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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 149.80 °C. @ 760.00 mm Hg
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| Boiling Point: | 380.61 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.396000 mmHg @ 20.00 °C. |
| Flash Point: | 360.00 °F. TCC ( 182.30 °C. ) (est)
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| logP (o/w): | -1.300 (est) |
| Soluble in: |
| | water, 1.00E+06 mg/L @ 20 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 923 mg/kg
Toxicon. Vol. 23, Pg. 815, 1985.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for 4-hydroxypyridine usage levels up to: | | | not for fragrance use.
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| Recommendation for 4-hydroxypyridine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| gamma- | hydroxypyridine | | | pyridin-4-ol | | 1H- | pyridin-4-one | | 4- | pyridinol | | 4- | pyridone |
Articles:
| PubMed:Synthesis, characterization and binding affinities of rhenium(I) thiosemicarbazone complexes for the estrogen receptor (α/β). |
| PubMed:The role of substrate strain in the mechanism of the carbon-carbon lyases. |
| PubMed:Switching the conductance of a molecular junction using a proton transfer reaction. |
| PubMed:The Flögel-three-component reaction with dicarboxylic acids - an approach to bis(β-alkoxy-β-ketoenamides) for the synthesis of complex pyridine and pyrimidine derivatives. |
| PubMed:An experimental and theoretical approach of spectroscopic and structural properties of a new chelidamate copper (II) complex. |
| PubMed:Syntheses, structures, properties and DFT study of hybrid inorganic-organic architectures constructed from trinuclear lanthanide frameworks and Keggin-type polyoxometalates. |
| PubMed:catena-Poly[[di-μ2-aqua-hexaaquabis(μ3-4-oxidopyridine-2,6-dicarboxylato)trimanganese(II)] trihydrate]: a new one-dimensional coordination polymer based on a trinuclear Mn(II) complex of chelidamic acid. |
| PubMed:Synthesis, structure and characterization of a helical seven-coordinated pyridine-2,6-dicarboxylate-bridged cadmium(II) complex. |
| PubMed:Synthesis of trans-(4-hydroxypyridine)(ammine)dichloroplatinum(II) and its activity in the human ovarian tumour models. |
| PubMed:Pseudopolymorphs of chelidamic acid and its dimethyl ester. |
| PubMed:Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening. |
| PubMed:Simplified bicyclic pyridinol analogues protect mitochondrial function. |
| PubMed:4-Pyridone-terephthalic acid-water (2/1/2) and bis(3-hydroxypyridinium) terephthalate. |
| PubMed:Decaaquabis(μ3-4-hydroxypyridine-2,6-dicarboxylato)bis(4-hydroxypyridine-2,6-dicarboxylato)tetramanganese(II) 3.34-hydrate: a new three-dimensional open metal-organic framework based on a tetranuclear Mn(II) complex of chelidamic acid and undecameric stitching water clusters. |
| PubMed:A practical two-step procedure for the preparation of enantiopure pyridines: Multicomponent reactions of alkoxyallenes, nitriles and carboxylic acids followed by a cyclocondensation reaction. |
| PubMed:A zeolitic porous lithium-organic framework constructed from cubane clusters. |
| PubMed:A three-component synthesis of beta-alkoxy-beta-keto-enamides--flexible precursors for 4-hydroxypyridine derivatives and their palladium-catalysed reactions. |
| PubMed:The effects of tautomerism on the nature of molecules in the solid state. |
| PubMed:Three-component synthesis of perfluoroalkyl- or perfluoroaryl-substituted 4-hydroxypyridine derivatives and their palladium-catalyzed coupling reactions. |
