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6,7-dimethoxycoumarin
2H-1-benzopyran-2-one, 6,7-dimethoxy-

Supplier Sponsors

Name:6,7-dimethoxychromen-2-one
CAS Number: 120-08-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-369-0
FDA UNII: H5841PDT4Y
Nikkaji Web:J5.319H
Beilstein Number:0169572
MDL:MFCD00006871
XlogP3-AA:1.90 (est)
Molecular Weight:206.19750000
Formula:C11 H10 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 145.50 °C. @ 760.00 mm Hg
Boiling Point: 369.24 °C. @ 760.00 mm Hg (est)
Flash Point: 332.00 °F. TCC ( 166.80 °C. ) (est)
logP (o/w): 1.331 (est)
Soluble in:
 alcohol
 water, 4172 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Scoparone 98%
BOC Sciences
For experimental / research use only.
Scoparone 0.99
Odor: characteristic
Use: The herbs of Artemisia scoparia, it protects against carbon tetrachloride-induced liver injury. antifungal activity; immunosuppression and vasorelaxation effects
ExtraSynthese
For experimental / research use only.
6,7-Dimethylesculetin (HPLC) ≥99%
Santa Cruz Biotechnology
For experimental / research use only.
Scoparone ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
6,7-Dimethoxycoumarin 98%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 180 mg/kg
BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Indian Journal of Medical Research. Vol. 60, Pg. 763, 1972.

oral-mouse LD50 280 mg/kg
Drugs of the Future. Vol. 3, Pg. 550, 1978.

intraperitoneal-rat LD50 190 mg/kg
Drugs of the Future. Vol. 3, Pg. 550, 1978.

oral-rat LD50 292 mg/kg
Drugs of the Future. Vol. 3, Pg. 550, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for 6,7-dimethoxycoumarin usage levels up to:
 not for fragrance use.
 
Recommendation for 6,7-dimethoxycoumarin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8417
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
6,7-dimethoxychromen-2-one
Chemidplus:0000120081
RTECS:GN6550000 for cas# 120-08-1
 
References:
 6,7-dimethoxychromen-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):8417
Pubchem (sid):134974882
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C09311
HMDB (The Human Metabolome Database):HMDB30818
FooDB:FDB002774
Export Tariff Code:2932.29.3000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 anise leaf
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 celery leaf
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 fennel seed
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 lemon bark
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 lemon leaf
Search Trop Picture
 lime fruit
Search Trop Picture
 mandarin pericarp
Search Trop Picture
 orange bark
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 petitgrain lemon
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 tarragon shoot
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Synonyms:
 aesculetin dimethyl ether
 benzopyran-2-one, 6,7-dimethoxy-
2H-1-benzopyran-2-one, 6,7-dimethoxy-
 coumarin, 6,7-dimethoxy-
6,7-dimethoxy-2-benzopyrone
6,7-dimethoxy-2H-1-benzopyran-2-one
6,7-dimethoxy-2H-chromen-2-one
6,7-dimethoxy-chromen-2-one
6,7-dimethoxybenzopyran-2-one
6,7-dimethoxychromen-2-one
6,7-dimethylesculetin
 escoparone
 scoparon
 scoparone
 

Articles:

PubMed:A new naphthol from the twigs and leaves of Pterospermum yunnanense.
PubMed:Novel Pentapeptide Activators of Mammalian And Mushroom Tyrosinase.
PubMed:Artemisia capillaris inhibits atopic dermatitis-like skin lesions in Dermatophagoides farinae-sensitized Nc/Nga mice.
PubMed:[Study on quality standard of Chimonanthus nitens leaf].
PubMed:[Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats].
PubMed:[Study on distributed patterns of scoparone and ayapin in Dendrobium species from Yunnan].
PubMed:Sphaeralcic acid and tomentin, anti-inflammatory compounds produced in cell suspension cultures of Sphaeralcea angustifolia.
