EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

carbamazepine
5H-dibenzo[b,f]azépine-5-carboxamide

Supplier Sponsors

Name:benzo[b][1]benzazepine-11-carboxamide
CAS Number: 298-46-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:206-062-7
FDA UNII: 33CM23913M
Nikkaji Web:J8.590A
Beilstein Number:1246090
MDL:MFCD00005073
XlogP3:2.50 (est)
Molecular Weight:236.27384000
Formula:C15 H12 N2 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 190.20 °C. @ 760.00 mm Hg
Boiling Point: 410.98 °C. @ 760.00 mm Hg (est)
Vapor Pressure:1.840000 mmHg @ 25.00 °C. (est)
Flash Point: 396.00 °F. TCC ( 202.40 °C. ) (est)
logP (o/w): 2.450
Soluble in:
 water, 17.66 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Carbamazepine >98%
Odor: characteristic
Use: Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 nM in rat brain synaptosomes.Carbamazepine (CBZ), first marketed under the tradename Tegretol in 1963, is a medication used primarily in the treatment of epilepsy and neuropathic pain
Glentham Life Sciences
Carbamazepine
Santa Cruz Biotechnology
For experimental / research use only.
Carbamazepine ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Carbamazepine powder
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-child TDLo 19 mg/kg/4W-I
PERIPHERAL NERVE AND SENSATION: FASCICULATIONS
Pediatrics. Vol. 73, Pg. 841, 1984.

oral-child TDLo 25926 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 320, 1993.

oral-child TDLo 55 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA
Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 323, 2000.

oral-child TDLo 65 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: COMA
Journal of Pediatrics. Vol. 121, Pg. 295, 1992.

oral-child TDLo 420 mg/kg/3W-I
BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: TREMOR SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 109, 1998.

oral-child TDLo 1050 mg/kg/6W-
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
American Journal of Psychiatry. Vol. 143, Pg. 1176, 1985.

oral-dog LD50 5620 mg/kg
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972.

oral-guinea pig LD50 920 mg/kg
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972.

oral-human TDLo 43 mg/kg
BEHAVIORAL: SLEEP BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING
British Medical Journal. Vol. 1, Pg. 754, 1977.

oral-man LDLo 54 mg/kg/9D-I
BLOOD: AGRANULOCYTOSIS KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED BEHAVIORAL: ATAXIA
Canadian Medical Association Journal. Vol. 132, Pg. 1040, 1985.

oral-man TDLo 94 mg/kg/11D-I
BLOOD: THROMBOCYTOPENIA
Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 305, 1990.

oral-man TDLo 160 mg/kg/3W-I
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Journal of Clinical Pyschopharmacology. Vol. 5, Pg. 185, 1985.

oral-man TDLo 253 mg/kg/6W-I
GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: LIVER FUNCTION TESTS IMPAIRED
Journal of Clinical Pyschopharmacology. Vol. 6, Pg. 251, 1986.

intraperitoneal-mouse LD50 114 mg/kg
Farmakologiya i Toksikologiya Vol. 53(4), Pg. 19, 1990.

oral-mouse LD50 529 mg/kg
Farmaco. Vol. 44, Pg. 595, 1989.

oral-rabbit LD50 2680 mg/kg
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972.

intraperitoneal-rat LD50 158 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 202, Pg. 106, 1973.

oral-rat LD50 1957 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Japanese Kokai Tokyo Koho Patents. Vol. #79-163823

Dermal Toxicity:
subcutaneous-mouse LD50 > 1000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 477, 1980.

subcutaneous-rat LD50 > 1500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 477, 1980.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for carbamazepine usage levels up to:
 not for fragrance use.
 