| PubMed:Studies on the synthesis and activity of three tripalladium complexes containing planaramine ligands. |
| PubMed:Synthesis, activity and binding with DNA of [{trans-PtCl(NH(3))(2)}(2)micro-{trans-Pd(4-hydroxypyridine) (2) (H(2)N(CH(2))(6)NH(2))(2)]Cl(4) (TH8). |
| PubMed:A new and flexible synthesis of 4-hydroxypyridines: rapid access to caerulomycins A, E and functionalized terpyridines. |
| PubMed:Coordination polymers with pyridine-2,4,6-tricarboxylic acid and alkaline-earth/lanthanide/transition metals: synthesis and X-ray structures. |
| PubMed:Construction of subphthalocyanine-porphyrin and subphthalocyanine-phthalocyanine heterodyads through axial coordination. |
| PubMed:Characterization of subdomain IIA binding site of human serum albumin in its native, unfolded, and refolded states using small molecular probes. |
| PubMed:Saccharide recognition-induced transformation of pyridine-pyridone alternate oligomers from self-dimer to helical complex. |
| PubMed:Sequential treatment with SN-38 followed by 5-fluorouracil shows synergistic cytotoxic activity in small cell lung cancer cells. |
| PubMed:A study on the inhibition of adenosine deaminase. |
| PubMed:Gas-phase tautomeric equilibrium of 4-hydroxypyrimidine with its ketonic forms: a free jet millimeterwave spectroscopy study. |
| PubMed:Studies on the activity of three palladium(II) compounds of the form: trans-PdL2Cl2 where L=2-hydroxypyridine, 3-hydroxypyridine, and 4-hydroxypyridine. |
| PubMed:Aminoacrylate intermediates in the reaction of Citrobacter freundii tyrosine phenol-lyase. |
| PubMed:Synthesis and characterization of metal-organic frameworks based on 4-hydroxypyridine-2,6-dicarboxylic acid and pyridine-2,6-dicarboxylic acid ligands. |
| PubMed:Reaction paths of tautomerization between hydroxypyridines and pyridones. |
| PubMed:Mn(II) staircase structures stitched by water clusters to a 3D metal-organic open framework: X-ray structural and magnetic studies. |
| PubMed:Synthesis, characterization and binding with DNA of four planaramineplatinum(II) complexes of the forms: trans-PtL2Cl2 and [PtL3Cl]Cl, where L = 3-hydroxypyridine, 4-hydroxypyridine and imidazo(1,2-alpha)pyridine. |
| PubMed:Synthesis and characterization of hydrogen-bonded assemblies of W6S8L6 clusters. |
| PubMed:Metal-ligand induced supramolecular polymerization: a route to responsive materials. |
| PubMed:Multistimuli, multiresponsive metallo-supramolecular polymers. |
| PubMed:Piericidins C5 and C6: new 4-pyridinol compounds produced by Streptomyces sp. and Nocardioides sp. |
| PubMed:4-Hydroxypyridine-2,6-dicarboxylatodioxovanadate(V) complexes: solid state and aqueous chemistry. |
| PubMed:Calixarenes as scaffolds: introduction of tridentate rare earth metal binding units into calix[4]arene. |
| PubMed:Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm). |
| PubMed:Chemoenzymatic synthesis of isogalactofagomine. |
| PubMed:Comparative induction of CYP1A1 expression by pyridine and its metabolites. |
| PubMed:Ethylenediamine-palladium(II) complexes with pyridine and its derivatives: synthesis, molecular structure and initial antitumor studies. |
| PubMed:Persistent induction of apoptosis and suppression of mitosis as the basis for curative therapy with S-1, an oral 5-fluorouracil prodrug in a colorectal tumor model. |
| PubMed:Comparison of the effects of pyridine and its metabolites on rat liver and kidney. |
| PubMed:Effect of haloperidol and its metabolites on dopamine and noradrenaline uptake in rat brain slices. |
| PubMed:Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia. |
