EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

atropine sulfate monohydrate
benzeneacetic acid, a-(hydroxymethyl)-, (6-methyl-6-azabicyclo[3.1.1]hept-3-yl)methyl ester, sulfate (2:1) (salt)

Supplier Sponsors

Name:(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate
CAS Number: 5908-99-6Picture of molecule3D/inchi
FDA UNII: 03J5ZE7KA5
Beilstein Number:6109275
MDL:MFCD00074815
Molecular Weight:694.84270000
Formula:C34 H50 N2 O11 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 806.70 °C. @ 760.00 mm Hg (est)
Flash Point: 827.00 °F. TCC ( 441.70 °C. ) (est)
logP (o/w): 2.137 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
AtropineSulfat 98%
BOC Sciences
For experimental / research use only.
Atropine Sulfate >98%
Odor: characteristic
Use: Atropine is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 2.5 nM.
ExtraSynthese
For experimental / research use only.
Atropine Sulfate (HPLC) ≥95%
Glentham Life Sciences
Atropine sulfate monohydrate
Penta International
ATROPINE SULFATE USP
Santa Cruz Biotechnology
For experimental / research use only.
Atropine Sulfate Monohydrate ≥97%
Sigma-Aldrich: Sigma
For experimental / research use only.
Atropine sulfate salt monohydrate ≥97% (TLC), crystalline
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for atropine sulfate monohydrate usage levels up to:
 not for fragrance use.
 
Recommendation for atropine sulfate monohydrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Tropane alkaloids in food and feed
View page or View pdf

ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :64663
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate
Chemidplus:0005908996
RTECS:CK2455000 for cas# 5908-99-6
 
References:
 (8-methyl-8-azabicyclo[3.2.1]octan-3-yl)3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):64663
Pubchem (sid):135022735
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2939.90.5000
ChemSpider:View
Formulations/Preparations:
•belladonna tincture, usp...prepn...of aq-alcoholic extract of...leaves. belladonna extract, nf...in pills or capsules...15 mg, equiv to approx 0.2 mg of atropine. belladonna leaf, usp...used for prepn of tincture & extract. atropine, nf, is main alkaloid of belladonna as free base. •dosage forms-injection: 0.8 mg0.5 ml; 0.3, 0.4, 0.5, & 1.2 mg1 ml; 0.25, 0.5 & 2.5 mg5 ml; 4 & 10 mg10 mgl; 8 mg20 ml; 15 mg30 ml;. ophthalmic ointment: 0.5 & 1%. ophthalmic solution: 0.5, 1, 2, & 3%. tablets: 0.4 & 0.6 mg. atropine sulfate •grade: technical, nf •atropine is usually employed in form of its sulfate salt.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 atropine sulfate
 benzeneacetic acid, a-(hydroxymethyl)-, (6-methyl-6-azabicyclo[3.1.1]hept-3-yl)methyl ester, sulfate (2:1) (salt)
(6-methyl-6-azabicyclo[3.1.1]hept-3-yl)methyl 3-hydroxy-2-phenylpropanoate sulfate (2:1)
(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate
 

Articles:

PubMed:[Simultaneous determination of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid with HPLC].
PubMed:Quantitative proton nuclear magnetic resonance for the structural and quantitative analysis of atropine sulfate.
PubMed:Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: increased startle reactivity and perseverative behavior.
PubMed:Hyperglycemic and stressogenic effects of monocrotophos in rats: evidence for the involvement of acetylcholinesterase inhibition.
PubMed:Effect of atropine sulfate on gastric emptying and gastrocecal transit time evaluated by using the [1-(13)C]acetic acid and lactose-[(13)C]ureide breath test in conscious rats.
PubMed:Chinese dumpling scare hits Japan--a case of methamidophos food poisoning.
PubMed:Investigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractions.
PubMed:Changes in spontaneous contractions of rat ileum by aflatoxin in vitro.
PubMed:Impurity profiling of atropine sulfate by microemulsion electrokinetic chromatography.
PubMed:Identification and estimation of the levo isomer in raw materials and finished products containing atropine and/or hyoscyamine.
PubMed:[Conservative treatment of hypertrophic pyloric stenosis in children].
PubMed:Determination of atropine (hyoscyamine) sulfate in commercial products by liquid chromatography with UV absorbance and fluorescence detection: multilaboratory study.
PubMed:Effects of selected anticholinergics on acoustic startle response in rats.
PubMed:Dose-response curves and time-course effects of selected anticholinergics on locomotor activity in rats.
PubMed:Central cholinergic regulation of pancreatic polypeptide secretion in conscious dogs.
PubMed:The effect of the loss of molar teeth on spatial memory and acetylcholine release from the parietal cortex in aged rats.
PubMed:Modulation of pancreatic secretion of individual digestive enzymes in octreotide (SMS 201-995)-infused rats.
PubMed:Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival.
PubMed:Determination of diphenoxylate hydrochloride and atropine sulfate in combination drug formulations by liquid chromatography.
PubMed:A case of swallowing-induced atrioventricular block after myocardial infarction.
PubMed:Behavioral and pharmacological assessment of butyrylcholinesterase in rats.
PubMed:Effect of cimetidine and omeprazole on gastric ulcer healing of rats with limited food intake time.
PubMed:Effects of atropine on operant test battery performance in rhesus monkeys.
PubMed:A subchronic toxicity study of two inhaled aerosolized atropine sulfate formulations in rats and dogs.
PubMed:Heart rate spectral analysis of fasting-induced bradycardia of cattle.
PubMed:Dissociating performance and learning deficits on spatial navigation tasks in rats subjected to cholinergic muscarinic blockade.
PubMed:Physostigmine-insensitive behavioral excitatory effects of atropine in squirrel monkeys.
PubMed:Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats.
PubMed:Chemosensitivity of lobster,Homarus americanus, to secondary plant compounds: Unused receptor capabilities.
PubMed:Central vs peripheral anticholinergic effects on repeated acquisition of behavioral chains.
PubMed:Adrenal innervation may be an extrapituitary mechanism able to regulate adrenocortical rhythmicity in rats.
PubMed:Effects of tricyclic antidepressant and anticholinergic drugs on fixed-interval responding in the squirrel monkey.
PubMed:Changes in schedule-controlled response and schedule-induced drinking after cholinergic blockers in rats.
PubMed:The biological properties of aspartame. II. Actions involving the gastrointestinal system.
PubMed:Suppression of mouse killing by lateral hypothalamic infusion of atropine sulfate in the rat: a general behavioral suppression.
PubMed:Effect of atropine and vagotomy on pancreatic polypeptide response to a meal in dogs.
PubMed:Effect of atropine on food-stimulated gastrin release after truncal vagotomy in man.
PubMed:After vagotomy atropine suppresses gastrin release by food.
 
Notes:
None found
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