| PubMed:Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver-kidney microfluidic data and pharmacokinetic-system biology models. |
| PubMed:Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline. |
| PubMed:Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water. |
| PubMed:2-Hydrazinobenzothiazole-based etheno-adduct repair protocol (HERP): a method for quantitative determination of direct repair of etheno-bases. |
| PubMed:In situ footprinting of E. coli transcription elongation complex with chloroacetaldehyde. |
| PubMed:Preactivated oxazaphosphorines designed for isophosphoramide mustard delivery as bulk form or nanoassemblies: synthesis and proof of concept. |
| PubMed:Chemical display of pyrimidine bases flipped out by modification-dependent restriction endonucleases of MspJI and PvuRts1I families. |
| PubMed:The nephrotoxic Ifosfamide-metabolite chloroacetaldehyde interferes with renal extracellular matrix homeostasis. |
| PubMed:Effects of DNA repair gene polymorphisms on DNA damage in human lymphocytes induced by a vinyl chloride metabolite in vitro. |
| PubMed:Transformation efficiency and formation of transformation products during photochemical degradation of TCE and PCE at micromolar concentrations. |
| PubMed:[Classical oxazaphosphorines--metabolism and therapeutic properties--new implications]. |
| PubMed:Chloroacetonitrile and n,2-dichloroacetamide formation from the reaction of chloroacetaldehyde and monochloramine in water. |
| PubMed:Atmospheric chemistry and environmental assessment of inhalational fluroxene. |
| PubMed:Automated platform for sensor-based monitoring and controlled assays of living cells and tissues. |
| PubMed:A novel approach of periodate oxidation coupled with HPLC-FLD for the quantitative determination of 3-chloro-1,2-propanediol in water and vegetable oil. |
| PubMed:Surface-activated chemical ionization-electrospray mass spectrometry in the analysis of urinary thiodiglycolic acid. |
| PubMed:Concurrent modulation of extracellular levels of noradrenaline and cAMP during stress and by anxiogenic- or anxiolytic-like neuropeptides in the prefrontal cortex of awake rats. |
| PubMed:Acrolein and chloroacetaldehyde: an examination of the cell and cell-free biomarkers of toxicity. |
| PubMed:Characterization and application of a newly synthesized 2-deoxyribose-5-phosphate aldolase. |
| PubMed:Use of precision-cut renal cortical slices in nephrotoxicity studies. |
| PubMed:Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip. |
| PubMed:Determination of cellular aminopropyltransferase activity using precolumn fluorescent etheno-derivatization with high-performance liquid chromatography. |
| PubMed:A sensitive HPLC-based method to quantify adenine nucleotides in primary astrocyte cell cultures. |
| PubMed:Novel AlkB dioxygenases--alternative models for in silico and in vivo studies. |
| PubMed:Sensor-based cell and tissue screening for personalized cancer chemotherapy. |
| PubMed:Involvement of four different intracellular sites in chloroacetaldehyde- induced oxidative stress cytotoxicity. |
| PubMed:Liquid chromatography-tandem mass spectrometry quantification of 6-thioguanine in DNA using endogenous guanine as internal standard. |
| PubMed:Identification of 3,N(4)-etheno-5-methyl-2'-deoxycytidine in human DNA: a new modified nucleoside which may perturb genome methylation. |
| PubMed:Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. |
| PubMed:One-pot synthesis of chiral aziridines by a domino reaction by using desulfonylative formation on the N-tosyl imine of chloroacetaldehyde with an asymmetric Mannich reaction as a key step. |
| PubMed:One-pot synthesis of chiral α-substituted β,γ-epoxy aldehyde derivatives through an asymmetric aldol reaction of chloroacetaldehyde. |
| PubMed:Effects of chloroacetaldehyde in 2-chloroethanol-induced cardiotoxicity. |
| PubMed:The role of AlkB protein in repair of 1,N⁶-ethenoadenine in Escherichia coli cells. |
| PubMed:Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells. |
| PubMed:Kinetics and mechanism of the atmospheric reactions of atomic chlorine with 1-penten-3-ol and (Z)-2-penten-1-ol: an experimental and theoretical study. |
| PubMed:Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity. |
| PubMed:Human base excision repair creates a bias toward -1 frameshift mutations. |
| PubMed:Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. |
| PubMed:Oxazaphosphorines: new therapeutic strategies for an old class of drugs. |
| PubMed:Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway. |
| PubMed:Kinetics and mechanism of chlorine-atom-initiated oxidation of allyl alcohol, 3-buten-2-ol, and 2-methyl-3-buten-2-ol. |
| PubMed:Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells. |
| PubMed:Protective effects of fomepizole on 2-chloroethanol toxicity. |
| PubMed:Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells. |
| PubMed:Chloroacetaldehyde-induced mutagenesis in Escherichia coli: the role of AlkB protein in repair of 3,N(4)-ethenocytosine and 3,N(4)-alpha-hydroxyethanocytosine. |
| PubMed:Ifosfamide metabolite chloroacetaldehyde inhibits cell proliferation and glucose metabolism without decreasing cellular ATP content in human breast cancer cells MCF-7. |
| PubMed:Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation. |
| PubMed:Targets of chloroacetaldehyde-induced nephrotoxicity. |
| PubMed:Environmentally relevant parameters affecting PCB degradation: carbon source- and growth phase-mitigated effects of the expression of the biphenyl pathway and associated genes in Burkholderia xenovorans LB400. |
| PubMed:Ifosfamide nephrotoxicity in children: a mechanistic base for pharmacological prevention. |
| PubMed:New ifosfamide analogs designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity. |
