chlorzoxazone
5-chloro-2-hydroxybenzoxazole

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  Product(s):
  95-25-0 Chlorzoxazone >98%
  Chlorzoxazone is a muscle-relaxing drug, and a probe for human liver cytochrome P-450IIE1.

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  GP6973 Chlorzoxazone

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  C2237 Chlorzoxazone >98.0%(GC)(T)
  SDS

Name: 5-chloro-3H-1,3-benzoxazol-2-one CAS Number: 95-25-0 3D/inchi Other(deleted CASRN): 32850-84-3 ECHA EINECS - REACH Pre-Reg: 202-403-9 FDA UNII: H0DE420U8G Nikkaji Web: J3.950K MDL: MFCD00005717 XlogP3: 1.80 (est) Molecular Weight: 169.56628000 Formula: C7 H4 Cl N O2 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:pharmaceuticals / chemical synthisis   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 191.50 °C. @ 760.00 mm Hg Boiling Point: 336.90 °C. @ 760.00 mm Hg (est) Vapor Pressure: 0.000056 mmHg @ 25.00 °C. (est) Flash Point: 316.00 °F. TCC ( 157.50 °C. ) (est) logP (o/w): 1.816 (est) Soluble in:   water, 2709 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. Chlorzoxazone >98% Odor: characteristic Use: Chlorzoxazone is a muscle-relaxing drug, and a probe for human liver cytochrome P-450IIE1. Glentham Life Sciences Chlorzoxazone Sigma-Aldrich: Sigma For experimental / research use only. Chlorzoxazone sds TCI AMERICA For experimental / research use only. Chlorzoxazone >98.0%(GC)(T) sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intraperitoneal-hamster LD50 166 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. oral-hamster LD50 662 mg/kg BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. intraperitoneal-mammal (species unspecified) LD50 550 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Chimica Therapeutica. Vol. 6, Pg. 65, 1971. oral-man TDLo 50 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA American Journal of Emergency Medicine. Vol. 16, Pg. 393, 1998. intraperitoneal-mouse LD50 50 mg/kg National Technical Information Service. Vol. AD277-689 oral-mouse LD50 440 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 242, 1967. intraperitoneal-rat LD50 150 mg/kg BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. oral-rat LD50 763 mg/kg BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. Dermal Toxicity: subcutaneous-mouse LD50 170 mg/kg BEHAVIORAL: ANTICONVULSANT Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 247, 1962. Inhalation Toxicity: Not determined   Safety in Use Information: Category: pharmaceuticals / chemical synthisis Recommendation for chlorzoxazone usage levels up to:   not for fragrance use.   Recommendation for chlorzoxazone flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View ClinicalTrials.gov:search Daily Med:search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA Substance Registry Services (TSCA):95-25-0 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :2733 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 5-chloro-3H-1,3-benzoxazol-2-one Chemidplus:0000095250 RTECS:DM5250000 for cas# 95-25-0   References:   5-chloro-3H-1,3-benzoxazol-2-one NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 95-25-0 Pubchem (cid): 2733 Pubchem (sid): 134971727   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View KEGG (GenomeNet): C07931 HMDB (The Human Metabolome Database): HMDB14500 Export Tariff Code: 2934.99.4400 MedlinePlusSupp: View ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms: 2- benzoxazolinone, 5-chloro- 2- benzoxazolol, 5-chloro- 2(3H)- benzoxazolone, 5-chloro- 5- chlorbenzoxazolin-2-one 5- chloro-1,3-benzoxazol-2(3H)-one 5- chloro-2-benzoxazolinone 5- chloro-2-hydroxybenzoxazole 5- chloro-2,3-dihydro-2-oxo-1,3-benzoxazole 5- chloro-2(3H)-benzoxazolone 5- chloro-3-hydrobenzoxazol-2-one 5- chloro-3(H)-2-benzoxazolone 5- chloro-3H-1,3-benzoxazol-2-one 5- chloro-3H-benzooxazol-2-one 5- chloro-3H-benzoxazol-2-one 5- chloro-benzooxazol-2-ol 5- chlorobenzoxazol-2-one 5- chlorobenzoxazolidone 5- chlorobenzoxazolin-2-one   chloroxazone   chlorsoxazone   chlorzoxane   chlorzoxazon 2- hydroxy-5-chlorobenzoxazole   myoflexin   myoflexine   neoflex   paraflex   parafon   pathorysin   relaxazone   solaxin   Articles:   None found yet. Try the PubMed Search.

Notes: a centrally acting central muscle relaxant with sedative properties. it is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (from martindale, the extra pharmacopoea, 30th ed, p1202)