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cetrimonium bromide
hexadecyltrimethylammonium bromide

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CAS Number: 57-09-0Picture of molecule3D/inchi
Other(deleted CASRN):104302-76-3
ECHA EINECS - REACH Pre-Reg:200-311-3
Beilstein Number:3598189
Molecular Weight:364.45474000
Formula:C19 H42 Br N
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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DG SANTE Food Contact Materials:hexadecyltrimethylammonium bromide
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 240.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 9.651 mg/L @ 25 °C (est)
 water, 1.00E+05 mg/L @ 25 °C (exp)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
antistatic agents
surfactant - emulsifying
American International Chemical, LLC.
Cetrimonium Bromide
BOC Sciences
For experimental / research use only.
Zephirol Related Compound 5 >98%
Odor: characteristic
Use: One of the impurities of Zephirol, a quaternary ammonium compound, has been found to be effective in the treatment of herpes, hepatitis and other infections.
EMD Millipore
For experimental / research use only.
Cetyltrimethylammonium Bromide, Molecular Biology Grade
Glentham Life Sciences
(1-Hexadecyl)trimethylammonium bromide
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Cetyltrimethylammonium Bromide ≥99%
Sigma-Aldrich: Sigma
For experimental / research use only.
Hexadecyltrimethylammonium bromide BioXtra, ≥99%
Spec-Chem Industry
SpecKareTM CB
For experimental / research use only.
Hexadecyltrimethylammonium Bromide >98.0%(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 106 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 331, 1975.

intravenous-mouse LD50 32 mg/kg
Acta Pharmacologica et Toxicologica. Vol. 47, Pg. 17, 1980.

intraperitoneal-rabbit LD50 125 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 210, 1966.

intravenous-rat LD50 44 mg/kg
Acta Pharmacologica et Toxicologica. Vol. 47, Pg. 17, 1980.

oral-rat LD50 410 mg/kg
Yakkyoku. Pharmacy. Vol. 31, Pg. 471, 1980.

Dermal Toxicity:
subcutaneous-guinea pig LD50 100 mg/kg
"Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969Vol. 5, Pg. 40, 1976.

subcutaneous-rabbit LD50 125 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 210, 1966.

Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for cetrimonium bromide usage levels up to:
 not for fragrance use.
Recommendation for cetrimonium bromide flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety assessment of the substance, montmorillonite clay modified with hexadecyltrimethylammonium bromide, for use in food contact materials
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):57-09-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5974
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:BQ7875000 for cas# 57-09-0
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:57-09-0
Pubchem (cid):5974
Pubchem (sid):134970697
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
KEGG (GenomeNet):C11275
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2923.90.0000
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
 acetoquat ctab
 ammonium, hexadecyltrimethyl-, bromide
 arquad 16/60
 centimide bromide
 cetyl trimethyl ammonium bromide
 cetyl trimethylammonium bromide
N-cetyl-N,N,N-trimethylammonium bromide
 cetyltrimethyl ammonium bromide
 cetyltrimethylammonium bromide
N-cetyltrimethylammonium bromide
 cirrasol OD
 cycloton V
1-hexadecanaminium, N,N,N-trimethyl-, bromide
1-hexadecanaminium, N,N,N-trimethyl-, bromide (1:1)
 hexadecyl trimethyl ammonium bromide
N-hexadecyl-N,N,N-trimethylammonium bromide
(1-hexadecyl)trimethylammonium bromide
 hexadecyltrimethyl ammonium bromide
 hexadecyltrimethylamine, bromide
 hexadecyltrimethylammonium bromide
1-hexadecyltrimethylammonium bromide
 lissolamin V
 lissolamine V
 rhodaquat M 242B99
 softex KW
N,N,N-trimethyl-1-hexadecanaminium bromide
N,N,N-trimethylhexadecan-1-aminium bromide
 varisoft CTB 40


