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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 155.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 385.80 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 394.00 °F. TCC ( 201.30 °C. ) (est)
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| logP (o/w): | 1.920 |
| Soluble in: |
| | water, 5121 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-dog LDLo 10 mg/kg
Toxicon. Vol. 6, Pg. 99, 1968.
intraperitoneal-mouse LD50 25 mg/kg
"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(1), Pg. 74, 1982.
oral-mouse LD50 2500 ug/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Science. Vol. 134, Pg. 1617, 1961.
oral-rat LD50 112 mg/kg
Voprosy Pitaniya. Problems of Nutrition. Vol. 42(5), Pg. 67, 1984.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for juglone usage levels up to: | | | not for fragrance use.
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| Recommendation for juglone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | akhnot | | 5- | hydroxy-1,4-naftochinon | | 5- | hydroxy-1,4-naphthoquinone | | 5- | hydroxy-1,4-naphthosemiquinone | | 5- | hydroxynaphthalene-1,4-dione | | 5- | hydroxynaphthoquinone | | | juglon | | 1,4- | naphthoquinone, 5-hydroxy- | | 1,4- | naphthoquinone, 5-hydroxy- (8CI) | | | nucin | | | regianin | | | yuglon
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Articles:
| PubMed:Essential oil alloaromadendrene from mixed-type Cinnamomum osmophloeum leaves prolongs the lifespan in Caenorhabditis elegans. |
| PubMed:Antioxidant Activity and Delayed Aging Effects of Hot Water Extract from Chamaecyparis obtusa var. formosana Leaves. |
| PubMed:Seasonal variation of the main individual phenolics and juglone in walnut (Juglans regia) leaves. |
| PubMed:Antimutagenic and antioxidant properties of plumbagin and other naphthoquinones. |
| PubMed:Potent and specific bactericidal effect of juglone (5-hydroxy-1,4-naphthoquinone) on the fire blight pathogen Erwinia amylovora. |
| PubMed:HPLC determination of phenolic acids, flavonoids and juglone in walnut leaves. |
| PubMed:Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. |
| PubMed:In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum. |
| PubMed:Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism. |
| PubMed:Formation of 5-Hydroxy-3-methoxy-1,4-naphthoquinone and 8-Hydroxy-4-methoxy-1,2-naphthoquinone from Juglone. |
| PubMed:A label-free electrochemical immunosensor for direct, signal-on and sensitive pesticide detection. |
| PubMed:Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans. |
| PubMed:The virulence factor PEB4 (Cj0596) and the periplasmic protein Cj1289 are two structurally related SurA-like chaperones in the human pathogen Campylobacter jejuni. |
| PubMed:Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis. |
| PubMed:Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor. |
| PubMed:Simultaneous detection of pro- and antioxidative effects in the variants of the deoxyribose degradation assay. |
| PubMed:Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1. |
| PubMed:Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. |
| PubMed:Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis. |
| PubMed:Phenolic acids, syringaldehyde, and juglone in fruits of different cultivars of Juglans regia L. |
| PubMed:Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria. |
| PubMed:Proteome-level differences between auxinic-herbicide-susceptible and -resistant wild mustard (Sinapis arvensis L.). |
| PubMed:Impact of dietary allelochemicals on gypsy moth (Lymantria dispar) caterpillars: importance of midgut alkalinity. |
| PubMed:Comparison of the antioxidant activities of extra virgin olive oils. |
| PubMed:Functional conservation of phosphorylation-specific prolyl isomerases in plants. |
| PubMed:Regulation of aflatoxin production by naphthoquinones of walnut (Juglans regia). |
| PubMed:Volatile components of green walnut husks. |
| PubMed:Namibian chewing stick, Diospyros lycioides, contains antibacterial compounds against oral pathogens. |
| PubMed:Pro- and antioxidative properties of cortical tissue preparations from human brain exhibiting NMDA-receptor characteristics. |
| PubMed:Differential toxicity of juglone (5-hydroxy-1,4-naphthoquinone) and related naphthoquinones to saturniid moths. |
| PubMed:Black walnut toxicosis in ten horses. |
| PubMed:Chemical ecology of the luna moth : Effects of host plant on detoxification enzyme activity. |
| PubMed:[Hygienic characteristics of a naphthoquinone preservative (juglone)]. |
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3D/inchi