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cis-4-hydroxy-dextro-proline
D-proline, 4-hydroxy-, (4R)-

Supplier Sponsors

Name:(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid
CAS Number: 2584-71-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:219-963-5
FDA UNII: Search
Nikkaji Web:J192.095B
Beilstein Number:0081439
MDL:MFCD00005252
XlogP3-AA:-3.30 (est)
Molecular Weight:131.13133000
Formula:C5 H9 N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 243.00 °C. @ 760.00 mm Hg
Boiling Point: 355.20 °C. @ 760.00 mm Hg (est)
Flash Point: 335.00 °F. TCC ( 168.60 °C. ) (est)
logP (o/w): -1.840 (est)
Soluble in:
 water, 3.947e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
cis-4-Hydroxy-D-proline 95%
Changzhou Longo Chemical
cis-4-Hydroxy-D-proline
Glentham Life Sciences
cis-4-Hydroxy-D-prolin
Santa Cruz Biotechnology
For experimental / research use only.
cis-4-Hydroxy-D-proline 99%
Sigma-Aldrich: Sigma
For experimental / research use only.
cis-4-Hydroxy-D-proline
TCI AMERICA
For experimental / research use only.
cis-4-Hydroxy-D-proline >98.0%(HPLC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for cis-4-hydroxy-dextro-proline usage levels up to:
 not for fragrance use.
 
Recommendation for cis-4-hydroxy-dextro-proline flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :440014
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid
Chemidplus:0002584716
 
References:
 (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):440014
Pubchem (sid):135060188
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C03440
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.90.9500
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(2R,4R)-(+)-4-hydroxy-2-pyrrolidine carboxylic acid
(4R)-4-hydroxy-D-proline
cis-4-hydroxy-D-proline
dextro-allo-hydroxyproline
(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid
D-proline, 4-hydroxy-, (4R)-
 

Articles:

PubMed:Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Δ(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.
PubMed:Promotion of cardiac differentiation of brown adipose derived stem cells by chitosan hydrogel for repair after myocardial infarction.
PubMed:Stemness and transdifferentiation of adipose-derived stem cells using L-ascorbic acid 2-phosphate-induced cell sheet formation.
PubMed:Discovery of new enzymes and metabolic pathways by using structure and genome context.
PubMed:Control of hydroxyproline catabolism in Sinorhizobium meliloti.
PubMed:Identification of a hydroxyproline transport system in the legume endosymbiont Sinorhizobium meliloti.
PubMed:Substrate specificity of the amino acid transporter PAT1.
PubMed:Collagen synthesis is required for ascorbic acid-enhanced differentiation of mouse embryonic stem cells into cardiomyocytes.
PubMed:Oxidation of 3,4-dehydro-D-proline and other D-amino acid analogues by D-alanine dehydrogenase from Escherichia coli.
PubMed:Transport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1.
PubMed:Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents.
PubMed:Pyrrolidine PNA: a novel conformationally restricted PNA analogue.
PubMed:Further study on the specificity of D-amino acid oxidase and D-aspartate oxidase and time course for complete oxidation of D-amino acids.
PubMed:Synthesis and biological evaluation of 4-purinylpyrrolidine nucleosides.
PubMed:Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer.
PubMed:Proline and proline derivatives as anticonvulsants.
PubMed:Induction of endothelial cell migration by proline analogs and its relevance to angiogenesis.
PubMed:Biosynthesis of trans-4-hydroxy-L-proline by Streptomyces griseoviridus.
PubMed:Epimerization of trans-4-hydroxy-L-proline to cis-4-hydroxy-D-proline during acid hydrolysis of collagen.
 
Notes:
None found
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