boric acid
 
Notes:
None found
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      02-34800 BORIC ACID POWDER
      02-34801 BORIC ACID GRANULAR
       
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boric acid (Click)
CAS Number: 10043-35-3Picture of molecule
Other: 12795-04-9
ECHA EINECS - REACH Pre-Reg: 233-139-2
FDA UNII: R57ZHV85D4
Nikkaji Web: J43.588K
Beilstein Number: 1697939
MDL: MFCD00011337
Molecular Weight: 61.83251000
Formula: B H3 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: substances for use only as components of adhesives for food packaging, transporting, or holding food
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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 FDA/DG SANTE Petitions, Reviews, Notices:
EU SANCO Boric acid View-review
DG SANTE Food Additives: boric acid
DG SANTE Food Contact Materials: boric acid
FDA Mainterm: BORIC ACID
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.180 Components of paper and paperboard in contact with dry food.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart C--Antioxidants and Stabilizers
Sec. 178.2010 Antioxidants and/or stabilizers for polymers.


FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.30 Substances used in the manufacture of paper and paperboard products used in food packaging.
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Physical Properties:
Appearance: white powder (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.43500 @  25.00 °C.
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -0.610 (est)
Soluble in:
 water, 2.117e+005 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
buffering agents
denaturants
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Suppliers:
EMD Millipore
For experimental / research use only.
Boric Acid
Graham Chemical
Boric Acid
Kraft Chemical
Boric Acid
Penta International
BORIC ACID GRANULAR
Penta International
BORIC ACID POWDER
Santa Cruz Biotechnology
For experimental / research use only.
Boric Acid ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Boric Acid for electrophoresis, ≥99.5%
Silver Fern Chemical
Boric Acid
Odor: characteristic
Use: Boric Acid is a weak acid of boron often used as an antiseptic, insecticide, flame retardant, neutron absorber, or precursor to other chemical compounds. It exists in the form of colorless crystals or a white powder that dissolves in water.
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  2660 mg/kg
JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.

intravenous-rat LD50  1330 mg/kg
BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950

oral-child TDLo  500 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Toxicology, Clinical Toxicology. Vol. 24, Pg. 269, 1986.

oral-dog LDLo  1780 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING BRAIN AND COVERINGS: MENINGEAL CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS
JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.

parenteral-dog LDLo  1000 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Rassegna di Terapia e Patologia Clinica. Vol. 1, Pg. 472, 1929.

oral-guinea pig LDLo  1000 mg/kg
GASTROINTESTINAL: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING
Revista de la Asociacion Medica Argentina. Vol. 46, Pg. 1493, 1932.

oral-man LDLo  429 mg/kg
CARDIAC: OTHER CHANGES KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 345, 1993.

unreported-man LDLo  147 mg/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

unreported-man TDLo  170 mg/kg
BEHAVIORAL: WAKEFULNESS BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING
Rassegna di Terapia e Patologia Clinica. Vol. 1, Pg. 472, 1929.

intravenous-mouse LD50  1240 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 117, 1961.

oral-mouse LD50  3450 mg/kg
JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.

intraperitoneal-mouse LDLo  800 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA
"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.

intravenous-rabbit LDLo  800 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.

oral-rabbit LDLo  4000 mg/kg
BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950

parenteral-rabbit LDLo  670 mg/kg
Rassegna di Terapia e Patologia Clinica. Vol. 1, Pg. 472, 1929.

Dermal Toxicity:
subcutaneous-rat LD50 1400 mg/kg
"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., 1964Vol. -, Pg. 693, 1964.

skin-child LDLo 1500 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
Quarterly Journal of Pharmacy & Pharmacology. Vol. 6, Pg. 714, 1933.

skin-child LDLo 4000 mg/kg/4D
Muenchener Medicinische Wochenschrift. Vol. 52, Pg. 763, 1905.

subcutaneous-dog LDLo 1000 mg/kg
BRAIN AND COVERINGS: MENINGEAL CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: CYANOSIS
JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.

subcutaneous-guinea pig LD50 1200 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: TREMOR GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950

skin-man LDLo 2430 mg/kg
SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.

subcutaneous-mouse LD50 1740 mg/kg
JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.

subcutaneous-rabbit LDLo 150 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

subcutaneous-rat LD50 1400 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA
"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.

Inhalation Toxicity:
inhalation-rat LCLo 28 mg/m3/4H
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 27, 1982.

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Safety in Use Information:
Category: substances for use only as components of adhesives for food packaging, transporting, or holding food
Recommendation for boric acid usage levels up to:
 not for fragrance use.
 