PubMed:Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma.
J-Stage:Extraction of High-Quality RNA from Rubber Tree Leaves
PubMed:Comparative study on anti-oxidant and anti-inflammatory activities of Caesalpinia crista and Centella asiatica leaf extracts.
PubMed:Effects of dietary Centella asiatica (L.) Urban on growth performance, nutrient digestibility, blood composition in piglets vaccinated with Mycoplasma hyopneumoniae.
PubMed:Anti-diabetic effect of a combination of andrographolide-enriched extract of Andrographis paniculata (Burm f.) Nees and asiaticoside-enriched extract of Centella asiatica L. in high fructose-fat fed rats.
PubMed:Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity.
PubMed:Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding.
PubMed:[Analysis on preparation and characterization of asiaticoside-loaded flexible nanoliposomes].
PubMed:Anti-inflammaging and antiglycation activity of a novel botanical ingredient from African biodiversity (Centevita™).
PubMed:Evaluation of Analgesic and Anti-Inflammatory Activity of Chloroform and Methanol Extracts of Centella asiatica Linn.
PubMed:In vitro evidence that an aqueous extract of Centella asiatica modulates α-synuclein aggregation dynamics.
PubMed:Antioxidant activity of herbaceous plant extracts protect against hydrogen peroxide-induced DNA damage in human lymphocytes.
PubMed:Asiatic acid isolated from Centella asiatica inhibits TGF-β1-induced collagen expression in human keloid fibroblasts via PPAR-γ activation.
PubMed:Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells.
PubMed:Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of Centella asiatica.
PubMed:Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
PubMed:Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban.
PubMed:Statistical Analysis of Metal Chelating Activity of Centella asiatica and Erythroxylum cuneatum Using Response Surface Methodology.
PubMed:Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism.
PubMed:Evaluation of amygdaloid neuronal dendritic arborization enhancing effect of Centella asiatica (Linn) fresh leaf extract in adult rats.
PubMed:Efficacy of asiatic acid, a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats.
PubMed:Centella asiatica protects against UVB-induced HaCaT keratinocyte damage through microRNA expression changes.
PubMed:Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts.
PubMed:Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model.
PubMed:Inhibition of cPLA2 and sPLA2 activities in primary cultures of rat cortical neurons by Centella asiatica water extract.
PubMed:Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats.
PubMed:Anxiolytic effects of standardized extract of Centella asiatica (ECa 233) after chronic immobilization stress in mice.
PubMed:Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study.
PubMed:Improved in vitro and in vivo collagen biosynthesis by asiaticoside-loaded ultradeformable vesicles.
PubMed:Development of photochemoprotective herbs containing cosmetic formulations for improving skin properties.
PubMed:A new method for preparing pentacyclic triterpene rich Centella asiatica extracts.
PubMed:Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action.
PubMed:Effect of an herbal mouth rinse in preventing periodontal inflammation in an experimental gingivitis model: a pilot study.
PubMed:A β-cyclodextrin, polyethyleneimine and silk fibroin hydrogel containing Centella asiatica extract and hydrocortisone acetate: releasing properties and in vivo efficacy for healing of pressure sores.
PubMed:Evaluation of antioxidant activity of two important memory enhancing medicinal plants Baccopa monnieri and Centella asiatica.
PubMed:Aqueous extract of Centella asiatica promotes corneal epithelium wound healing in vitro.
PubMed:TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecular, and vascular application in preventive and clinical medicine. A status paper.
PubMed:In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension.
PubMed:Centella asiatica extracts modulate hydrogen peroxide-induced senescence in human dermal fibroblasts.
PubMed:Exploring the role of "Brahmi" (Bocopa monnieri and Centella asiatica) in brain function and therapy.
PubMed:Enhancement of the skin-protective activities of Centella asiatica L. Urban by a nano-encapsulation process.
PubMed:The inductive effects of Centella asiatica on rat spermatogenic cell apoptosis in vivo.
PubMed:Protective role of Centella asiatica on lead-induced oxidative stress and suppressed reproductive health in male rats.
PubMed:Wound repair and anti-inflammatory potential of essential oils from cones of Pinaceae: preclinical experimental research in animal models.
PubMed:Wound healing acceleration effect of endemic Ononis species growing in Turkey.
PubMed:The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients.
PubMed:Triterpene composition and bioactivities of Centella asiatica.
PubMed:In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19).
PubMed:The antiepileptic effect of Centella asiatica on the activities of Na/K, Mg and Ca-ATPases in rat brain during pentylenetetrazol-induced epilepsy.
