EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

7-hydroxy-4-methyl coumarin
4-methylumbelliferone

Supplier Sponsors

Name:7-hydroxy-4-methylchromen-2-one
CAS Number: 90-33-5Picture of molecule3D/inchi
Other(deleted CASRN):56275-29-7
ECHA EINECS - REACH Pre-Reg:201-986-7
FDA UNII: 3T5NG4Q468
Nikkaji Web:J3.914D
Beilstein Number:0142217
MDL:MFCD00006866
XlogP3:1.90 (est)
Molecular Weight:176.17136000
Formula:C10 H8 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless crystals (est)
Food Chemicals Codex Listed: No
Boiling Point: 377.40 °C. @ 760.00 mm Hg (est)
Flash Point: 346.00 °F. TCC ( 174.40 °C. ) (est)
logP (o/w): 2.370 (est)
Soluble in:
 water, 5210 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
7-Hydroxy-4-methylcoumarin 98%
BOC Sciences
For experimental / research use only.
4-Methylumbelliferone >98%
Carbosynth
For experimental / research use only.
4-Methylumbelliferone
ExtraSynthese
For experimental / research use only.
4-Methylumbelliferone
Glentham Life Sciences
4-Methylumbelliferone
Parchem
7-hydroxy-4-methyl coumarin
Santa Cruz Biotechnology
For experimental / research use only.
4-Methylumbelliferone
Sigma-Aldrich
For experimental / research use only.
Hymecromone
TCI AMERICA
For experimental / research use only.
4-Methylumbelliferone >98.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for 7-hydroxy-4-methyl coumarin usage levels up to:
 not for fragrance use.
 
Recommendation for 7-hydroxy-4-methyl coumarin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):90-33-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5280567
National Institute of Allergy and Infectious Diseases:Data
7-hydroxy-4-methylchromen-2-one
Chemidplus:0000090335
EPA/NOAA CAMEO:hazardous materials
RTECS:GN7000000 for cas# 90-33-5
 
References:
 7-hydroxy-4-methylchromen-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:90-33-5
Pubchem (cid):5280567
Pubchem (sid):134970942
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C03081
HMDB (The Human Metabolome Database):Search
YMDB (Yeast Metabolome Database):YMDB00971
Export Tariff Code:2932.29.4500
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
7-hydroxy-4-methyl-2H-1-benzopyran-2-one
 hymecromone
beta-methyl unbelliferone
4-methyl-7-hydroxycoumarin
7-hydroxy-4-methylcoumarin
 coumarin, 7-hydroxy-4-methyl-
4-methylumbelliferone
7-hydroxy-4-methylchromen-2-one
 

Articles:

PubMed:Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice.
PubMed:Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction.
PubMed:Comparative biological study of roots, stems, leaves, and seeds of Angelica shikokiana Makino.
PubMed:4-methylumbelliferone inhibits angiogenesis in vitro and in vivo.
PubMed:Deglycosylation of liquiritin strongly enhances its inhibitory potential towards UDP-glucuronosyltransferase (UGT) isoforms.
PubMed:Modulation of root branching by a coumarin derivative.
PubMed:Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system.
PubMed:Phospholipase A2 and antioxidant enzyme activities in normal and PSE pork.
PubMed:Hypolipidemic effect of Pleurotus eryngii extract in fat-loaded mice.
PubMed:Light emitting diode induced chemiluminescence and its application as a detector for high performance liquid chromatography.
PubMed:Serogroup distribution and virulence characteristics of sorbitol-negative Escherichia coli from food and cattle stool.
PubMed:Determination of viable Escherichia coli using antibody-coated paramagnetic beads with fluorescence detection.
PubMed:Deficient UDP-glucuronosyltransferase detoxification enzyme activity in the small intestinal mucosa of patients with coeliac disease.
PubMed:Efficient enzymatic synthesis of 4-methylumbelliferyl N-acetyllactosaminide and 4-methylumbelliferyl sialyl N-acetyllactosaminides employing beta-D-galactosidase and sialyltransferases.
PubMed:Study of beta-glucosidase production by wine-related yeasts during alcoholic fermentation. A new rapid fluorimetric method to determine enzymatic activity.
PubMed:Hydrolase and glycosynthase activity of endo-1,3-beta-glucanase from the thermophile Pyrococcus furiosus.
PubMed:Overexpression and characterization of a novel chitinase from Trichoderma atroviride strain P1.
PubMed:A medium for the presumptive detection of Enterobacter sakazakii in infant formula: interlaboratory study.
PubMed:Polar organic solvent added to an aqueous solution changes hydrolytic property of lipase.
PubMed:Kinetic studies on the hydrolysis of N-acetylated and N-deacetylated derivatives of 4-methylumbelliferyl chitobioside by the family 18 chitinases ChiA and ChiB from Serratia marcescens.
PubMed:Cloning and characterization of two alpha-glucosidases from Bifidobacterium adolescentis DSM20083.
PubMed:Utilization of fluorogenic assay for rapid detection of Escherichia coli in acidic fruit juice.
PubMed:A colorimetric and fluorometric microplate assay for the detection of microcystin-LR in drinking water without preconcentration.
PubMed:An alternative approach for enumeration of Escherichia coli in foods.
PubMed:Rapid methods to enumerate Escherichia coli in foods using 4-methylumbelliferyl-beta-D-glucuronide.
PubMed:Screening of non-Saccharomyces wine yeasts for the production of beta-D-xylosidase activity.
PubMed:False-positive fluorescence by pink salmon tissue and staphylococci in a rapid test for Escherichia coli.
PubMed:An evaluation of the use of 4-methylumbelliferyl-beta-D-glucuronide (MUG) in different solid media for the detection and enumeration of Escherichia coli in foods.
PubMed:Comparison of commercially available kits with standard methods for the detection of coliforms and Escherichia coli in foods.
PubMed:Enzyme capture assay for rapid identification of Escherichia coli in blood cultures.
PubMed:A rapid method for detection of N-acetylglucosaminidase-type chitinase activity in crossed immunoelectrophoresis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels using 4-methylumbelliferyl-N-acetyl-D-glucosaminide as substrate.
PubMed:A highly sensitive and fast nonradioactive method for detection of polymerase chain reaction products.
PubMed:Evaluation of a rapid fluorogenic method for the detection of Escherichia coli in dairy products.
PubMed:[Use of methylumbelliferylglucuronide (MUG) for the rapid identification of E. coli in food microbiology].
PubMed:Glucuronidase assay in a rapid MPN determination for recovery of Escherichia coli from selected foods.
PubMed:Fluorogenic assay for rapid detection of Escherichia coli in food.
PubMed:[Detection of low lipase activities in food].
PubMed:Monensin-based medium for determination of total gram-negative bacteria and Escherichia coli.
PubMed:Evaluation of a fluorogenic assay for detection of Escherichia coli in foods.
PubMed:Fluorogenic selective and differential medium for isolation of fecal streptococci.
PubMed:Fluorogenic assays for immediate confirmation of Escherichia coli.
PubMed:[Total blood bile acid concentration after meal-test in acute and chronic liver disorders: influence of a choleretic agent. Preventive note].
 
Notes:
None found
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