dyphylline
7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

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  CODE121363 CODE121363
  Product(s):
  479-18-5 Dyphylline >98%
  Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor

Name: 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione CAS Number: 479-18-5 3D/inchi Other(deleted CASRN): 52756-53-3 ECHA EINECS - REACH Pre-Reg: 207-526-1 FDA UNII: 263T0E9RR9 Nikkaji Web: J2.054K Beilstein Number: 0284563 MDL: MFCD00005759 XlogP3: -1.80 (est) Molecular Weight: 254.24638000 Formula: C10 H14 N4 O4 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:cosmetic ingredient for skin conditioning   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Appearance: white solid (est) Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 161.50 °C. @ 760.00 mm Hg Boiling Point: 589.60 °C. @ 760.00 mm Hg (est) Flash Point: 591.00 °F. TCC ( 310.40 °C. ) (est) logP (o/w): -1.100 (est) Soluble in:   water, 3.33E+05 mg/L @ 25 °C (exp)   water, 1.93e+004 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: CosIng: cosmetic data Cosmetic Uses: skin conditioning   Suppliers: BOC Sciences For experimental / research use only. Dyphylline >98% Odor: characteristic Use: Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor Sigma-Aldrich: Sigma For experimental / research use only. 7-(2,3-Dihydroxypropyl)theophylline sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intraperitoneal-mouse LD50 195 mg/kg Strahlentherapie. Vol. 127, Pg. 245, 1965. intravenous-mouse LD50 1080 mg/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 288, 1970. oral-mouse LD50 1954 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 343, 1956. oral-rat LD > 400 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 35, Pg. 266, 1946. intravenous-rat LD50 860 mg/kg Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957. Dermal Toxicity: subcutaneous-mouse LD50 1052 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 601, 1956. subcutaneous-rat LD50 1253 mg/kg Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957. Inhalation Toxicity: Not determined   Safety in Use Information: Category: cosmetic ingredient for skin conditioning Recommendation for dyphylline usage levels up to:   not for fragrance use.   Recommendation for dyphylline flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View ClinicalTrials.gov:search Daily Med:search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA GENetic TOXicology:Search EPA Substance Registry Services (TSCA):479-18-5 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :3182 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione Chemidplus:0000479185 RTECS:XH5100000 for cas# 479-18-5   References:   7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione NIST Chemistry WebBook: Search Inchi Pubchem (cid): 3182 Pubchem (sid): 134974003   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View KEGG (GenomeNet): D00691 HMDB (The Human Metabolome Database): Search Export Tariff Code: 2933.90.9500 MedlinePlusSupp: View ChemSpider: View Wikipedia: View Formulations/Preparations: •tablets (200 mg), elixir (100 mg15 ml), & ampuls (500 mg2 ml) are avail. •oral: elixir 100 mg15 ml; tablets 200 mg; tablets (timed-release) 400 mg. elixir 160 mg15 ml; tablets 200 & 400 mg. injection: soln 250 mgml in 2 & 10 ml containers.   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms:   aristophyllin   asthmolysin   astmamasit   astrophyllin   circain   circair   coronal   coronarin   corphyllin (1,2- dihydroxy-3-propyl)thiophyllin   dihydroxypropyl theophylline 7-(2,3- dihydroxypropyl)-1,3-dimethylpurine-2,6-dione 7-(2,3- dihydroxypropyl)-1,3-dimethylxanthine 7-(2,3- dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione 7-(2,3- dihydroxypropyl)theophylline 7-(beta,gamma- dihydroxypropyl)theophylline   dilor-400 1,3- dimethyl-7-(2,3-dihydroxypropyl)xanthine 7-(2,3- dioxypropyl)theophylline   diphyllin   diphylline   diprofillin   diprofilline   diprophyllin   diprophylline   diprophyllinum   dipropylline   droxine   dyflex   glyfyllin   glyphyllin   glyphylline   glyphyllinum   hiphyllin   hyphylline   liactemin   lufyllin   neophyl   neophyllin   neophyllin M   neophylline   neostenovasan   neothylline   neutrafil   neutraphyllin   neutraphylline   propyphyllin   protheophylline   purifilin 1H- purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl 1H- purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-, (+-)-   silbephyllin   silbephylline   solufilin   solufyllin   soluphyllin   synthophylline   tefilan   teofen   tesfen   theal   thefylan   theophylline, 7-(2,3-dihydroxypropyl)-   Articles:   None found yet. 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Notes: a theophylline derivative with broncho- and vasodilator properties. it is used in the treatment of asthma, cardiac dyspnea, and bronchitis.