| PubMed:Detection and quantification of (R) and (S)-dechloroethylifosfamide metabolites in plasma from children by enantioselective LC/MS/MS. |
| PubMed:Structure of the 1,N2-ethenodeoxyguanosine adduct opposite cytosine in duplex DNA: Hoogsteen base pairing at pH 5.2. |
| PubMed:Chiral NHC-catalyzed oxodiene Diels-Alder reactions with alpha-chloroaldehyde bisulfite salts. |
| PubMed:AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. |
| PubMed:Engineering a catabolic pathway in plants for the degradation of 1,2-dichloroethane. |
| PubMed:Chemical mapping of cytosines enzymatically flipped out of the DNA helix. |
| PubMed:Determination of leukocyte DNA 6-thioguanine nucleotide levels by high-performance liquid chromatography with fluorescence detection. |
| PubMed:Mechanisms of the ifosfamide-induced inhibition of endocytosis in the rat proximal kidney tubule. |
| PubMed:In vivo mesna and amifostine do not prevent chloroacetaldehyde nephrotoxicity in vitro. |
| PubMed:Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research. |
| PubMed:AlkB influences the chloroacetaldehyde-induced mutation spectra and toxicity in the pSP189 supF shuttle vector. |
| PubMed:Influence of short-term use of dexamethasone on the pharmacokinetics of ifosfamide in patients. |
| PubMed:The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: in vitro studies in renal tubular cells. |
| PubMed:Repression by binding of H-NS within the transcription unit. |
| PubMed:Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals. |
| PubMed:[14C]bis(2-chloroethoxy)methane: comparative absorption, distribution, metabolism and excretion in rats and mice. |
| PubMed:Necrotic pathway in human osteosarcoma Saos-2 cell death induced by chloroacetaldehyde. |
| PubMed:Mesna or cysteine prevents chloroacetaldehyde-induced cell death of human proximal tubule cells. |
| PubMed:Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice. |
| PubMed:Ifosfamide toxicity in cultured proximal renal tubule cells. |
| PubMed:Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy. |
| PubMed:Coping with polychlorinated biphenyl (PCB) toxicity: Physiological and genome-wide responses of Burkholderia xenovorans LB400 to PCB-mediated stress. |
| PubMed:Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells. |
| PubMed:Directed evolution of an industrial biocatalyst: 2-deoxy-D-ribose 5-phosphate aldolase. |
| PubMed:Ifosfamide-induced nephrotoxicity: mechanism and prevention. |
| PubMed:Selective alteration of the rate-limiting step in cytosolic aldehyde dehydrogenase through random mutagenesis. |
| PubMed:Application of biological activated carbon anaerobic reactor for treatment of hazardous chemicals. |
| PubMed:Matrix isolation and theoretical study of the photochemical reaction of CrCl2O2 with chloroethenes. |
| PubMed:Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention. |
| PubMed:Sequence-specific p53 gene damage by chloroacetaldehyde and its repair kinetics in Escherichia coli. |
| PubMed:Enantioselective metabolism of ifosfamide by the kidney. |
| PubMed:Insights into the hydrogen-abstraction reactions of diol dehydratase: relevance to the catalytic mechanism and suicide inactivation. |
| PubMed:Metabolism and transport of oxazaphosphorines and the clinical implications. |
| PubMed:Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine. |
| PubMed:Chloroacetaldehyde- and acrolein-induced death of human proximal tubule cells. |
| PubMed:Disturbed Ca2+-signaling by chloroacetaldehyde: a possible cause for chronic ifosfamide nephrotoxicity. |
| PubMed:Polymorphisms of DNA repair gene XPD and DNA damage of workers exposed to vinylchloride monomer. |
| PubMed:AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo. |
| PubMed:Synthesis, characterisation and theoretical calculations of 2,6-diaminopurine etheno derivatives. |
| PubMed:Chloroacetaldehyde: mode of antitumor action of the ifosfamide metabolite. |
| PubMed:A tubule cell model for ifosfamide nephrotoxicity. |
| PubMed:Dynamic analysis of metabolic effects of chloroacetaldehyde and cytochalasin B on tumor cells using bioelectronic sensor chips. |
| PubMed:Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4]triazine: synthesis of an alpha 2/3-selective GABA agonist. |
| PubMed:Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases. |
| PubMed:Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450. |
| PubMed:Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity. |
| PubMed:Mismatch dependent uracil/thymine-DNA glycosylases excise exocyclic hydroxyethano and hydroxypropano cytosine adducts. |
| PubMed:Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. |
| PubMed:Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. |
| PubMed:Renal ontogeny of ifosfamide nephrotoxicity. |
| PubMed:Analysis of drug action on tumor cell metabolism using electronic sensor chips. |
| PubMed:DNA damage and mutations produced by chloroacetaldehyde in a CpG-methylated target gene. |
| PubMed:Degradation pathway of 2-chloroethanol in Pseudomonas stutzeri strain JJ under denitrifying conditions. |
| PubMed:Role of mismatch-specific uracil-DNA glycosylase in repair of 3,N4-ethenocytosine in vivo. |
| PubMed:Suicide inactivation of dioldehydratase by glycolaldehyde and chloroacetaldehyde: an examination of the reaction mechanism. |
| PubMed:Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder. |
| PubMed:Dissociation of the ground state vinoxy radical and its photolytic precursor chloroacetaldehyde: electronic nonadiabaticity and the suppression of the H+ketene channel. |
| PubMed:S-Adenosyl methionine/S-adenosyl-L-homocysteine ratio determination by capillary electrophoresis employed as a monitoring tool for the antiviral effectiveness of adenosine analogs. |
