EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

bromocresol green

Supplier Sponsors

CAS Number: 76-60-8Picture of molecule3D/inchi
Other(deleted CASRN):641-19-0
ECHA EINECS - REACH Pre-Reg:200-972-8
Nikkaji Web:J2.821E
Beilstein Number:0372527
XlogP3:6.50 (est)
Molecular Weight:698.01958000
Formula:C21 H14 Br4 O5 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:coloring agents (for surface only)
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 218.50 °C. @ 760.00 mm Hg
Boiling Point: 626.00 °C. @ 760.00 mm Hg (est)
Flash Point: 630.00 °F. TCC ( 332.40 °C. ) (est)
logP (o/w): 7.800 (est)
Soluble in:
 water, 2.66e-005 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: cosmetic colorants
BOC Sciences
For experimental / research use only.
Bromocresol Green
ECSA Chemicals
EMD Millipore
For experimental / research use only.
Bromocresol Green
Glentham Life Sciences
Bromocresol Green
Santa Cruz Biotechnology
For experimental / research use only.
Bromocresol Green
For experimental / research use only.
Bromocresol Green ACS reagent, Dye content 95 %
For experimental / research use only.
Bromocresol Green
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD > 1600 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 3083, 1996.

Dermal Toxicity:
subcutaneous-rat LD > 1600 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 3083, 1996.

Inhalation Toxicity:
Not determined
Safety in Use Information:
coloring agents (for surface only)
Recommendation for bromocresol green usage levels up to:
 not for fragrance use.
Recommendation for bromocresol green flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):76-60-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6451
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:SJ7456000 for cas# 76-60-8
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:76-60-8
Pubchem (cid):6451
Pubchem (sid):134971682
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:3204.19.5000
FDA Color Additive Status ListView
Potential Blenders and core components note
None Found
Potential Uses:
 cosmetic colorants
Occurrence (nature, food, other):note
 not found in nature
4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methylphenol] S,S-dioxide
 bromcresol green
 bromo cresol green
a,a-bis(3,5-dibromo-4-hydroxy-o-tolyl)-a-hydroxytoluenesulfonic Acid g-sultone
 phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methyl-
 phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methyl-
 phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methyl-, S,S-dioxide
 phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methyl-, S,S-dioxide
 uvitex OB


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PubMed:A revised method for determination of serum mercaptalbumin and non-mercaptalbumin by high-performance liquid chromatography coupled with postcolumn bromocresol green reaction.
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PubMed:Automated spectrophotometric analyzer for rapid single-point titration of seawater total alkalinity.
PubMed:Albumin concentration determined by the modified bromocresol purple method is superior to that by the bromocresol green method for assessing nutritional status in malnourished patients with inflammation.
PubMed:Laboratory performance in albumin and total protein measurement using a commutable specimen: results of a College of American Pathologists study.
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PubMed:A role of prostaglandin transporter in regulating PGE₂ release from human bronchial epithelial BEAS-2B cells in response to LPS.
PubMed:Evaluation of a point-of-care portable analyzer for measurement of plasma immunoglobulin G, total protein, and albumin concentrations in ill neonatal foals.
PubMed:Albumin oxidation leads to neutrophil activation in vitro and inaccurate measurement of serum albumin in patients with diabetic nephropathy.
PubMed:A New extractive spectrophotometric method for determination of rizatriptan dosage forms using bromocresol green.
PubMed:Application of Sephadex LH-20 for Microdetermination of Dopamine by Solid Phase Spectrophotometry.
PubMed:A simple medium modification for isolation, growth and enumeration of Acidithiobacillus thiooxidans (syn. Thiobacillus thiooxidans) from water samples.
PubMed:Serum zinc levels in children and adolescents with type-1 diabetes mellitus.
PubMed:Development of regenerative dye impregnated mesoporous silica materials for assessing exposure to ammonia.
PubMed:Blood separation on microfluidic paper-based analytical devices.
PubMed:Examine growth inhibition pattern and lactic acid production in Streptococcus mutans using different concentrations of xylitol produced from Candida tropicalis by fermentation.
PubMed:[Relativity among starch quantity, polysaccharides content and total alkaloid content of Dendrobium loddigesii].
PubMed:Retinoic acid increases hypoxia-inducible factor-1α through intracrine prostaglandin E(2) signaling in human renal proximal tubular cells HK-2.