PubMed:A simple and sensitive method for the determination of fibric acids in the liver by liquid chromatography.
PubMed:Total synthesis of six 3,4-unsubstituted coumarins.
PubMed:Regulation of 3β-hydroxysteroid dehydrogenase and sulphotransferase 2A1 gene expression in primary porcine hepatocytes by selected sex-steroids and plant secondary metabolites from chicory (Cichorium intybus L.) and wormwood (Artemisia sp.).
PubMed:Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties.
PubMed:Simultaneous determination of 12 coumarins in bamboo leaves by HPLC.
PubMed:Two new ceramides from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms.
PubMed:Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity.
PubMed:[Chemical constituents of chloroform fraction from leaves of Chimonanthus salicifolius].
PubMed:Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives.
PubMed:Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.).
PubMed:7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro.
PubMed:Dispersive liquid-liquid microextraction combined with microwave-assisted derivatization for determining lipoic acid and its metabolites in human urine.
PubMed:Evaluation of the hypolipidemic activity of 6,7-dimethoxycoumarin on placental tissue factor mRNA expression in experimental anti-phospholipid syndrome.
PubMed:Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes.
PubMed:Identification and quantification of total coumarins from Urtica dentata Hand and its roles in promoting immune tolerance via TLR4-mediated dendritic cell immaturation.
PubMed:Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice.
PubMed:Proteomics analysis of hepatoprotective effects for scoparone using MALDI-TOF/TOF mass spectrometry with bioinformatics.
PubMed:Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris.
PubMed:Phenols and flavonoids from the aerial part of Euphorbia hirta.
PubMed:Recent Studies and Progression of Yin Chen Hao ( Yīn Chén Hāo), a Long-term Used Traditional Chinese Medicine.
PubMed:High-performance liquid chromatographic analysis for quantitation of marker compounds of Artemisia capillaris Thunb.
PubMed:[A new natural product from root of Angelica dahurica cv. Qibaizhi].
PubMed:Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone.
PubMed:Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.
PubMed:Metabolomics study on the hepatoprotective effect of scoparone using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry.
PubMed:Changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate-induced experimental hepatic injury after Yinchenhao Decoction () treatment.
PubMed:Citrus phenylpropanoids and defence against pathogens. Part II: gene expression and metabolite accumulation in the response of fruits to Penicillium digitatum infection.
PubMed:Citrus phenylpropanoids and defence against pathogens. Part I: metabolic profiling in elicited fruits.
PubMed:Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation.
PubMed:[Coumarins from Skimmia arborescens and its anti-inflammatory effect].
PubMed:Simultaneous determination of five active compounds in chimonanthus nitens by double-development HPTLC and scanning densitometry.
PubMed:Collagenase inhibitors from Viola yedoensis.
PubMed:Pharmacokinetics and tissue distribution study of scoparone in rats by ultraperformance liquid-chromatography with tandem high-definition mass spectrometry.
PubMed:[Study on antibacterial active components from Viola yedoensis].
PubMed:Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography.
PubMed:Simultaneous in vivo RP-HPLC-DAD quantification of multiple-component and drug-drug interaction by pharmacokinetics, using 6,7-dimethylesculetin, geniposide and rhein as examples.
PubMed:Biologically active constituents of Aglaia erythrosperma.
PubMed:Stimulation of Airway and Intestinal Mucosal Secretion by Natural Coumarin CFTR Activators.
PubMed:Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents.
PubMed:Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities.
PubMed:The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats.
PubMed:Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor.
PubMed:Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice.
PubMed:Quantitation of the glutathione in human peripheral blood by matrix-assisted laser desorption ionization time-of-flight mass spectrometry coupled with micro-scale derivatization.
PubMed:[Studies on the chemical constituents from Lobelia chinensis].
PubMed:Extraction and identification of three major aldose reductase inhibitors from Artemisia montana.
PubMed:Studying submicrosecond protein folding kinetics using a photolabile caging strategy and time-resolved photoacoustic calorimetry.
