine design. |
| PubMed:Metal Complexes for DNA-Mediated Charge Transport. |
| PubMed:Enantioselective syntheses of carbocyclic nuleosides 5'-homocarbovir, epi-4'-homocarbovir and their cyclopropylamine analogs using facially selective Pd-mediated allylations. |
| PubMed:Adjuvant effect of cationic liposomes and CpG depends on administration route. |
| PubMed:Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor. |
| PubMed:Cyclopropylamines from N,N-dialkylcarboxamides and Grignard reagents in the presence of titanium tetraisopropoxide or methyltitanium triisopropoxide. |
| PubMed:A new class of antitumor trans-amine-amidine-Pt(II) cationic complexes: influence of chemical structure and solvent on in vitro and in vivo tumor cell proliferation. |
| PubMed:Scalable synthesis of a prostaglandin EP4 receptor antagonist. |
| PubMed:Differences between amine- and phosphine-boranes: synthesis, photoelectron spectroscopy, and quantum chemical study of the cyclopropylic derivatives. |
| PubMed:Neoadjuvant immunotherapy enhances radiosensitivity through natural killer cell activation. |
| PubMed:Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. |
| PubMed:Diversity synthesis of N-substituted 2-amino-1,6-naphthyridine derivatives under microwave irradiation. |
| PubMed:C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite. |
| PubMed:Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide. |
| PubMed:Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors. |
| PubMed:Conformational preferences and basicities of monofluorinated cyclopropyl amines in comparison to cyclopropylamine and 2-fluoroethylamine. |
| PubMed:Synthesis of highly functionalized pyrrolidines via a selective iodide-mediated ring expansion of methylenecyclopropyl amides. |
| PubMed:Synthesis of a C-glucosylated cyclopropylamide and evaluation as a glycogen phosphorylase inhibitor. |
| PubMed:Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines. |
| PubMed:Electrochemical mass spectrometric studies on 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine. |
| PubMed:In vitro metabolism of a model cyclopropylamine to reactive intermediate: insights into trovafloxacin-induced hepatotoxicity. |
| PubMed:Quantification and comparison of toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia. |
| PubMed:Long-range electron and hole transport through DNA with tethered cyclometalated iridium(III) complexes. |
| PubMed:Mechanisms of trovafloxacin hepatotoxicity: studies of a model cyclopropylamine-containing system. |
| PubMed:Synthesis and characterization of iridium(III) cyclometalated complexes with oligonucleotides: insights into redox reactions with DNA. |
| PubMed:Charge separation in a ruthenium-quencher conjugate bound to DNA. |
| PubMed:Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. |
| PubMed:The Kulinkovich reaction in the synthesis of constrained n,n-dialkyl neurotransmitter analogues. |
| PubMed:trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. |
| PubMed:CpG-induced IFNgamma expands TLR4-specific IL-18 responses in vivo. |
| PubMed:Asymmetric synthesis of cyclopropylamines starting from N-sulfinyl alpha-chloro ketimines. |
| PubMed:Microglial cells and peritoneal macrophages release activin A upon stimulation with Toll-like receptor agonists. |
| PubMed:EPR studies of amine radical cations. Part 2. Thermal and photo-induced rearrangements of propargylamine and allylamine radical cations in low-temperature freon matrices. |
| PubMed:Synthesis of beta-lactams by Ag+-induced ring expansion of 1-hydroxycyclopropylamines: a theoretical analysis. |
| PubMed:Reassessment of the structural composition of the alkenone distributions in natural environments using an improved method for double bond location based on GC-MS analysis of cyclopropylimines. |
| PubMed:Electron paramagnetic resonance study of the mononuclear Al species formed in the reaction of Al atoms and cyclopropylamine at 77 k in an adamantane matrix. |
| PubMed:Cytochrome P450-catalyzed oxidation of N-benzyl-N-cyclopropylamine generates both cyclopropanone hydrate and 3-hydroxypropionaldehyde via hydrogen abstraction, not single electron transfer. |
