EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

alpha-chloralose
1,2-O-(2,2,2-trichloroethylidene)-alpha-D-glucofuranose

Supplier Sponsors

Name:1-[(2R,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol
CAS Number: 15879-93-3Picture of molecule3D/inchi
Other(deleted CASRN):910889-31-5
ECHA EINECS - REACH Pre-Reg:240-016-7
FDA UNII: 238BZ29MUE
Beilstein Number:0085418
MDL:MFCD00005542
XlogP3:1.00 (est)
Molecular Weight:309.52687000
Formula:C8 H11 Cl3 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:herbicides / pesticides
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 182.00 °C. @ 760.00 mm Hg
Boiling Point: 504.41 °C. @ 760.00 mm Hg (est)
Flash Point: 498.00 °F. TCC ( 258.90 °C. ) (est)
logP (o/w): 1.020
Soluble in:
 water, 4440 mg/L @ 15 °C (exp)
 water, 1453 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Carbosynth
For experimental / research use only.
a-Chloralose
Indis NV
For experimental / research use only.
Alpha-Chloralose
Penta International
ALPHA-CHLORALOSE
Santa Cruz Biotechnology
For experimental / research use only.
a-Chloralose ≥98% (85% alpha, 15% beta)
Sigma-Aldrich: Sigma
For experimental / research use only.
a-Chloralose
sds
TCI AMERICA
For experimental / research use only.
alpha-Chloralose (contains β-isomer) >85.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-bird - wild LD50 9 mg/kg
Journal de Toxicologie Clinique et Experimentale. Vol. 6(3), Pg. 175, 1986.

oral-cat LD50 250 mg/kg
CARDIAC: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT
Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.

intraperitoneal-cat LDLo 150 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 3, Pg. 191, 1897.

oral-chicken LD50 300 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Wildlife Diseases. Vol. 24, Pg. 684, 1988.

oral-dog LD50 250 mg/kg
CARDIAC: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT
Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.

intraperitoneal-dog LDLo 400 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 3, Pg. 191, 1897.

intravenous-dog LDLo 120 mg/kg
"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A012, Pg. 1984

oral-man LDLo 214 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES
Forensic Science International. Vol. 104, Pg. 59, 1999.

intraperitoneal-mouse LD50 175 mg/kg
BEHAVIORAL: ANALGESIA BEHAVIORAL: ATAXIA BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1727, 1971.

oral-mouse LD50 200 mg/kg
Farm Chemicals Handbook. Vol. -, Pg. C68, 1991.

oral-quail LD50 31600 ug/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

oral-rat LD50 400 mg/kg
Pesticide Manual. Vol. 9, Pg. 135, 1991.

Dermal Toxicity:
subcutaneous-rat LDLo 200 mg/kg
"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 70, 1973.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
herbicides / pesticides
Recommendation for alpha-chloralose usage levels up to:
 not for fragrance use.
 
Recommendation for alpha-chloralose flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):15879-93-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :27525
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
1-[(2R,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol
Chemidplus:0015879933
RTECS:FM9450000 for cas# 15879-93-3
 
References:
 1-[(2R,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:15879-93-3
Pubchem (cid):27525
Pubchem (sid):134992992
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
KEGG (GenomeNet):C18707
HMDB (The Human Metabolome Database):HMDB31727
FooDB:FDB008390
Export Tariff Code:2940.00.6000
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 anhydroglucochloral
(R)-1-((2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol
1,2-O-(2,2,2-trichloroethylidene)-alpha-D-glucofuranose
1-[(2R,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol
 

Articles:

PubMed:Hyponeophagia: a measure of anxiety in the mouse.
PubMed:On the use of α-chloralose for repeated BOLD fMRI measurements in rats.
PubMed:Acute inhibition of the hypothalamic paraventricular nucleus decreases renal sympathetic nerve activity and arterial blood pressure in water-deprived rats.
PubMed:Alpha-chloralose immobilization of rock doves in Ohio.
PubMed:Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics.
PubMed:Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats.
PubMed:Effect of capsaicin pretreatment on capsaicin-induced catecholamine secretion from the adrenal medulla in rats.
PubMed:The effects of chronic two-fold dietary vitamin E supplementation on subarachnoid hemorrhage-induced brain hypoperfusion.
 
Notes:
a derivative of chloral hydrate that was used as a sedative but has been replaced by safer and more effective drugs. its most common use is as a general anesthetic in animal experiments. Bird repellant in grain seeds
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