PubMed:Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice.
PubMed:Immunosuppressive constituents from Urtica dentata Hand.
PubMed:Chemical constituents and antimicrobial activities of Canthium horridum.
PubMed:Effect of mobile phase additives on the resolution of four bioactive compounds by RP-HPLC.
PubMed:[Main chemical components for clearing heat and relieving sore throat in different germplasm of Canarium album].
PubMed:Sodium bicarbonate induces crystalline wax generation, activates host-resistance, and increases imazalil level in rind wounds of oranges, improving the control of green mold during storage.
PubMed:Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats.
PubMed:Effects of scoparone on dopamine release in PC12 cells.
PubMed:Synthesis and antiprotozoal activity of 4-arylcoumarins.
PubMed:Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells.
PubMed:Rapid analysis of constituents of Radix Cyathulae using hydrophilic interaction-reverse phase LC-MS.
PubMed:[Isolation and identification of chemical constituents from peels of Citrus changshan-huyou Y.B. Chang].
PubMed:A simple RP-HPLC method for quantification of columbianadin in rat plasma and its application to pharmacokinetic study.
PubMed:Anti-allergic effects of scoparone on mast cell-mediated allergy model.
PubMed:Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells.
PubMed:Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells.
PubMed:[Studies on chemical constituents of Ranunculus japonicus].
PubMed:Host-pathogen-biocontrol agent interaction as affected by sequential application of Na2CO3 and CaCl2.
PubMed:Abiotic stresses sequentially applied enhance natural resistance and reduce postharvest decay.
PubMed:Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
PubMed:New constituents of Artemisia monosperma Del.
PubMed:Simultaneous determination of 6,7-dimethylesculetin and geniposide in rat plasma and its application to pharmacokinetic studies of Yin Chen Hao Tang preparation.
PubMed:Minor compounds from the stem bark of Chinese mangrove associate Catunaregam spinosa.
PubMed:[Studies on chemical constituents of Sarcandra glabra].
PubMed:Effect of scoparone on neurite outgrowth in PC12 cells.
PubMed:A new oxygenated ursane derivative from Canthium multiflorum.
PubMed:Simultaneous determination of 13 bioactive compounds in Herba Artemisiae Scopariae (Yin Chen) from different harvest seasons by HPLC-DAD.
PubMed:Anticomplementary principles of a Chinese multiherb remedy for the treatment and prevention of SARS.
PubMed:Pharmacokinetic studies of a Chinese triple herbal drug formula.
PubMed:Involvement of limonene hydroperoxides formed after oil gland injury in the induction of defense response against Penicillium digitatum in lemon fruit.
PubMed:A new sesquiterpene and other terpenoid constituents of Chisocheton penduliflorus.
PubMed:Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation.
PubMed:Determination and pharmacokinetics of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of yinchenhao tang.
PubMed:Development of a rapid and validated method for investigating the metabolism of scoparone in rat using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry.
PubMed:A rapid and sensitive UPLC-ESI MS method for analysis of isofraxidin, a natural antistress compound, and its metabolites in rat plasma.
PubMed:Antimicrobial activity of wax and hexane extracts from Citrus spp. peels.
PubMed:Simultaneous analysis of trans- and cis-isomers of 2-glucosyloxycinnamic acids and coumarin derivatives in Dendrobium thyrsiflorum by high-performance liquid chromatography (HPLC)-photodiode array detection (DAD)-electrospray ionization (ESI)-tandem mass spectrometry (MS).
PubMed:Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida.
PubMed:Scoparone inhibits ultraviolet radiation-induced lipid peroxidation.
PubMed:Induction of phytoalexins biosynthesis in orange fruit by the biocontrol yeast Rhodotorula glutinis.
PubMed:[Studies on chemical constituents from fruits of Paliurus ramosissimus].
PubMed:Inhibition of cytokine-mediated nitric oxide synthase expression in rat insulinoma cells by scoparone.
PubMed:[Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro].
