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bromochloromethane
methylene bromochloride

Supplier Sponsors

Name:bromo(chloro)methane
CAS Number: 74-97-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-826-3
FDA UNII: 45WX84110G
Nikkaji Web:J2.384A
Beilstein Number:1730801
MDL:MFCD00000880
XlogP3-AA:1.70 (est)
Molecular Weight:129.38294000
Formula:C H2 Br Cl
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.99100 @ 25.00 °C.
Boiling Point: 68.00 °C. @ 760.00 mm Hg
Vapor Pressure:143.000000 mmHg @ 25.00 °C. (est)
Flash Point: -9.00 °F. TCC ( -22.90 °C. ) (est)
logP (o/w): 1.410
Soluble in:
 water, 1.67E+04 mg/L @ 25 °C (exp)
 water, 5779 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Sigma-Aldrich: Aldrich
For experimental / research use only.
Bromochloromethane, contains 50 ppm BHT as inhibitor (may contain up to), ≥99.5%
sds
TCI AMERICA
For experimental / research use only.
Bromochloromethane >98.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 4300 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC
Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 382, 1947.

oral-rat LD50 5000 mg/kg
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 390, 1969.

Dermal Toxicity:
skin-rabbit LD50 > 20000 mg/kg
National Technical Information Service. Vol. AD-A062-138

Inhalation Toxicity:
inhalation-mouse LC50 12030 mg/m3/7H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: GENERAL ANESTHETIC
Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 382, 1947.

inhalation-rat LCLo 28800 ppm/15M
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: TREMOR
U.S. Army, Chemical Corps Medical Laboratories Research Reports. Vol. #113, Pg. 1952
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for bromochloromethane usage levels up to:
 not for fragrance use.
 
Recommendation for bromochloromethane flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy
View page or View pdf

EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):74-97-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6333
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
bromo(chloro)methane
Chemidplus:0000074975
EPA/NOAA CAMEO:hazardous materials
RTECS:74-97-5
 
References:
 bromo(chloro)methane
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:74-97-5
Pubchem (cid):6333
Pubchem (sid):134970578
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C02661
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2903.40.0070
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 bromo(chloro)methane
monobromomonochloromethane
 chloromethyl bromide
 fluorocarbon 1011
 methane, bromochloro-
 methylene bromochloride
 

Articles:

PubMed:[Influences of high-fat diet and methanogens inhibitor on the cecal microbiota and fat metabolism in C57BL/6J mice].
PubMed:An antimethanogenic nutritional intervention in early life of ruminants modifies ruminal colonization by Archaea.
PubMed:Improving pulsed radiofrequency glow discharge for time-of-flight mass spectrometry simultaneous elemental and molecular analysis.
PubMed:In vitro-in vivo study on the effects of plant compounds on rumen fermentation, microbial abundances and methane emissions in goats.
PubMed:Nutritional intervention in early life to manipulate rumen microbial colonization and methane output by kid goats postweaning.
PubMed:Effect of bromochloromethane and fumarate on phylogenetic diversity of the formyltetrahydrofolate synthetase gene in bovine rumen.
PubMed:Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats.
PubMed:Effect of bromochloromethane on methane emission, rumen fermentation pattern, milk yield, and fatty acid profile in lactating dairy goats.
PubMed:Responses in digestion, rumen fermentation and microbial populations to inhibition of methane formation by a halogenated methane analogue.
PubMed:Tuneable microsecond-pulsed glow discharge design for the simultaneous acquisition of elemental and molecular chemical information using a time-of-flight mass spectrometer.
PubMed:Inhibition of methanogens by bromochloromethane: effects on microbial communities and rumen fermentation using batch and continuous fermentations.
PubMed:Synthesis of nanoscale carceplexes from deep-cavity cavitands.
PubMed:Isobaric and isochoric freezing of CH2BrCl and isostructural relations between CH2Cl2, CH2Br2 and CH2BrCl.
PubMed:Quantitation and diversity analysis of ruminal methanogenic populations in response to the antimethanogenic compound bromochloromethane.
PubMed:Combined vacuum ultraviolet laser and synchrotron pulsed field ionization study of CH2BrCl.
PubMed:On the location of conical intersections in CH2BrCl using MS-CASPT2 methods.
PubMed:Metabolism of mono- and dihalogenated C1 and C2 compounds by Xanthobacter autotrophicus growing on 1,2-dichloroethane.
PubMed:Reduction of greenhouse gases from anaerobic piggery wastewater treatment by bromochloromethane in Taiwan.
PubMed:Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TA100: structure-activity analysis and mutation spectra.
PubMed:Detection limits for time-resolved coherent two-dimensional vibrational spectroscopy.
PubMed:Correlations of Henry's Law Gas-Solid Virial Coefficients and Chromatographic Retention Times for Hydrocarbons and Halocarbons Adsorbed on Carbopack C Carbon.
PubMed:Predicting vehicle effects on the dermal absorption of halogenated methanes using physiologically based modeling.
PubMed:Physiologically based modeling of nonsteady state dermal absorption of halogenated methanes from an aqueous solution.
PubMed:Preparation of Aminoalkyl Chlorohydrin Hydrochlorides: Key Building Blocks for Hydroxyethylamine-Based HIV Protease Inhibitors.
PubMed:Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.
PubMed:Quantitative structure-activity relationship models correctly predict the toxic and aneuploidizing properties of six halogenated methanes in Aspergillus nidulans.
PubMed:Effect of isoniazid or phenobarbital pretreatment on the metabolism of dihalomethanes to carbon monoxide.
PubMed:Dermal absorption of neat and aqueous volatile organic chemicals in the Fischer 344 rat.
PubMed:Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans.
PubMed:Determining kinetic constants of chlorinated ethane metabolism in the rat from rates of exhalation.
PubMed:Damage to protein synthesis concurrent with lipid peroxidation in rat liver slices: effect of halogenated compounds, peroxides, and vitamin E1.
PubMed:Synthesis and oral antifungal activity of novel azolylpropanolones and related compounds.
PubMed:Halogenated compounds as inducers of lipid peroxidation in tissue slices.
PubMed:A physiologically based simulation approach for determining metabolic constants from gas uptake data.
PubMed:A physiological pharmacokinetic model for dermal absorption of vapors in the rat.
PubMed:Dermal absorption of dihalomethane vapors.
PubMed:Chemical reactivity and mutagenicity of some dihalomethanes.
PubMed:The inhalation toxicity of pyrolysis products of bromochloromethane (CH2BrCl) and bromotrifluoromethane (CBrF3).
PubMed:Some solvent effects on the solvent extraction of 8-quinolinol.
PubMed:The toxicity of bromochloromethane (methylene chlorobromide) as determined on laboratory animals.
 
Notes:
inhibitor of ruminal methane production.
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