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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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| Soluble in: |
| | water, 80.82 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for cis-stilbene oxide usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for cis-stilbene oxide flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | bibenzyl, alpha,alpha'-epoxy-, cis- | | cis-2,3- | diphenyl oxirane | | (2R,3S)-2,3- | diphenyloxirane | | | oxirane, 2,3-diphenyl-, cis- (9CI) | | (Z)- | stilbene oxide | | | stilbene oxide, cis- |
Articles:
| PubMed:A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol. |
| PubMed:Highly enantioselective iron(II)-catalyzed opening reaction of aromatic meso-epoxides with indoles. |
| PubMed:Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis. |
| PubMed:Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. |
| PubMed:An electric field-induced change in the selectivity of a metal oxide-catalyzed epoxide rearrangement. |
| PubMed:Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. |
| PubMed:Modular, active, and robust Lewis acid catalysts supported on a metal-organic framework. |
| PubMed:Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. |
| PubMed:Regulation of JH epoxide hydrolase versus JH esterase activity in the cabbage looper, Trichoplusia ni, by juvenile hormone and xenobiotics. |
| PubMed:The Saccharomyces cerevisiae ORF YNR064c protein has characteristics of an 'orphaned' epoxide hydrolase. |
| PubMed:Parallel mechanistic studies on the counterion effect of manganese salen and porphyrin complexes on olefin epoxidation by iodosylarenes. |
| PubMed:Functional analysis of human microsomal epoxide hydrolase genetic variants. |
| PubMed:Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. |
| PubMed:Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster. |
| PubMed:Kinetics and mechanism of rhenium-catalyzed O atom transfer from epoxides. |
| PubMed:Non-synonymous single nucleotide alterations in the microsomal epoxide hydrolase gene and their functional effects. |
| PubMed:Brassica napus soluble epoxide hydrolase (BNSEH1). |
| PubMed:Overexpression of Arabidopsis thaliana soluble epoxide hydrolase 1 in Pichia pastoris and characterisation of the recombinant enzyme. |
| PubMed:Activation of nitrous oxide and selective epoxidation of alkenes catalyzed by the manganese-substituted polyoxometalate, [Mn(III)2ZnW(Zn2W9O34)2]10-. |
| PubMed:Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries. |
| PubMed:Comparative metabolism and excretion of benzo(a)pyrene in 2 species of ictalurid catfish. |
| PubMed:First success of catalytic epoxidation of olefins by an electron-rich iron(III) porphyrin complex and H2O2: imidazole effect on the activation of H2O2 by iron porphyrin complexes in aprotic solvent. |
| PubMed:Metabolic activation of the proestrogens trans-stilbene and trans-stilbene oxide by rat liver microsomes. |
| PubMed:Cress and potato soluble epoxide hydrolases: purification, biochemical characterization, and comparison to mammalian enzymes. |
| PubMed:Reduction of stilbene oxide and styrene oxide to the corresponding alkenes by intestinal bacteria. |
| PubMed:Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase. |
| PubMed:Epoxide hydrolase--polymorphism and role in toxicology. |
| PubMed:Induction of hepatic heme oxygenase and changes in cytochrome P-450s in response to oxidative stress produced by stilbenes and stilbene oxides in rats. |
| PubMed:Characterization of epoxide hydrolase activity in Alternaria alternata f. sp. lycopersici. Possible involvement in toxin production. |
| PubMed:Assessment of possible protective roles of selenium, zinc, and cis-stilbene oxide against acute T-2 toxin poisoning: a preliminary report. |
| PubMed:Selective Oxygen Transfers with Iron(III) Porphyrin Nitrite. |
| PubMed:Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene. |
| PubMed:Development of an in situ toxicity assay system using recombinant baculoviruses. |
| PubMed:Kinetic parameters of lymphocyte microsomal epoxide hydrolase in carbamazepine hypersensitive patients. Assessment by radiometric HPLC. |
| PubMed:Induction of metallothionein synthesis by glutathione depletion after trans- and cis-stilbene oxide administration in rats. |
| PubMed:Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy. |
| PubMed:Kinetics and stereochemistry of the microsomal epoxide hydrolase-catalyzed hydrolysis of cis-stilbene oxides. |