| PubMed:Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death. |
| PubMed:Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics. |
| PubMed:[Chips instead of mice: cells on bioelectronic sensor-chips as an alternative to animal experiments]. |
| PubMed:Functional cellular assays with multiparametric silicon sensor chips. |
| PubMed:New nucleoside analogs from 2-amino-9-(beta-D-ribofuranosyl)purine. |
| PubMed:Renal-tubule metabolism of ifosfamide to the nephrotoxic chloroacetaldehyde: pharmacokinetic modeling for estimation of intracellular levels. |
| PubMed:Cytoprotective and anticancer properties of coenzyme Q versus capsaicin. |
| PubMed:Enzymology of repair of etheno-adducts. |
| PubMed:Neurological toxicity of ifosfamide. |
| PubMed:Pharmacology of ifosfamide. |
| PubMed:Photocatalytic oxidation of gaseous 2-chloroethyl ethyl sulfide over TiO2. |
| PubMed:Microphysiological testing for chemosensitivity of living tumor cells with multiparametric microsensor chips. |
| PubMed:Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells. |
| PubMed:Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells. |
| PubMed:Regioselective synthesis of 1,N(2)-etheno-2'-deoxyguanosine and its generation in oligomeric DNA. |
| PubMed:Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde. |
| PubMed:Determination of tenofovir in human plasma by high-performance liquid chromatography with spectrofluorimetric detection. |
| PubMed:Multiparametric sensor chips for chemosensitivity testing of sensitive and resistant tumor cells. |
| PubMed:High-performance liquid chromatographic technique for detection of a fluorescent analogue of ADP-ribose in isolated blood vessel preparations. |
| PubMed:Stem cell toxicity of oxazaphosphorine metabolites in comparison to their antileukemic activity. |
| PubMed:Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies. |
| PubMed:Toxicity of chloroacetaldehyde is similar in adult and pediatric kidney tubules. |
| PubMed:Analysis of 3,N(4)-ethenocytosine in DNA and in human urine by isotope dilution gas chromatography/negative ion chemical ionization/mass spectrometry. |
| PubMed:Simultaneous determination of six adenyl purines in human plasma by high-performance liquid chromatography with fluorescence derivatization. |
| PubMed:Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin. |
| PubMed:Determination of pyrimethamine in animal tissue and egg by liquid chromatography with fluorescence detection. |
| PubMed:Human kidney tubules detoxify chloroacetaldehyde, a presumed nephrotoxic metabolite of ifosfamide. |
| PubMed:Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model. |
| PubMed:Sensitive gas chromatographic determination of the cyclophosphamide metabolite 2-dechloroethylcyclophosphamide in human plasma. |
| PubMed:2-Chloroacetaldehyde induces epsilondA DNA adducts in DNA of Raji cells as demonstrated by an improved HPLC-fluorimetry method. |
| PubMed:Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells. |
| PubMed:Evaluation of a fluorogenic derivatization method for the reversed-phase HPLC analysis of 2'-beta-fluoro-2',3'-dideoxyadenosine, a new anti-AIDS drug. |
| PubMed:Approach to a multiparametric sensor-chip-based tumor chemosensitivity assay. |
| PubMed:Technical Advance: a novel technique for the sensitive quantification of acyl CoA esters from plant tissues. |
| PubMed:Fluorometric determination of 2'-beta-fluoro-2',3'-dideoxyadenosine 5'-triphosphate, the active metabolite of a new anti-human immunodeficiency virus drug, in human lymphocytes. |
| PubMed:Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites. |
| PubMed:Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5. |
| PubMed:Intravenous ifosfamide/mesna is associated with depletion of plasma thiols without depletion of leukocyte glutathione. |
| PubMed:Metabolism of ifosfamide to chloroacetaldehyde contributes to antitumor activity in vivo. |
| PubMed:Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde. |
| PubMed:Localization of chloroacetaldehyde-induced DNA damage in human p53 gene by DNA polymerase fingerprint analysis. |
| PubMed:Mammalian enzymatic repair of etheno and para-benzoquinone exocyclic adducts derived from the carcinogens vinyl chloride and benzene. |
| PubMed:Thermal destabilization of DNA oligonucleotide duplexes by exocyclic adducts on adenine or cytosine depends on both the base and the size of adduct. |
| PubMed:Detection and quantification of 1,N(6)-ethenoadenine in human placental DNA by mass spectrometry. |
| PubMed:Suspected ifosfamide-induced neurotoxicity. |
| PubMed:Quantification of 5-methylcytosine in DNA by the chloroacetaldehyde reaction. |
| PubMed:The role of the Escherichia coli mug protein in the removal of uracil and 3,N(4)-ethenocytosine from DNA. |
| PubMed:Toxicity of ifosfamide and its metabolite chloroacetaldehyde in cultured renal tubule cells. |
| PubMed:A new passive sampler for regulated workplace aldehydes. |
| PubMed:High-performance liquid chromatographic-fluorescent method to determine chloroacetaldehyde, a neurotoxic metabolite of the anticancer drug ifosfamide, in plasma and in liver microsomal incubations. |
| PubMed:Increased urinary losses of carnitine during ifosfamide chemotherapy. |
| PubMed:Chemical stability and fate of the cytostatic drug ifosfamide and its N-dechloroethylated metabolites in acidic aqueous solutions. |
| PubMed:Monooxygenase-mediated 1,2-dichloroethane degradation by Pseudomonas sp. strain DCA1. |
| PubMed:Ifosfamide-induced stomatocytosis and mesna-induced echinocytosis: influence on biorheological properties of blood. |
| PubMed:Inhibition and stimulation of long-chain fatty acid oxidation by chloroacetaldehyde and methylene blue in rats. |
