EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

6-aminocaproic acid
hexanoic acid, 6-amino-

Supplier Sponsors

Name:6-aminohexanoic acid
CAS Number: 60-32-2Picture of molecule3D/inchi
Other(deleted CASRN):87867-96-7
ECHA EINECS - REACH Pre-Reg:200-469-3
FDA UNII: U6F3787206
Nikkaji Web:J1.398F
Beilstein Number:0906872
MDL:MFCD00008238
XlogP3:-3.00 (est)
Molecular Weight:130.16704000
Formula:C6 H12 N O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 205.00 °C. @ 760.00 mm Hg
Boiling Point: 255.64 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.005000 mmHg @ 25.00 °C. (est)
Flash Point: 227.00 °F. TCC ( 108.40 °C. ) (est)
logP (o/w): 0.027 (est)
Soluble in:
 water, 2.56e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: not used anymore
 
Suppliers:
BOC Sciences
For experimental / research use only.
Aminocaproic acid >98%
Odor: characteristic
Use: Aminocaproic acid is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis.
Glentham Life Sciences
6-Aminohexanoic acid, USP grade
Glentham Life Sciences
6-Aminohexanoic acid
Indis NV
For experimental / research use only.
6-Aminocaproic Acid
Penta International
AMINOCAPROIC ACID USP
Sigma-Aldrich: Sigma
For experimental / research use only.
6-Aminocaproic Acid ≥99% (titration), powder
sds
TCI AMERICA
For experimental / research use only.
6-Aminocaproic Acid >98.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-dog LD50 > 7000 mg/kg
Drugs in Japan Vol. 6, Pg. 79, 1982.

intravenous-dog LDLo 2150 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Pharmacologist. Vol. 3, Pg. 62, 1961.

intravenous-guinea pig LDLo 19800 mg/kg
Anesthesie, Analgesie, Reanimation. Vol. 22, Pg. 481, 1965.

oral-man TDLo 1778 mg/kg/8D-
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: HEMATURIA
American Journal of Kidney Diseases. Vol. 8, Pg. 441, 1986.

intravenous-mouse LD50 4900 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Anesthesie, Analgesie, Reanimation. Vol. 22, Pg. 481, 1965.

oral-mouse LD50 14300 mg/kg
Drugs in Japan Vol. 6, Pg. 79, 1982.

intravenous-rabbit LD50 2000 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.

oral-rat LD > 10000 mg/kg
Pharmacologist. Vol. 3, Pg. 62, 1961.

intraperitoneal-rat LD50 7000 mg/kg
Pharmacologist. Vol. 3, Pg. 62, 1961.

intravenous-rat LD50 3300 mg/kg
Pharmacologist. Vol. 3, Pg. 62, 1961.

Dermal Toxicity:
subcutaneous-mouse LD50 5790 mg/kg
Drugs in Japan Vol. -, Pg. 62, 1995.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for 6-aminocaproic acid usage levels up to:
 not for fragrance use.
 
Recommendation for 6-aminocaproic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):60-32-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :564
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
6-aminohexanoic acid
Chemidplus:0000060322
RTECS:MO6300000 for cas# 60-32-2
 
References:
 6-aminohexanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:60-32-2
Pubchem (cid):564
Pubchem (sid):134972930
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C02378
HMDB (The Human Metabolome Database):HMDB01901
FooDB:FDB022729
Export Tariff Code:2922.49.4050
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 acepramin
 acikaprin
 afibrin
 amikar
6-amino hexanoic acid
6-amino-hexanoic acid
6-amino-N-caproic acid
6-amino-N-hexanoic acid
6-aminocaproicacid
6-aminohexanoic acid
6-aminohexanoicacid
 capranol
 caproamin
 epsamon
 hemopar
 hexanoic acid, 6-amino-
 respramin
 

Articles:

PubMed:Expanding lysine industry: industrial biomanufacturing of lysine and its derivatives
PubMed:Cutaneous small-vessel vasculitis
PubMed:The use of antifibrinolytic agents in spine surgery. A meta-analysis
PubMed:Antifibrinolytic therapy in cardiac surgery
PubMed:Rapid method for the determination of citrate, phosphate and sulfite in seafood by capillary zone electrophoresis
PubMed:[Treatment of acute allergic manifestations by epsilon-aminocaproic acid. Study of allergies to drugs, food or other substances and intolerance to iodinated contrast products]
PubMed:Review and application of serine protease inhibition in coronary artery bypass graft surgery
PubMed:Review of recently approved alternatives to anticoagulation with warfarin for emergency clinicians
PubMed:(125)I-Labeled murine anti-CD20 antigen monoclonal antibody NuB2 conjugated to one or three octaarginine (maleimide-(6-aminocaproic acid)(2)-(D-Arg)(8)-(D-Tyr)) peptide chains
PubMed:Progress in the emergency management of hereditary angioedema: focus on new treatment options in the United States
PubMed:Bisphosphonate-polyaspartamide conjugates as bone targeted drug delivery systems
PubMed:Hapten synthesis and antibody production for the development of a melamine immunoassay
PubMed:Coronary artery bypass grafting after aprotinin: are we doing better?
PubMed:Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minima
PubMed:An enzymatic method for the production of 6-oxohexanoic acid from 6-aminohexanoic acid by an enzyme oxidizing ?-amino compounds from Phialemonium sp. AIU 274
PubMed:Determination of glycyrrhizin in liqueurs by on-line coupled capillary isotachophoresis with capillary zone electrophoresis
PubMed:Characterization and Comparison of Wine Lees by Liquid Chromatography-Mass Spectrometry in High-Resolution Mode
PubMed:Regulatory effect of amino acids on the pasting behavior of potato starch is attributable to its binding to the starch chain
PubMed:Lifestyle and dietary influences on nosebleed severity in hereditary hemorrhagic telangiectasia
PubMed:Lytic antimicrobial activity of hen egg white lysozyme immobilized to polystyrene beads
PubMed:New aspects of naturally occurring proteases in bovine milk
PubMed:Determination of egg white lysozyme by on-line coupled capillary isotachophoresis with capillary zone electrophoresis
PubMed:Aprotinin in cardiac surgery patients: is the risk worth the benefit?
PubMed:A sensitivity-improved enzyme-linked immunosorbent assay for fenvalerate: a new approach for hapten synthesis and application to tea samples
PubMed:Cyclic oligomers in polyamide for food contact material: quantification by HPLC-CLND and single-substance calibration
PubMed:Development and validation of a micellar electrokinetic capillary chromatography method for the determination of goserelin and related substances
PubMed:Novel yellow compounds, dilysyldipyrrolones A and B, formed from xylose and lysine by the Maillard reaction
PubMed:Production and specificity of polyclonal antibodies to hexanal-lysine adducts
PubMed:FTIR determination of ligand-induced secondary and tertiary structural changes in bovine plasminogen
PubMed:Conditions for the formation of dilysyl-dipyrrolones A and B, and novel yellow dipyrrolone derivatives formed from xylose and amino acids in the presence of lysine
PubMed:Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia--complete inhibition by diethylmaleate in a 5-week feeding study
PubMed:Preliminary investigation of the properties of somatic cell proteases
PubMed:[ON THE FORMATION OF WATER-SOLUBLE SUBSTANCES FOLLOWING STORAGE OF WASHED PERFOL BOTTLES]
 
Notes:
an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. Aminocaproic acid (marketed as Amicar) is a drug used to treat bleeding disorders. It is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. It is a derivative of the amino acid lysine. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. [HMDB]
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