EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

colcemid
demecolcine

Supplier Sponsors

Name:(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
CAS Number: 477-30-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-514-6
FDA UNII: Z01IVE25KI
Nikkaji Web:J9.231B
Beilstein Number:2822892
MDL:MFCD00075459
XlogP3:1.40 (est)
Molecular Weight:371.43325000
Formula:C21 H25 N O5
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 3161 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Colcemide ≥98% ( HPLC)
Odor: characteristic
Use: An antineoplastic alkaloid from Colchicum autumnale L. isolated from Colchicum autumnale L. ADCs Cytotoxin
EMD Millipore
For experimental / research use only.
Colcemid
sds
Glentham Life Sciences
Demecolcine
Santa Cruz Biotechnology
For experimental / research use only.
Colcemid ≥97%
Sigma-Aldrich: Sigma
For experimental / research use only.
Demecolcine ≥98% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for colcemid usage levels up to:
 not for fragrance use.
 
Recommendation for colcemid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :220401
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
Chemidplus:0000477305
RTECS:GH0800000 for cas# 477-30-5
 
References:
 (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):220401
Pubchem (cas):477-30-5
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.50.3000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 colchicum autumnale
Search Trop Picture
 
Synonyms:
 benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-
 deacetyl-N-methylcolchicine
 demecolcin
 demecolcine
N-methyl-N-deacetylcolchicine
 reichstein's F
 substance F
(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
 

Articles:

PubMed:Evaluation of drugs and stationary growth on the cell cycle of Giardia intestinalis.
PubMed:Nanocavity effect on photophysical properties of colchicine: a proof by circular dichroism study and picosecond time-resolved analysis in various reverse micellar assemblies.
PubMed:[Cytogenetic characterization of the neotropical fish Brycon henni (Pisces: Characidae)].
PubMed:[Comparison of TK gene mutation assay in TK6 and TK6-E6 cell induced by vinblastin and colcemid].
PubMed:p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents.
PubMed:Flow cytometric analysis of the cell-cycle distribution of spleen lymphocytes isolated from Fischer 344 rats exposed to ethyl nitrosourea.
PubMed:Cytoskeletal modulation of plasma membrane events induced by interferon-alpha.
PubMed:[Immediate results of polychemotherapy in esophageal cancer patients].
PubMed:Polyploidy and aneuploidy induced by colcemid in Drosophila melanogaster.
PubMed:Effects of food seasonings on the cell cycle and chromosome morphology of mammalian cells in vitro with special reference to turmeric.
PubMed:A new method of measuring the rate of shedding of epithelial cells from the intestinal villus of the rat.
 
Notes:
None found
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