PubMed:Stimulation of melanogenesis by scoparone in B16 melanoma cells.
PubMed:[Studies on the chemical constituents in herb of Ranunculus japonicus].
PubMed:Biocontrol of aflatoxins B1, B2, G1, G2, and fumonisin B1 with 6,7-dimethoxycoumarin, a phytoalexin from Citrus sinensis.
PubMed:Kinetics study of the photocleavage of (coumarin-4-yl)methyl esters.
PubMed:Production of three O-methhylated esculetins with Escherichia coli expressing O-methyltransferase from poplar.
PubMed:Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida).
PubMed:Biological and physical approaches to improve induced resistance against green mold of stored citrus fruit.
PubMed:The structural elucidation of a novel iridoid derivative from Tachiadenus longiflorus (Gentianaceae) using the LSD programme and quantum chemical computations.
PubMed:Chemical modification of the internal surfaces of cylindrical pores of submicrometer size in poly(ethylene terephthalate).
PubMed:Yb(OTf)3-catalyzed reactions of 5-alkylidene Meldrum's acids with phenols: one-pot assembly of 3,4-dihydrocoumarins, 4-chromanones, coumarins, and chromones.
PubMed:Investigations of the Malagasy species Tachiadenus longiflorus Grisebach (Gentianaceae): linking chemical finding and traditional usage.
PubMed:Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells.
PubMed:Psoralen and coumarin photochemistry in HSA complexes and DMPC vesicles.
PubMed:Simultaneous determination of mycophenolic acid and valproic acid based on derivatization by high-performance liquid chromatography with fluorescence detection.
PubMed:IP3 production in the hypersensitive response of lemon seedlings against Alternaria alternata involves active protein tyrosine kinases but not a G-protein.
PubMed:Sodium carbonate treatment induces scoparone accumulation, structural changes, and alkalinization in the albedo of wounded citrus fruits.
PubMed:Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma Plus LPS.
PubMed:Microstructured scaffolds for liver tissue cultures of high cell density: morphological and biochemical characterization of tissue aggregates.
PubMed:[Studies on the chemical constituents in herb of Ranunculus sceleratus].
PubMed:[Studies on chemical constituents in bud of Artemisia scoparia (III)].
PubMed:Antifungal constituents of Melicope borbonica.
PubMed:A modern examination of an ancient cure.
PubMed:New coumarins from Cedrelopsis grevei.
PubMed:Secondary metabolites from Cedrelopsis grevei (Ptaeroxylaceae).
PubMed:Scoparone inhibits tissue factor expression in lipopolysaccharide-activated human umbilical vein endothelial cells.
PubMed:Pharmacokinetics of a novel anti-asthmatic, scoparone, in the rabbit serum assessed by a simple HPLC method.
PubMed:Vasorelaxing properties and bio-guided fractionation of Cedrelopsis grevei.
PubMed:Anticarcinogenic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione a curcumin analog on DMH-induced colon cancer model.
PubMed:Signal transduction in lemon seedlings in the hypersensitive response against Alternaria alternata: participation of calmodulin, G-protein and protein kinases.
PubMed:Coumarins from Cedrelopsis grevei (Ptaeroxylaceae).
PubMed:Sessiline, a new nitrogenous compound from the fruits of Acanthopanax sessiliflorus.
PubMed:[Studies on chemical constituents in the fruit of Canarium album Raeusch].
PubMed:Effects of the chestnut inner shell extract on the expression of adhesion molecules, fibronectin and vitronectin, of skin fibroblasts in culture.
PubMed:Preliminary structure-antiangiogenic activity relationships of 4-senecioyloxymethyl-6,7-dimethoxycoumarin.
PubMed:Phytochemical constituents from the fruits of Acanthopanax sessiliflorus.
PubMed:Arteminin, a new coumarin from Artemisia apiacea.
PubMed:Enzyme inhibitory constituents from Duranta repens.
PubMed:Transcriptional activation of cytochrome P450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit.
