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alpha-chymotrypsin

Supplier Sponsors

CAS Number: 9004-07-3
Other(deleted CASRN):8049-46-5
ECHA EC Number:232-671-2
FDA UNII: Search
MDL:MFCD00130481
Category:enzyme preparations and microorganisms
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 564 Protease from Bacillus licheniformis View - notice PDF
 
Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American Laboratories
Chymotrypsin 944
BOC Sciences
For experimental / research use only.
Chymotrypsin 95%
Pangaea Sciences
Chymotrypisn USP
Sigma-Aldrich: Sigma
For experimental / research use only.
a-Chymotrypsin from bovine pancreas Type II, lyophilized powder, =40 units/mg protein
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 4000 mg/kg
Drugs in Japan Vol. 6, Pg. 202, 1982.

intravenous-rat LD50 84 mg/kg
Drugs in Japan Vol. 6, Pg. 202, 1982.

intraperitoneal-rat LD50 65.10 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 42, 1950.

oral-mouse LD50 > 6000 mg/kg
Drugs in Japan Vol. 6, Pg. 202, 1982.

intravenous-mouse LD50 89 mg/kg
Drugs in Japan Vol. 6, Pg. 202, 1982.

intravenous-guinea pig LDLo 50000 units/kg
CARDIAC: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BLOOD: HEMORRHAGE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 164, 1956.

intramuscular-mouse LD50 104 mg/kg
Drugs in Japan Vol. 6, Pg. 202, 1982.

intravenous-rabbit LD50 24000 units/kg
GASTROINTESTINAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BLOOD: HEMORRHAGE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 164, 1956.

intramuscular-rat LD50 116 mg/kg
Drugs in Japan Vol. 6, Pg. 202, 1982.

intraperitoneal-rat LD50 65100 ug/kg
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 42, 1950.

Dermal Toxicity:
subcutaneous-rat LD50 250 mg/kg
Drugs in Japan Vol. 6, Pg. 202, 1982.

subcutaneous-mouse LD50 185 mg/kg
Drugs in Japan Vol. 6, Pg. 202, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
enzyme preparations and microorganisms
Recommendation for alpha-chymotrypsin usage levels up to:
 not for fragrance use.
 
Recommendation for alpha-chymotrypsin flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety evaluation of a food enzyme containing trypsin and chymotrypsin from porcine pancreas
View page or View pdf

Safety evaluation of a food enzyme containing trypsin, chymotrypsin, elastase and carboxypeptidase from porcine pancreas
View page or View pdf

Safety evaluation of a food enzyme containing trypsin and chymotrypsin from porcine pancreas
View page or View pdf

ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9004-07-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
Chemidplus:0009004073
RTECS:GC3050000 for cas# 9004-07-3
 
References:
Pubchem (sid):135287285
 
Other Information:
HMDB (The Human Metabolome Database):Search
FooDB:FDB010150
Export Tariff Code:3507.90.0000
FDA Listing of Food Additive Status:View
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 alpha-chymotrypsin
Search PMC Picture
 
Synonyms:
 alfapsin
 avazyme
 chimotripsina
 chymolase
 chymotrypsin A
 chymotrypsin, alpha-, type II, from bovine pancreas
 chymotrypsine
 chymozym
 protease from bacillus licheniformis
 quimotrase
 zolyse
 

Articles:

