EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

aldrithiol
2,2'-dipyridyldisulfide

Supplier Sponsors

CAS Number: 2127-03-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:218-343-1
FDA UNII: L6X912UPBU
Nikkaji Web:J39.097F
Beilstein Number:154629
MDL:MFCD00006287
Molecular Weight:220.31776000
Formula:C10 H8 N2 S2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 356.10 °C. @ 760.00 mm Hg (est)
Flash Point: 337.00 °F. TCC ( 169.20 °C. ) (est)
logP (o/w): 2.530 (est)
Soluble in:
 water, 771.3 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2,2'-Dithiodipyridine >98.0%(GC)(T)
Carbosynth
For experimental / research use only.
2,2'-Dipyridinyl disulfide
EMD Millipore
For experimental / research use only.
2,2'-Dipyridyl disulfide
Endeavour Specialty Chemicals
2,2'-Dithiodipyridine
Speciality Chemical Product Groups
Glentham Life Sciences
2,2'-Dithiodipyridine
Robinson Brothers
2,2'-Dithiodipyridine
https://www.robinsonbrothers.uk/chemistry-competences
Sigma-Aldrich: Aldrich
For experimental / research use only.
Aldrithiol™-2 98%
TCI AMERICA
For experimental / research use only.
2,2'-Dipyridyl Disulfide [for Peptide Synthesis] >98.0%(GC)(T)
Tengzhou Jitian Aroma Chemiclal
2-Pyridinyl disulfide
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for aldrithiol usage levels up to:
 not for fragrance use.
 
Recommendation for aldrithiol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :65093
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(pyridin-2-yldisulfanyl)pyridine
Chemidplus:0002127039
 
References:
 2-(pyridin-2-yldisulfanyl)pyridine
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):65093
Pubchem (sid):135022175
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.39.9100
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 aldrithiol-2
 di(2-pyridyl) disulfide
2-dipyridyl disulfide
2,2'-dipyridyl disulfide
2,2'-dipyridyldisulfide
2,2'-disulfanediyldipyridine
2,2'-dithiobispyridine
2,2'-dithiodipyridine
2-(pyridin-2-yldisulfanyl)pyridine
2-pyridin-2-yldisulfanylpyridine
 pyridine, 2,2'-dithiobis- (9CI)
 pyridine, 2,2'-dithiodi- (8CI)
2-pyridinyl disulfide
bis(2-pyridinyl) disulfide
bis(2-pyridyl) disulfide
 

Articles:

PubMed:Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline.
PubMed:Modulation of HIV-1-induced activation of plasmacytoid dendritic cells by 6-desfluoroquinolones.
PubMed:Third-generation breathing metal-organic framework with selective, stepwise, reversible, and hysteretic adsorption properties.
PubMed:Broad and potent cellular and humoral immune responses after a second late HIV-modified vaccinia virus ankara vaccination in HIV-DNA-primed and HIV-modified vaccinia virus Ankara-boosted Swedish vaccinees.
PubMed:Identification of labile Zn sites in drug-target proteins.
PubMed:Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents.
PubMed:FT-IR, micro-Raman and UV-vis spectroscopic and quantum chemical investigations of free 2,2'-dithiodipyridine and its metal (Co, Cu and Zn) halide complexes.
PubMed:Composite blends of gold nanorods and poly(t-butylacrylate) beads as new substrates for SERS.
PubMed:Novel chiral derivatization reagents possessing a pyridylthiourea structure for enantiospecific determination of amines and carboxylic acids in high-throughput liquid chromatography and electrospray-ionization mass spectrometry for chiral metabolomics identification.
PubMed:Use of RT-defective HIV virions: new tool to evaluate specific response in chronic asymptomatic HIV-infected individuals.
PubMed:Generation and characterization of a defective HIV-1 Virus as an immunogen for a therapeutic vaccine.
PubMed:Simultaneous determination of DL-lactic acid and DL-3-hydroxybutyric acid enantiomers in saliva of diabetes mellitus patients by high-throughput LC-ESI-MS/MS.
PubMed:Dichloridobis(pyridine-2-thiol-ato-κ²N,S)tin(IV): a new polymorph.
PubMed:Toxic role of K+ channel oxidation in mammalian brain.
PubMed:Production of interferon α by human immunodeficiency virus type 1 in human plasmacytoid dendritic cells is dependent on induction of autophagy.
PubMed:Fermentation, fractionation and purification of streptokinase by chemical reduction method.
PubMed:S-glutathionylation of troponin I (fast) increases contractile apparatus Ca2+ sensitivity in fast-twitch muscle fibres of rats and humans.
