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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 460.94 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 420.00 °F. TCC ( 215.80 °C. ) (est)
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| logP (o/w): | 5.003 (est) |
| Soluble in: |
| | water, 1.772 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for alpha-naphthoflavone usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for alpha-naphthoflavone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 7,8- | benzoflavone | | 4H- | naphtho(1,2-b)pyran-4-one, 2-phenyl- | | 4H- | naphtho[1, 2-b]pyran-4-one, 2-phenyl- | | 4H- | naphtho[1,2-b]pyran-4-one, 2-phenyl- | | a- | naphthoflavone | | a- | naphthylflavone | | 2- | phenyl-4H-benzo[h]chromen-4-one | | 2- | phenyl-4H-naphtho(1,2-b)pyran-4-one | | 2- | phenyl-4H-naphtho[1,2-b]pyran-4-one | | 2- | phenyl-4H-naphthol(1,2-b)pyran-4-one | | 2- | phenyl-benzo[h]chromen-4-one | | 2- | phenylbenzo(h)chromen-4-one | | 2- | phenylbenzo[h]chromen-4-one |
Articles:
| PubMed:Effect of dihydromyricetin on benzo[a]pyrene activation in rats. |
| PubMed:α-Naphthoflavone modulates inflammatory response in adipocytes-macrophages interaction through NFκB signaling. |
| PubMed:Metabolism of chamaechromone in vitro with human liver microsomes and recombinant human drug-metabolizing enzymes. |
| PubMed:Synergistic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and N-nitrosodiethylamine on cell malignant transformation. |
| PubMed:α-Naphthoflavone inhibits 3T3-L1 pre-adipocytes differentiation via modulating p38MAPK signaling. |
| PubMed:Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes. |
| PubMed:Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes. |
| PubMed:In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken, and pigs. |
| PubMed:Mutagenic activation and detoxification of benzo[a]pyrene in vitro by hepatic cytochrome P450 1A1 and phase II enzymes in three meat-producing animals. |
| PubMed:Metabolites of galangin by 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor. |
| PubMed:Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design. |
| PubMed:EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs. |
| PubMed:A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. |
| PubMed:Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes. |
| PubMed:Estrogen receptor alpha as a target for indole-3-carbinol. |
| PubMed:alpha-Naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation. |
| PubMed:Intestinal metabolism of PAH: in vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium. |
| PubMed:Protection by quercetin against cooking oil fumes-induced DNA damage in human lung adenocarcinoma CL-3 cells: role of COX-2. |
| PubMed:Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells. |
| PubMed:Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites. |
| PubMed:Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment: CYP-dependent activation of food and environmental mutagens. |
| PubMed:Antioxidant protection against PCB-mediated endothelial cell activation. |
| PubMed:Inhibition of mouse and human CYP 1A- and 2E1-dependent substrate metabolism by the isoflavonoids genistein and equol. |
| PubMed:The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. |
| PubMed:Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor. |
| PubMed:Metabolism of the aryl hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro. |
| PubMed:Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2. |
| PubMed:The metabolism and DNA binding of the cooked-food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in precision-cut rat liver slices. |
| PubMed:Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: alpha-naphthoflavone, beta-naphthoflavone and trout CYP1A1 peptide antibody. |
| PubMed:Metabolic activation of the food mutagen 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]indole (Trp-P-1) in endothelial cells of cytochrome P-450-induced mice. |
| PubMed:Metabolic activation of the food mutagen Trp-P-1 in endothelial cells of heart and kidney in cytochrome P450-induced mice. |
| PubMed:The role of sulfation and/or acetylation in the metabolism of the cooked-food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Salmonella typhimurium and isolated rat hepatocytes. |
| PubMed:Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. |
| PubMed:Cytochrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines. |
| PubMed:Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids. |
| PubMed:Covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein in microsomal incubations and isolated rat hepatocytes. |
| PubMed:Cytochrome P4501A2 constitutively expressed from transduced DNA mediates metabolic activation and DNA-adduct formation of aromatic amine carcinogens in NIH 3T3 cells. |
| PubMed:Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. |
| PubMed:Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes. |
| PubMed:4-(2-amino-1-methylimidazo[4,5-b]pyrid-6-yl)phenyl sulfate--a major metabolite of the food mutagen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) in the rat. |
| PubMed:Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxamino-PhIP, a directly acting genotoxic metabolite. |
| PubMed:Activation of the food-derived mutagen 2-amino-3-methylimidazo[4, 5-f]quinoline by human-liver microsomes. |
| PubMed:Modulation of the mutagenic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in bacteria with rat-liver 9000 x g supernatant or monolayers of rat hepatocytes as an activation system. |
| PubMed:Correlation of placental microsomal activities with protein detected by antibodies to rabbit cytochrome P-450 isozyme 6 in preparations from humans exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans. |
| PubMed:Effects of dietary constituents on the metabolism of chemical carcinogens. |
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3D/inchi