EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

bicine
N,N-di(2-hydroxyethyl)glycine

Supplier Sponsors

Name:2-[bis(2-hydroxyethyl)amino]acetic acid
CAS Number: 150-25-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:205-755-1
FDA UNII: 1J484QFI1O
Nikkaji Web:J39.915I
Beilstein Number:1769362
XlogP3-AA:-3.80 (est)
Molecular Weight:163.17341000
Formula:C6 H13 N O4
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 3.515e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Bicine ≥99% (Titration)
Glentham Life Sciences
BICINE
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for bicine usage levels up to:
 not for fragrance use.
 
Recommendation for bicine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8761
National Institute of Allergy and Infectious Diseases:Data
2-[bis(2-hydroxyethyl)amino]acetic acid
Chemidplus:0000150254
RTECS:MB9700000 for cas# 150-25-4
 
References:
 2-[bis(2-hydroxyethyl)amino]acetic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):8761
Pubchem (cas):150-25-4
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
HMDB (The Human Metabolome Database):HMDB11727
FooDB:FDB028408
Export Tariff Code:2922.50.5000
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
N,N-di(2-hydroxyethyl)glycine
 glycine, N,N-bis(2-hydroxyethyl)-
2-[bis(2-hydroxyethyl)amino]acetic acid
 

Articles:

PubMed:Amphiphilic Polymer-Based Fluorescent Probe for Enantioselective Recognition of Amino Acids in Immiscible Water and Organic Phases.
PubMed:Chitosan-Promoted Direct Electrochemistry of Human Sulfite Oxidase.
PubMed:Analyzing Amyloid-β Peptide Modulation Profiles and Binding Sites of γ-Secretase Modulators.
PubMed:Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes.
PubMed:A role for glutamate-333 of Saccharomyces cerevisiae cystathionine γ-lyase as a determinant of specificity.
PubMed:Prestorage in ovo injection of biological buffers: an approach to improve hatchability in long-term stored eggs.
PubMed:Potent inhibition of starch-synthase by Tris-type buffers is responsible for the perpetuation of the primer myth for starch biosynthesis.
PubMed:Effects of membrane lipids on the activity and processivity of purified γ-secretase.
PubMed:Effects of L-arginine on refolding of lysine-tagged human insulin-like growth factor 1 expressed in Escherichia coli.
PubMed:The synthesis and biological activity of lipophilic derivatives of bicine conjugated with N³-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP)-an inhibitor of glucosamine-6-phosphate synthase.
PubMed:Lateral diffusion of manganese in the rat brain determined by T(1) relaxation time measured by (1)H MRI.
PubMed:Mn-bicine: a low affinity chelate for manganese ion enhanced MRI.
PubMed:Synthesis, X-Ray Structure, and Characterization of Catena-bis(benzoate)bis{N,N-bis(2-hydroxyethyl)glycinate}cadmium(II).
PubMed:Overexpression, crystallization and preliminary X-ray analysis of xylulose-5-phosphate/fructose-6-phosphate phosphoketolase from Bifidobacterium breve.
PubMed:Stable adducts of nerve agents sarin, soman and cyclosarin with TRIS, TES and related buffer compounds--characterization by LC-ESI-MS/MS and NMR and implications for analytical chemistry.
PubMed:Bis{2-[bis-(2-hy-droxy-eth-yl)amino]-acetato-κO,N,O'}zinc(II).
PubMed:PEG-based thermogels: applicability in physiological media.
PubMed:A cost-effective device for the rapid transfer of gel-separated proteins onto membranes.
PubMed:Sorption behaviour of lanthanum(III), neodymium(III), terbium(III), thorium(IV) and uranium(VI) on Amberlite XAD-4 resin functionalized with bicine ligands.
PubMed:Loading dependent swelling and release properties of novel biodegradable, elastic and environmental stimuli-sensitive polyurethanes.
PubMed:A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein.
PubMed:Impact of ligand protonation on higher-order metal complexation kinetics in aqueous systems.
PubMed:Direct and remarkably efficient conversion of methane into acetic acid catalyzed by amavadine and related vanadium complexes. A synthetic and a theoretical DFT mechanistic study.
PubMed:Crystal structure of KPC-2: insights into carbapenemase activity in class A beta-lactamases.
PubMed:Proteomic profile changes in membranes of ethanol-tolerant Clostridium thermocellum.
PubMed:Crystallization and preliminary X-ray diffraction data of the complex between human centrin 2 and a peptide from the protein XPC.
PubMed:A novel Bicine running buffer system for doubled sodium dodecyl sulfate - polyacrylamide gel electrophoresis of membrane proteins.
PubMed:Production of two types of exopolysaccharide by Novosphingobium rosa.
PubMed:Buffers for the physiological pH range: acidic dissociation constants of zwitterionic compounds in various hydroorganic media.
PubMed:Thermodynamic study of the second-stage dissociation of N,N-bis-(2-hydroxyethyl)glycine (bicine) in water at different ionic strength and different solvent mixtures.
PubMed:Ionic mobilities of duplex and frayed wire DNA in discontinuous buffer electrophoresis: evidence of interactions with amino acids.
PubMed:Effects of nitrogen forms on the production of cyanobacterial toxin microcystin-IR by an isolated Microcystis aeruginosa.
PubMed:Trypsin activity assay in substrate-specific one- and two-dimensional gels: a powerful method to separate and characterize novel proteases in active form in biological samples.
PubMed:The effect of pH on the growth of saprotrophic and ectomycorrhizal ammonia fungi in vitro.
PubMed:The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin.
PubMed:Crystallization and preliminary diffraction data of BaP1, a haemorrhagic metalloproteinase from Bothrops asper snake venom.
PubMed:Determination of the affinity of each component of a composite quaternary transition-state analogue complex of creatine kinase.
PubMed:Analysis and enantioresolution of donepezil by capillary electrophoresis.
PubMed:Conservation of phosphorylation state of cardiac phosphofructokinase during in vitro hypothermic hypoxia.
PubMed:An interlaboratory comparison of physiological and genetic properties of four Saccharomyces cerevisiae strains.
PubMed:Thin-layer ion-exchange chromatography of proteins.
PubMed:Investigation of a primary requirement of organ preservation solutions: supplemental buffering agents improve hepatic energy production during cold storage.
PubMed:Tris Is a Competitive Inhibitor of K+ Activation of the Vacuolar H+-Pumping Pyrophosphatase.
PubMed:Electrophoretic separation of betaA4 peptides (1-40) and (1-42).
PubMed:Preparation and analytical properties of a chelating resin containing bicine groups.
PubMed:Differentiation by preparative continuous free flow-isoelectric focusing of cyclosporin A inhibitable peptidyl-prolyl cis/trans isomerase of human erythrocytes.
PubMed:Silver-staining of proteins in polyacrylamide gels: a general overview.
PubMed:Assessment of the capabilities of capillary zone electrophoresis for the determination of hippuric and orotic acid in whey.
PubMed:Proton transfer roles of lysine 64 and glutamic acid 64 replacing histidine 64 in the active site of human carbonic anhydrase II.
PubMed:Crystallization and oligomeric structure of rat liver arginase.
PubMed:A new multiphasic buffer system for sodium dodecyl sulfate-polyacrylamide gel electrophoresis of proteins and peptides with molecular masses 100,000-1000, and their detection with picomolar sensitivity.
PubMed:Inhibition of an outwardly rectifying anion channel by HEPES and related buffers.
PubMed:Effect of pH on the accumulation kinetics of pentachlorophenol in goldfish.
PubMed:Measurement of oxidation-reduction midpoint potentials by room temperature electron paramagnetic resonance potentiometry.
PubMed:Aminoacylase I from hog kidney: anion effects and the pH dependence of kinetic parameters.
PubMed:Studies on the interference of selected substances with two modifications of the Lowry protein determination.
PubMed:Effect of zwitterionic buffers on measurement of small masses of protein with bicinchoninic acid.
PubMed:Solubilization and partial characterization of fatty acyl-CoA:sphingosine acyltransferase (ceramide synthetase) from rat liver and brain.
PubMed:A role for interstitial matrix in tissue tension of alveolar wall.
PubMed:Standard electromotive force of the H2-AgCl;Ag cell in 30, 40, and 50 mass% dimethyl sulfoxide/water from -20 to 25 degrees C: pK2 and pH values for a standard "Bicine" buffer solution at subzero temperatures.
PubMed:Histochemical demonstration of guanase in human liver with guanine in bicine buffer as substrate.
PubMed:Determination of theophylline binding to human serum proteins by isotachophoresis.
PubMed:Control of the generator current in solitary rods of the Ambystoma tigrinum retina.
PubMed:Isolation and enumeration of Campylobacter jejuni from poultry products by a selective enrichment method.
PubMed:Free-metal ion depletion by "Good's" buffers.
PubMed:Covalent cross-linking of the bovine somatotropin dimer. Effects on growth-promoting, receptor-binding and immunological activities and preliminary characterization of the self-association.
PubMed:Ca2+ coupling in vascular smooth muscle: Mg2+ and buffer effects on contractility and membrane Ca2+ movements.
PubMed:In vitro labeling of proteins by reductive methylation: application to proteins involved in supramolecular structures.
PubMed:A sensitive new method for measurement of guanase with 8-azaguanine in bicine bis-hydroxy ethyl glycine buffer as substrate.
PubMed:Affinity labelling of liver alcohol dehydrogenase. Effects of pH and buffers on affinity labelling with iodoacetic acid and (R, S)-2-bromo-3-(5-imidazolyl)propionic acid.
PubMed:Inactivation of crystalline tobacco ribulosebisphosphate carboxylase by modification of arginine residues with 2,3-butanedione and phenylglyoxal.
PubMed:Clinical evaluation of measurement of serum guanase activity as a screening test of liver damage.
PubMed:Uptake of purine bases and nucleosides in African trypanosomes.
PubMed:Adverse effects of artificial buffers on contractile responses of arterial and venous smooth muscle.
PubMed:Changes in apparent pH on freezing aqueous buffer solutions and their relevance to biochemical electron-paramagnetic-resonance spectroscopy.
PubMed:Kinetics and control of bovine adrenal glucose-6-phosphate dehydrogenase.
PubMed:Alkaline ribonuclease and phosphodiesterase activity in rat liver plasma membranes.
PubMed:Base exchange reactions of the phospholipids in rat brain particles.
PubMed:Production of interferon in serum-free human leukocyte suspensions.
 
Notes:
Bicine is a general purpose buffer for biological research. Useful pH range is 7.6 - 9.0. Its applications include: tissue culture,phosphorylation and photophosphorylation, fixative transmission electron microscopy, protein synthesis and preventing binding to non-receptor materials. It is a degradation product of alkanolamine and alkylalkanolamine solutions. [HMDB]
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