PubMed:Hyperforin changes the zinc-storage capacities of brain cells.
PubMed:Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1.
PubMed:Purely heterometallic lanthanide(III) macrocycles through controlled assembly of disulfide bonds for dual color emission.
PubMed:Modulation of contractile apparatus Ca2+ sensitivity and disruption of excitation-contraction coupling by S-nitrosoglutathione in rat muscle fibres.
PubMed:Toxicity and metabolism of copper pyrithione and its degradation product, 2,2'-dipyridyldisulfide in a marine polychaete.
PubMed:Plasmacytoid dendritic cells, Janus-faced sentinels: progesterone, guilty or innocent?
PubMed:Strong HIV-specific CD4+ and CD8+ T-lymphocyte proliferative responses in healthy individuals immunized with an HIV-1 DNA vaccine and boosted with recombinant modified vaccinia virus ankara expressing HIV-1 genes.
PubMed:HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells.
PubMed:Simple and practical derivatization procedure for enhanced detection of carboxylic acids in liquid chromatography-electrospray ionization-tandem mass spectrometry.
PubMed:Inactivation of respiratory syncytial virus by zinc finger reactive compounds.
PubMed:Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation.
PubMed:Tonsillar application of AT-2 SIV affords partial protection against rectal challenge with SIVmac239.
PubMed:Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence.
PubMed:Hepatic ischemia induced immediate oxidative stress after reperfusion and determined the severity of the reperfusion-induced damage.
PubMed:Thiol protection in membrane protein purifications: a study with phage holins.
PubMed:Dendritic cell differentiation and maturation in the presence of HIV type 2 envelope.
PubMed:Enhanced antibody responses elicited by a CpG adjuvant do not improve the protective effect of an aldrithiol-2-inactivated simian immunodeficiency virus therapeutic AIDS vaccine.
PubMed:Inhibition of acetylcholinesterase by metabolites of copper pyrithione (CuPT) and its possible involvement in vertebral deformity of a CuPT-exposed marine teleostean fish.
PubMed:Statistical optimization of the silylation reaction of a mercaptosilane with silanol groups on the surface of silica gel.
PubMed:In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection.
PubMed:Size-dependence of Fermi energy of gold nanoparticles loaded on titanium(iv) dioxide at photostationary state.
PubMed:Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells.
PubMed:Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course.
PubMed:Oxidation of myofilament protein sulfhydryl groups reduces the contractile force and its Ca2+ sensitivity in human cardiomyocytes.
PubMed:Altered oxidant-mediated intraneuronal zinc mobilization in a triple transgenic mouse model of Alzheimer's disease.
PubMed:Exploration of the polar microenvironment around the reactive cysteine in rabbit muscle creatine kinase.
PubMed:Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1.
PubMed:Evaluation of aldrithiol-2-inactivated preparations of HIV type 1 subtypes A, B, and D as reagents to monitor T cell responses.
PubMed:A dendritic cell-based vaccine for treating HIV infection: background and preliminary results.
PubMed:Invariant Thr244 is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans.
PubMed:Rapid determination of histamine and its metabolites in mice hair by ultra-performance liquid chromatography with time-of-flight mass spectrometry.
PubMed:CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection.
PubMed:Releasable luciferin-transporter conjugates: tools for the real-time analysis of cellular uptake and release.
PubMed:Mechanistic characterization of the MSDH (methylmalonate semialdehyde dehydrogenase) from Bacillus subtilis.
PubMed:In vitro proteolysis of phosphoenolpyruvate carboxylase from developing castor oil seeds by an endogenous thiol endopeptidase.
PubMed:Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells.
PubMed:Evidence that the species barrier of human immunodeficiency virus-1 does not extend to uptake by the blood--brain barrier: comparison of mouse and human brain microvessels.
PubMed:Thiol-disulphide interchange in tubulin: kinetics and the effect on polymerization.
PubMed:Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins.
PubMed:Therapeutic dendritic-cell vaccine for chronic HIV-1 infection.
PubMed:Development of reactive thiol-modified monolithic capillaries and in-column surface functionalization by radical addition of a chromatographic ligand for capillary electrochromatography.
PubMed:Human immunodeficiency virus type 1 gp120 induces abnormal maturation and functional alterations of dendritic cells: a novel mechanism for AIDS pathogenesis.
PubMed:Direct heterogeneous electron transfer of theophylline oxidase.
PubMed:CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells.
PubMed:Noninfectious X4 but not R5 human immunodeficiency virus type 1 virions inhibit humoral immune responses in human lymphoid tissue ex vivo.