| PubMed:Binding of phenol and analogues to alanine complexes of tyrosine phenol-lyase from Citrobacter freundii: implications for the mechanisms of alpha,beta-elimination and alanine racemization. |
| PubMed:Validation of whole chick embryo cultures, whole rat embryo cultures and aggregating embryonic brain cell cultures using six pairs of coded compounds. |
| PubMed:Potential for carboxylation-dehydroxylation of phenolic compounds by a methanogenic consortium. |
| PubMed:New 4-hydroxypyridine and 4-hydroxyquinoline derivatives as inhibitors of NADH-ubiquinone reductase in the respiratory chain. |
| PubMed:[Presynaptic effects of aminopyridines on the neuromuscular junction of vertebrates]. |
| PubMed:Rapid liquid chromatographic determination of clopidol in chicken muscles. |
| PubMed:Tissue residues of clopidol (3,5-dichloro-2,6-dimethyl-4-pyridinol) in chickens in relation to withdrawal times. |
| PubMed:Increase in transmitter release from motor nerve terminals induced by some pyridine derivatives. |
| PubMed:Synthesis of potential anticancer agents. Pyrido[4,3-b][1,4]oxazines and pyrido[4,3-b][1,4]thiazines. |
| PubMed:New broad-spectrum cephalosporins with anti-pseudomonal activity. II. Synthesis and antibacterial activity of 7 beta-[2-acylamino-2-(4-hydroxyphenyl)acetamido]-3-[ (1-methyl-1H-tetrazol-5-yl)thiomethyl]ceph-3-em-4-carboxylic acids. |
| PubMed:New broad-spectrum cephalosporins with anti-pseudomonal activity. I. Synthesis and antibacterial activity of 7 beta-[D-2-[(4-hydroxy-1,5-naphthyridine-3-carbonylamino)- and (4-hydroxypyridine-3-carbonylamino)]-2-(4-hydoxyphenyl)acetamido] cephalosporins. |
| PubMed:Metabolism of carcinogenic and non-carcinogenic N-nitroso-N-methylaminopyridines. II. Investigations in vivo. |
| PubMed:Vitamin K-dependent carboxylase. Partial purification and properties of the enzyme-substrate complex. |
| PubMed:Metabolism of carcinogenic and non-carcinogenic N-nitroso-N-methylaminopyridines. I. Investigations in vitro. |
| PubMed:In vitro inhibition of vitamin K dependent carboxylation by tetrachloropyridinol and the imidazopyridines. |
| PubMed:Microbial metabolism of the pyridine ring. The metabolism of pyridine-3,4-diol (3,4-dihydroxypyridine) by Agrobacterium sp. |
| PubMed:Microbial metabolism of the pyridine ring. The hydroxylation of 4-hydroxypyridine to pyridine-3,4-diol (3,4-dihydroxypyridine) by 4-hydroxypyridine-3-hydroxylase. |
| PubMed:Synthesis and anticoccidial activity of 3-fluoro-5-chloro- and -bromo-2,6-dimethyl-4-pyridinol. |
| PubMed:Microbial metabolism of the pyridine ring. Formation of pyridinediols (dihydroxypyridines) as intermediates in the degradation of pyridine compounds by micro-organisms. |
| PubMed:Antimalarial activity of clopidol, 3,5-dichloro-2,6-dimethyl-4-pyridinol, and its esters, carbonates, and sulfonates. |
| PubMed:Potency and coagulation factor effects of 2,3,5,6-tetrachloro-4-pyridinol compared to warfarin and its antagonism by vitamin K. |
| PubMed:2,3,5,6-tetrachloro-4-pyridinol: a new chemical structure for anticoagulant activity. |
| PubMed:Inhibition of carotenoid synthesis as a mechanism of action of amitrole, dichlormate, and pyriclor. |
| PubMed:The metabolism of 4-hydroxypyridine by Agrobacterium sp.: a new ring cleavage of the pyridine nucleus. |
| PubMed:[Nitration of 2-methyl-4-hydroxypyridine and 2-methyl-4-ethoxypyridine]. |
| PubMed:Fluorescence studies on some hydroxypyridines including compounds of the vitamin B6 group. |
| PubMed:[Synthesis of heterocyclic compounds with nitrogen. 98. Reaction of alpha-halogenated ketones with 3-nitro-4-hydroxypyridine and with 3-amino-4-hydroxypyridine]. |
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3D/inchi