Recommendation for boric acid flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Statement on the Boric Acid and Sodium borate as nutrient sources of boron by the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC)
View page or View pdf
Scientific Opinion on the re-evaluation of boric acid (E 284) and sodium tetraborate (borax) (E 285) as food additives
View page or View pdf
EPI System: View
ECHA (ESR): View
ClinicalTrials.gov: search
Daily Med: search
NIOSH International Chemical Safety Cards: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 10043-35-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7628
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 boric acid
Chemidplus: 0010043353
EPA/NOAA CAMEO: hazardous materials
RTECS: 10043-35-3
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References:
 boric acid
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 10043-35-3
Pubchem (cid): 7628
Pubchem (sid): 135268957
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C12486
HMDB (The Human Metabolome Database): HMDB35731
Export Tariff Code: 2810.00.0000
Haz-Map: View
Household Products: Search
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antimicrobial agents 
 oral care agents 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 basilit b
 boracic acid
orthoboric acid
 boricacid
 borofax
 boron trihydroxide
 dr.'s 1 flea terminator DF
 dr.'s 1 flea terminator DFPBO
 dr.'s 1 flea terminator DT
 dr.'s 1 flea terminator DTPBO
 flea prufe
 super flea eliminator
 three elephant
 trihydroxyborone
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Articles:
PubMed: A study on chemical composition and detection of chemical adulteration in tetra pack milk samples commercially available in Multan.
PubMed: Aquaglyceroporins: generalized metalloid channels.
PubMed: Doehlert design-desirability function multi-criteria optimal separation of 17 phenolic compounds from extra-virgin olive oil by capillary zone electrophoresis.
PubMed: Homoarginine, β-ODAP, and asparagine contents of grass pea landraces cultivated in Turkey.
PubMed: Asymmetrical behavioral response towards two boron toxicants depends on the ant species (Hymenoptera: Formicidae).
PubMed: Impact of platinum on the soil invertebrate Folsomia candida.
PubMed: Cellular responses in the Malpighian tubules of Scaptotrigona postica (Latreille, 1807) exposed to low doses of fipronil and boric acid.
PubMed: Effect of different GRAS compounds in the control of apples blue mould.
PubMed: [Determination of sixteen food additives in beverage by capillary zone electrophoresis].
PubMed: Spectrofluorimetric determination of ellagic acid in brandy.
PubMed: Efficacy of commercial baits and new active ingredients against firebrats and silverfish (Zygentoma: Lepismatidae).
PubMed: Influence of toxic bait type and starvation on worker and queen mortality in laboratory colonies of Argentine ant (Hymenoptera: Formicidae).
PubMed: Field enhancement sample stacking for analysis of organic acids in traditional Chinese medicine by capillary electrophoresis.
PubMed: Rapid and sensitive determination of sulfonamide residues in milk and chicken muscle by microfluidic chip electrophoresis.
PubMed: An optical test strip for the detection of benzoic acid in food.
PubMed: Microchip electrophoresis of bacteria using lipid-based liquid crystalline nanoparticles.
PubMed: Insecticidal and repellent effects of tea tree (Melaleuca alternifolia) oil against Lucilia cuprina.
PubMed: Reproductive toxicity parameters and biological monitoring in occupationally and environmentally boron-exposed persons in Bandirma, Turkey.
PubMed: Analytical methods for SiO2 and other inorganic oxides in titanium dioxide or certain silicates for food additive specifications.
PubMed: Phosphate additives determination in meat products by 31-phosphorus nuclear magnetic resonance using new internal reference standard: hexamethylphosphoroamide.
PubMed: Identification of causative agents and species in shrimp implicated in a food poisoning case in Taiwan.
PubMed: Use of multivariate statistical techniques to optimize the simultaneous separation of 13 phenolic compounds from extra-virgin olive oil by capillary electrophoresis.
PubMed: The effects of some boron compounds against heavy metal toxicity in human blood.
PubMed: [Determination of four amino acids in tea by capillary zone electrophoresis and direct ultraviolet detection without derivatization].
PubMed: Candidiasis (vulvovaginal).
PubMed: Chronic boron exposure and human semen parameters.
PubMed: Stability and reproducibility of a single-sample urinary C-peptide/creatinine ratio and its correlation with 24-h urinary C-peptide.
PubMed: Determination of total lead in lipstick: development and validation of a microwave-assisted digestion, inductively coupled plasma-mass spectrometric method.
PubMed: Receptor activated Ca(2+) release is inhibited by boric acid in prostate cancer cells.
PubMed: Morphological alterations induced by boric acid and fipronil in the midgut of worker honeybee (Apis mellifera L.) larvae : Morphological alterations in the midgut of A. mellifera.
PubMed: The effects of boric acid on sister chromatid exchanges and chromosome aberrations in cultured human lymphocytes.
PubMed: Risk assessment of boron in glass wool insulation.