PubMed:Lactobacillus gasseri requires peptides, not proteins or free amino acids, for growth in milk.
PubMed:Purification, characterization and immunoreactivity of β'-component, a major allergen from the roe of large yellow croaker (Pseudosciaena crocea).
PubMed:Purification and characterisation of plantaricin ZJ008, a novel bacteriocin against Staphylococcus spp. from Lactobacillus plantarum ZJ008.
PubMed:Structural identification and proteolytic effects of the hatching enzyme from starfish Asterias amurensis.
PubMed:Fractionation of protein hydrolysates of fish and chicken using membrane ultrafiltration: investigation of antioxidant activity.
PubMed:Purification and characterization of a novel fibrinolytic α chymotrypsin like serine metalloprotease from the edible mushroom, Lyophyllum shimeji.
PubMed:Bioavailability of the anti-clostridial bacteriocin thuricin CD in gastrointestinal tract.
PubMed:Effect of limited enzymatic hydrolysis on linoleic acid binding properties of β-lactoglobulin.
PubMed:Hemolytic activity of venom from crown-of-thorns starfish Acanthaster planci spines.
PubMed:A selective artificial enzyme inhibitor based on nanoparticle-enzyme interactions and molecular imprinting.
PubMed:Reduction of major peanut allergens Ara h 1 and Ara h 2, in roasted peanuts by ultrasound assisted enzymatic treatment.
PubMed:Characterization of a fibrinolytic enzyme secreted by Bacillus amyloliquefaciens CB1 and its gene cloning.
PubMed:Nutritional and antinutritional evaluation of raw and processed Australian wattle (Acacia saligna) seeds.
PubMed:Chymotrypsin selectively digests β-lactoglobulin in whey protein isolate away from enzyme optimal conditions: potential for native α-lactalbumin purification.
PubMed:Screening for lactic acid bacteria capable of inhibiting Campylobacter jejuni in in vitro simulations of the broiler chicken caecal environment.
PubMed:Isolation and characterization of an agarase-producing bacterial strain, Alteromonas sp. GNUM-1, from the West Sea, Korea.
PubMed:In vitro study on digestion of pumpkin oil cake protein hydrolysate: evaluation of impact on bioactive properties.
PubMed:Screening of whey protein isolate hydrolysates for their dual functionality: influence of heat pre-treatment and enzyme specificity.
PubMed:Purification and determination of two novel antioxidant peptides from flounder fish (Paralichthys olivaceus) using digestive proteases.
PubMed:Antioxidant effects of ovotransferrin and its hydrolysates.
PubMed:Production of bacteriocin by Leuconostoc mesenteroides 406 isolated from Mongolian fermented mare's milk, airag.
PubMed:A hemocyte-derived Kunitz-BPTI-type chymotrypsin inhibitor, HlChI, from the ixodid tick Haemaphysalis longicornis, plays regulatory functions in tick blood-feeding processes.
PubMed:Purification and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from an enzymatic hydrolysate of duck skin byproducts.
PubMed:Solvent selection and optimization of α-chymotrypsin-catalyzed synthesis of N-Ac-Phe-Tyr-NH2 using mixture design and response surface methodology.
PubMed:Identification of a new IgE-binding epitope of peanut oleosin that cross-reacts with buckwheat.
PubMed:The interaction of α-chymotrypsin with one persistent organic pollutant (dicofol): spectroscope and molecular modeling identification.
PubMed:Protective effect of a novel antioxidative peptide purified from a marine Chlorella ellipsoidea protein against free radical-induced oxidative stress.
PubMed:Stability of milk fat globule membrane proteins toward human enzymatic gastrointestinal digestion.
PubMed:Thermophysical characterization of tilapia myosin and its subfragments.
PubMed:Thermal denaturation of tilapia myosin and its subunits as affected by constantly increasing temperature.
PubMed:In vitro gastric and intestinal digestions of pulsed light-treated shrimp extracts.
PubMed:A Novel endo-1,4-β-mannanase from Bispora antennata with good adaptation and stability over a broad pH range.
PubMed:Purification of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide with an antihypertensive effect from loach (Misgurnus anguillicaudatus).
PubMed:Purification and characterization of a major fibrinolytic enzyme from Bacillus amyloliquefaciens MJ5-41 isolated from Meju.
PubMed:Free radical scavenging and angiotensin-I converting enzyme inhibitory peptides from Pacific cod (Gadus macrocephalus) skin gelatin.
PubMed:Biochemical activities of Brochothrix thermosphacta.
PubMed:Characterization of two safe Enterococcus strains producing enterocins isolated from Egyptian dairy products.
PubMed:Enzymatic treatment of peanut kernels to reduce allergen levels.
PubMed:Purification, amino acid sequence and characterization of the class IIa bacteriocin weissellin A, produced by Weissella paramesenteroides DX.
PubMed:Gut proteases target Yersinia invasin in vivo.