PubMed:[Effects of Shensu II Recipe on the expressions of transforming growth factor-beta1, and plasminogen activator inhibitor-1 in the focal segmental glomerulosclerosis rats].
PubMed:Bromocresol green/mesoporous silica adsorbent for ammonia gas sensing via an optical sensing instrument.
PubMed:Visible spectrophotometric method for the determination of aripiprazole in tablets.
PubMed:Triphenylmethane dyes, an alternative for mediated electronic transfer systems in glucose oxidase biofuel cells.
PubMed:A high-throughput colorimetric assay to measure the activity of glutamate decarboxylase.
PubMed:Influence of the assay for measuring serum albumin on corrected total calcium in chronic hemodialysis patients.
PubMed:Cadmium hydroxide nanowire loaded on activated carbon as efficient adsorbent for removal of Bromocresol Green.
PubMed:Novel, simple and low-cost alternative method for fabrication of paper-based microfluidics by wax dipping.
PubMed:Protein trafficking rates assessed by quantum dot quenching with bromocresol green.
PubMed:Serum globulins contribute to the discrepancies observed between the bromocresol green and bromocresol purple assays of serum albumin concentration.
PubMed:A preliminary report on the functioning and data collection capabilities of a web-based nutrition algorithm for patients with chronic kidney disease.
PubMed:Quantitative estimation and correlation of serum albumin levels in clinically healthy subjects and chronic periodontitis patients.
PubMed:Potential nephrotoxicity in African mud catfish (Clarias gariepinus) following exposure to compost derived humic acid.
PubMed:Use of two sulfonthalein dyes in the extraction-free spectrophotometric assay of tramadol in dosage forms and in spiked human urine based on ion-pair reaction.
PubMed:Strength of interactions between immobilized dye molecules and sol-gel matrices.
PubMed:Spectrophotometric determination of peptic ulcer sulfur-containing drugs in bulk form and in tablets.
PubMed:Colorimetric method for the estimation of escitalopram oxalate in tablet dosage form.
PubMed:Oxidative modifications impair albumin quantification.
PubMed:Kinetics independent spectrometric analysis using non-linear calibration modelling and exploitation of concentration gradients generated by a flow-batch system for albumin and total protein determination in blood serum.
PubMed:Ischemia-modified albumin levels in patients with end-stage renal disease patients on hemodialysis: does albumin analysis method affect albumin-adjusted ischemia-modified albumin levels?
PubMed:Multivariate image analysis-thin layer chromatography (MIA-TLC) for simultaneous determination of co-eluting components.
PubMed:Mathematical modeling of dispersion in single interface flow analysis.
PubMed:Isolation, characterization and optimization of indigenous acetic acid bacteria and evaluation of their preservation methods.
PubMed:Secondary hyperparathyroidism and anemia in children treated by hemodialysis.
PubMed:Spectrophotometric and HPLC determinations of anti-diabetic drugs, rosiglitazone maleate and metformin hydrochloride, in pure form and in pharmaceutical preparations.
PubMed:["Corrected" calcium: calcium status underestimation in non-hypoalbuminemic patients and in hypercalcemic patients].
PubMed:Ultrafiltration separation of aquatic natural organic matter: chemical probes for quality assurance.
PubMed:Spectrophotometric determination of lamotrigine in pharmaceutical preparations and urine by charge-transfer complexation.
PubMed:A new spectrophotometric method for the determination of tianeptine in tablets using ion-pair reagents.
PubMed:Development of a volatile amine sensor for the monitoring of fish spoilage.
PubMed:Photometric detection in flow analysis systems using integrated PEDDs.
PubMed:Equilibrium constant of the gamma-sultone and extraction constant of sodium and potassium ions from water into benzene in presence of 18-crown-6 and bromocresol green.
PubMed:Extractive spectrophotometric methods for the assay of sildenafil citrate (Viagra) in pure form and in pharmaceutical formulations.
PubMed:Liquid-liquid extraction of platinum(II) with cyclic tetrathioethers.
PubMed:Extractive spectrophotometric determination of some phenothiazine derivatives in pharmaceutical preparations.
PubMed:Flow injection spectrophotometric determination of boron in ceramic materials.
PubMed:Isolation and characterization of potential probiotic lactobacilli from pig feces.
PubMed:Immunoglobulin classes and nutritional factors in plasma and breast milk of lactating mothers in Nigeria.