PubMed:A new diprenyl coumarin and alkaloids from the bark of Zanthoxylum dimorphophyllum (Rutaceae).
PubMed:Determinations of morin, quercetin and their conjugate metabolites in serum.
PubMed:Participation of the phosphoinositide metabolism in the hypersensitive response of Citrus limon against Alternaria alternata.
PubMed:Oxidative hydrolysis of scoparone by cytochrome p450 CYP2C29 reveals a novel metabolite.
PubMed:Two new germacranolides from Magnolia grandiflora.
PubMed:A new phorbol diester from Aleurites moluccana.
PubMed:Mode of action of hot-water dip in reducing decay of lemon fruit.
PubMed:Cold preservation of rat cultured hepatocytes: the scoparone effect.
PubMed:Ultraviolet C irradiation at 0.5 kJ.m(-)(2) reduces decay without causing damage or affecting postharvest quality of star ruby grapefruit (C. paradisi Macf.).
PubMed:6,7-dimethoxycoumarin attenuated cisplatin-induced DNA interstrand crosslink and DNA-protein crosslink in primary cultured rabbit kidney proximal tubular cells.
PubMed:Fractionation and analysis of Artemisia capillaris Thunb. by affinity chromatography with human serum albumin as stationary phase.
PubMed:Screening for biological activity and chemical composition of Euodia borbonica var. borbonica (Rutaceae), a medicinal plant in Reunion Island.
PubMed:Mono- and sesquiterpenes and antifungal constituents from Artemisia species.
PubMed:Two new constituents from the leaves of magnolia coco
PubMed:The discriminative stimulus effects of KA 672, a putative cognitive enhancer: evidence for a 5-HT1A component.
PubMed:Interaction of phosphatidic acid and phosphatidylserine with the Ca2+-ATPase of sarcoplasmic reticulum and the mechanism of inhibition.
PubMed:Effects of pH on phosphorylation of the Ca2+-ATPase of sarcoplasmic reticulum by inorganic phosphate.
PubMed:[Chemical constituents of Aralia fargesii Franch].
PubMed:The mechanism of inhibition of the Ca(2+)-ATPase of skeletal-muscle sarcoplasmic reticulum by the cross-linker o-phthalaldehyde.
PubMed:Simultaneous radiometric and fluorimetric detection of lauric acid metabolites using high-performance liquid chromatography following esterification with 4-bromomethyl-6,7-dimethoxycoumarin in human and rat liver microsomes.
PubMed:Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential.
PubMed:Minor constituents from Bupleurum fruticosum roots.
PubMed:Effects of Chinese herbal products on mammalian retinal functions.
PubMed:Structure-activity relationship of coumarins in xanthine oxidase inhibition.
PubMed:Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation.
PubMed:Effects of polycations on Ca2+ binding to the Ca(2+)-ATPase.
PubMed:Identification of Mycobacterium tuberculosis and M. avium complex directly from smear-positive sputum specimens and BACTEC 12B cultures by high-performance liquid chromatography with fluorescence detection and computer-driven pattern recognition models.
PubMed:Effects of gel phase phospholipid on the Ca(2+)-ATPase.
PubMed:Analysis of mycolic acids by high-performance liquid chromatography and fluorimetric detection. Implications for the identification of mycobacteria in clinical samples.
PubMed:Effects of K+ on the binding of Ca2+ to the Ca(2+)-ATPase of sarcoplasmic reticulum.
PubMed:Characterization of the single Ca(2+)-binding site on the Ca(2+)-ATPase reconstituted with short- or long-chain phosphatidylcholines.
PubMed:[Quantitative analysis of 6,7-dimethylesculetin and capillarisine in Artemisia capillaris Thunb. and prescriptions containing the crude drug].
PubMed:Product autofluorescence activation in the cytochrome P450 monooxygenase system.
PubMed:Morphological evidence for the antiatherogenic effect of scoparone in hyperlipidaemic diabetic rabbits.