Recommendation for carbamazepine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2554
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
benzo[b][1]benzazepine-11-carboxamide
Chemidplus:0000298464
RTECS:HN8225000 for cas# 298-46-4
 
References:
 benzo[b][1]benzazepine-11-carboxamide
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):2554
Pubchem (sid):135269948
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C06868
HMDB (The Human Metabolome Database):HMDB14704
Export Tariff Code:2933.90.8000
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
oral: capsules, extended-release: 200 mg carbatrol (with povidone), (shire us); 300 mg carbatrol (with povidone), (shire us). suspension: 100 mg5 ml carbamazepine suspension, (actavis), carbamazepine suspension, (morton grove), carbamazepine suspension, (taro); tegretol ( with propylene glycol), (novartis). tablets: 200 mg epitol (scored), (teva), tegretol (scored), (novartis). tablets, chewable: 100 mg tegretol (scored), (novartis). tablets, extended-release: 100 mg tegretol-xr (with mannitol), (novartis); 200 mg tegretol-xr (with mannitol), (novartis); 400 mg tegretol-xr (with mannitol), (novartis).
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 benzo[b][1]benzazepine-11-carboxamide
 calepsin
 carbamazepen
 carbamazepin
 carbamazepinum
 carbamezepine
5-carbamoyl-5H-dibenz(b,f)azepine
5-carbamoyl-5H-dibenz[b,f]azepine
5-carbamoyl-5H-dibenzo(b,f)azepine
5-carbamoyldibenzo(b,f)azepine
5-carbamyl-5H-dibenzo(b,f)azepine
5-carbamyldibenzo(b,f)azepine
 carbamzepine
 carbatrol
 carbazepine
 carbelan
5H-dibenz(b,f)azepine-5-carboxamide
5H-dibenz[b,f]azepine-5-carboxamide
5H-dibenz[b,f]azepine-5-carboximidic acid
5H-dibenzb,fazepine-5-carboxamide
5H-dibenzo[b,f]azépine-5-carboxamide
 equetro
 neurotol
 novo-carbamaz
 sirtal
 stazepin
 tegretal
 tegretol Cr
2-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene-2-carboxamide
 

Articles:

