EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

sodium paraben
benzoic acid, 4-hydroxy-, sodium salt (1:1)

Supplier Sponsors

CAS Number: 114-63-6Picture of molecule3D/inchi
Other(deleted CASRN):178120-64-4
ECHA EINECS - REACH Pre-Reg:204-051-1
FDA UNII: V6102T509B
Beilstein Number:4163553
Molecular Weight:160.10421928
Formula:C7 H5 Na O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
BOC Sciences
For experimental / research use only.
4-hydroxybenzoic acid sodium salt
Santa Cruz Biotechnology
For experimental / research use only.
Sodium 4-hydroxybenzoate ≥99%
For experimental / research use only.
Sodium 4-hydroxybenzoate
For experimental / research use only.
Sodium 4-Hydroxybenzoate >99.0%(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 1200 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.

oral-mouse LD50 2200 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Recommendation for sodium paraben usage levels up to:
 not for fragrance use.
Recommendation for sodium paraben flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):114-63-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :16219477
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
RTECS:DH2900000 for cas# 114-63-6
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:114-63-6
Pubchem (cid):16219477
Pubchem (sid):134974536
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2918.29.7500
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
 benzoic acid, 4-hydroxy-, monosodium salt
 benzoic acid, 4-hydroxy-, sodium salt (1:1)
 benzoic acid, p-hydroxy-, sodium salt
4-hydroxybenzoic acid sodium salt
p-hydroxybenzoic acid sodium salt
 sodium 4-hydroxybenzoate
monosodium 4-hydroxybenzoate
 sodium p-hydroxybenzoate
monosodium p-hydroxybenzoate