| PubMed:Metabolic activation of vinyl chloride by rat liver microsomes: low-dose kinetics and involvement of cytochrome P450 2E1. |
| PubMed:In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. |
| PubMed:Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein. |
| PubMed:Endogenous and exogenous DNA lesions recognized by N-alkylpurine-DNA glycosylases. |
| PubMed:Chloromethyl ketones are insulin-like stimulators of lipid synthesis in locust fat body. |
| PubMed:Genotoxic bifunctional aldehydes produce specific images in the comet assay. |
| PubMed:Sequence-dependent extrusion of a small DNA hairpin at the N4 virion RNA polymerase promoters. |
| PubMed:Determination of ATP and its metabolites released from rat caudal artery by isocratic ion-pair reversed-phase high-performance liquid chromatography. |
| PubMed:Measurement of adenosine concentration in aqueous and vitreous. |
| PubMed:Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo. |
| PubMed:Excretion kinetics of ifosfamide side-chain metabolites in children on continuous and short-term infusion. |
| PubMed:Differential cytotoxicity of Ifosfamide and its metabolites in renal epithelial cell cultures. |
| PubMed:Cloning, sequence and expression of a linear plasmid-based and a chromosomal homolog of chloroacetaldehyde dehydrogenase-encoding genes in Xanthobacter autotrophicus GJ10. |
| PubMed:Toxicity, pharmacokinetics, and in vitro hemodialysis clearance of ifosfamide and metabolites in an anephric pediatric patient with Wilms' tumor. |
| PubMed:Novel substrates of yeast alcohol dehydrogenase-3. 4-dimethylamino-cinnamaldehyde and chloroacetaldehyde. |
| PubMed:Involvement of glutamate 399 and lysine 192 in the mechanism of human liver mitochondrial aldehyde dehydrogenase. |
| PubMed:Stimulation of respiration by methylene blue in rat liver mitochondria. |
| PubMed:A 13C NMR study of 2-(13)C-chloroacetaldehyde, a metabolite of ifosfamide and cyclophosphamide, in the isolated perfused rabbit heart model. Initial observations on its cardiotoxicity and cardiac metabolism. |
| PubMed:Ifosfamide cytotoxicity on human tumor and renal cells: role of chloroacetaldehyde in comparison to 4-hydroxyifosfamide. |
| PubMed:DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells. |
| PubMed:The electrophilic, mutagenic and tumorigenic activities of phenyl and 4-nitrophenyl vinyl ethers and their epoxide metabolites. |
| PubMed:The GST T1 and CYP2E1 genotypes are possible factors causing vinyl chloride induced abnormal liver function. |
| PubMed:Is the white-ivory assay of Drosophila melanogaster a useful tool in genetic toxicology? |
| PubMed:Urinary excretion of ifosfamide, 4-hydroxyifosfamide, 3- and 2-dechloroethylifosfamide, mesna, and dimesna in patients on fractionated intravenous ifosfamide and concomitant mesna therapy. |
| PubMed:Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line. |
| PubMed:Ifosfamide metabolite chloroacetaldehyde causes renal dysfunction in vivo. |
| PubMed:Adenine quantitation in yeast extracts and fermentation media and its relationship to protein expression and cell growth in adenine auxotrophs of Saccharomyces cerevisiae. |
| PubMed:Inhibition of (mono)amine oxidase activity and prevention of ifosfamide encephalopathy by methylene blue. |
| PubMed:High resolution mapping of E.coli transcription elongation complex in situ reveals protein interactions with the non-transcribed strand. |
| PubMed:1,N6-ethenodeoxyadenosine, a DNA adduct highly mutagenic in mammalian cells. |
| PubMed:Modulation by acrolein and chloroacetaldehyde of multidrug resistance mediated by the multidrug resistance-associated protein (MRP). |
| PubMed:TTA.TAA triplet repeats in plasmids form a non-H bonded structure. |
| PubMed:2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity. |
| PubMed:Formation of a combined H-DNA/open TATA box structure in the promoter sequence of the human Na,K-ATPase alpha2 gene. |
| PubMed:Ifosfamide nephrotoxicity: limited influence of metabolism and mode of administration during repeated therapy in paediatrics. |
| PubMed:Characterization by two-endpoint comparisons of the genetic toxicity profiles of vinyl chloride and related etheno-adduct forming carcinogens in Drosophila. |
| PubMed:Adaptation of Pseudomonas sp. GJ1 to 2-bromoethanol caused by overexpression of an NAD-dependent aldehyde dehydrogenase with low affinity for halogenated aldehydes. |
| PubMed:Measurement of adenosine by capillary zone electrophoresis with on-column isotachophoretic preconcentration. |
| PubMed:DNA damage: chemistry, repair, and mutagenic potential. |
| PubMed:Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans. |
| PubMed:Oxidative metabolism of 1-(2-chloroethyl)-3-alkyl-3- (methylcarbamoyl)triazenes: formation of chloroacetaldehyde and relevance to biological activity. |
| PubMed:Methylene blue and the neurotoxic mechanisms of ifosfamide encephalopathy. |
| PubMed:1,N6-ethenoadenine and 3,N4-ethenocytosine are excised by separate human DNA glycosylases. |
| PubMed:An intramolecular triplex in the human gamma-globin 5'-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin. |
| PubMed:Molecular analysis of mutations induced by 2-chloroacetaldehyde, the ultimate carcinogenic form of vinyl chloride, in human cells using shuttle vectors. |
| PubMed:Detection of mutagen specific adduct formation in DNA using sequencing methodology. |
| PubMed:4-Chlorothreonine is substrate, mechanistic probe, and mechanism-based inactivator of serine hydroxymethyltransferase. |
| PubMed:Spectrofluorimetric determination of 2-chloro-2'-deoxyadenosine (cladribine) in human plasma by photochemical reaction and chloroacetaldehyde derivatization. |
| PubMed:Lack of uniformity in the mutational spectra of chlorohydroxyfuranones in Salmonella typhimurium strain TA100. |
