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curcumin
(1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione

Supplier Sponsors

Name:(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
CAS Number: 458-37-7Picture of molecule3D/inchi
Other(deleted CASRN):15845-47-3
ECHA EINECS - REACH Pre-Reg:207-280-5
FDA UNII: IT942ZTH98
Nikkaji Web:J5.762B
Beilstein Number:2306965
MDL:MFCD00008365
XlogP3-AA:3.20 (est)
Molecular Weight:368.38560000
Formula:C21 H20 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:coloring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 460 Curcuminoids purified from turmeric (Curcuma longa L.) View - notice PDF
GRN 686 Curcumin from turmeric (Curcuma longa L.) View - notice PDF
GRN 822 Curcumin View - notice PDF
JECFA Food Additive: Curcumin
GSFA Codex: Curcumin (100(i))
DG SANTE Food Additives:curcumin
 
Physical Properties:
Appearance:orange yellow crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 181.00 to 183.00 °C. @ 760.00 mm Hg
logP (o/w): 3.290 (est)
Soluble in:
 alcohol
 water, 7.475 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data2
CosIng:cosmetic data
Cosmetic Uses: antioxidants
 
Suppliers:
AIDP
Turmeric 95% Curcumin 95% min.
Alfa Biotechnology
For experimental / research use only.
Curcumin 98%
American International Chemical, LLC.
CURCUMIN (Tumeric) 95% Curcuma Longa
American International Chemical, LLC.
Curcumin
Asean Aromatics
Curcumin 95%
BOC Sciences
For experimental / research use only.
Curcumin >98%
Odor: characteristic
Use: Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae).
Charkit Chemical
CURCUMIN (BIOAVAILABLE) CURQNETIC
Charkit Chemical
CURCUMIN 95% 100 MESH FINE POWDER
Charkit Chemical
CURCUMIN 95% GRANULAR
Charkit Chemical
CURCUMIN 95% POWDERED
Chr. Hansen A/S
Turmeric
Flavor: characteristic
longa L, commonly known as turmeric, is a member of the ginger family. The root plant, native to India, is widely used by locals to spice and tint food and has gained popularity in the West in products such as curry powder. The primary pigment in turmeric is curcumin. Turmeric is greenish yellow by nature and is typically used to color products such as beverages, ice cream and confectionery. Turmeric-based colors are very tolerant of heat and pH extremes. Interestingly, in addition to its coloring properties, the pigment curcumin displays antioxidant characteristics.
Coompo
For experimental / research use only.
Curcumin from Plants ≥96%
Odor: characteristic
Use: Antiedemic, antiinflammatory agent. Bile stimulant showing hepatoprotective props. Possesses bactericidal and fungicidal props. Antitumour agent functioning through apoptosis. Nutriceutical. Shows antioxidant activity. In both in vitro and animal studies, curcumin has shown antitumor, antioxidant, antiarthritic, antiamyloid, anti-ischemic, and anti-inflammatory properties.
ExtraSynthese
For experimental / research use only.
Curcumin (HPLC) ≥97.5%
Foodchem International
Curcumin Extract
Glentham Life Sciences
Curcumin, pure, 98%
Glentham Life Sciences
Curcumin
Indenta Group
Curcumin Powder
Indo World Trading
Curcumin 95%
Maypro Industries
Curcumin
Minerva Flavours and Fragrances
Curcumin 95%
Nacalai USA
For experimental / research use only.
Curcumin 1
P.L. Thomas
Curcumin
Pangaea Sciences
Curcumin
Plant Lipids
Curcumin Powder
Rung International
Curcumin
Odor: characteristic
Use: The turmeric roots are pulled from the ground and separated from the rest of the plant and dried. The dried rhizome is is ground and curcumin is extracted using a solvent. It has to be de-flavored before use in certain applications. Oleoresin is made be evaporating the mother liquor to a non pourable syrup.
Sigma-Aldrich: Sigma
For experimental / research use only.
Curcumin from Curcuma longa (Turmeric), powder
sds
Synthite Industries
Curcumin 95%
E-books and Brochures
Synthite Industries
Curcumin
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 2000 mg/kg
Planta Medica. Vol. 64, Pg. 353, 1998.