PubMed: Sensitive determination of biogenic amines by capillary electrophoresis with a new fluorogenic reagent 3-(4-fluorobenzoyl)-2-quinolinecarboxaldehyde.
PubMed: Plants tolerant of high boron levels.
PubMed: Relative attractiveness of baits to Paratrechina longicornis (Hymenoptera: Formicidae).
PubMed: Candidiasis (vulvovaginal).
PubMed: Genotoxicity of five food preservatives tested on root tips of Allium cepa L.
PubMed: Sensitive determination of carbohydrates labelled with p-nitroaniline by capillary electrophoresis with photometric detection using a 406 nm light-emitting diode.
PubMed: Boron and the kidney.
PubMed: [Scientific research related to food additives and acrylamide].
PubMed: Effects of single and repeated exposure to biocidal active substances on the barrier function of the skin in vitro.
PubMed: Effects of hyperthermia and boric acid on skeletal development in rat embryos.
PubMed: Educational intervention to control cockroach allergen exposure in the homes of hispanic children in Los Angeles: results of the La Casa study.
PubMed: Enzymatic determination of urea in milk by sequential injection with spectrophotometric and conductometric detection.
PubMed: Regulation system for protease production in Vibrio vulnificus.
PubMed: Water solutions of boric acid and sugar for management of German cockroach populations in livestock production systems.
PubMed: Influence of the extracting solvent upon the structural properties of Amaranth (Amaranthus hypochondriacus) glutelin.
PubMed: Improving extraction of fumonisin mycotoxins from Brazilian corn-based infant foods.
PubMed: Dietary boron supplementation enhances the effects of estrogen on bone mineral balance in ovariectomized rats.
PubMed: Comparisons of toxic baits for controlling the cockroach, Blattella germanica: attractiveness and feeding stimulation.
PubMed: A method for determining fumonisin B1 in corn using immunoaffinity column clean-up and thin layer chromatography/densitometry.
PubMed: Optimization of the separation of phenolic compounds by micellar electrokinetic capillary chromatography.
PubMed: Sol-gel composite films with controlled release of biocides.
PubMed: Determination of borates in caviare by ion-exclusion chromatography.
PubMed: Boron exposure from consumer products.
PubMed: Individual and combined genotoxic response of boric acid and aflatoxin B1 in Escherichia coli PQ37.
PubMed: An assessment of boric acid and borax using the IEHR Evaluative Process for Assessing Human Developmental and Reproductive Toxicity of Agents. Expert Scientific Committee.
PubMed: The developmental toxicity of boric acid in rabbits.
PubMed: Developmental toxicity NOAEL and postnatal recovery in rats fed boric acid during gestation.
PubMed: Noncancer risk assessment: reproductive toxicology.
PubMed: [Disinfection of wood in mushroom growing cellars with Mycetox].
PubMed: Toxicity and carcinogenicity studies of boric acid in male and female B6C3F1 mice.
PubMed: The developmental toxicity of boric acid in mice, rats, and rabbits.
PubMed: Perak, Malaysia, mass poisoning. Tale of the Nine Emperor Gods and rat tail noodles.
PubMed: An outbreak of a food-related illness resembling boric acid poisoning.
PubMed: A rapid, sensitive thin layer chromatography procedure for the detection of fumonisin B1 and B2.
PubMed: Developmental toxicity of boric acid in mice and rats.
PubMed: Aflatoxin in betel nut and its control by use of food preservatives.
PubMed: An outbreak of aflatoxicosis and boric acid poisoning in Malaysia: a clinicopathological study.
PubMed: Interactive effects of boron, selenium, and dietary protein on survival, growth, and physiology in mallard ducklings.
PubMed: Normal boron excretion levels and borates related gastroenteritis cases in Singapore.
PubMed: Quantitative aspects of two methods to dissolve collagen-free muscle proteins from acetone dry powders of Guelders ring sausage.
PubMed: [Quantitative determination of the protein content of milk by ultraviolet spectrophotometry. 3. Determination of proteins in preserved milk samples].
PubMed: Boric acid toxicity.
PubMed: A boric acid-rodenticide mixture used in the control of coexisting rodent-cockroach infestations.
PubMed: Gastro-intestinal absorption and in vitro release of boric acid from water-emulsifying ointments.
PubMed: Unaffected blood boron levels in newborn infants treated with a boric acid ointment.
PubMed: Absorption of boric acid through human skin depending on the type of vehicle.
PubMed: Colorimetric determination of boric acid in prawns, shrimp, and salted jelly fish by chelate extraction with 2-ethyl-1,3-hexanediol.
PubMed: [Determination of boric acid (H3BO3) in shellfish and various foods].
PubMed: [Thin-layer chromatography of sugars (author's transl)].
PubMed: Collaborative study of the determination of boric acid in foods by atomic absorption spectrophotometry.
PubMed: TOXICITY OF BORIC ACID THROUGH SKIN AND MUCOUS MEMBRANES.
PubMed: BORIC ACID AND BABY POWDERS.
PubMed: [Priority of public health or of contaminated butter? The resolution issued in 1940 on boric acid remains without effect].
PubMed: A buffered boric acid lactose medium for enrichment and presumptive identification of Escherichia coli.
PubMed: A PRELIMINARY NOTE ON A NEW ASPECT OF THE EFFECTS OF BORIC ACID AS A FOOD PRESERVATIVE.
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