| PubMed:The benzene metabolite p-benzoquinone forms adducts with DNA bases that are excised by a repair activity from human cells that differs from an ethenoadenine glycosylase. |
| PubMed:Genetic adaptation of bacteria to halogenated aliphatic compounds. |
| PubMed:High-performance liquid chromatographic determination of diadenosine 5',5'"-p1,p4-tetraphosphate with precolumn fluorescence derivatization and its application to metabolism study in whole blood. |
| PubMed:Ifosfamide and mesna: effects on the Na/H exchanger activity in renal epithelial cells in culture (LLC-PK1). |
| PubMed:Triple-helix specific ligands stabilize H-DNA conformation. |
| PubMed:The use of 2-hydroperoxytetrahydrofuran as a reagent to sequence cytosine and to probe non-Watson-Crick DNA structures. |
| PubMed:Distortion after monofunctional alkylation by mitomycin C of a dodecamer containing its major binding site. |
| PubMed:Comparison of continuous infusion and bolus administration of ifosfamide in children. |
| PubMed:Enzymatic and chemical probing of an S1 nuclease-sensitive site upstream from the human CFTR gene. |
| PubMed:Determination of adenine nucleotides by fluorescence detection using high-performance liquid chromatography and post-column derivatisation with chloroacetaldehyde. |
| PubMed:Determination of plasma adenosine by high-performance liquid chromatography with column switching and fluorometric detection. |
| PubMed:Genetics and biochemistry of 1,2-dichloroethane degradation. |
| PubMed:Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney. |
| PubMed:Detection of small quantities of double stranded DNA by enhanced fluorescence of substituted aldehyde modified polydeoxynucleotide-ethidium bromide complexes. |
| PubMed:Ifosfamide and carboplatin combined with 41.8 degrees C whole-body hyperthermia in patients with refractory sarcoma and malignant teratoma. |
| PubMed:Selective determination of adenine-containing compounds by capillary electrophoresis with laser-induced fluorescence detection. |
| PubMed:The induction of adaptive response to alkylating agents in Escherichia coli reduces the frequency of specific C-->T mutations in chloroacetaldehyde-treated M13 glyU phage. |
| PubMed:Chloroacetaldehyde-induced hepatocyte cytotoxicity. Mechanisms for cytoprotection. |
| PubMed:Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna. |
| PubMed:Gradual and oriented B-Z transition in 5'-untranscribed region of mouse ribosomal DNA. |
| PubMed:Ifosfamide clinical pharmacokinetics. |
| PubMed:Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. |
| PubMed:Identification of chloroacetaldehyde dehydrogenase involved in 1,2-dichloroethane degradation. |
| PubMed:Toxicity of ifosfamide, cyclophosphamide and their metabolites in renal tubular cells in culture. |
| PubMed:The non-B-DNA structure of d(CA/TG)n differs from that of Z-DNA. |
| PubMed:Monofunctional adducts of platinum(II) produce in DNA a sequence-dependent local denaturation. |
| PubMed:All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase. |
| PubMed:[Molecular basis of mutagenic activity of vinyl chloride]. |
| PubMed:Molecular mechanisms of chloroacetaldehyde-induced cytotoxicity in isolated rat hepatocytes. |
| PubMed:Identification of DNA adducts at specific locations by sequencing techniques. |
| PubMed:Effect of ifosfamide metabolites on sodium-dependent phosphate transport in a model of proximal tubular cells (LLC-PK1) in culture. |
| PubMed:Ifosfamide. Patient care management. |
| PubMed:Substrate specificity of rat liver aldehyde dehydrogenase with chloroacetaldehydes. |
| PubMed:The analysis of ifosfamide and its metabolites (review). |
| PubMed:Enhancement of ethidium bromide fluorescence in double-stranded DNA reacted with chloroacetaldehyde. |
| PubMed:Chloroacetaldehyde-induced mutagenesis in Escherichia coli: specificity of mutations and modulation by induction of the adaptive response to alkylating agents. |
| PubMed:Formation of ethenocarbaldehyde derivatives of adenosine and cytidine in reactions with mucochloric acid. |
| PubMed:Structural polymorphism of homopurine-homopyrimidine sequences at neutral pH. |
| PubMed:Toxicity studies in fertilized zebrafish eggs treated with N-methylamine, N,N-dimethylamine, 2-aminoethanol, isopropylamine, aniline, N-methylaniline, N,N-dimethylaniline, quinone, chloroacetaldehyde, or cyclohexanol. |
| PubMed:Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma. |
| PubMed:Simultaneous determination of nerve-induced adenine nucleotides and nucleosides released from rabbit pulmonary artery. |
| PubMed:Vinyl carbamate epoxide, a major strong electrophilic, mutagenic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate (urethane). |
| PubMed:Conformational junctions between left-handed DNA in (dA-dT)16 and contiguous B-DNA in a supercoiled plasmid contain chemically reactive bases. |
| PubMed:Development of monoclonal antibodies specific for 1,N2-ethenodeoxyguanosine and N2,3-ethenodeoxyguanosine and their use for quantitation of adducts in G12 cells exposed to chloroacetaldehyde. |
| PubMed:Ifosfamide, mesna, and nephrotoxicity in children. |
| PubMed:Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy. |
| PubMed:32P-postlabelling methods for cyclic DNA adducts. |
| PubMed:Gas chromatographic determination of 2- and 3-dechloroethylifosfamide in plasma and urine. |
| PubMed:Fluorometric quantitation of adenosine concentration in small samples of extracellular fluid. |
| PubMed:Transcriptionally driven cruciform formation in vivo. |
| PubMed:The enigma of ifosfamide encephalopathy. |
| PubMed:Inhibition of sodium-dependent transport systems in LLC-PK1 cells by metabolites of ifosfamide. |
| PubMed:Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II. |