| PubMed:Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. |
| PubMed:First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands. |
| PubMed:Sequence dependence of charge transport through DNA domains. |
| PubMed:Pressure-induced polymorphism in cyclopropylamine. |
| PubMed:Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines. |
| PubMed:Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes. |
| PubMed:Fluorinated phenylcyclopropylamines. Part 4: effects of aryl substituents and stereochemistry on the inhibition of monoamine oxidases by 1-aryl-2-fluoro-cyclopropylamines. |
| PubMed:Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines. |
| PubMed:Synthesis and properties of gem-(difluorocyclopropyl)amine derivatives of bicyclo[n.1.0]alkanes. |
| PubMed:Fluorinated phenylcyclopropylamines as inhibitors of monoamine oxidases. |
| PubMed:Stereochemistry of cyclopropane formation involving group IV organometallic complexes. |
| PubMed:Preliminary evidence of the role of hydrogen peroxide in the degradation of benzo[a]pyrene by a non-white rot fungus Fusarium solani. |
| PubMed:Molecular orbital calculations of ring opening of the isoelectronic cyclopropylcarbinyl radical, cyclopropoxy radical, and cyclopropylaminium radical cation series of radical clocks. |
| PubMed:Early upregulation of kinin B1 receptors in retinal microvessels of the streptozotocin-diabetic rat. |
| PubMed:Theoretical study of the mechanism of the formation of 3-unsubstituted 4,4-disubstituted beta-lactams by silver-induced ring expansion of alkoxycyclopropylamines: a new synthetic route to 4-alkoxycarbonyl-4-alkyl-2-azetidinones. |
| PubMed:Stereocontrolled synthesis of 3-(trans-2-aminocyclopropyl)alanine, a key component of belactosin A. |
| PubMed:Cyclopropane structural units from homoaldol adducts. |
| PubMed:Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine. |
| PubMed:Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. |
| PubMed:Inter-subunit cross-linking of methylamine dehydrogenase by cyclopropylamine requires residue alphaPhe55. |
| PubMed:Radical cation-mediated annulation. Stereoselective construction of bicyclo[5.3.0]decan-3-ones by aerobic oxidation of cyclopropylamines. |
| PubMed:Detection of aminium ion intermediates: N-cyclopropyl versus N-carboxymethyl groups as reporters. |
| PubMed:Effect of mobile phase amine additives on enantioselectivity for phenylalanine analogs. |
| PubMed:N-dealkylation of an N-cyclopropylamine by horseradish peroxidase. Fate of the cyclopropyl group. |
| PubMed:Enzymatic N-dealkylation of an N-cyclopropylamine: an unusual fate for the cyclopropyl group. |
| PubMed:Cytotoxicity of two novel cisplatin analogues, (CPA)2Pt[DOLYM] and (DACH)Pt[DOLYM], to human cancer cells in vitro. |
| PubMed:Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine. |
| PubMed:Synthesis and serotonin receptor affinities of a series of trans-2-(indol-3-yl)cyclopropylamine derivatives. |
| PubMed:A major role for prostacyclin in nitric oxide-induced ocular vasorelaxation in the piglet. |
| PubMed:High antagonist potency of GT-2227 and GT-2331, new histamine H3 receptor antagonists, in two functional models. |
| PubMed:Enantiomeric Synthesis of L-(or 1'R,2'S)-Carbocyclic Cyclopropyl Nucleosides. |
| PubMed:Model Studies of TTQ-Containing Amine Dehydrogenases. |
| PubMed:Novel 19-(cyclopropylamino)-androst-4-en-3,17-dione: a mechanism-based inhibitor of aromatase. |
| PubMed:Mechanisms of the biphasic effects of peroxides on the retinal vasculature of newborn and adult pigs. |
| PubMed:Mechanistic studies on the monoamine oxidase B catalyzed oxidation of 1,4-disubstituted tetrahydropyridines. |
| PubMed:In vitro anti-Mycobacterium avium activities of quinolones: predicted active structures and mechanistic considerations. |
| PubMed:Synthesis, structure, and antitumor activity of 1,3-dithiol- and 1,3-dithiolan-2-ylidenemalonatoplatinum(II) complexes. |
| PubMed:Reaction of lysyl oxidase with trans-2-phenylcyclopropylamine. |
| PubMed:Inhibition and activation of porcine squalene epoxidase. |