PubMed:Spectroelectrochemical study of heme- and molybdopterin cofactor-containing chicken liver sulphite oxidase.
PubMed:Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells.
PubMed:Presentation of exogenous whole inactivated simian immunodeficiency virus by mature dendritic cells induces CD4+ and CD8+ T-cell responses.
PubMed:Potent immune response against HIV-1 and protection from virus challenge in hu-PBL-SCID mice immunized with inactivated virus-pulsed dendritic cells generated in the presence of IFN-alpha.
PubMed:Sites, mechanism of action and lack of reversibility of primate lentivirus inactivation by preferential covalent modification of virion internal proteins.
PubMed:Determination of homocysteine in human plasma by micellar electrokinetic chromatography and in-capillary detection reaction with 2,2'-dipyridyl disulfide.
PubMed:[Functionalization of oligonucleotides containing internucleotide phosphoamide bonds].
PubMed:SH oxidation coordinates subunits of rat brain ryanodine receptor channels activated by calcium and ATP.
PubMed:Thiol oxidation by 2,2'-dithiodipyridine induced calcium mobilization in MG63 human osteosarcoma cells.
PubMed:Effects of oxidation and reduction on contractile function in skeletal muscle fibres of the rat.
PubMed:Adsorption of 2,2'-dipyridyl disulfide on Au/Pt core/shell bimetallic clusters loaded on TiO2: fine control of adsorptivity for organosulfur compounds.
PubMed:Therapeutic dendritic-cell vaccine for simian AIDS.
PubMed:Design and synthesis of a hydrophilic fluorescent derivatization reagent for carboxylic acids, 4-N-(4-N-aminoethyl)piperazino-7-nitro-2,1,3-benzoxadiazole (NBD-PZ-NH2), and its application to capillary electrophoresis with laser-induced fluorescence detection.
PubMed:Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
PubMed:Quantitative measurement of fusion of HIV-1 and SIV with cultured cells using photosensitized labeling.
PubMed:Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCs.
PubMed:Determination of whole blood cholinesterase in different animal species using specific substrates.
PubMed:In vitro human immunodeficiency virus eradication by autologous CD8(+) T cells expanded with inactivated-virus-pulsed dendritic cells.
PubMed:A fluorogenic reagent, 4-mercapto-7-methylthio-2,1,3-benzoxadiazole for carboxylic acids, designed by prediction of the fluorescence intensity.
PubMed:Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine.
PubMed:p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis.
PubMed:HIV-1 gp120 stimulates the production of beta-chemokines in human peripheral blood monocytes through a CD4-independent mechanism.
PubMed:Solid-state structure and solution behavior of eight-coordinate Sm(III) poly(pyrazolyl)borate compounds.
PubMed:Specific thiol determination by micellar electrokinetic chromatography and on-column detection reaction with 2,2'-dipyridyldisulfide.
PubMed:Use of whole blood for spectrophotometric determination of cholinesterase activity in dogs.
PubMed:Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release.
PubMed:Block of sodium channels by divalent mercury: role of specific cysteinyl residues in the P-loop region.
PubMed:Effect of sulfhydryl reagents on the regulatory system of the L-type Ca channel in frog ventricular myocytes.
PubMed:Mechanisms of hydrogen peroxide-induced calcium dysregulation in PC12 cells.
PubMed:Comparison of different diluents and chromophores for spectrophotometric determination of livestock blood cholinesterase activity.
PubMed:Use of dipyridyl-dithio substrates to measure directly the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes.
PubMed:2,2'-Bispyridyl disulfide rapidly induces intramolecular disulfide bonds in peptides.
PubMed:Kvbeta1.2 subunit coexpression in HEK293 cells confers O2 sensitivity to kv4.2 but not to Shaker channels.
PubMed:Chemical inactivation of retroviral infectivity by targeting nucleocapsid protein zinc fingers: a candidate SIV vaccine.
PubMed:CD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.
PubMed:Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins.
PubMed:Screening system for urease inhibitors using 13C-NMR.
PubMed:Inhibition of Friend virus replication by a compound that reacts with the nucleocapsid zinc finger: anti-retroviral effect demonstrated in vivo.
PubMed:Synthesis of 3'-thioribonucleosides and their incorporation into oligoribonucleotides via phosphoramidite chemistry.
PubMed:A classical enzyme active center motif lacks catalytic competence until modulated electrostatically.
PubMed:Highly ordered molten globule-like state of ovalbumin at acidic pH: native-like fragmentation by protease and selective modification of Cys367 with dithiodipyridine.