oral-mouse LD50 > 2000 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 25, Pg. 447, 1973.

intraperitoneal-mouse LD50 1500 mg/kg
Indian Journal of Medical Research. Vol. 64, Pg. 601, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
coloring agents
Recommendation for curcumin usage levels up to:
 not for fragrance use.
 
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of curcumin (E 100) as a food additive
View page or View pdf

Refined exposure assessment for curcumin (E 100)
View page or View pdf

Curcumin and normal functioning of joints: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):458-37-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :969516
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Chemidplus:0000458377
EPA/NOAA CAMEO:hazardous materials
RTECS:MI5230000 for cas# 458-37-7
 
References:
 (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:458-37-7
Pubchem (cid):969516
Pubchem (sid):134973130
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10443
HMDB (The Human Metabolome Database):HMDB02269
FooDB:FDB012292
Export Tariff Code:2914.50.2000
FDA Listing of Food Additive Status:View
FDA Color Additive Status ListView
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
Formulations/Preparations:
derivatives: tincture (20% in 60% ethanol), fluid extract, & oleoresin. deriv of turmeric
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 cosmetic colorants
 
Occurrence (nature, food, other):note
 ginger plant
Search Trop Picture
 ginger rhizome
Search Trop Picture
 turmeric
Search Trop Picture
 turmeric plant
Search Trop Picture
 turmeric rhizome
Search Trop Picture
 turmeric root
Search Trop Picture
 turmeric sap
Search Trop Picture
 turmeric tubers
Search Trop Picture
 zedoary
Search Trop Picture
 
Synonyms:
 c.i. 75300
 C.I. natural yellow 3
 ci 75300
 CI natural yellow 3
 curcumine
 curcuminoids purified from turmeric (curcuma longa l.)
 curcurmin
1,5-di(vanillyliden)acetylaceton
1,5-divanillyliden-2,4-pentandion
1,6-heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-
1,6-heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-
(1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
(E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
 natural yellow 3
 

Articles:

Info:EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed:Encapsulation altered starch digestion: toward developing starch-based delivery systems.
J-Stage:Antioxidation and Tyrosinase Inhibition of Polyphenolic Curcumin Analogs
PubMed:Sensory evaluation of dry-fermented sausage containing ground deodorized yellow mustard.
PubMed:Curcumin binds tubulin, induces mitotic catastrophe, and impedes normal endothelial cell proliferation.
PubMed:Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme oxygenase-1 expression in brain microvascular endothelial cells.
PubMed:Oxidative metabolites of curcumin poison human type II topoisomerases.
PubMed:Induced mutation in β-CAROTENE HYDROXYLASE results in accumulation of β-carotene and conversion of red to orange color in pepper fruit.
PubMed:Curcumin for the prevention of acute lung injury in sepsis: is it more than the flavor of the month?
PubMed:Antioxidants in bakery products: a review.
PubMed:Potential of spice-derived phytochemicals for cancer prevention.
PubMed:Radioprotection and radiosensitization by curcumin.
PubMed:Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3.
PubMed:Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.
PubMed:Light reflected from colored mulches affects aroma and phenol content of sweet basil (Ocimum basilicum L.) leaves.
PubMed:Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines.
PubMed:Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell.
 
Notes:
a yellow-orange dye obtained from tumeric, the powdered root of curcuma longa. it is used in the preparation of curcuma paper and the detection of boron. curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes. Isol. from Curcuma zedoaria (zedoary) and other Curcuma spp. flavouring ingredient. Natural colouring matter used extensively in Indian curries etc. Nutriceutical with anticancer and antiinflammatory props.
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