PubMed:Serum zinc and albumin levels in pulmonary tuberculosis patients with and without HIV.
PubMed:Milk composition studies in transgenic goats expressing recombinant human butyrylcholinesterase in the mammary gland.
PubMed:Disparate outcomes in pediatric peritoneal dialysis patients by gender/race in the End-Stage Renal Disease Clinical Performance Measures project.
PubMed:Diversity and dynamics of lactobacilli populations during ripening of RDO Camembert cheese.
PubMed:The commutability of external quality assurance serum and reference serum materials between the VITROS Albumin Slide and four other routine albumin methods.
PubMed:A new method of optical detection of yeast acidification power.
PubMed:[Contents mensuration of total alkaloid in Uncaria rhynchophylla by acid dye colorimetry].
PubMed:Spectrophotometric determination of hyoscine butylbromide and famciclovir in pure form and in pharmaceutical formulations.
PubMed:Protein error of pH indicators in the presence of detergents.
PubMed:A critical comparison of analytical flow systems exploiting streamlined and pulsed flows.
PubMed:Spectrophotometric determination of dopaminergic drugs used for Parkinson's disease, cabergoline and ropinirole, in pharmaceutical preparations.
PubMed:Spectrophotometric determination of carvedilol in pharmaceutical formulations through charge-transfer and ion-pair complexation reactions.
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PubMed:Spectrophotometric determination of gatifloxacin in pure form and in pharmaceutical formulation.
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PubMed:Clinical oral doses of dexamethasone decreases intrinsic clearance of quinidine, a cytochrome P450 3A substrate in dogs.
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PubMed:Spectrophotometric determination of certain antidepressants in pharmaceutical preparations.
PubMed:The value of serum albumin in pretreatment assessment and monitoring of therapy in HIV/AIDS patients.
PubMed:Low serum albumin levels in patients with paroxysmal atrial fibrillation: what does it mean?
PubMed:Permeability of acetic acid through organic films at the air-aqueous interface.
PubMed:Impact of freeze-drying on ionization of sulfonephthalein probe molecules in trehalose-citrate systems.
PubMed:Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation using methyl orange and bromocresol green reagents.
PubMed:Transepithelial urate transport by avian renal proximal tubule epithelium in primary culture.
PubMed:Simple extractive colorimetric determination of levofloxacin by acid-dye complexation methods in pharmaceutical preparations.
PubMed:A sensitive and economical modified method for estimation of cerebrospinal fluid proteins.
PubMed:Revisiting mortality predictability of serum albumin in the dialysis population: time dependency, longitudinal changes and population-attributable fraction.
PubMed:Inhibitors of prostaglandin transport and metabolism augment protease-activated receptor-2-mediated increases in prostaglandin E2 levels and smooth muscle relaxation in mouse isolated trachea.
PubMed:Photochemical cleavage and release of carboxylic acids from alpha-keto amides.
PubMed:Removal of non-ionic organic pollutants from water via liquid-liquid extraction.
PubMed:Extractive spectrophotometric methods for the determination of oxomemazine hydrochloride in bulk and pharmaceutical formulations using bromocresol green, bromocresol purple and bromophenol blue.
PubMed:Study on bromocresol green-cetyltrimethylammonium-deoxyribonucleic acids system by resonance light scattering spectrum methods.
PubMed:Spectrophotometric methods for the determination of the antidepressant drug paroxetine hydrochloride in tablets.
PubMed:Theoretical analysis concerning the characteristics of a dye-binding method for determining serum protein based on protein error of pH indicator: effect of buffer concentration of the color reagent on the color development.
PubMed:Transport of prostaglandin E1 across the blood-brain barrier in rats.
PubMed:Serum albumin-adjusted phenytoin levels: an approach for predicting drug efficacy in patients with epilepsy, suitable for developing countries.
PubMed:Nutrition counseling impacts serum albumin levels.
PubMed:Extractive spectrophotometric methods for the determination of nifedipine in pharmaceutical formulations using bromocresol green, bromophenol blue, bromothymol blue and eriochrome black T.
PubMed:Simultaneous photometric determination of albumin and total protein in animal blood plasma employing a multicommutated flow system to carried out on line dilution and reagents solutions handling.
PubMed:Extractive spectrophotometric methods for determination of lercanidipine.