| PubMed:1,N2-ethenodeoxyguanosine: properties and formation in chloroacetaldehyde-treated polynucleotides and DNA. |
| PubMed:Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse. |
| PubMed:Utilization of glutathione during 1,2-dihaloethane metabolism in rat hepatocytes. |
| PubMed:Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection. |
| PubMed:Intramolecular dG.dG.dC triplex detected in Escherichia coli cells. |
| PubMed:Roles of the vinyl chloride oxidation products 1-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases [corrected]. |
| PubMed:Analysis of DNA strand breaks induced in rodent liver in vivo, hepatocytes in primary culture, and a human cell line by chlorinated acetic acids and chlorinated acetaldehydes. |
| PubMed:H-DNA and Z-DNA in the mouse c-Ki-ras promoter. |
| PubMed:Determination of 9-[(2-phosphonylmethoxy)ethyl]adenine in rat urine by high-performance liquid chromatography with fluorescence detection. |
| PubMed:Cross-adaptive response in Escherichia coli caused by pretreatment with H2O2 against formaldehyde and other aldehyde compounds. |
| PubMed:Determination of urinary 2- and 3-dechloroethylated metabolites of ifosfamide by high-performance liquid chromatography. |
| PubMed:Mechanisms of mutagenesis by exocyclic DNA adducts. Construction and in vitro template characteristics of an oligonucleotide bearing a single site-specific ethenocytosine. |
| PubMed:A sensitive fluorescence assay for quantitation of fludarabine and metabolites in biological fluids. |
| PubMed:Detection of triple-helix related structures adopted by poly(dG)-poly(dC) sequences in supercoiled plasmid DNA. |
| PubMed:Involvement of a large plasmid in the degradation of 1,2-dichloroethane by Xanthobacter autotrophicus. |
| PubMed:Improved high-pressure liquid chromatographic-fluorometric assay for measurement of adenosine in plasma. |
| PubMed:Evidence for the mutagenic potential of the vinyl chloride induced adduct, N2, 3-etheno-deoxyguanosine, using a site-directed kinetic assay. |
| PubMed:Formation of (dA-dT)n cruciforms in Escherichia coli cells under different environmental conditions. |
| PubMed:Di(1,N6-ethenoadenosine)5', 5'''-P1,P4-tetraphosphate, a fluorescent enzymatically active derivative of Ap4A. |
| PubMed:Metabolism and pharmacokinetics of oral and intravenous ifosfamide. |
| PubMed:Torsional stress stabilizes extended base unpairing in suppressor sites flanking immunoglobulin heavy chain enhancer. |
| PubMed:Derivatization-liquid chromatographic assay of chloroacetaldehyde in biological samples. |
| PubMed:Distortions induced in double-stranded oligonucleotides by the binding of cis- or trans-diammine-dichloroplatinum(II) to the d(GTG) sequence. |
| PubMed:2-Chloroacetaldehyde and 2-chloroacetal are potent inhibitors of DNA synthesis in animal cells. |
| PubMed:Chloroacetaldehyde is a powerful inducer of mitotic aneuploidy in Aspergillus nidulans. |
| PubMed:Formation of N2,3-ethanoguanine in DNA after in vitro treatment with the therapeutic agent, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea. |
| PubMed:Influence of beta-adrenergic stimulation and contraction frequency on rat heart interstitial adenosine. |
| PubMed:Mechanisms of mutagenesis by the vinyl chloride metabolite chloroacetaldehyde. Effect of gene-targeted in vitro adduction of M13 DNA on DNA template activity in vivo and in vitro. |
| PubMed:Nucleophilic selectivity and reaction kinetics of chloroethylene oxide assessed by the 4-(p-nitrobenzyl)pyridine assay and proton nuclear magnetic resonance spectroscopy. |
| PubMed:Comparison of mutagenic activities of several peroxyacyl nitrates. |
| PubMed:Nucleophilic selectivity as a determinant of carcinogenic potency (TD50) in rodents: a comparison of mono- and bi-functional alkylating agents and vinyl chloride metabolites. |
| PubMed:Non-B DNA structure: preferential target for the chemical carcinogen glycidaldehyde. |
| PubMed:Investigation of RecA--polynucleotide interactions from the measurement of LexA repressor cleavage kinetics. Presence of different types of complex. |
| PubMed:Synthesis of N2,3-ethenodeoxyguanosine, N2,3-ethenodeoxyguanosine 5'-phosphate, and N2,3-ethenodeoxyguanosine 5'-triphosphate. Stability of the glycosyl bond in the monomer and in poly(dG,epsilon dG-dC). |
| PubMed:Cationic metal-specific structures adopted by the poly(dG) region and the direct repeats in the chicken adult beta A globin gene promoter. |
| PubMed:The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo. |
| PubMed:Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication. |
| PubMed:The DNA bending by acetylaminofluorene residues and by apurinic sites. |
| PubMed:High-pressure-liquid-chromatographic and fluorimetric methods for the determination of adenine released from ribosomes by ricin and gelonin. |
| PubMed:Chemical probes of the conformation of DNA modified by cis-diamminedichloroplatinum(II). |
| PubMed:Mechanisms of mutagenesis by chloroacetaldehyde. |
| PubMed:Liquid holding increases mutation induction by formaldehyde and some other cross-linking agents in Escherichia coli K12. |
| PubMed:1,N6-etheno-2'-deoxyadenosine and 3,N4-etheno-2'-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride. |
| PubMed:HPLC-32P-postlabelling analysis of 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine. |
| PubMed:High-performance liquid chromatographic analysis of DNA composition and DNA modification by chloroacetaldehyde. |
| PubMed:Formation of interstrand cross-links in chloroacetaldehyde-treated DNA demonstrated by ethidium bromide fluorescence. |
| PubMed:Mechanistic studies on chloral toxicity: relationship to trichloroethylene carcinogenesis. |
| PubMed:Chloroacetaldehyde reacts with Z-DNA. |
| PubMed:Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA. |
