EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

7-ethoxycoumarin
7-ethoxy-2H-chromen-2-one

Supplier Sponsors

Name:7-ethoxychromen-2-one
CAS Number: 31005-02-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:250-429-4
FDA UNII: C8K66XCQ6L
Nikkaji Web:J315H
Beilstein Number:146200
MDL:MFCD00006877
XlogP3:2.30 (est)
Molecular Weight:190.19830000
Formula:C11 H10 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 345.00 °C. @ 760.00 mm Hg (est)
Flash Point: 290.00 °F. TCC ( 143.10 °C. ) (est)
logP (o/w): 2.310 (est)
Soluble in:
 water, 813.1 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
7-Ethoxycoumarin > 95%
Odor: characteristic
Use: 7-Ethoxycoumarin is a substrate for cytochrome CYP2B6.
ExtraSynthese
For experimental / research use only.
7-Ethoxycoumarin (HPLC) ≥95%
Santa Cruz Biotechnology
For experimental / research use only.
7-Ethoxycoumarin
Sigma-Aldrich: Aldrich
For experimental / research use only.
7-Ethoxycoumarin 99.5%
sds
TCI AMERICA
For experimental / research use only.
7-Ethoxycoumarin >97.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for 7-ethoxycoumarin usage levels up to:
 not for fragrance use.
 
Recommendation for 7-ethoxycoumarin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :35703
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
7-ethoxychromen-2-one
Chemidplus:0031005024
 
References:
 7-ethoxychromen-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):35703
Pubchem (sid):134999220
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C11052
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.20.4500
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
2H-1-benzopyran-2-one, 7-ethoxy-
7-ethoxy-1-benzopyran-2-one
7-ethoxy-2H-1-benzopyran-2-one
7-ethoxy-2H-chromen-2-one
7-ethoxychromen-2-one
 

Articles:

PubMed:Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants.
PubMed:Influence of cigarette smoke on the L-ascorbic acid metabolism and the activities of drug-metabolizing enzyme in rats.
PubMed:Thyme (Thymus vulgaris L.) leaves and its constituents increase the activities of xenobiotic-metabolizing enzymes in mouse liver.
PubMed:Allogeneic cell therapy for the treatment of liver disease.
PubMed:Inhibition of cytochrome p450 enzymes by enrofloxacin in the sea bass (Dicentrarchus labrax).
PubMed:Antimutagenicity of ethanol extracts of bee glue against environmental mutagens.
PubMed:Beta2-agonist abuse in food producing animals: use of in vitro liver preparations to assess biotransformation and potential target residues for surveillance.
PubMed:Modulation of cytochrome P-450-dependent monooxygenases, glutathione and glutathione S-transferase in rat liver by geniposide from Gardenia jasminoides.
PubMed:Use of fresh and cryopreserved hepatocytes to study the metabolism of pesticides in food-producing animals and rats.
PubMed:Metabolism of [ring-U-14C] agaritine by precision-cut rat, mouse and human liver and lung slices.
PubMed:Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices.
PubMed:Effect of swimming exercise and ethanol on rat liver P450-dependent monooxygenases.
PubMed:Influence of metabolism in skin on dosimetry after topical exposure.
PubMed:Comparison of maturation of drug-metabolizing enzymes in calves with functioning or nonfunctioning rumen.
PubMed:Food restriction and stimulation of monooxygenation of p-nitroanisole in perfused rat liver.
PubMed:Studies on the acute effects of coumarin and some coumarin derivatives in the rat.
PubMed:Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices.
PubMed:Effects of soya bean flakes and liquorice root extract on enzyme induction and toxicity in B6C3F1 mice.
PubMed:Enzyme induction of the early chick embryo by airborne particulate extracts.
PubMed:Suppression of benzo[a]pyrene metabolism by accumulation of triacylglycerols in rat hepatocytes: effect of high-fat and food-restricted diets.
PubMed:Enzyme activities associated with carcinogen metabolism in liver and nonhepatic tissues of rats maintained on high fat and food-restricted diets.
PubMed:Maturational development of drug-metabolizing enzymes in sheep.
PubMed:Maturational development of drug-metabolizing enzymes in dogs.
PubMed:Dietary selenium protects against acute toxicity of T-2 toxin in rats.
PubMed:Metabolism of xenobiotics during percutaneous penetration: role of absorption rate and cutaneous enzyme activity.
PubMed:Studies of cytotoxicity and metabolic competence with the rat intestinal cell line IEC-17.
PubMed:Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation.
PubMed:Interactions of heterocyclic Maillard products with the hepatic microsomal monooxygenase system.
PubMed:Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: in vivo induction.
PubMed:Difference between species in response to a 3,5-dichloropyridyloxyphenoxy compound: induction of cytochrome P-450 and/or peroxisome proliferation.
PubMed:Effects of dietary Schizandra chinensis, brussels sprouts and Illicium verum extracts on carcinogen metabolism systems in mouse liver.
PubMed:Comparison of the effects of various flavonoids on ethoxycoumarin deethylase activity of rat intestinal and hepatic microsomes.
PubMed:Potent induction of human placental mono-oxygenase activity by previous dietary exposure to polychlorinated biphenyls and their thermal degradation products.
PubMed:Effects of semisynthetic diets on xenobiotic metabolizing enzyme activity and morphology of small intestinal mucosa in humans.
PubMed:Adipose tissue content as a modifier of the tissue distribution, biological effects, and excretion of a hexachlorobiphenyl in C57BL/6J and DBA/JBOMf mice.
PubMed:Hepatic biotransformation in farmed blue fox and raccoon dog.
PubMed:Drug-oxidizing mono-oxygenase system in liver microsomes of goldfish (Carassius auratus).
 
Notes:
None found
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