PubMed:Steric and electronic requirements for chloroflavone congeners as hepatic microsomal monooxygenase inducers.
PubMed:Effect of some hydroxycoumarins on complement-mediated hemolysis in human serum.
PubMed:Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells.
PubMed:Applicability of cultured hepatocytes derived from goat, sheep and cattle in comparative drug metabolism studies.
PubMed:Inhibitory effects of phenolics on xanthine oxidase.
PubMed:Methyltransferase activity in Allanthm altissima cell suspension cultures.
PubMed:Binding of Ca2+ to the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum: kinetic studies.
PubMed:Binding of Ca2+ to the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum: equilibrium studies.
PubMed:Facilitation of retinal function recovery by natural products after temporary ischemic occlusion of central retinal artery.
PubMed:Investigation of derivatization reagents for the analysis of diarrhetic shellfish poisoning toxins by liquid chromatography with fluorescence detection.
PubMed:1-(Tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur) determined in rat hair as an index of drug exposure.
PubMed:Protection by scoparone against the alterations of plasma lipoproteins, vascular morphology and vascular reactivity in hyperlipidaemic diabetic rabbit.
PubMed:[Effects of scoparone on hemodynamics in anesthetized rabbits].
PubMed:[Effects of 6,7-dimethoxycoumarin on experimental arrhythmia].
PubMed:Labeling of immunoglobulins with bifunctional, sulfhydryl-selective, and photoreactive coumarins.
PubMed:[Effects of 6,7-dimethoxycoumarin on left ventricular function and hemodynamics in anesthetized cats].
PubMed:Localization of Cys-344 on the (Ca(2+)-Mg(2+)-ATPase of sarcoplasmic reticulum using resonance energy transfer.
PubMed:Regioselective O-demethylation of scoparone (6,7-dimethoxycoumarin) to assess cytochrome P450 activities in vitro in rat. Effects of gonadal steroids and the involvement of constitutive P450 enzymes.
PubMed:Differences in the effects of model inducers of cytochrome P450 on the biotransformation of scoparone in rat and hamster liver.
PubMed:Further differentiation of 2'- and 4'-chloroflavones as inducers of hepatic microsomal monooxygenases in rats.
PubMed:Scoparone O-demethylase assay is not useful to differentiate the effects of model inducers of cytochrome P-450 in rabbit and guinea pig liver.
PubMed:Synthesis of aminoalkanols derivatives of 6,7-dimethoxy-2H-1-benzopyran-2-one with antiarrhythmic activity.
PubMed:Vasodilator effect of scoparone (6,7-dimethoxycoumarin) from a Chinese herb.
PubMed:Possible mechanism of immunosuppressive effect of scoparone (6,7-dimethoxycoumarin).
PubMed:Labeling the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum with 4-(bromomethyl)-6,7-dimethoxycoumarin: detection of conformational changes.
PubMed:Effects of various medium formulations and attachment substrata on the performance of cultured ruminant hepatocytes in biotransformation studies.
PubMed:Comparative effects of chloroflavone congeners as inducers of hepatic microsomal monooxygenases in rats.
PubMed:New fluorescent derivatives of cyclosporin for use in immunoassays.
PubMed:Accumulation of Scoparone in Heat-Treated Lemon Fruit Inoculated with Penicillium digitatum Sacc.
PubMed:Identification of eight coumarins occurring with psoralen, xanthotoxin, and bergapten on leaf surfaces.
PubMed:[Studies on the chemical constituents of Rutaceae++ plants. LXVI. The chemical constituents of Toddalia asiatica (L.) Lam. (T. aculeata Pers.). (1). Chemical constituents of the root bark].
PubMed:Vasorelaxants from Chinese herbs, emodin and scoparone, possess immunosuppressive properties.
PubMed:2-propyl-1-aminopentane, its deamination by monoamine oxidase and semicarbazide-sensitive amine oxidase, conversion to valproic acid and behavioral effects.