PubMed:Oxidation of sarcoplasmic proteins during processing of Cantonese sausage in relation to their aggregation behaviour and in vitro digestibility.
PubMed:Paenibacillus polymyxa JB05-01-1 and its perspectives for food conservation and medical applications.
PubMed:Isolation of bacteriocin-like substances producing bacteria from finished cattle-manure compost and activity evaluation against some food-borne pathogenic and spoilage bacteria.
PubMed:Enhanced thermal and ultrasonic stability of a fungal protease encapsulated within biomimetically generated silicate nanospheres.
PubMed:Toxicity of hydrolyzed vicilins toward Callosobruchus maculatus and phytopathogenic fungi.
PubMed:Gene cloning, overexpression, and characterization of a xylanase from Penicillium sp. CGMCC 1669.
PubMed:Purification and characterization of a Kunitz-type trypsin inhibitor from Acacia victoriae Bentham seeds.
PubMed:Optimal alpha-chymotrypsin-catalyzed synthesis of N-Ac-Phe-Gly-NH(2).
PubMed:Characterization of porcine plasma protein-based films as affected by pretreatment and cross-linking agents.
PubMed:Purification and antioxidant properties of bigeye tuna (Thunnus obesus) dark muscle peptide on free radical-mediated oxidative systems.
PubMed:Characterization of antilisterial bacteriocins produced by Enterococcus faecium and Enterococcus durans isolates from Hispanic-style cheeses.
PubMed:Incidence of nisin Z production in Lactococcus lactis subsp. lactis TFF 221 isolated from Thai fermented foods.
PubMed:In vitro evaluation of the probiotic properties of human intestinal Bifidobacterium species and selection of new probiotic candidates.
PubMed:Effect of meat cooking on physicochemical state and in vitro digestibility of myofibrillar proteins.
PubMed:Physicochemical and bitterness properties of enzymatic pea protein hydrolysates.
PubMed:Subtractive screening for probiotic properties of lactobacillus species from the human gastrointestinal tract in the search for new probiotics.
PubMed:Antihypertensive effect of angiotensin i converting enzyme-inhibitory peptide from hydrolysates of Bigeye tuna dark muscle, Thunnus obesus.
PubMed:Fate of the two-component lantibiotic lacticin 3147 in the gastrointestinal tract.
PubMed:Effect of oxidation on in vitro digestibility of skeletal muscle myofibrillar proteins.
PubMed:Changes in allergenicity and digestibility of squid tropomyosin during the Maillard reaction with ribose.
PubMed:In vitro fermentation studies for selection and evaluation of Bacillus strains as starter cultures for the production of okpehe, a traditional African fermented condiment.
PubMed:Purification and characterization of two bacteriocins produced by lactic acid bacteria isolated from Mongolian airag.
PubMed:Inhibition of Vibrio parahaemolyticus by a bacteriocin-like inhibitory substance (BLIS) produced by Vibrio mediterranei 1.
PubMed:Studies on kinetics and thermostability of a novel acid invertase from Fusarium solani.
PubMed:Food-protein enzymatic hydrolysates possess both antimicrobial and immunostimulatory activities: a "cause and effect" theory of bifunctionality.
PubMed:Purification, characterization and amino acid sequencing of divergicin M35: a novel class IIa bacteriocin produced by Carnobacterium divergens M35.
PubMed:Effects of protein engineering of canola procruciferin on its physicochemical and functional properties.
PubMed:Effects of designed sulfhydryl groups and disulfide bonds into soybean proglycinin on its structural stability and heat-induced gelation.
PubMed:Kinetic study on the changes in the susceptibility of egg white proteins to enzymatic hydrolysis induced by heat and high hydrostatic pressure pretreatment.
PubMed:Purification and properties of proteinaceous trypsin inhibitors in the skin mucus of pufferfish Takifugu pardalis.
PubMed:Characterization of thoeniicin 447, a bacteriocin isolated from Propionibacterium thoenii strain 447.
PubMed:Enzyme activity of alpha-chymotrypsin after derivatization with phenolic compounds.
PubMed:Heat-induced changes in the susceptibility of egg white proteins to enzymatic hydrolysis: a kinetic study.
PubMed:Epsilon-polylysine inhibits pancreatic lipase activity and suppresses postprandial hypertriacylglyceridemia in rats.
PubMed:Inhibitory specificity change of the ovomucoid third domain of the silver pheasant upon introduction of an engineered Cys14-Cys39 bond.
PubMed:Isolation of nisin-producing Lactococcus lactis WNC 20 strain from nham, a traditional Thai fermented sausage.
PubMed:Deodorization of soybean proteins by enzymatic and physicochemical treatments.
PubMed:Aspartame optical biosensor with bienzyme-immobilized eggshell membrane and oxygen-sensitive optode membrane.
PubMed:Bacteriocin-producing lactic Acid bacteria isolated from traditional fermented food.
PubMed:(S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors.