| PubMed:Inhibition of cholesterol synthesis by cyclopropylamine derivatives of squalene in human hepatoblastoma cells in culture. |
| PubMed:Synthesis of [carbonyl-14C]sparfloxacin. |
| PubMed:Inhibition by cyclopropylamine of the quinoprotein methylamine dehydrogenase is mechanism-based and causes covalent cross-linking of alpha and beta subunits. |
| PubMed:Oxidation of cycloalkylamines by cytochrome P-450. Mechanism-based inactivation, adduct formation, ring expansion, and nitrone formation. |
| PubMed:Deprenyl antagonizes acute lethality of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. |
| PubMed:Overview of the present state of MAO inhibitors. |
| PubMed:Microscale syntheses of anti-tumour platinum compounds labelled with 191Pt. |
| PubMed:In vivo distribution studies of radioactively labelled platinum complexes; cis-dichlorodiammine platinum(II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum(IV), cis-dichloro-bis-cyclopropylamine platinum(II), and cis-diammine 1,1-cyclobutanedicarboxylate platinum(II) in patients with malignant disease, using a gamma camera. |
| PubMed:Effect of alpha-methylation on inactivation of monoamine oxidase by N-cyclopropylbenzylamine. |
| PubMed:Bacterial degradation of N-cyclopropylmelamine. The steps to ring cleavage. |
| PubMed:Synthesis and evaluation of substituted 2-phenylcyclobutylamines as analogues of hallucinogenic phenethylamines: lack of LSD-like biological activity. |
| PubMed:Mutagenic properties of N-cyclopropyl and N-allyl-N-nitroso compounds. Studies on the nature of alkylating species. |
| PubMed:N-[2-(o-iodophenoxy)ethyl]cyclopropylamine hydrochloride (LY121768), a potent and selective irreversible inhibitor of type A monoamine oxidase. |
| PubMed:A comparative study of the distribution in the male rat of platinum-labelled cis-dichlorodiammine platinum (II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (I), and cis-dichloro-bis-cyclopropylamine platinum (II). |
| PubMed:Isomeric cyclopropyl ring-methylated homologues of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, an hallucinogen analogue. |
| PubMed:Blood clearance of three radioactively labelled platinum complexes: cis-dichlorodiammine platinum II, cis, trans-dichlorodihydroxy-bis-(isopropylamine) platinum IV, and cis-dichloro-bis-cyclopropylamine platinum II, in patients with malignant disease. |
| PubMed:Elevation of epinephrine concentration in rat brain by LY51641, a selective inhibitor of type A monoamine oxidase. |
| PubMed:Effect of 2-(p-chlorophenyl)cyclopropylamine on 5-hydroxyindole concentration and monoamine oxidase activity in rat brain. |
| PubMed:Pyridoxal 5'-phosphate levels in brain after treatments which impair cerebral glucose metabolism. |
| PubMed:Analysis of the cardiac stimulant properties of (3,4-dihydroxyphenyl)-cyclopropylamine (ASL-7003) and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (A6,7DTN). |
| PubMed:Conformational analogues of dopamine. Synthesis and pharmacological activity of (E)- and (Z)-2-(3,4-dihydroxyphenyl)cyclopropylamine hydrochlorides. |
| PubMed:Resolution and absolute configuration of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, a potent hallucinogen analogue. |
| PubMed:Irritable aggression and open field behavior in rats given 2-phenylcyclopropylamines. |
| PubMed:Selective in vivo inhibition of monoamine oxidase in rat tissues by N-[2-(O-chlorophenoxy)-ethyl]-cyclopropylamine. |
| PubMed:(+/-)(E)-2-(3,4-Dihydroxyphenyl)cyclopropylamine hydrochloride (ASL-7003): a rigid analogue of dopamine. |
| PubMed:Inhibition of monoamine oxidase by N-phenacyl-cyclopropylamine. |
| PubMed:Effects of three monoamine oxidase inhibitors on ethanol preference in mice. |
| PubMed:2-(4-imidazolyl)cyclopropylamine. |
| PubMed:Kinetic studies and effects in vivo of a new monoamine oxidase inhibitor, N-[2-(o-chlorophenoxy)-ethyl]-cyclopropylamine. |
| PubMed:A preliminary evaluation of trans-d1-2-phenyl-cyclopropylamine hydrochloride in the ambulatory treatment of depression. |
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3D/inchi