PubMed:Dystonia.
PubMed:Tinnitus.
PubMed:Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream.
PubMed:Trigeminal neuralgia.
PubMed:Lactation studies of anticonvulsants: A quality review.
PubMed:Potential of newly isolated wild Streptomyces strains as agents for the biodegradation of a recalcitrant pharmaceutical, carbamazepine.
PubMed:Modeling uptake of selected pharmaceuticals and personal care products into food crops from biosolids-amended soil.
PubMed:Presence of the pharmaceutical drug carbamazepine in coastal systems: Effects on bivalves.
PubMed:Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice.
PubMed:The effects of the pharmaceutical carbamazepine on life history characteristics of flat-headed mayflies (Heptageniidae) and aquatic resource interactions.
PubMed:The effects of the psychiatric drug carbamazepine on freshwater invertebrate communities and ecosystem dynamics.
PubMed:[Pharmacogenetic research in the association between human leukocyte antigen and adverse drug reactions].
PubMed:Irrigation of root vegetables with treated wastewater: evaluating uptake of pharmaceuticals and the associated human health risks.
PubMed:Crushed tablets: does the administration of food vehicles and thickened fluids to aid medication swallowing alter drug release?
PubMed:Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals.
PubMed:Ancestry-based pharmacogenomics, adverse reactions and carbamazepine: is the FDA warning correct?
PubMed:[Future direction of pharmacogenomics: identification of genes associated with risk of adverse drug reactions using genome-wide association study].
PubMed:Update on once-daily zonisamide monotherapy in partial seizures.
PubMed:Fate and uptake of pharmaceuticals in soil-plant systems.
PubMed:The determination of pharmaceutical residues in cooked and uncooked marine bivalves using pressurised liquid extraction, solid-phase extraction and liquid chromatography–tandem mass spectrometry.
PubMed:Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model.
PubMed:Biodegradability of pharmaceutical compounds in agricultural soils irrigated with treated wastewater.
PubMed:Predictive validity of a MK-801-induced cognitive impairment model in mice: implications on the potential limitations and challenges of modeling cognitive impairment associated with schizophrenia preclinically.
PubMed:Clinically significant drug interactions with atypical antipsychotics.
PubMed:Carbamazepine suppresses calpain-mediated autophagy impairment after ischemia/reperfusion in mouse livers.
PubMed:The determination of pharmaceutical residues in cooked and uncooked marine bivalves using pressurised liquid extraction, solid-phase extraction and liquid chromatography-tandem mass spectrometry.
PubMed:Fingerprinting groundwater pollution in catchments with contrasting contaminant sources using microorganic compounds.
PubMed:Is Atyaephyra desmarestii a useful candidate for lethal and sub-lethal toxicity tests on pharmaceutical compounds?
PubMed:Effect of pharmaceuticals exposure on acetylcholinesterase (AchE) activity and on the expression of AchE gene in the monogonont rotifer, Brachionus koreanus.
PubMed:Interaction of carbamazepine with herbs, dietary supplements, and food: a systematic review.
PubMed:Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables.
PubMed:A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012.
PubMed:Adsorption of carbamazepine by carbon nanotubes: effects of DOM introduction and competition with phenanthrene and bisphenol A.
PubMed:Glutamic acid decarboxylase gene disruption reveals signalling pathway(s) governing complex morphogenic and metabolic events in Trichoderma atroviride.
PubMed:Relationship between the HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis.
PubMed:Foliar sorption of emerging and priority contaminants under controlled conditions.
PubMed:Is pomegranate juice a potential perpetrator of clinical drug-drug interactions? Review of the in vitro, preclinical and clinical evidence.
PubMed:Anti-solvent co-crystallization of carbamazepine and saccharin.
PubMed:Evaluation of unlicensed and off-label antiepileptic drugs prescribed to children: Brazilian Regulatory Agency versus FDA.
PubMed:Grapefruit and drug interactions.
PubMed:A rapid and sensitive liquid chromatography-tandem mass spectrometric assay for cycloserine in 50μL of human plasma: Its pharmacokinetic application.
PubMed:Boceprevir: a recently approved protease inhibitor for hepatitis C virus infection.
PubMed:Carbamazepine-induced hypersensitivity syndrome in chronic schizophrenia.
PubMed:Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego-Oliva Marshlands (Valencia, eastern Spain).
PubMed:Plant uptake of pharmaceutical chemicals detected in recycled organic manure and reclaimed wastewater.
PubMed:Occurrence of micro-organic pollutants on phosphorus recovery from urine.
PubMed:A pilot survey of 39 Victorian WWTP effluents using a high speed luminescent umu test in conjunction with a novel GC-MS-database technique for automatic identification of micropollutants.
PubMed:Fatal serotonin syndrome precipitated by oxcarbazepine in a patient using an selective serotonin reuptake inhibitor.
