methylthioadenosine
5'-S-methyl-5'-thioadenosine

Supplier Sponsors

• 
  BOC Sciences

  Best of Chemicals Supplier
  Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
  BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
  BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
  Email:	Marketing
  US Email:	Marketing
  Email:	Sales
  US Email:	Sales
  Voice: 1-631-485-4226
  Fax: 1-631-614-7828
  US Voice: 1-631-485-4226
  US Fax: 1-631-614-7828
  Europe	44-203-286-1088
  Facebook
  Twitter
  Linkedin
  Blog
  Get the App!
  CODE120747 CODE120747
  Product(s):
  2457-80-9 5'-S-Methyl-5'-thioadenosine 0.98
  Methylthioadenosine, also known as MTA and 5'-Methylthioadenosine, is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues.

Name: (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol CAS Number: 2457-80-9 3D/inchi FDA UNII: 634Z2VK3UQ Nikkaji Web: J419.054H Beilstein Number: 0042420 MDL: MFCD00010533 XlogP3-AA: -0.30 (est) Molecular Weight: 297.33815000 Formula: C11 H15 N5 O3 S NMR Predictor: Predict (works with chrome, Edge or firefox) Category:cosmetic ingredient for skin conditioning   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Soluble in:   water, 3607 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: CosIng: cosmetic data Cosmetic Uses: skin conditioning   Suppliers: BOC Sciences For experimental / research use only. 5'-S-Methyl-5'-thioadenosine 0.98 Odor: characteristic Use: Methylthioadenosine, also known as MTA and 5'-Methylthioadenosine, is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues.   Safety Information:   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: Not determined Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: cosmetic ingredient for skin conditioning Recommendation for methylthioadenosine usage levels up to:   not for fragrance use.   Recommendation for methylthioadenosine flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :439176 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol Chemidplus:0002457809 RTECS:AU7410000 for cas# 2457-80-9   References:   (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol NIST Chemistry WebBook: Search Inchi Pubchem (cid): 439176 Pubchem (sid): 135056035   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View Golm Metabolome Database: Search KEGG (GenomeNet): C00170 HMDB (The Human Metabolome Database): HMDB01173 FooDB: FDB022465 YMDB (Yeast Metabolome Database): YMDB00178 Export Tariff Code: 2934.90.5000 ChemSpider: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms:   adenosine thiomethylpentose   adenosine, 5'-S-methyl-5'-thio- (2R,3R,4S,5S)-2-(6- aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol 5- deoxy-5-(methyl thio) adenosine   methyl thioadenosine 5'-S- methyl-5'-thioadenosine   vitamin L2   Articles:   None found yet. Try the PubMed Search.

Notes: 5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. It is produced from S-adenosylmethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory product. MTA is metabolized solely by MTA-phosphorylase, to yield 5-methylthioribose-1-phosphate and adenine, a crucial step in the methionine and purine salvage pathways, respectively. Evidence suggests that MTA can affect cellular processes in many ways. For instance, MTA has been shown to influence regulation of gene expression, proliferation, differentiation and apoptosis (PMID 15313459). 5-Methylthioadenosine can be found in human urine. Elevated excretion appears in children with severe combined immunodeficiency syndrome (PMID 3987052) [HMDB]