PubMed:Development studies on determination of preservatives decomposition products.
PubMed:Biochemical characterization of Aspergillus oryzae native tannase and the recombinant enzyme expressed in Pichia pastoris.
PubMed:Evaluating food additives as antifungal agents against Monilinia fructicola in vitro and in hydroxypropyl methylcellulose-lipid composite edible coatings for plums.
PubMed:Prevalence of sensitivity to food and drug additives in patients with chronic idiopathic urticaria.
PubMed:Antimicrobial and antibiofilm effects of selected food preservatives against Salmonella spp. isolated from chicken samples.
PubMed:The role of xerostomia in burning mouth syndrome: a case-control study.
PubMed:New sorbent in the dispersive solid phase extraction step of quick, easy, cheap, effective, rugged, and safe for the extraction of organic contaminants in drinking water treatment sludge.
PubMed:Application properties of oral gels as media for administration of minitablets and pellets to paediatric patients.
PubMed:[Severe allergic reaction due to a rectal enema].
PubMed:Drug-excipient compatibility studies in binary mixtures of avobenzone.
PubMed:Accelerated stability and bioassay of a new oral ╬▒-ketoglutarate formulation for treating cyanide poisoning.
PubMed:Esterification of sodium 4-hydroxybenzoate by ultrasound-assisted solid-liquid phase-transfer catalysis using dual-site phase-transfer catalyst.
PubMed:[Destruction of aromatic hydrocarbons by the Rhodococcus wratislaviensis KT112-7 strain isolated from waste products of a salt-mining factory].
PubMed:Solid lipid nanoparticles as effective reservoir systems for long-term preservation of multidose formulations.
PubMed:Greener liquid chromatography using a guard column with micellar mobile phase for separation of some pharmaceuticals and determination of parabens.
PubMed:Key role for efflux in the preservative susceptibility and adaptive resistance of Burkholderia cepacia complex bacteria.
PubMed:Surfactant and temperature effects on paraben transport through silicone membranes.
PubMed:Determination of preservatives in cosmetics, cleaning agents and pharmaceuticals using fast liquid chromatography.
PubMed:Different strategies for the preconcentration and separation of parabens by capillary electrophoresis.
PubMed:Ovariectomized mouse uterotrophic assay of 36 chemicals.
PubMed:Simultaneous determination of eleven preservatives in cosmetics by micellar electrokinetic chromatography.
PubMed:Hospitalised neonates in Estonia commonly receive potentially harmful excipients.
PubMed:A new reconstitutable oral paediatric hydrocortisone solution containing hydroxypropyl-╬▓-cyclodextrin.
PubMed:HPLC-fluorescence method for measurement of the uremic toxin indoxyl sulfate in plasma.
PubMed:Application of vesicular coacervate phase for microextraction based on solidification of floating drop.
PubMed:Dissociation constants of parabens and limiting conductances of their ions in water.
PubMed:Far infrared-assisted extraction followed by MEKC for the simultaneous determination of flavones and phenolic acids in the leaves of Rhododendron mucronulatum Turcz.
PubMed:Development and application of a validated stability-indicating high-performance liquid chromatographic method using photodiode array detection for simultaneous determination of granisetron, methylparaben, propylparaben, sodium benzoate, and their main degradation products in oral pharmaceutical preparations.
PubMed:In vitro analyses of the effects of heparin and parabens on Candida albicans biofilms and planktonic cells.
PubMed:Kinetic study of a complex triangular reaction system in alkaline aqueous-ethanol medium using on-line transmission FTIR spectroscopy and BTEM analysis.
PubMed:Antioxidant activity of papaya seed extracts.
PubMed:Monolithic capillary columns synthesized from a single phosphate-containing dimethacrylate monomer for cation-exchange chromatography of peptides and proteins.
PubMed:Interaction and solubilization of some phenolic antioxidants in Pluronic® micelles.
PubMed:Contact allergy to preservatives. Analysis of IVDK data 1996-2009.
PubMed:A novel antimicrobial and antithrombotic lock solution for hemodialysis catheters: a multi-center, controlled, randomized trial.
PubMed:Preservatives and fragrances in selected consumer-available cosmetics and detergents.
PubMed:Enhancement of plant essential oils' aqueous solubility and stability using alpha and beta cyclodextrin.
PubMed:Identification and characterization of a novel CprA reductive dehalogenase specific to highly chlorinated phenols from Desulfitobacterium hafniense strain PCP-1.
PubMed:Simultaneous determination of electroactive and non-electroactive food preservatives by novel capillary electrophoresis with amperometric detection.
PubMed:Electrophoretic deposition of TiO2 and composite TiO2-MnO2 films using benzoic acid and phenolic molecules as charging additives.
PubMed:Photostabilization of papaverine hydrochloride solutions.
PubMed:Progress in decontamination by halophilic microorganisms in saline wastewater and soil.
PubMed:[Analysis of preservatives used in cosmetic products: salicylic acid, sodium benzoate, sodium dehydroacetate, potassium sorbate, phenoxyethanol, and parabens].
PubMed:Interaction between liquid protein solution and omeprazole suspension.
PubMed:Mechanisms of membrane transport of poorly soluble drugs: role of micelles in oral absorption processes.
PubMed:Ultrasound-assisted emulsification-microextraction of phenolic preservatives in water.
PubMed:Comparative toxicity of preservatives on immortalized corneal and conjunctival epithelial cells.
PubMed:Curative and preventive activity of hydroxypropyl methylcellulose-lipid edible composite coatings containing antifungal food additives to control citrus postharvest green and blue molds.
PubMed:Microbial inactivation properties of a new antimicrobial/antithrombotic catheter lock solution (citrate/methylene blue/parabens).
PubMed:Inhibition of Penicillium digitatum and Penicillium italicum by hydroxypropyl methylcellulose-lipid edible composite films containing food additives with antifungal properties.
PubMed:Influence of preservatives on the stability of ethyl glucuronide and ethyl sulphate in urine.
PubMed:Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p.
PubMed:Simultaneous determination of some water-soluble vitamins and preservatives in multivitamin syrup by validated stability-indicating high-performance liquid chromatography method.
PubMed:Simultaneous determination of p-hydroxybenzoic acid and parabens by capillary electrophoresis with improved sensitivity in nonaqueous media.
PubMed:Predicting blood-brain barrier penetration of drugs by microemulsion liquid chromatography with corrected retention factor.
PubMed:Determination of some phenolic acids in Majorana hortensis by capillary electrophoresis with online electrokinetic preconcentration.
PubMed:New validated liquid chromatographic and chemometrics-assisted UV spectroscopic methods for the determination of two multicomponent cough mixtures in syrup.