PubMed:An ethnopharmacological study on Verbascum species: from conventional wound healing use to scientific verification.
PubMed:In vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin.
PubMed:A clinical study on the management of generalized anxiety disorder with Centella asiatica.
PubMed:Evaluation of the wound healing potentials of two subspecies of Hypericum perforatum on cultured NIH3T3 fibroblasts.
PubMed:Antispermatogenic and antifertility effect of Pegaga (Centella asiatica L) on the testis of male Sprague-Dawley rats.
PubMed:Use of asiatic pennywort Centella asiatica aqueous extract as a bath treatment to control columnaris in Nile tilapia.
PubMed:Evaluation of an onion extract, Centella asiatica, and hyaluronic acid cream in the appearance of striae rubra.
PubMed:Total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical plants.
PubMed:In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica.
PubMed:Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats.
PubMed:Prophylaxis with Centella asiatica confers protection to prepubertal mice against 3-nitropropionic-acid-induced oxidative stress in brain.
PubMed:3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease.
PubMed:Centella asiatica Improves Physical Performance and Health-Related Quality of Life in Healthy Elderly Volunteer.
PubMed:Antioxidant and cytotoxic activities of Centella asiatica (L) Urb.
PubMed:Adulticidal and larvicidal efficacy of some medicinal plant extracts against tick, fluke and mosquitoes.
PubMed:Protection of DNA and membranes from gamma-radiation induced damages by Centella asiatica.
PubMed:Modulation of lipid metabolism by Centella asiatica in oxidative stress rats.
PubMed:In vitro and in vivo modulation of cartilage degradation by a standardized Centella asiatica fraction.
PubMed:Determination of asiatic acid in beagle dog plasma after oral administration of Centella asiatica extract by precolumn derivatization RP-HPLC.
PubMed:Comparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study.
PubMed:Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress.
PubMed:Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts.
PubMed:Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model.
PubMed:Protective antioxidant effect of Centella asiatica bioflavonoids on lead acetate induced neurotoxicity.
PubMed:Studies on Indian green leafy vegetables for their antioxidant activity.
PubMed:Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid induced oxidative stress and mitochondrial dysfunctions in brain regions of prepubertal mice.
PubMed:An in vitro investigation of herbs traditionally used for kidney and urinary system disorders: potential therapeutic and toxic effects.
PubMed:[Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography].
PubMed:Mosquito larvicidal activity of oleic and linoleic acids isolated from Citrullus colocynthis (Linn.) Schrad.
PubMed:Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria.
PubMed:Topical formulation of a new plant extract complex with refirming properties. Clinical and non-invasive evaluation in a double-blind trial.
PubMed:Centella asiatica water extract inhibits iPLA2 and cPLA2 activities in rat cerebellum.
PubMed:Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide.
PubMed:Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism.
PubMed:Enhancement of hippocampal CA3 neuronal dendritic arborization by Centella asiatica (Linn) fresh leaf extract treatment in adult rats.
PubMed:Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica.
PubMed:Electrospun gelatin fiber mats containing a herbal-Centella asiatica-extract and release characteristic of asiaticoside.
PubMed:Apoptosis induction of Centella asiatica on human breast cancer cells.
PubMed:Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.
PubMed:Antigenotoxic role of Centella asiatica L. extract against cyproterone acetate induced genotoxic damage in cultured human lymphocytes.
PubMed:Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity.
PubMed:Treatment with Centalla asiatica (Linn) fresh leaf extract enhances learning ability and memory retention power in rats.
PubMed:Beneficial effects of Centella asiatica aqueous extract against arsenic-induced oxidative stress and essential metal status in rats.
PubMed:[Determination of aisaticoside in Centella asiatica extract by HPLC-ELSD].
PubMed:The anti-thrombotic active constituents from Centella asiatica.
PubMed:Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts.
PubMed:Centella asiatica (L.) leaf extract treatment during the growth spurt period enhances hippocampal CA3 neuronal dendritic arborization in rats.
PubMed:Effect of Centella asiatica L (Umbelliferae) on normal and dexamethasone-suppressed wound healing in Wistar Albino rats.
PubMed:In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method.
PubMed:Adriamycin induced myocardial failure in rats: protective role of Centella asiatica.
PubMed:Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats.