PubMed:Mechanism and characteristics of protein release from lactitol-based cross-linked hydrogel.
PubMed:Physicochemical properties and susceptibility to proteolytic digestion of myoglobin-phenol derivatives.
PubMed:Bactericidal action of egg yolk phosvitin against Escherichia coliunder thermal stress.
PubMed:Enzymatic hydrolysis, grease permeation, and water barrier properties of zein isolate coated paper.
PubMed:Occurrence of nisin Z production in Lactococcus lactis BFE 1500 isolated from wara, a traditional Nigerian cheese product.
PubMed:Isolation of peptides from an enzymatic hydrolysate of food proteins and characterization of their taste properties.
PubMed:Isolation, purification and partial characterization of plantaricin 423, a bacteriocin produced by Lactobacillus plantarum.
PubMed:Characterization and antimicrobial spectrum of bifidocin B, a bacteriocin produced by Bifidobacterium bifidum NCFB 1454.
PubMed:Detection and characterization of a bacteriocin produced by Lactococcus lactis subsp. cremoris R isolated from radish.
PubMed:Improving the thermostability of Bacillus stearothermophilus neutral protease by introducing proline into the active site helix.
PubMed:Isolation and amino acid sequences of two Kunitz-type protease inhibitors from the sea anemone Anthopleura aff. xanthogrammica.
PubMed:Botulinum neurotoxin type A: limited proteolysis by endoproteinase Glu-C and alpha-chymotrypsin enhanced following reduction; identification of the cleaved sites and fragments.
PubMed:Amperometric bienzymic sensor for aspartame.
PubMed:Anti-aflatoxigenic activity of Lactobacillus casei pseudoplantarum.
PubMed:Simultaneous measurement of metabolic flux in portally-drained viscera, liver, spleen, kidney and hindquarter in the conscious pig.
PubMed:The primary structure and characterization of carbohydrate chains of the extracellular glycoprotein proteinase inhibitor from latex of Carica papaya.
PubMed:Production and characterization of enterocin 900, a bacteriocin produced by Enterococcus faecium BFE 900 from black olives.
PubMed:Behavior of Listeria monocytogenes in Mozzarella cheese in presence of Lactococcus lactis.
PubMed:Bacteriocin production by Carnobacterium piscicola LV 61.
PubMed:Continuous enzymatic production of oligopeptides: synthesis of an enkephalin pentapeptide in a multistage bioreactor.
PubMed:Molecular cloning of silkworm (Bombyx mori) antichymotrypsin. A new member of the serpin superfamily of proteins from insects.
PubMed:Identification and characterization of two bacteriocin-producing strains of Lactococcus lactis isolated from vegetables.
PubMed:Effect of different proteolytic enzymes on the nature of subunit composition of arachins from groundnut (Arachis hypogaea L.).
PubMed:The nature of the unhydrolysed fraction of alpha-globulin, the major protein component of Sesamum indicum L. hydrolysed by alpha-chymotrypsin.
PubMed:Production of an Amylase-Sensitive Bacteriocin by an Atypical Leuconostoc paramesenteroides Strain.
PubMed:Patchwork-structure serpins from silkworm (Bombyx mori) larval hemolymph.
PubMed:[Analysis of food and feed by partial sequences of characteristic protein components (carrier peptides). 1. Isolation and structural determination of wheat-specific peptides from chymotryptic hydrolysates of gliadin].
PubMed:Continuous synthesis of a tripeptide by successive condensation and transesterification catalyzed by two immobilized proteinases in organic solvent.
PubMed:Enzymic method for the spectrophotometric determination of aspartame in beverages.
PubMed:Enzymatic synthesis of the precursor of Leu-enkephalin in water-immiscible organic solvent systems.
PubMed:Biochemical characteristics of trypsin inhibitor from wheat grain, beta variety.
PubMed:Limited proteolysis of silkworm antitrypsin by several proteinases.
PubMed:Resistance of alpha-globulin from Sesamum indicum L. to proteases in relationship to its structure.
PubMed:Gelation of the heat-induced complex between kappa-casein and alpha-lactalbumin.
PubMed:Characterization and mode of action of a purified bacteriocin from the oral bacterium Streptococcus mutans RM-10.
PubMed:[Chemical composition of seeds from Cucumeropsis mannii Naudin and their suitability as food].
PubMed:The effects of pregnancy and lactation on the activities of trypsin and alpha-chymotrypsin in the rat pancreas.
PubMed:Effect of reductive alkylation of the epsilon-amino group of lysyl redsidues of casein on its nutritive value in rats.
PubMed:Immobilized enzymes on chitosan columns: alpha-chymotrypsin and acid phosphatase.
 
Notes:
a serine endopeptidase secreted by the pancreas as its zymogen, chymotrypsinogen and carried in the pancreatic juice to the duodenum where it is activated by trypsin. it selectively cleaves aromatic amino acids on the carboxyl side.
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