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Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 98.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.84600 @ 25.00 °C.
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| Refractive Index: | 1.43650 @ 20.00 °C.
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| Melting Point: | -101.00 to -98.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 102.20 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 31.438999 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 2.41 ( Air = 1 ) |
| Flash Point: | 48.00 °F. TCC ( 8.89 °C. )
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| logP (o/w): | 0.600 |
| Soluble in: |
| | alcohol | | | water, 1.50E+05 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | T+ N - Very toxic, Dangerous for the environment. |
R 11 - Highly flammable.
R 23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
R 37/38 - Irritating to respiratory system and skin.
R 41 - Risk of serious damage to eyes.
R 48/22 - Harmful: danger of serious damage to health by prolonged exposure if swallowed.
R 50 - Very toxic to aquatic organisms.
R 68 - Possible risk of irreversible effects.
S 02 - Keep out of the reach of children.
S 09 - Keep container in a well-ventilated place.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 28 - After contact with skin, wash immediately with plenty of water.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 240 mg/kg
Biochemical Journal. Vol. 34, Pg. 1196, 1940.
intraperitoneal-mouse LD50 160 mg/kg
Personal Communication from H. Zollner, Institut fur Biochemie, Der Universitat, Gras, Oct. 23, 1975Vol. 23OCT1975
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| Dermal Toxicity: |
skin-rabbit LD50 380 mg/kg
Union Carbide Data Sheet. Vol. 4/21/1967
subcutaneous-rat LD50 140 mg/kg
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.
subcutaneous-mouse LD50 160 mg/kg
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.
subcutaneous-dog LDLo 568 mg/kg
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884.
subcutaneous-guinea pig LDLo 1331 mg/kg
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884.
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| Inhalation Toxicity: |
inhalation-rat LC50 4000 mg/m3/30M
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT
Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.
inhalation-mouse LC50 1510 mg/m3/2H
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: ATAXIA
BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 6(9), Pg. 34, 1962.
inhalation-human TCLo 12 mg/m3/10M
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
JAMA, Journal of the American Medical Association. Vol. 165, Pg. 1908, 1957.
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Safety in Use Information:
| Category: | | flavoring agents |
| Recommendation for (E)-2-buten-1-al usage levels up to: | | | not for fragrance use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (2E)- | but-2-enal | | (E)- | but-2-enal | | trans- | but-2-enal | | trans-2- | buten-1-al | | (2E)-2- | butenal | | (E)-2- | butenal | | trans-2- | butenal | | 2- | butenal, (2E)- | | trans-2- | butenaldehyde | | (E)- | crotonal | | (E)- | crotonaldehyde | | trans- | crotonaldehyde | | | crotonaldehyde, (E)- | | (E)- | crotonic aldehyde | | | topanel |
Articles:
| PubMed:Activation of the Keap1/Nrf2 pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L. |
| J-Stage:Effects of Aliphatic Aldehydes on the Growth and Patulin Production of Penicillium expansum in Apple Juice |
| PubMed:Development of three stable isotope dilution assays for the quantitation of (E)-2-butenal (crotonaldehyde) in heat-processed edible fats and oils as well as in food. |
| PubMed:Signatures of isomerization in photodissociation of trans- crotonaldehyde probed by multiphoton ionization mass spectrometry. |
| PubMed:Effects of aliphatic aldehydes on the growth and patulin production of Penicillium expansum in apple juice. |
| PubMed:Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives. |
| PubMed:Contribution of cation-π interactions in iminium catalysis. |
| PubMed:Human aldo-keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells. |
| PubMed:Kinetics studies of the gas-phase reactions of NO3 radicals with series of 1-alkenes, dienes, cycloalkenes, alkenols, and alkenals. |
| PubMed:A computational study of the mechanism of the unimolecular elimination of α,β-unsaturated aldehydes in the gas phase. |
| PubMed:Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal. |
| PubMed:Atmospheric reaction of OH radicals with 1,3-butadiene and 4-hydroxy-2-butenal. |
| PubMed:Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence. |
| PubMed:Modulation of pumpkin glutathione S-transferases by aldehydes and related compounds. |
| PubMed:1,N2-deoxyguanosine adducts of acrolein, crotonaldehyde, and trans-4-hydroxynonenal cross-link to peptides via Schiff base linkage. |
| PubMed:Aldehyde-induced xanthine oxidase activity in raw milk. |
| PubMed:Structure-antimutagenic activity relationships of benzalacetone derivatives against UV-induced mutagenesis in E. coli WP2uvrA and gamma-induced mutagenesis in Salmonella typhimurium TA2638. |
| PubMed:Volatile aldehydes are promising broad-spectrum postharvest insecticides. |
| PubMed:Role of 1,N2-propanodeoxyguanosine adducts as endogenous DNA lesions in rodents and humans. |
| PubMed:Structural and kinetic determinants of aldehyde reduction by aldose reductase. |
| PubMed:Purification and characterization of two enone reductases from Saccharomyces cerevisiae. |
| PubMed:Structures of acrolein-guanine adducts: a semi-empirical self-consistent field and nuclear magnetic resonance spectral study. |
| PubMed:Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1. |
| PubMed:Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal. |
| PubMed:Genotoxic effects of the alpha, beta-unsaturated aldehydes 2-trans-butenal, 2-trans-hexenal and 2-trans, 6-cis-nonadienal. |
| PubMed:Mechanism-based inactivation of porcine kidney diamine oxidase by 1,4-diamino-2-butene. |
| PubMed:Effects of age and dietary restriction on liver glutathione transferase activities in Lobund-Wistar rats. |
| PubMed:Human Mu-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue. |
| PubMed:Identification and characterization of deoxyguanosine-crotonaldehyde adducts. Formation of 7,8 cyclic adducts and 1,N2,7,8 bis-cyclic adducts. |
| PubMed:The reaction of xanthine oxidase with aldehydic products of lipid peroxidation. |
| PubMed:Detection of exocyclic guanine adducts in hydrolysates of hepatic DNA of rats treated with N-nitrosopyrrolidine and in calf thymus DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine. |
| PubMed:Inhibition of microsomal cytochrome c reductase activity by a series of alpha, beta-unsaturated aldehydes. |
| PubMed:Mutagenicity and toxicity studies of several alpha,beta-unsaturated aldehydes in the Salmonella typhimurium mutagenicity assay. |
| PubMed:Inhibition by reactive aldehydes of superoxide anion radical production in stimulated human neutrophils. |
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3D/inchi