| PubMed:Determination of adenosine in fetal perfusates of human placental cotyledons using fluorescence derivatization and reversed-phase high-performance liquid chromatography. |
| PubMed:Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposure. |
| PubMed:Development of techniques to monitor for exposure to vinyl chloride: monoclonal antibodies to ethenoadenosine and ethenocytidine. |
| PubMed:An ultimate chemical carcinogen, N-acetoxy-2-acetylaminofluorene, detects non-B DNA structures that are reactive with chloroacetaldehyde in supercoiled plasmid DNA. |
| PubMed:Investigations on metabolism and carcinogenicity of 1,1,2-trichloroethane. |
| PubMed:The chemical carcinogen, chloroacetaldehyde, modifies a specific site within the regulatory sequence of human cytomegalovirus major immediate early gene in vivo. |
| PubMed:Inhibition of restriction endonuclease cleavage due to site-specific chemical modification of the B-Z junction in supercoiled DNA. |
| PubMed:The segment inversion site of herpes simplex virus type 1 adopts a novel DNA structure. |
| PubMed:Kinetic studies of recA protein binding to a fluorescent single-stranded polynucleotide. |
| PubMed:Unusual conformational effect exerted by Z-DNA upon its neighboring sequences. |
| PubMed:Measurement by fluorescence of interstitial adenosine levels in normoxic, hypoxic, and ischemic perfused rat hearts. |
| PubMed:Vinyl chloride: an assessment of the risk of occupational exposure. |
| PubMed:Determination of adenosine ribo- and deoxyribonucleotides as their 1-N6-etheno derivatives by reversed-phase ion-pair high-performance liquid chromatography. |
| PubMed:The use of suicide substrates to select mutants of Escherichia coli lacking enzymes of alcohol fermentation. |
| PubMed:Dechloroethylation of ifosfamide and neurotoxicity. |
| PubMed:New adducts of chloroethylene oxide and chloroacetaldehyde with pyrimidine nucleosides. |
| PubMed:A sensitive high-performance liquid chromatographic procedure with fluorometric detection for the analysis of decarboxylated S-adenosylmethionine and analogs in urine samples. |
| PubMed:Chemical modification of adenine and cytosine residues with chloroacetaldehyde at the nucleoside and the tRNA level: the structural effect of chloroacetaldehyde modification. |
| PubMed:Reaction kinetics and cytosine adducts of chloroethylene oxide and chloroacetaldehyde: direct observation of intermediates by FTNMR and GC-MS. |
| PubMed:Neutral reactions of haloacetaldehydes with polynucleotides: mechanisms, monomer and polymer products. |
| PubMed:Detection of DNA base damage by 32P-postlabelling: TLC separation of 5'-deoxynucleoside monophosphates. |
| PubMed:Repair of etheno DNA adducts by N-glycosylases. |
| PubMed:Reaction of chloroacetaldehyde with poly(dA-dT) and poly(dC-dG) and its effect upon the accuracy of DNA synthesis. |
| PubMed:Covalent binding of reactive intermediates to hemoglobin in the mouse as an approach to studying the metabolic pathways of 1,2-dichloroethane. |
| PubMed:Metabolic activation of vinyl chloride, formation of nucleic acid adducts and relevance to carcinogenesis. |
| PubMed:Investigations on metabolism, genotoxic effects and carcinogenicity of 2,2'-dichlorodiethylether. |
| PubMed:Mutagenic and promutagenic properties of DNA adducts formed by vinyl chloride metabolites. |
| PubMed:Evaluation of the mutagenicity of 1,N6-ethenoadenine- and 3,N4-ethenocytosine-nucleosides in Salmonella typhimurium. |
| PubMed:Quantitation of etheno adducts by fluorescence detection. |
| PubMed:The role of cyclic base adducts in vinyl-chloride-induced carcinogenesis: studies on nucleic acid alkylation in vivo. |
| PubMed:High-pressure liquid chromatographic methods for determining arabinosyladenine-5'-monophosphate, arabinosyladenine, and arabinosylhypoxanthine in plasma and urine. |
| PubMed:Mutagenicity and toxicity of chloroethylene oxide and chloroacetaldehyde. |
| PubMed:Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling. |
| PubMed:[Metabolism of 1,2-dichloroethane in the human body in acute poisonings]. |
| PubMed:Fluorometric determination of adenine nucleotides and adenosine by ion-paired, reverse-phase, high-performance liquid chromatography. |
| PubMed:An investigation of the role of microsomal oxidative metabolism in the in vivo genotoxicity of 1,2-dichloroethane. |
| PubMed:Assessment of mutagenic efficiency of two carcinogen-modified nucleosides, 1,N6-ethenodeoxyadenosine and O4-methyldeoxythymidine, using polymerases of varying fidelity. |
| PubMed:Metabolism of chloroethanes by rat liver nuclear cytochrome P-450. |
| PubMed:Absorption and fluorescence studies of the binding of the recA gene product from E. coli to single-stranded and double-stranded DNA. Ionic strength dependence. |
| PubMed:High-pressure liquid chromatographic-fluorometric detection of adenosine and adenine nucleotides: application to endogenous content and electrically induced release of adenyl purines in guinea pig vas deferens. |
| PubMed:Binding of gene 32 protein from phage T4 and recA gene product from E. coli to fluorescent single-stranded polynucleotides. |
| PubMed:Metabolism of genotoxic agents: halogenated compounds. |
| PubMed:Dose-response relationships for mutations induced in E. coli by some model compounds. With an addendum: Reaction kinetics in water of chloroethylene oxide, chloroacetaldehyde, and chloroacetone. |
| PubMed:Bacterial growth on 1,2-dichloroethane. |
| PubMed:Sensitive and selective assay for adenosine using high-pressure liquid chromatography with fluorometry. |
| PubMed:Evidence of chloroethylene oxide being the reactive metabolite of vinyl chloride towards DNA: comparative studies with 2,2'-dichlorodiethylether. |