PubMed:Determination of sorbic acid in margarine and butter by high-performance liquid chromatography with fluorescence detection.
PubMed:Biotransformation of scoparone used to monitor changes in cytochrome P450 activities in primary hepatocyte cultures derived from rats, hamsters and monkeys.
PubMed:Determination of the cytochrome P-450 IV marker, omega-hydroxylauric acid, by high-performance liquid chromatography and fluorimetric detection.
PubMed:[Influence of 6,7-dimethoxycoumarin on toxicity and pharmacodynamics of cyclophosphamide].
PubMed:Vascular dilatory action of Artemisia capillaris bud extracts and their active constituent.
PubMed:The sensitizing capacity of coumarins (III).
PubMed:The effect of scoparone, a coumarin derivative isolated from the Chinese crude drug Artemisiae capillaris flos, on the heart.
PubMed:Using the scoparone O-demethylase assay for categorizing types of hepatic microsomal monooxygenase inducers.
PubMed:Application of high-performance liquid chromatographic analysis of scoparone and its metabolites in the study of cytochrome P450 differentiation in vitro.
PubMed:Vascular dilatory action of the Chinese crude drug. II. Effects of scoparone on calcium mobilization.
PubMed:[Determination of choleretic constituents in Artemisia scoparia Waldst. et Kit. by TLC densitometry].
PubMed:Wheat rootlet growth inhibition test of Rwandese medicinal plants: active principles of Tetradenia riparia and Diplolophium africanum.
PubMed:Differentiation of cytochrome P-450 activities with scoparone as substrate. A rapid one-step HPLC-analysis.
PubMed:4-Bromomethyl-6,7-dimethoxycoumarin as a fluorescence reagent for precolumn derivatization of 5-fluorouracil compounds in high-performance liquid chromatography.
PubMed:Mechanism of hypotensive action of scoparone.
PubMed:Selective fluorescent labeling of the 50-, 26-, and 20-kilodalton heavy chain segments of myosin ATPase.
PubMed:[Separation and determination of the cholagogic components in bin hao (Artemisia scoparia) by HPLC].
PubMed:Gas chromatographic-mass spectrometric analysis of monodemethylated metabolites of 6,7- and 7,8-dimethoxycoumarin isomers.
PubMed:The activation of the cytochrome P-450 dependent monooxygenase system by light.
PubMed:Regioselective O-demethylation of scoparone: differentiation between rat liver cytochrome P-450 isozymes.
PubMed:[Studies on the chemical constituents of Pueraria lobata].
PubMed:Induction of cytochrome P-450 isozymes in liver microsomes of rats treated with the cardiotonic agent sulmazole.
PubMed:The effect of imipramine and desipramine on mixed function oxidase in rats.
PubMed:Radioisomers of scoparone (6,7-dimethoxycoumarin) as a tool for in vivo differentiation of various hepatic monooxygenase inducers in mice using the breath test technique.
PubMed:O-demethylation of scoparone and studies on the scoparone-induced spectral change of cytochrome P-450 in rat liver microsomes.
PubMed:Scoparone: effect on reproductive processes in rats.
PubMed:[A fluorometic test for microsomal monooxygenase activity in the rat liver with scoparone as substrate (author's transl)].
PubMed:Absorption, distribution & excretion of scoparone: a potent hypotensive agent.
PubMed:Hypotensive activity of some dihydroxycoumarins and their congeners.
PubMed:Pharmacological action of 6,7-dimethoxy coumarin (Scoparone) isolated from Artemisia scoparia, Waldst & Kit.
PubMed:MASS SPECTOMETRY IN STRUCTURAL AND STEREOCHEMICAL PROBLEMS. LXVI. MASS SPECTRAL FRAGMENTATION OF 6,7-DIMETHOXYCOUMARIN.
PubMed:Ayapin, scopoletin and 6,7-dimethoxycoumarin from Dendrobium thyrsiflorum (Reichb. f.).
 
Notes:
Found in several citrus oils
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