PubMed:Measurement of serum albumin by capillary zone electrophoresis, bromocresol green, bromocresol purple, and immunoassay methods.
PubMed:[Spectrophotometric study on the interaction of protein with acid dye].
PubMed:[pH sensors based on rubbery ormosils preparation and their spectrum studies].
PubMed:Longitudinal analysis of intermediate outcomes in adolescent hemodialysis patients.
PubMed:[Separation of dicarboxylic acid by thin-layer chromatography].
PubMed:Spectrophotometric determination of vitamin B1 in a pharmaceutical formulation using triphenylmethane acid dyes.
PubMed:Determination of diphenhydramine hydrochloride in some single tertiary alkylamine pharmaceutical preparations by flow injection spectrophotometry.
PubMed:Determination of the acid dissociation constant of bromocresol green and cresol red in water/AOT/isooctane reverse micelles by multiple linear regression and extended principal component analysis.
PubMed:Spectrophotometric determination of etidocaine in pharmaceutical (dental) formulation.
PubMed:Sample matrix is critical in the evaluation of a dry-slide bromocresol green method for human albumin.
PubMed:Simple spectrophotometric determination of cinnarizine in its dosage forms.
PubMed:Development and use of a new medium to detect yeasts of the genera Dekkera/Brettanomyces.
PubMed:Extractive spectrophotometric methods for determination of diltiazem HCl in pharmaceutical formulations using bromothymol blue, bromophenol blue and bromocresol green.
PubMed:Albumin as an outcome measure in haemodialysis in patients: the effect of variation in assay method.
PubMed:TLC fractionation and visualization of selected phenolic compounds applied as drugs.
PubMed:Spectrophotometric methods for the determination of benazepril hydrochloride in its single and multi-component dosage forms.
PubMed:The effect of anti-hypertensive therapy on urinary albumin excretion in Nigerian hypertensives.
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PubMed:Establishing albumin levels in sheep serum by a specific fluoroimmunoassay.
PubMed:Extracellular fluid volume determined by bioelectric impedance and serum albumin in CAPD patients.
PubMed:Dual pathways for organic anion secretion in renal proximal tubule.
PubMed:Interaction of bromocresol green with different serum albumins studied by fluorescence quenching.
PubMed:Development of a specific fluoroimmunoassay for ovine albumin.
PubMed:Simultaneous purification of human albumin and hemoglobin for use as environmental biomarkers.
PubMed:Serum bupivacaine concentrations during continuous extrapleural infusion.
PubMed:Characterization of associates in ternary mixtures of amines, diprotic acid dyes and quaternary ammonium compounds in dichloromethane and in dichloromethane/water systems.
PubMed:Ion-association method for the spectrophotometric determination of the antitussive drug noscapine.
PubMed:Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy.
PubMed:Microdetermination of proteins by resonance light scattering spectroscopy with bromophenol blue.
PubMed:A lifetime-based fluorescence resonance energy transfer sensor for ammonia.
PubMed:Extraction spectrophotometric determination of mercury(II) using thiacrown ethers and Bromocresol Green.
PubMed:Effect of cholephilic dyes on hepatic tight junctional permeability in the rat.
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PubMed:Spectrophotometric determination of molsidomine in pharmaceutical formulations using bromocresol green.
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PubMed:Spectrophotometric determination of tilidine using bromocresol green and bromophenol blue.
PubMed:Comparison of different methods of measuring protein and albumin in pigeon sera.
PubMed:Spectrophotometric determination of clonidine in dosage forms using bromocresol green.
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PubMed:Determination of albumin in caprine serum.
PubMed:Separation and quantitation of methenamine in urine by ion-pair extraction.
PubMed:[Bacterial flora in gastric juice taken at endoscopy in 93 normal subjects].
PubMed:A comparative study of some hydroxyanthraquinones as acid-base indicators.
PubMed:Evaluation of a bromocresol purple method for the determination of albumin adapted to the DuPont aca discrete clinical analyzer.
PubMed:Bromocresol purple dye-binding method for the estimation of serum albumin adapted to the SMA 12/60.
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PubMed:Analyte and matrix problems in the calibration and quality assessment of the bromocresol green method for albumin in serum.
PubMed:A study of the interaction between bromocresol green dye and bovine, ovine and equine serum globulins.
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PubMed:Serum albumin values from healthy cattle, sheep and horses determined by the immediate bromocresol green reaction and by agarose gel electrophoresis.
