EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2,6-dihydroxyanthraquinone
anthraflavic acid

Supplier Sponsors

Name:2,6-dihydroxyanthracene-9,10-dione
CAS Number: 84-60-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-544-3
FDA UNII: W83883330W
Nikkaji Web:J55.275E
Beilstein Number:2054127
MDL:MFCD00001228
XlogP3-AA:2.20 (est)
Molecular Weight:240.21456000
Formula:C14 H8 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 442.10 °C. @ 760.00 mm Hg (est)
Flash Point: 456.00 °F. TCC ( 235.30 °C. ) (est)
logP (o/w): 3.360 (est)
Soluble in:
 water, 0.31 mg/L @ 25 °C (exp)
 water, 72.76 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Anthraflavic acid >97.0%(GC)
Glentham Life Sciences
2,6-Dihydroxyanthraquinone
Santa Cruz Biotechnology
For experimental / research use only.
Anthraflavic acid >92%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Anthraflavic acid technical grade, 90%
sds
TCI AMERICA
For experimental / research use only.
Anthraflavic Acid >97.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 180 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#06773

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for 2,6-dihydroxyanthraquinone usage levels up to:
 not for fragrance use.
 
Recommendation for 2,6-dihydroxyanthraquinone flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):84-60-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6776
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2,6-dihydroxyanthracene-9,10-dione
Chemidplus:0000084606
RTECS:CB6675000 for cas# 84-60-6
 
References:
 2,6-dihydroxyanthracene-9,10-dione
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:84-60-6
Pubchem (cid):6776
Pubchem (sid):134972172
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C14267
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2914.69.5000
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
9,10-anthracenedione, 2,6-dihydroxy-
 anthraflavic acid
 anthraflavin
 anthraquinone, 2,6-dihydroxy-
2,6-dihydroxyanthracene-9,10-dione
 

Articles:

PubMed:Determination of the optical GAP in thin films of amorphous dilithium phthalocyanine using the Tauc and Cody models.
PubMed:Phenol transformation photosensitised by quinoid compounds.
PubMed:Electrical and optical properties of copper and nickel molecular materials with tetrabenzo [b,f,j,n] [1,5,9,13] tetraazacyclohexadecine thin films grown by the vacuum thermal evaporation technique.
PubMed:Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
PubMed:Interaction of anthracene and its oxidative derivatives with human serum albumin.
PubMed:The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases.
PubMed:Evidence for phosphorylation requirement for human bilirubin UDP-glucuronosyltransferase (UGT1A1) activity.
PubMed:Biosynthesis of drug glucuronides for use as authentic standards.
PubMed:Inhibition and active sites of UDP-glucuronosyltransferases 2B7 and 1A1.
PubMed:Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes.
PubMed:Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5.
PubMed:Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.
PubMed:Inhibitors of cAMP-dependent protein kinase impair long-term memory formation in day-old chicks.
PubMed:Structure-activity relationships of anthraquinones as inhibitors of 7-ethoxycoumarin O-deethylase and mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline.
PubMed:Extrapolation of in vitro antimutagenicity to the in vivo situation: the case for anthraflavic acid.
PubMed:Release of iron from ferritin by semiquinone, anthracycline, bipyridyl, and nitroaromatic radicals.
PubMed:Induction of rat hepatic cytochrome P-450 I proteins by the antimutagen anthraflavic acid.
PubMed:Exceptional activity of tannic acid among naturally occurring plant phenols in protecting against 7,12-dimethylbenz(a)anthracene-, benzo(a)pyrene-, 3-methylcholanthrene-, and N-methyl-N-nitrosourea-induced skin tumorigenesis in mice.
PubMed:Anthraflavic acid inhibits the mutagenicity of the food mutagen IQ: mechanism of action.
PubMed:Anthraflavic acid is a potent and specific inhibitor of cytochrome P-448 activity.
PubMed:Inhibition of polycyclic aromatic hydrocarbon-DNA adduct formation in epidermis and lungs of SENCAR mice by naturally occurring plant phenols.
PubMed:Inhibition of epidermal xenobiotic metabolism in SENCAR mice by naturally occurring plant phenols.
PubMed:Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by tannic acid, hydroxylated anthraquinones and hydroxylated cinnamic acid derivatives.
PubMed:Mutagenicity of anthraquinone and hydroxylated anthraquinones in the Ames/Salmonella microsome system.
 
Notes:
None found
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