EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

benztropine mesylate
8-azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-, endo-, methanesulfonate

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CAS Number: 132-17-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:205-048-8
FDA UNII: WMJ8TL7510
MDL:MFCD00074784
Molecular Weight:403.54193000
Formula:C22 H29 N O4 S
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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US Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 143.00 °C. @ 760.00 mm Hg
Boiling Point: 409.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000001 mmHg @ 25.00 °C. (est)
Flash Point: 248.00 °F. TCC ( 120.10 °C. ) (est)
logP (o/w): 4.962 (est)
Soluble in:
 water, 1.068 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Benztropine Mesylate >98%
Odor: characteristic
Use: Benztropine inhibits MTSET-induced inhibition of [3H]WIN binding to Wild-type dopamine transporter with EC50 of 28 ?M in concentration-dependent manner.
Carbosynth
For experimental / research use only.
Benztropine Mesylate
Santa Cruz Biotechnology
For experimental / research use only.
Benztropine Mesylate ≥98%
Sarchem Laboratories
For experimental / research use only.
Benztropine Mesylate
Sigma-Aldrich: Sigma
For experimental / research use only.
Benztropine Mesylate ≥98% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LDLo 33 mg/kg
Compilation of LD50 Values of New Drugs.

oral-human TDLo 100 ug/kg
BEHAVIORAL: TOXIC PSYCHOSIS
Proceedings of the European Society for the Study of Drug Toxicity. Vol. 8, Pg. 59, 1967.

intraperitoneal-mouse LD50 65 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 555, 1963.

intravenous-mouse LD50 24 mg/kg
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972.

oral-mouse LD50 91 mg/kg
Drugs in Japan Vol. 6, Pg. 775, 1982.

oral-rat LD50 940 mg/kg
Drugs in Japan Vol. 6, Pg. 775, 1982.

Dermal Toxicity:
subcutaneous-guinea pig LD50 80 mg/kg
AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962.

subcutaneous-mouse LD50 103 mg/kg
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972.

subcutaneous-rat LD50 353 mg/kg
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for benztropine mesylate usage levels up to:
 not for fragrance use.
 
Recommendation for benztropine mesylate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8584
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonicacid
Chemidplus:0000132172
RTECS:YM3150000 for cas# 132-17-2
 
References:
 (1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonicacid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):8584
Pubchem (sid):134973916
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):D00778
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.90.9500
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether methanesulfonate
(1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonicacid
 benzotropine methanesulfonate
 benzotropinemesylate
 benztropine mesilate
 benztropine methanesulfonate
8-azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-, endo-, methanesulfonate
8-azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-, methanesulfonate (9CI)
 cobrentin methanesulfonate
 cogentin
 cogentin methanesulfonate
3-diphenyl methoxytropane methanesulfonate
endo-3-(diphenylmethoxy)-8-methyl-8-azoniabicyclo(3.2.1)octane methanesulphonate
3-diphenylmethoxytropane mesylate
3-diphenylmethoxytropane methanesulfonate
 lopac-B-8262
N-methylbenztropine
 tropine benzohydryl ether methanesulfonate
 

Articles:

PubMed:Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats.
PubMed:The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration.
PubMed:Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors.
PubMed:Persistence of racial disparities in prescription of first-generation antipsychotics in the USA.
PubMed:Stimulant actions of histamine H1 antagonists on operant behavior in the squirrel monkey.
PubMed:Overeating after midbrain 6-hydroxydopamine: prevention by central injection of selective catecholamine reuptake blockers.
PubMed:Effects of dopaminergic agonists and antagonists of feeding in intact and 6-hydroxydopamine-treated rats.
PubMed:Delusions of pregnancy associated with increased prolactin concentrations produced by antipsychotic treatment.
PubMed:The effect of parasympathetic drugs on energy expenditure: relevance to the autonomic hypothesis.
PubMed:Azacitidine-associated hyperthermia and interstitial pneumonitis in a patient with myelodysplastic syndrome.
 
Notes:
a centrally active muscarinic antagonist that has been used in the symptomatic treatment of parkinson disease. benztropine also inhibits the uptake of dopamine.
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