PubMed:Simultaneous determination of sitagliptin and simvastatin in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.
PubMed:Efficacy of antimanic treatments in mixed states.
PubMed:Efficacy and safety of innovator versus generic drugs in patients with epilepsy: a systematic review.
PubMed:HLA-B*1502 allele is associated with a cross-reactivity pattern of cutaneous adverse reactions to antiepileptic drugs.
PubMed:Epilepsy (generalised).
PubMed:Tinnitus.
PubMed:Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field.
PubMed:Effect of the timing of food intake on the absorption and bioavailability of carbamazepine immediate-release tablets in beagle dogs.
PubMed:Reflex seizures in Rett syndrome.
PubMed:Review of risk from potential emerging contaminants in UK groundwater.
PubMed:Dementia.
PubMed:Antiepileptic drugs for bipolar disorder and the risk of suicidal behavior: a 30-year observational study.
PubMed:A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models.
PubMed:Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats.
PubMed:Transformation of the recalcitrant pharmaceutical compound carbamazepine by Pleurotus ostreatus: role of cytochrome P450 monooxygenase and manganese peroxidase.
PubMed:Morphine sensitization as a model of mania: comparative study of the effects of repeated lithium or carbamazepine administration.
PubMed:Physico-mechanical and stability evaluation of carbamazepine cocrystal with nicotinamide.
PubMed:Epilepsy (partial).
PubMed:Interactions of carbamazepine in soil: effects of dissolved organic matter.
PubMed:Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers.
PubMed:Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry.
PubMed:Simulation of clinical drug-drug interactions from hepatocyte CYP3A4 induction data and its potential utility in trial designs.
PubMed:Physicochemical and mechanical properties of carbamazepine cocrystals with saccharin.
PubMed:Utility of physiologically based absorption modeling in implementing Quality by Design in drug development.
PubMed:Levetiracetam Extended Release as Adjuvant Therapy for the Control of Partial-onset Seizures.
PubMed:Uptake of carbamazepine by cucumber plants--a case study related to irrigation with reclaimed wastewater.
PubMed:Do antiepileptic drugs increase the risk of suicidality in adult patients with epilepsy?: a critically appraised topic.
PubMed:Carbamazepine alone and in combination with doxycycline attenuates isoproterenol-induced cardiac hypertrophy.
PubMed:Pharmacogenetics of toxic epidermal necrolysis.
PubMed:Population-based severity, onset and type of drug-drug interactions in prescriptions.
PubMed:Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.
PubMed:Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death.
PubMed:[Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up].
PubMed:Human health risk assessment of pharmaceuticals in water: an uncertainty analysis for meprobamate, carbamazepine, and phenytoin.
PubMed:Dementia.
PubMed:Epilepsy (partial).
PubMed:Epilepsy (generalised).
PubMed:A novel HPLC method for quantification of 10 antiepileptic drugs or metabolites in serum/plasma using a monolithic column.
PubMed:Prescriber compliance with black box warnings in older adult patients.
PubMed:Occurrence of pharmaceutically active compounds in surface waters of the Henares-Jarama-Tajo River system (Madrid, Spain) and a potential risk characterization.
PubMed:Antimanic efficacy of retigabine in a proposed mouse model of bipolar disorder.
PubMed:Pharmacologic treatment of impulsive aggression with antiepileptic drugs.
PubMed:Effect of soybean administration on the pharmacokinetics of carbamazepine and omeprazole in rats.
PubMed:Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field.
PubMed:Epilepsy.
PubMed:Trigeminal neuralgia.
PubMed:Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field.
PubMed:Teratogenesis associated with antibipolar agents.
PubMed:[Pharmacokinetic problems in clinical practice: role of drug transporters].
PubMed:Don't live in a town where there are no doctors: toxic epidermal necrolysis initially misdiagnosed as oral thrush.
PubMed:Tinnitus.
PubMed:FDA: Epilepsy drugs may carry skin risks for Asians.
PubMed:Medication administration through enteral feeding tubes.
PubMed:Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations.
PubMed:For Asians only? The perils of ancestry-based drug prescribing.
PubMed:Update on pharmacotherapy guidelines for the treatment of neuropathic pain.
PubMed:Sorption and mobility of pharmaceutical compounds in soil irrigated with reclaimed wastewater.
PubMed:Generic substitution in the treatment of epilepsy: case evidence of breakthrough seizures.
PubMed:Genotoxic assessment of oxcarbazepine and carbamazepine in drosophila wing spot test.
PubMed:Generic antiepileptic drugs.
PubMed:Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy.
PubMed:Pharmaceutical and personal care products in tile drainage following land application of municipal biosolids.
PubMed:Runoff of pharmaceuticals and personal care products following application of biosolids to an agricultural field.