PubMed:Stabilising and destabilising modifications of cysteines in the E. coli outer membrane porin protein OmpC.
PubMed:Actions of sulfhydryl reagents on single ryanodine receptor Ca(2+)-release channels from sheep myocardium.
PubMed:Rapid kinetic studies of SH oxidation-induced calcium release from sarcoplasmic reticulum vesicles.
PubMed:Thiol oxidation by 2,2'-dithiodipyridine causes a reversible increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells. Role for inositol 1,4,5-trisphosphate-sensitive Ca2+ stores.
PubMed:Sensitive analytical method for the novel H1-receptor antagonist HSR-609 in human plasma and urine by high-performance liquid chromatography with pre-column fluorescent derivatization.
PubMed:Thiol oxidation and cytochrome P450-dependent metabolism of CCl4 triggers Ca2+ release from liver microsomes.
PubMed:Characterization of intermediates in the oxidation of zinc fingers in human immunodeficiency virus type 1 nucleocapsid protein P7.
PubMed:Rapid kinetic studies and structural determination of a cysteine proteinase mutant imply that residue 158 in caricain has a major effect upon the ability of the active site histidine to protonate a dipyridyl probe.
PubMed:Effects of reducing agents and oxidants on excitation-contraction coupling in skeletal muscle fibres of rat and toad.
PubMed:Heavy metals inhibit Pi-induced currents through human brush-border NaPi-3 cotransporter in Xenopus oocytes.
PubMed:Effect of anionic surfactant on the reaction of 2,2(1)-dithiobispyridine with bovine oxyhemoglobin as a function of temperature.
PubMed:Hepatotoxic effects of SH-reagents in human and rat hepatocyte cultures and in situ perfused rat livers.
PubMed:Automated spectrophotometric method using 2,2'-dithiodipyridine acid for determination of cholinesterase in whole blood.
PubMed:Characterization of the electrostatic perturbation of a catalytic site (Cys)-S-/(His)-Im+H ion-pair in one type of serine proteinase architecture by kinetic and computational studies on chemically mutated subtilisin variants.
PubMed:Characterization of human adenovirus proteinase activity in disrupted virus particles.
PubMed:Functional consequences of sulfhydryl modification in the pore-forming subunits of cardiovascular Ca2+ and Na+ channels.
PubMed:Human class 1 aldehyde dehydrogenase. Expression and site-directed mutagenesis.
PubMed:Enantiospecific determination of ibuprofen in rat plasma using chiral fluorescence derivatization reagent, (-)-2-[4-(1-aminoethyl)phenyl]-6- methoxybenzoxazole.
PubMed:Mechanism of cyclosporin A biosynthesis. Evidence for synthesis via a single linear undecapeptide precursor.
PubMed:Characterization of the covalent chromatography of thymidylate synthase on thiopropyl-Sepharose 6B.
PubMed:Synthesis of bleomycin A5 oligonucleotide derivatives and site-specific cleavage of the DNA target.
PubMed:Labeling of cysteine 231 in acetylcholinesterase from Torpedo nobiliana by the active-site directed reagent, 1-bromo-2-[14C] pinacolone. Effects of 2,2'-dipyridyl disulfide and other sulfhydryl reagents.
PubMed:Ionizable groups linked to the reaction of 2,2'-dithiobispyridine with hemoglobin.
PubMed:[Modification of a disulfide in the hinge region of rabbit IgG and study of the interaction of polyvalent ferritin antigen, protein A, and anti-IgG].
PubMed:Evidence for independent molecular identity and functional interaction of the haemagglutinin and cysteine proteinase (gingivain) of Porphyromonas gingivalis.
PubMed:Assessment of the relative cytotoxicity of Porphyromonas gingivalis cells, products, and components on human epithelial cell lines.
PubMed:Effect of sulfhydryl compounds on ATP-stimulated H+ transport and Cl- uptake in rabbit renal cortical endosomes.
PubMed:Reactivity of the essential thiol of Klebsiella aerogenes urease. Effect of pH and ligands on thiol modification.
PubMed:Unexpectedly facile synthesis of symmetrical P1,P2-dinucleoside-5'pyrophosphates.
PubMed:Changes of polymerization and conformation of hemoglobin S induced by thiol reagents.
PubMed:Reactive disulfide compounds induce Ca2+ release from cardiac sarcoplasmic reticulum.
PubMed:Reaction between sheep liver mitochondrial aldehyde dehydrogenase and various thiol-modifying reagents.
PubMed:New segment synthesis of alpha-inhibin-92 by the acyl disulfide method.