PubMed:[Healing activity of methanolic extract of the barks of Spathodea campanulata Beauv (Bignoniaceae) in rat experimental burn model].
PubMed:Immunomodulatory activities of Centella asiatica and Rhinacanthus nasutus extracts.
PubMed:Centella asiatica treatment during postnatal period enhances learning and memory in mice.
PubMed:Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry.
PubMed:Modification of gamma ray induced changes in the mouse hepatocytes by Centella asiatica extract: in vivo studies.
PubMed:Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro.
PubMed:Phlebotonics for venous insufficiency.
PubMed:Emerging role of Centella asiatica in improving age-related neurological antioxidant status.
PubMed:[Topical chemotherapy for the treatment of burns].
PubMed:Advanced formulation and pharmacological activity of hydrogel of the titrated extract of C. asiatica.
PubMed:Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats.
PubMed:Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica.
PubMed:Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats.
PubMed:Thai medicinal plants modulate nitric oxide and tumor necrosis factor-alpha in J774.2 mouse macrophages.
PubMed:Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats.
PubMed:Stimulation of asiaticoside accumulation in the whole plant cultures of Centella asiatica (L.) urban by elicitors.
PubMed:The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats.
PubMed:Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids.
PubMed:Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats.
PubMed:An improved HPLC method for quantitative determination of six triterpenes in Centella asiatica extracts and commercial products.
PubMed:Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice.
PubMed:Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats.
PubMed:Radioprotection of Swiss albino mouse by Centella asiatica extract.
PubMed:Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats.
PubMed:Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of emerging edible plants.
PubMed:In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins.
PubMed:Protection against radiation-induced conditioned taste aversion by Centella asiatica.
PubMed:Development of a novel dosage form for intramuscular injection of titrated extract of Centella asiatica in a mixed micellar system.
PubMed:Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats.
PubMed:Electrospray characterization of selected medicinal plant extracts.
PubMed:New innovations in scar management.
PubMed:Individuals at Risk of Coronary Heart Disease (CHD), its Prevention and Management by an Indigenous Compound.
PubMed:Creams for preventing stretch marks in pregnancy.
PubMed:Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants.
PubMed:Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds.
PubMed:Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats.
PubMed:In vitro evaluation of inhibitory nature of extracts of 18-plant species of Chhindwara against 3-keratinophilic fungi.
PubMed:Effects of Centella asiatica extract on dermal wound healing in rats.
PubMed:Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract.
PubMed:Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban.
PubMed:Allergic contact dermatitis due to Centella asiatica extract.
PubMed:Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer.
PubMed:Effects of plant extract Centella asiatica (Linn.) on cold restraint stress ulcer in rats.
PubMed:Allergic contact dermatitis from a cream containing Centella asiatica extract.
PubMed:Prophylaxis of Striae gravidarum with a topical formulation. A double blind trial.
PubMed:Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica.
PubMed:Effects of Centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins.
PubMed:Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs.
PubMed:Contact dermatitis due to madecassol.
PubMed:[Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside].
PubMed:[Centella asiatica extract in venous disorders of the lower limbs. Comparative clinico-instrumental studies with a placebo].
PubMed:[Use of a titrated extract of Centella asiatica in chronic hepatic disorders (author's transl)].
PubMed:[Modification of the kinetics of healing after iterative exeresis in the rat. Action of a triterpenoid and its derivatives on the duration of healing].
PubMed:[Animal study of the transcutaneous movement of the tritium-labelled active principles of Centella asiatica L. extract after administration in impregnated gauze or unguent].
PubMed:[Results of a controlled experiment of the titrated extract of Centella asiatica in a leper population with perforative foot lesions].
PubMed:Use of titrated extract of Centella asiatica (TECA) in bilharzial bladder lesions.
PubMed:[Action of the titrated extract of Centella Asiatica in the cicatrization of leg ulcers (10 mg. tablets). Apropos of 50 cases].
PubMed:Crude extract of Centella asiatica and products derived from its glycosides as oral antifertility agents.
PubMed:[On the treatment of cutaneous lesions with extract of "Centella asiatica"].
None found
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