PubMed:Mode of action of mood stabilizers: is the arachidonic acid cascade a common target?
PubMed:Monotherapy versus combined treatment with second-generation antipsychotics in bipolar disorder.
PubMed:Individual and mixture effects of selected pharmaceuticals and personal care products on the marine phytoplankton species Dunaliella tertiolecta.
PubMed:Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols.
PubMed:Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review.
PubMed:Effects of sodium valproate and carbamazepine on food competition aggression in pigeons.
PubMed:Overview of the clinical pharmacokinetics of oxcarbazepine.
PubMed:Tinnitus.
PubMed:Post-traumatic stress disorder.
PubMed:Bipolar disorder.
PubMed:Historical review of carbamazepine for the treatment of bipolar disorder.
PubMed:The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trials.
PubMed:Extended-release carbamazepine for acute bipolar mania: a review.
PubMed:Nonepileptic uses of antiepileptic drugs in children and adolescents.
PubMed:Active control trials for epilepsy: avoiding bias in head-to-head trials.
PubMed:Life-history consequences for Daphnia pulex exposed to pharmaceutical carbamazepine.
PubMed:Carbamazepine extended-release capsules in bipolar disorder.
PubMed:Oxcarbazepine in the treatment of child psychiatric disorders: a retrospective chart review.
PubMed:Familial rectal pain: a familial autonomic disorder as a cause of paroxysmal attacks in the newborn baby.
PubMed:Transient inhibition of cyp3a in rats by star fruit juice.
PubMed:Pharmaceutical data do not elude researchers.
PubMed:Carbamazepine extended-release capsules: a new treatment option for bipolar I disorder.
PubMed:Contribution of effluents from hospitals and private households to the total loads of diclofenac and carbamazepine in municipal sewage effluents--modeling versus measurements.
PubMed:In vitro assessment of modes of toxic action of pharmaceuticals in aquatic life.
PubMed:Pharmaceutical data elude researchers.
PubMed:Neural tube defects: pathogenesis and folate metabolism.
PubMed:Human pharmaceuticals, hormones, and personal care product ingredients in runoff from agricultural fields irrigated with treated wastewater.
PubMed:Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats.
PubMed:Influence of high fat diet (butter) on pharmacokinetics of phenytoin and carbamazepine.
PubMed:Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat.
PubMed:Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic pain.
PubMed:Determination of polar drug residues in sewage and surface water applying liquid chromatography-tandem mass spectrometry.
PubMed:Clinical experience with aripiprazole treatment in ten elderly patients with schizophrenia or schizoaffective disorder: retrospective case studies.
PubMed:Choice of rotation speed (rpm) for bio-relevant drug dissolution testing using a crescent-shaped spindle.
PubMed:Pharmacokinetic interactions of topiramate.
PubMed:Clinical pharmacokinetics of levetiracetam.
PubMed:Newer anticonvulsants in the treatment of bipolar disorder.
PubMed:Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society.
PubMed:Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
PubMed:Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
PubMed:Chronic prenatal exposure to carbamazepine and behavior effects on mice offspring.
PubMed:Regulatory considerations of pharmaceutical solid polymorphism in Abbreviated New Drug Applications (ANDAs).
PubMed:The use of folic acid for the prevention of neural tube defects and other congenital anomalies.
PubMed:Effect of concomitantly administered honey on the pharmacokinetics of carbamazepine in healthy volunteers.
PubMed:Pharmacokinetics and metabolism of topiramate.
PubMed:The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?
PubMed:Applications of a new device (spindle) for improved characterization of drug release (dissolution) of pharmaceutical products.
PubMed:The bioequivalence and therapeutic efficacy of generic versus brand-name psychoactive drugs.
PubMed:Dietary carbamazepine administration decreases liver pyruvate carboxylase activity and biotinylation by decreasing protein and mRNA expression in rats.
PubMed:New antiepileptic drugs.
PubMed:Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac.
PubMed:Oxcarbazepine final market image tablet formulation bioequivalence study after single administration and at steady state in healthy subjects.
PubMed:Effect of honey on carbamazepine kinetics in rabbits.
PubMed:Side effect profiles and behavioral consequences of antiepileptic medications.
PubMed:The abundance and function of biotin-dependent enzymes are reduced in rats chronically administered carbamazepine.
PubMed:Differential effects of carbamazepine on negatively versus positively reinforced responding.
PubMed:Neurologic drug-psychotropic drug update.
PubMed:Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.
PubMed:Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder.
PubMed:Three new drugs for epilepsy: levetiracetam, oxcarbazepine, and zonisamide.
PubMed:Epilepsy in Pregnant Women.
PubMed:Clinical experience with topiramate dosing and serum levels in children 12 years or under with epilepsy.
