6-aminocaproic acid
hexanoic acid, 6-amino-
 
Notes:
an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. Aminocaproic acid (marketed as Amicar) is a drug used to treat bleeding disorders. It is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. It is a derivative of the amino acid lysine. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. [HMDB]
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      01-24400 AMINOCAPROIC ACID USP
       
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6-aminohexanoic acid (Click)
CAS Number: 60-32-2Picture of molecule
Other: 87867-96-7
ECHA EINECS - REACH Pre-Reg: 200-469-3
FDA UNII: U6F3787206
Nikkaji Web: J1.398F
Beilstein Number: 0906872
MDL: MFCD00008238
XlogP3: -3.00 (est)
Molecular Weight: 130.16704000
Formula: C6 H12 N O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 205.00 °C. @ 760.00 mm Hg
Boiling Point: 255.64 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.005000 mm/Hg @ 25.00 °C. (est)
Flash Point: 227.00 °F. TCC ( 108.40 °C. ) (est)
logP (o/w): 0.027 (est)
Soluble in:
 water, 2.56e+005 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: not used anymore
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Suppliers:
Glentham Life Sciences
6-Aminohexanoic acid
Penta International
AMINOCAPROIC ACID USP
Sigma-Aldrich: Sigma
For experimental / research use only.
6-Aminocaproic Acid ≥99% (titration), powder
TCI AMERICA
For experimental / research use only.
6-Aminocaproic Acid >98.0%(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-dog LD50  > 7000 mg/kg
Drugs in Japan Vol. 6, Pg. 79, 1982.

intravenous-dog LDLo  2150 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Pharmacologist. Vol. 3, Pg. 62, 1961.

intravenous-guinea pig LDLo  19800 mg/kg
Anesthesie, Analgesie, Reanimation. Vol. 22, Pg. 481, 1965.

oral-man TDLo  1778 mg/kg/8D-
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: HEMATURIA
American Journal of Kidney Diseases. Vol. 8, Pg. 441, 1986.

intravenous-mouse LD50  4900 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Anesthesie, Analgesie, Reanimation. Vol. 22, Pg. 481, 1965.

oral-mouse LD50  14300 mg/kg
Drugs in Japan Vol. 6, Pg. 79, 1982.

intravenous-rabbit LD50  2000 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.

oral-rat LD  > 10000 mg/kg
Pharmacologist. Vol. 3, Pg. 62, 1961.

intraperitoneal-rat LD50  7000 mg/kg
Pharmacologist. Vol. 3, Pg. 62, 1961.

intravenous-rat LD50  3300 mg/kg
Pharmacologist. Vol. 3, Pg. 62, 1961.

Dermal Toxicity:
subcutaneous-mouse LD50 5790 mg/kg
Drugs in Japan Vol. -, Pg. 62, 1995.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for 6-aminocaproic acid usage levels up to:
 not for fragrance use.
 
Recommendation for 6-aminocaproic acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 60-32-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 564
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 6-aminohexanoic acid
Chemidplus: 0000060322
RTECS: MO6300000 for cas# 60-32-2
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References:
 6-aminohexanoic acid
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 60-32-2
Pubchem (cid): 564
Pubchem (sid): 134972930
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
UM BBD: Search
KEGG (GenomeNet): C02378
HMDB (The Human Metabolome Database): HMDB01901
FooDB: FDB022729
Export Tariff Code: 2922.49.4050
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 acepramin
 acikaprin
 afibrin
 amikar
6-amino hexanoic acid
6-amino-hexanoic acid
6-amino-N-caproic acid
6-amino-N-hexanoic acid
6-aminocaproicacid
6-aminohexanoic acid
6-aminohexanoicacid
 capranol
 caproamin
 epsamon
 hemopar
 hexanoic acid, 6-amino-
 respramin
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