PubMed:Properties of the principal anion-exchange mechanism in human neutrophils.
PubMed:Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding.
PubMed:Disulfide bond formation between the active-site thiol and one of the several free thiol groups of chymopapain.
PubMed:Effects of diethylstilbestrol, 2,2'-dithiodipyridine, and chloral hydrate on the esterase activity of sheep liver cytoplasmic aldehyde dehydrogenase.
PubMed:Rat hepatic cholesterol 7 alpha-hydroxylase: biochemical properties and comparison to constitutive and xenobiotic-inducible cytochrome P-450 enzymes.
PubMed:Purification of cathepsin B by a new form of affinity chromatography.
PubMed:Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity-probe kinetics, steady-state kinetics and resonance Raman spectroscopy of some dithioacyl derivatives.
PubMed:The effect of 5,5'-dithiobis(1-methyltetrazole) on cytoplasmic aldehyde dehydrogenase and its implications for cephalosporin-alcohol reactions.
PubMed:Purification and properties of mitochondrial monoamine oxidase type A from human placenta.
PubMed:High concentrations of aldehydes slow the reaction of cytoplasmic aldehyde dehydrogenase with thiol-group modifiers.
PubMed:Abnormal redox status of membrane-protein thiols in sickle erythrocytes.
PubMed:Preparation of cathepsins B and H by covalent chromatography and characterization of their catalytic sites by reaction with a thiol-specific two-protonic-state reactivity probe. Kinetic study of cathepsins B and H extending into alkaline media and a rapid spectroscopic titration of cathepsin H at pH 3-4.
PubMed:Modification of thiol groups in cytoplasmic aldehyde dehydrogenase.
PubMed:Reaction of hemerythrin with disulfides.
PubMed:The time course of the interaction of sheep liver cytoplasmic aldehyde dehydrogenase with 2,2'- and 4,4'-dithiodipyridine: a comparison with the action of disulfiram.
PubMed:Natural structural variation in enzymes as a tool in the study of mechanism exemplified by a comparison of the catalytic-site structure and characteristics of cathepsin B and papain. pH-dependent kinetics of the reactions of cathepsin B from bovine spleen and from rat liver with a thiol-specific two-protonic-state probe (2,2'-dipyridyl disulphide) and with a specific synthetic substrate (N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide).
PubMed:Multiple oxidation products of sulfhydryl groups near the active site of thiolase I from porcine heart.
PubMed:The thiol groups of the Folch-Pi protein from bovine white matter. Exposure, reactivity and significance.
PubMed:The activation of aldehyde dehydrogenase by diethylstilboestrol and 2,2'-dithiodipyridine.
PubMed:Characterization of papaya peptidase A as a cysteine proteinase of Carica papaya L. with active-centre properties that differ from those of papain by using 2,2'-dipyridyl disulphide and 4-chloro-7-nitrobenzofurazan as reactivity probes. Use of two-protonic-state electrophiles in the identification of catalytic-site thiol groups.
PubMed:Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.
PubMed:Synthesis of macrolide prostaglandin analogs.
PubMed:Effect of homogeneous magnetic fields on responses to toxic stimulation in Spirostomum ambiguum.
PubMed:A rapid and sensitive spectrophotometric method for determination of hydrogen sulfide with 2,2'-dipyridyl disulfide.
PubMed:Effects of the reduction and S-carbamidomethylation on the conformation, activity and heparin-binding capacity of human antithrombin III.
PubMed:Studies on the effect of reagent and protein charges on reactivity of the beta 93 sulfhydryl group of human hemoglobin using selected mutations.
PubMed:Reactivity of the thiol group in human and bovine albumin at pH 3--9, as measured by exchange with 2,2'-dithiodipyridine.
PubMed:Reversible activation of rat liver microsomal glutathione S-transferase activity by 5,5'-dithiobis(2-nitrobenzoic acid) and 2,2'-dipyridyl disulfide.
PubMed:A kinetic method for the study of solvent environments of thiol groups in proteins involving the use of a pair of isomeric reactivity probes and a differential solvent effect. Investigation of the active centre of ficin by using 2,2'- and 4,4'- dipyridyl disulphides as reactivity probes.
PubMed:2,2'-Dithiodipyridine activates aldehyde dehydrogenase and protects the enzyme against inactivation by disulfiram.
PubMed:The modification of cholinesterase activity by 5,5'-dithiobis-(2-nitrobenzoic acid) included in the coupled spectrophotometric assay. Evidence for a non-catalytic substrate-binding site.
 
Notes:
disulfide is an important moiety in this cpd.
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