| PubMed:Selective induction of rat liver phase II enzymes by N-heterocycle analogues of phenanthrene: a response exhibiting high correlation between UDP-glucuronosyltransferase and microsomal epoxide hydrolase activities. |
| PubMed:Effects of environmentally encountered epoxides on mouse liver epoxide-metabolizing enzymes. |
| PubMed:Comparative studies of the effects of stilbene compounds on hepatic ornithine decarboxylase and S-adenosylmethionine decarboxylase induction in rats. |
| PubMed:Expression of arylhydrocarbon hydroxylase, epoxide hydrolases, glutathione S-transferase and UDP-glucuronosyltransferases in H5-6 hepatoma cells. |
| PubMed:Rat and human liver cytosolic epoxide hydrolases: evidence for multiple forms at level of protein and mRNA. |
| PubMed:Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage. |
| PubMed:Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyltransferases in rat skin. |
| PubMed:Effect of hypolipidemic compounds on lauric acid hydroxylation and phase II enzymes. |
| PubMed:Microsomal and cytosolic epoxide hydrolase and glutathione S-transferase activities in the gill, liver, and kidney of the rainbow trout, Salmo gairdneri. Baseline levels and optimization of assay conditions. |
| PubMed:The low reactivity of 5H-dibenzo[a, d]cycloheptene 10,11-oxide in microsomal epoxide hydrolase catalysed hydration. |
| PubMed:Immunochemical comparison of human and rhesus monkey liver microsomal and the hepatocellular carcinoma-induced human serum epoxide hydrolases (preneoplastic antigens): basis for an enzyme-linked immunoabsorbent assay. |
| PubMed:Human liver cytosolic epoxide hydrolases. |
| PubMed:Hepatic epoxide hydrolase activities and their induction by clofibrate and diethylhexylphthalate in various strains of mice. |
| PubMed:Metabolism of tridiphane (2-(3,5-dichlorophenyl)-2(2,2,2-trichloroethyl)oxirane) by hepatic epoxide hydrolases and glutathione S-transferases in mouse. |
| PubMed:Purification of microsomal epoxide hydrolase from liver of rhesus monkey: partial separation of cis- and trans-stilbene oxide hydrolase. |
| PubMed:The effect of tridiphane (2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane) on hepatic epoxide-metabolizing enzymes: indications of peroxisome proliferation. |
| PubMed:Inhibition of epoxide hydrolases and glutathione S-transferases by 2-, 3-, and 4-substituted derivatives of 4'-phenylchalcone and its oxide. |
| PubMed:Stereoselectivity and enantioselectivity of glutathione S-transferase toward stilbene oxide substrates. |
| PubMed:Hepatic levels of cytosolic, microsomal and 'mitochondrial' epoxide hydrolases and other drug-metabolizing enzymes after treatment of mice with various xenobiotics and endogenous compounds. |
| PubMed:Subcellular and organ distribution of cholesterol epoxide hydrolase in the rat. |
| PubMed:Epoxide hydrolysis in the cytosol of rat liver, kidney, and testis. Measurement in the presence of glutathione and the effect of dietary clofibrate. |
| PubMed:Effect of aging on testicular epoxide hydrolase and glutathione-S-transferase activities in mice. |
| PubMed:Comparison of crude and affinity purified cytosolic epoxide hydrolases from hepatic tissue of control and clofibrate-fed mice. |
| PubMed:Subcellular distribution, catalytic properties and partial purification of epoxide hydrolase in the human adrenal gland. |
| PubMed:Hereditary interindividual differences in the glutathione transferase activity towards trans-stilbene oxide in resting human mononuclear leukocytes are due to a particular isozyme(s). |
| PubMed:Properties of cytosolic epoxide hydrolase purified from the liver of untreated and clofibrate-treated mice. Characterization of optimal assay conditions, substrate specificity and effects of modulators on the catalytic activity. |
| PubMed:Effect of dietary clofibrate on epoxide hydrolase activity in tissues of mice. |
| PubMed:Epoxide metabolism in the liver of mice treated with clofibrate (ethyl-alpha-(p-chlorophenoxyisobutyrate)), a peroxisome proliferator. |
| PubMed:Cyclopropyl oxiranes: reversible inhibitors of cytosolic and microsomal epoxide hydrolases. |
| PubMed:A methodology for the analysis of the preneoplastic antigen. |
| PubMed:Measurement and characterization of membrane-bound and soluble epoxide hydrolase activities in resting mononuclear leukocytes from human blood. |
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3D/inchi