PubMed:[Ciguatera: clinical relevance of a marine neurotoxin].
PubMed:Delavirdine: clinical pharmacokinetics and drug interactions.
PubMed:Effect of grapefruit intake on carbamazepine bioavailability: a case report.
PubMed:The importance of folic acid.
PubMed:The influence of food on the bioavailability of a twice-daily controlled release carbamazepine formulation.
PubMed:[Excessive weight loss caused by dysphagia in superior laryngeal nerve neuralgia--a case report].
PubMed:Clinical pharmacokinetics of mirtazapine.
PubMed:Carbamazepine suppresses methamphetamine-induced Fos expression in a regionally specific manner in the rat brain. Possible neural substrates responsible for antimanic effects of mood stabilizers.
PubMed:Oxcarbazepine approved for partial seizures.
PubMed:The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures.
PubMed:Pharmacokinetic and pharmacodynamic consequences of metabolism-based drug interactions with alprazolam, midazolam, and triazolam.
PubMed:Isoniazid drug and food interactions.
PubMed:A multiple-dose safety and bioequivalence study of a narrow therapeutic index drug: a case for carbamazepine.
PubMed:Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy.
PubMed:Pharmacokinetic evaluation of twice-daily extended-release carbamazepine (CBZ) and four-times-daily immediate-release CBZ in patients with epilepsy.
PubMed:A limited sampling method for the estimation of AUC and Cmax of carbamazepine and carbamazepine epoxide following a single and multiple dose of a sustained-release product.
PubMed:Newer antiepileptic drugs: gabapentin, lamotrigine, felbamate, topiramate and fosphenytoin.
PubMed:Lithium plus valproate as maintenance polypharmacy for patients with bipolar I disorder: a review.
PubMed:Influence of food on the bioavailability of a carbamazepine slow-release formulation.
PubMed:Lithium, but not carbamazepine, potentiates hyperactivity induced by intra-accumbens cholera toxin.
PubMed:Clinical pharmacokinetics of nefazodone.
PubMed:Recent advances in the pharmacotherapy of epilepsy.
PubMed:A limited sampling method for the estimation of flunarizine area under the curve (AUC) and maximum plasma concentration (Cmax).
PubMed:Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations.
PubMed:Monotherapy trials of new antiepileptic drugs.
PubMed:In vitro dissolution profile comparison and IVIVR. Carbamazepine case.
PubMed:The pharmacology of impulsive behaviour in rats: the effects of drugs on response choice with varying delays of reinforcement.
PubMed:In vitro embryotoxicity of carbamazepine and carbamazepine-10, 11-epoxide.
PubMed:Effects of anticonvulsants in a novel operant learning paradigm in rats: comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents.
PubMed:Use of lithium, carbamazepine, and valproic acid in a state-operated psychiatric hospital.
PubMed:Overview of the pharmacokinetics of fluvoxamine.
PubMed:Interactions of warfarin with drugs and food.
PubMed:The influence of food on the disposition of the antiepileptic oxcarbazepine and its major metabolites in healthy volunteers.
PubMed:[Acute catatonia and neuroleptic malignant syndrome. A case of infantile psychosis].
PubMed:Clinical pharmacology and pharmacokinetics of oxcarbazepine.
PubMed:Oxcarbazepine: clinical development program.
PubMed:Pharmacokinetic optimisation of oral antifungal therapy.
PubMed:Effects of humidity and temperature on in vitro dissolution of carbamazepine tablets.
PubMed:Norplant: a welcome new contraceptive.
PubMed:Advances in the pharmacotherapy of epilepsy.
PubMed:The pharmacologic treatment of conduct disorders and rage outbursts.
PubMed:Carbamazepine produces nonspecific effects on cocaine self-administration in rats.
PubMed:Carbamazepine and folic acid in trigeminal neuralgia patients.
PubMed:Clinical toleration and safety of azithromycin.
PubMed:Weight gain, increased appetite, and excessive food intake induced by carbamazepine.
PubMed:Spina bifida in infants of women treated with carbamazepine during pregnancy.
PubMed:Generic substitutions for antiepileptic drugs.
PubMed:Effects of carbamazepine on self-administration of intravenously delivered cocaine in rats.
PubMed:From the Food and Drug Administration.
PubMed:In vivo determination of valproate binding constants during sole and multi-drug therapy.
PubMed:Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948.
PubMed:In vitro dissolution profile of water-insoluble drug dosage forms in the presence of surfactants.
PubMed:Liquid chromatographic determination of carbamazepine in tablets.
PubMed:Persistent upregulation of brain adenosine receptors in response to chronic carbamazepine treatment.
PubMed:Isoniazid interactions.
PubMed:Influence of food on the bioavailability of drugs.
PubMed:Drugs 5 years later: carbamazepine.
PubMed:A case of periodic somnolence whose sleep was induced by glucose.
 
Notes:
an anticonvulsant used to control grand mal and psychomotor or focal seizures. its mode of action is not fully understood, but some of its actions resemble those of phenytoin; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.
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