EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes


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CAS Number: 5508-58-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:226-852-5
Nikkaji Web:J3.154.642G
Beilstein Number:0042762
XlogP3-AA:2.20 (est)
Molecular Weight:350.45510000
Formula:C20 H30 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 225.00 to 226.00 °C. @ 760.00 mm Hg
Boiling Point: 557.32 °C. @ 760.00 mm Hg (est)
Flash Point: 384.00 °F. TCC ( 195.50 °C. ) (est)
logP (o/w): 0.424 (est)
Soluble in:
 water, 146.9 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
Alfa Biotechnology
For experimental / research use only.
Andrographolide 98%
BOC Sciences
For experimental / research use only.
Andrographolide >98%
Odor: characteristic
Use: Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
Changsha Organic Herb
Andrographis Paniculata Extract
For experimental / research use only.
Andrographolide from Plants ≥96%
Odor: characteristic
Use: Andrographolide is a labdane diterpenoid that shown anti-inflammatory, immuno- suppressant and neuroprotective effects, andrographolide is used experimentally in different areas of research, including Cell signaling, immunomodulation and stroke.
For experimental / research use only.
Andrographolide (HPLC) ≥95%
Santa Cruz Biotechnology
For experimental / research use only.
Andrographolide ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Andrographolide 98%
For experimental / research use only.
Andrographolide >98.0%(HPLC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 11460 mg/kg
Indian Journal of Medical Research. Vol. 92, Pg. 276, 1990.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic ingredient for skin conditioning
Recommendation for andrographolide usage levels up to:
 not for fragrance use.
Recommendation for andrographolide flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5318517
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:LU3490750 for cas# 5508-58-7
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5318517
Pubchem (sid):135023123
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C20214
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.20.5050
VCF-Online:VCF Volatile Compounds in Food
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 andrographis paniculata leaves
Search Trop Picture


PubMed:Positive therapy of andrographolide in vocal fold leukoplakia.
PubMed:Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore.
PubMed:Simultaneous determination of 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate in rat plasma by UHPLC-ESI-MS/MS after administration of xiyanping injection: application to a pharmacokinetic study.
PubMed:Evaluation of the effect of andrographolide on atherosclerotic rabbits induced by Porphyromonas gingivalis.
PubMed:Potential anti-angiogenic sulfates of andrographolide.
PubMed:The genotoxicity and cytotoxicity assessments of andrographolide in vitro.
PubMed:Andrographolide-induced pi class of glutathione S-transferase gene expression via PI3K/Akt pathway in rat primary hepatocytes.
PubMed:Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome.
PubMed:Cytochrome P450 induction properties of food and herbal-derived compounds using a novel multiplex RT-qPCR in vitro assay, a drug-food interaction prediction tool.
PubMed:Effects of andrographolide on sexual functions, vascular reactivity and serum testosterone level in rodents.
PubMed:Induction of heme oxygenase 1 and inhibition of tumor necrosis factor alpha-induced intercellular adhesion molecule expression by andrographolide in EA.hy926 cells.
PubMed:Quantification of andrographolide sodium bisulphite in urine after intravenous injection to rats by LC-MS/MS.
PubMed:Andrographolide inhibits ICAM-1 expression and NF-κB activation in TNF-α-treated EA.hy926 cells.
PubMed:Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines.
PubMed:Activation of the cAMP/CREB/inducible cAMP early repressor pathway suppresses andrographolide-induced gene expression of the pi class of glutathione S-transferase in rat primary hepatocytes.
PubMed:The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
PubMed:Modulation of the expression of the pi class of glutathione S-transferase by Andrographis paniculata extracts and andrographolide.
PubMed:Infrared-metabolomics approach in detecting changes in Andrographis paniculata metabolites due to different harvesting ages and times.
PubMed:Separation of andrographolide and neoandrographolide from the leaves of Andrographis paniculata using high-speed counter-current chromatography.
PubMed:Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetics.
PubMed:Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes.
PubMed:Highly efficient and regioselective acylation of pharmacologically interesting cordycepin catalyzed by lipase in the eco-friendly solvent 2-methyltetrahydrofuran.
PubMed:Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition.
PubMed:Absorption of andrographolides from Andrographis paniculata and its effect on CCl(4)-induced oxidative stress in rats.
PubMed:Analysis of urinary andrographolides and antioxidant status after oral administration of Andrographis paniculata leaf extract in rats.
a phytogenic antineoplastic agent; activates caspase 8 and induces apoptosis.
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