| PubMed:Long-range conformational transition in yeast tRNAPhe, induced by the Y-base removal and detected by chloroacetaldehyde modification. |
| PubMed:3-aminopyridine 1,N6-ethenoadenine dinucleotide phosphate: a fluorescent reagent for NADP-requiring enzymes. |
| PubMed:2-Chloroacetaldehyde: a metabolite of cyclophosphamide in the rat. |
| PubMed:2-Chloroacetaldehyde, a metabolite of cyclophosphamide in the rat. |
| PubMed:Hepatic microsomal metabolism of the dichloroethanes. |
| PubMed:Binding of RecA protein to single-stranded nucleic acids: spectroscopic studies using fluorescent polynucleotides. |
| PubMed:Direct observation of complexes formed between recA protein and a fluorescent single-stranded deoxyribonucleic acid derivative. |
| PubMed:Chloroacetaldehyde-treated ribo- and deoxyribopolynucleotides. 1. Reaction products. |
| PubMed:Chloroacetaldehyde-treated ribo- and deoxyribopolynucleotides. 2. Errors in transcription by different polymerases resulting from ethenocytosine and its hydrated intermediate. |
| PubMed:Determination of chloroacetaldehyde in air by differential pulse polarography. |
| PubMed:Adenosine measurement by a rapid HPLC-fluorometric method: induced changes of adenosine content in regions of rat brain. |
| PubMed:The 1,2-dichloroethylenes: their metabolism by hepatic cytochrome p-450 in vitro. |
| PubMed:The nucleotide sequence of tRNA4Val of Drosophila melanogaster. Chloroacetaldehyde modification as an aid to RNA sequencing. |
| PubMed:Detection of N2,3-ethanoguanine in DNA after treatment with chloroacetaldehyde in vitro. |
| PubMed:Fluorescence modification of Escherichia coli 5S RNA. |
| PubMed:The reaction of adenine and cytosine residues in tRNA with chloroacetaldehyde. |
| PubMed:Metabolism of a DDT metabolite via a chloroepoxide. |
| PubMed:Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis. |
| PubMed:The induction of errors during in vitro DNA synthesis following chloroacetaldehyde-treatment of poly(dA-dT) and poly(dC-dG) templates. |
| PubMed:A simple fluorometric method for cAMP: application to studies of brain adenylate cyclase activity. |
| PubMed:Detection of mutagen-induced lesions in isolated DNA by marker rescue of Bacillus subtilis phage phi 105. |
| PubMed:The reactions of thiouridines and thiouracils with chloroacetaldehyde; mechanistic considerations. |
| PubMed:Carcinogenicity of chloroethylene oxide, an ultimate reactive metabolite of vinyl chloride, and bis(chloromethyl)ether after subcutaneous administration and in initiation-promotion experiments in mice. |
| PubMed:Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice. |
| PubMed:Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde. |
| PubMed:Identification of S-(carboxymethyl)-L-cysteine and thiodiglycolic acid, urinary metabolites of 2,2'-bis-(chloroethyl)-ether in the rat. |
| PubMed:Exposure of DNA bases induced by the interaction of DNA and calf thymus DNA helix-destabilizing protein. |
| PubMed:Interactions of vinyl chloride with rat-liver DNA in vivo. |
| PubMed:Osmium-labeled polynucleotides: reaction of osmium tetraoxide, with poly-1,N6-ethenoadenylic acid. |
| PubMed:New observations concerning the chloroacetaldehyde reaction with some tRNA constituents. Stable intermediates, kinetics and selectivity of the reaction. |
| PubMed:Mutagenicity of halogenated alkanes and their derivatives. |
| PubMed:A correlation between the secondary structure of DNA and the reactivity of adenine residues with chloroacetaldehyde. |
| PubMed:[Mechanism of the reaction of adenosine-5'-phosphate with chloroacetaldehyde]. |
| PubMed:Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast. |
| PubMed:Location of accessible bases in Escherichia coli formylmethionine transfer RNA as determined by chemical modification. |
| PubMed:Mutagenicity and metabolism of vinyl chloride and related compounds. |
| PubMed:Vinyl chloride mutagenicity via the metabolites chlorooxirane and chloroacetaldehyde monomer hydrate. |
| PubMed:The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride. |
| PubMed:Microsomal metabolism of triazenylimidazoles. |
| PubMed:Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde. |
| PubMed:Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide. |
| PubMed:Mutagenicity of vinyl chloride, chloroethyleneoxide, chloroacetaldehyde and chloroethanol. |
| PubMed:Human, rat and mouse liver-mediated mutagenicity of vinyl chloride in S. typhimurium strains. |
| PubMed:Mechanistic, inhibitory and stereochemical studies on cytoplasmic and mitochondrial serine transhydorxymethylases. |
| PubMed:Chloroacetaldehyde-modified dinucleoside phosphates. Dynamic fluorescence quenching and quenching due to intramolecular complexation. |
| PubMed:Effect of chemically modified 70S RNA from avian myeloblastosis virus (AMV) upon the activity of AMV DNA polymerase. |
| PubMed:Electron spin resonance studies with dioldehydrase. II. The hyperfine structure of proposed radical intermediates derived from isotopic substitution in 2-chloroacetaldehyde. |
| PubMed:A simple fluorimetric microassay for adenine compounds in platelets and plasma and its application to studies on the platelet release reaction. |
| PubMed:Flavin 1, N 6 -ethenoadenine dinucleotide: dynamic and static quenching of fluorescence. |
| PubMed:Physical studies of chloroacetaldehyde labelled fluorescent DNA. |
| PubMed:A fluorescent analog of nicotinamide adenine dinucleotide. |
| PubMed:Studies on the mechanism of action of coenzyme B 12 . The formation of 5'-deoxyadenosine and B 12(r) in the reaction of dioldehydrase with chloroacetaldehyde. |
| PubMed:Toxicity profile of chloroacetaldehyde. |
| PubMed:[Chemical resistance of certain materials in media containing chloroacetaldehyde, trichloroethane, hydrochloric acid, and chloroacetic acid]. |
3D/inchi