PubMed:Determination of blood ammonia using the Ammonia Checker.
PubMed:Selective method for the isolation of Sporolactobacillus from food and environment sources.
PubMed:Evaluation of the Dupont aca bromocresol purple albumin method.
PubMed:Plasma albumin determination on the Cobas Bio centrifugal analyser using bromocresol green.
PubMed:[Atrophic fundic gastritis unrecognized in gastroscopy: detection by local deposition of bromocresol green and pH-metry of the mucous lumen].
PubMed:Decline of serum albumin concentration at calving in dairy cows: its relationship with age and association with subsequent fertility.
PubMed:[Analysis and stability of suxamethonium chloride. 1. Detection and quantitative determination of the intact active agent with its degradation products].
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PubMed:PAH transport in rock crab urinary bladder. II. Luminal and serosal steps.
PubMed:[Determination of serum albumin concentration in pigs using bromcresol green].
PubMed:Probing the micelle/water interface by a rapid laser-induced proton pulse.
PubMed:[Determination of proteinuria in children: changes in results according to the methods used (author's transl)].
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PubMed:Inverse dependence of binding constants upon albumin concentration. Results for L-tryptophan and three anionic dyes.
PubMed:PAH transport in rock crab (Cancer irroratus) urinary bladder.
PubMed:[Primary selection method for microorganism producers of organic acids].
PubMed:Renal handling of 2,4-D by the dogfish shark (Squalus acanthias).
PubMed:Metabolism of vasoactive hormones in human isolated lung.
PubMed:Bromocresol purple, a non-specific colour reagent for the determination of serum albumin.
PubMed:Decreased binding of drugs and dyes to plasma proteins from rats with acute renal failure: effects of ureter ligation and intramuscular injection of glycerol.
PubMed:Rapid pH and deltamuH+ jump by short laser pulse.
PubMed:Kinetics studies on the renal transport of probenecid in vitro.
PubMed:Studies on extraction of beryllium from thiocyanate solutions by quaternary ammonium halides.
PubMed:Interaction of phenolsulphonphthalein dyes with rabbit plasma and rabbit serum albumin.
PubMed:Radioaffinity assay, a new approach to binding assays applied to the measurement of serum albumin.
PubMed:Thermometric enzyme linked immunosorbent assay in continuous flow system: optimization and evaluation using human serum albumin as a model system.
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PubMed:Structural requirements for, and the effects of chemicals on, the rat pulmonary inactivation of prostaglandins.
PubMed:Spectrophotometric determination of diphenhydramine. HC1 in pharmaceutical preparations.
PubMed:Thin layer chromatographic identification of some sympathomimetic amines.
PubMed:Renal handling of phenol red. II. The mechanism of substituted phenolsulphophthalein (PSP) dye transport in rabbit kidney tubules in vitro.
PubMed:Effects of pH indicators on various activities of chromatophroes of Rhodospirillum rubrum.
PubMed:Fragments of bovine serum albumin produced by limited proteolysis. Conformation and ligand binding.
PubMed:Dependence upon bile volume of the biliary excretion of bromocresol green and amaranth in the anaesthetized rat.
PubMed:Spectrophotometric determination of lidocaine in some pharmaceutical preparations using bromocresol green.
PubMed:Flash photometric experiments on the photochemical cycle of bacteriorhodopsin.
PubMed:Estimation of glycoalkaloids as solasodine in Solanum laciniatum.
PubMed:An assessment of the suitability of bromocresol green for the determination of serum albumin.
PubMed:A study of the interaction of bromocresol green with isolated serum globulin fractions.
PubMed:[Serum albumin assay by bromocresol green method: application to different automatic apparatus].
PubMed:Acid-base equilibria in ethylene glycol--I: definition of pH and determination of pk-values of acid-base indicators.
PubMed:Measurement of urine albumin using bromocresol green.
PubMed:Relative dye-binding capacity of albumin from several species with HABA, bromocresol green and Spectru AB-2.
PubMed:Dissociation constants of sulfamic acid, salicylic acid, thymol blue, and bromocresol green in anhydrous N,N-dimethylformamide.
PubMed:Scanning of cellulose acetate electropherograms after protein dyeing with bromocresol green.
PubMed:Scanning of paper electrophoretograms after protein dyeing with bromocresol green.
an indicator and reagent. it has been used in serum albumin determinations and as a ph indicator.
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