laureth-23
poly(oxy-1,2-ethanediyl), .alpha.-dodecyl-.omega.-hydroxy- (23 mol EO average molar ratio)
 
Notes:
polyethylene glycol monododecyl ether (average polymer n=9).
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2-dodecoxyethanol (peg-23) (Click)
CAS Number: 9002-92-0Picture of molecule
Other: 101008-55-3
ECHA ELINCS - REACH Pre-Reg: 500-002-6
FDA UNII: J89TKQ5R54
Nikkaji Web: J92.963H
Beilstein Number: 1748129
XlogP3: 5.10 (est)
Formula: (C2 H4 O)mult-C12 H26 O
NMR Predictor: Predict (works with chrome or firefox)
Category: emulsifiers, surfactants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 304.00 to  305.00 °C. @ 760.00 mm Hg (est)
Flash Point: > 220.00 °F. TCC ( > 104.44 °C. )
logP (o/w): 4.909 (est)
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Organoleptic Properties:
Odor Strength: none
 
Odor Description:
at 100.00 %. 
bland
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: cleansing agents
emulsifying agents
surfactants
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Suppliers:
Croda
Brij™ L23
Odor: bland
Use: Easy-to-handle pastillated form; solubiliser and dispersant.
Kao Corporation
EMULGEN 123P
Odor: characteristic
Use: Emulsifier for cosmetics and pharmaceuticals
Lipo Chemicals
Lipocol® L-23
Odor: characteristic
Use: Lipocol® L-23 is used as a cleansing agent and solubilizer in acne scrubs, medicated shampoos, scalp treatment products and bubble baths. It is a primary component of emulsifier systems for antiperspirants, depilatories and cleansing creams and lotions. It is an efficient perfume solubilizer for shampoo and liquid detergents.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-guinea pig LD50  38 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

oral-guinea pig LD50  384 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

intraperitoneal-mouse LD50  160 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intraperitoneal-mouse LD50  160 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

intravenous-mouse LD50  100 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intravenous-mouse LD50  100 mg/kg
Toxicology and Applied Pharmacology. Vol. 7, Pg. 206, 1965.

oral-mouse LD50  1170 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

oral-mouse LD50  1170 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

oral-mouse LD50  3500 mg/kg
American Perfumer and Cosmetics. Vol. 77, Pg. 35, 1962.

oral-mouse LD50  4940 mg/kg
American Perfumer and Cosmetics. Vol. 77, Pg. 35, 1962.

intratracheal-rabbit LD50  > 15 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976.

intravenous-rabbit LD50  36 mg/kg
KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

parenteral-rabbit LD50  > 75 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976.

intraperitoneal-rat LD50  125 mg/kg
GASTROINTESTINAL: OTHER CHANGES
Food and Cosmetics Toxicology. Vol. 8, Pg. 125, 1970.

intravenous-rat LD50  27 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intravenous-rat LD50  27 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

intravenous-rat LD50  390 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

oral-rat LD50  1000 mg/kg
LIVER: FATTY LIVER DEGERATION GASTROINTESTINAL: OTHER CHANGES GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Food and Cosmetics Toxicology. Vol. 8, Pg. 125, 1970.

oral-rat LD50  4150 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

oral-rat LD50  8600 mg/kg
Soap, Perfumery & Cosmetics. Vol. 38, Pg. 47, 1965.

Dermal Toxicity:
subcutaneous-mouse LD50 792 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

subcutaneous-mouse LD50 792300 ug/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

subcutaneous-rat LD50 953 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

subcutaneous-rat LD50 954 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: emulsifiers, surfactants
Recommendation for laureth-23 usage levels up to:
 not for fragrance use.
 
Recommendation for laureth-23 flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 9002-92-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 24750
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 2-dodecoxyethanol (peg-23)
Chemidplus: 0009002920
EPA/NOAA CAMEO: hazardous materials
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References:
 2-dodecoxyethanol (peg-23)
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 9002-92-0
Pubchem (cid): 24750
Pubchem (sid): 135050657
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): D01539
HMDB (The Human Metabolome Database): Search
Haz-Map: View
Household Products: Search
ChemSpider: View
Formulations/Preparations:
grades or purity: usually 100%
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 ameroxol LE-23
 brij 23
 brij 35P
 brij L23
 brij L23-25
 britex L 230
 chemal LA 23
2-dodecoxyethanol (peg-23)
 emulgen 123P
 ethosperse LA 23
 lipocol L-23
 macol LA-23
 peg-23 lauryl ether
 poly(oxy-1,2-ethanediyl), .alpha.-dodecyl-.omega.-hydroxy- (23 mol EO average molar ratio)
 polyethylene glycol (23) lauryl ether
 polyethylene glycol (23) monolauryl ether
 polyoxyethylene (23) lauryl ether
 polyoxyethylene (23) monolauryl ether
 simulsol P 23
 volpo L 23
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