PubMed:On-line pretreatment and determination of parabens in cosmetic products by combination of flow injection analysis, solid-phase extraction and micellar electrokinetic chromatography.
PubMed:Separation and determination of ketoprofen, methylparaben and propylparaben in pharmaceutical preparation by micellar electrokinetic chromatography.
PubMed:Optimisation of the caco-2 permeability assay using experimental design methodology.
PubMed:Analysis of the antimicrobial activity of local anaesthetics used for dental analgesia.
PubMed:Heteroscedasticity of retention factor and adequate modeling in micellar liquid chromatography.
PubMed:Mycoflora of two types of Portuguese dry-smoked sausages and inhibitory effect of sodium benzoate, potassium sorbate, and methyl p-hydroxybenzoate on mold growth rate.
PubMed:Pressurized liquid extraction with in-cell clean-up followed by gas chromatography-tandem mass spectrometry for the selective determination of parabens and triclosan in indoor dust.
PubMed:Application of a validated method in the stability study of colistin sulfate and methylparaben in a veterinary suspension formulation by high-performance liquid chromatography with a diode array detector.
PubMed:Inhibition of conidia germination and mycelial growth of Botrytis cinerea by some alternative chemicals.
PubMed:Study of hydroxy propyl guar derivative for its gelling property and it's use in the formulation of tenoxicam gels.
PubMed:Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein.
PubMed:Determination of parabens and triclosan in indoor dust using matrix solid-phase dispersion and gas chromatography with tandem mass spectrometry.
PubMed:Effect of formulation factors on in-vitro permeation of diclofenac from experimental and marketed aqueous eye drops through excised goat cornea.
PubMed:[Contact allergy to preservatives contained in cosmetics].
PubMed:Phenotypic alterations and cytokine production in THP-1 cells in response to allergens.
PubMed:Assay of artemether, methylparaben and propylparaben in a formulated paediatric antimalarial dry suspension.
PubMed:Identification and classification of skin sensitizers: identifying false positives and false negatives.
PubMed:[Kanamycin induced ototoxicity in three kinds of mouse strains and its effects on the expression of na-K-2Cl co-transporter-1 in stria vascularis].
PubMed:Stimulation of polyprenyl 4-hydroxybenzoate transferase activity by sodium cholate and 3-[(cholamidopropyl)dimethylammonio]-1-propanesulfonate.
PubMed:Optimisation of a solid-phase microextraction method for the determination of parabens in water samples at the low ng per litre level.
PubMed:Sodium cation affinities of MALDI matrices determined by guided ion beam tandem mass spectrometry: application to benzoic acid derivatives.
PubMed:Application and validation of chemometrics-assisted spectrophotometry and liquid chromatography for the simultaneous determination of six-component pharmaceuticals.
PubMed:Liquid chromatography and chemometric-assisted spectrophotometric methods for the analysis of two multicomponent mixtures containing cough suppressant drugs.
PubMed:Separation and determination of clotrimazole, methylparaben and propylparaben in pharmaceutical preparation by micellar electrokinetic chromatography.
PubMed:Comparison of microemulsion electrokinetic chromatography and micellar electrokinetic chromatography methods for the analysis of phenolic compounds.
PubMed:Controlling the proliferation of Zygosaccharomyces bailii in ephedrine anti-phlegm cough mixture.
PubMed:Application of a capillary electrophoresis method for simultaneous determination of preservatives in pharmaceutical formulations.
PubMed:Safety of ingredients used in cosmetics.
PubMed:Stability of an Extemporaneously Compounded Propylthiouracil Suspension.
PubMed:Partition of antimicrobial additives in an intravenous emulsion and their effect on emulsion physical stability.
PubMed:Compatibility of sennoside A and B with pharmaceutical excipients.
PubMed:Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury.
PubMed:Optimization by experimental design and artificial neural networks of the ion-interaction reversed-phase liquid chromatographic separation of twenty cosmetic preservatives.
PubMed:Improving the aqueous solubility of triclosan by solubilization, complexation, and in situ salt formation.
PubMed:Determination of chlorpheniramine maleate and tincture ipecac in dosage form by liquid chromatography with ultraviolet detection.
PubMed:Antiprotozoal activities of symmetrical bishydroxamic acids.
PubMed:Allergy and toxic reactions to local anesthetics.
PubMed:Biotransformation of 3,5-dibromo-4-hydroxybenzonitrile under denitrifying, Fe(III)-reducing, sulfidogenic, and methanogenic conditions.
PubMed:Larvicidal effects of mineral turpentine, low aromatic white spirits, aqueous extracts of Cassia alata, and aqueous extracts, ethanolic extracts and essential oil of betel leaf (Piper betle) on Chrysomya megacephala.
PubMed:Electrochemical oxidation of p-hydroxybenzoic and protocathecuic acids at a dimensional stable anode (DSA) in the presence of NaCl.
PubMed:High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate.
PubMed:4-Hydroxybenzoate uptake in Klebsiella planticola strain DSZ1 is driven by DeltapH.
PubMed:Shellac formulations to reduce epiphytic survival of coliform bacteria on citrus fruit postharvest.
PubMed:Properties of diphenolase from Vanilla planifolia (Andr.) shoot primordia cultured in vitro.
PubMed:Analytical control of a pharmaceutical formulation of sodium picosulfate by capillary zone electrophoresis.
PubMed:Oxidation of p-hydroxybenzoic acid by Fenton's reagent.
PubMed:Argentometric titration for the determination of liquid chromatographic injection reproducibility.
PubMed:Separation and determination of haloperidol, parabens and some of their degradation products by micellar electrokinetic chromatography.
PubMed:Effects of mono-, di- and tri-hydroxybenzoic acids on the nitrosation of propranolol: structure-activity relationship.
PubMed:Comparison of HOCl traps with myeloperoxidase inhibitors in prevention of low density lipoprotein oxidation.
PubMed:Stability of extemporaneous norfloxacin suspension.
PubMed:Spontaneous hydrolysis of 4-trifluoromethylphenol to a quinone methide and subsequent protein alkylation.
PubMed:Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice.
PubMed:Adsorption of esters of p-hydroxybenzoic acid by filter membranes: mechanism and effect of formulation and processing parameters.
PubMed:Effect of ecological factors on the inhibitory spectrum and activity of bacteriocins.
PubMed:First derivative spectrophotometric and high-performance liquid chromatographic determination of cinchocaine hydrochloride in presence of its acid degradation product.
PubMed:Mechanism for the enzymatic formation of 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate during the biosynthesis of methanopterin.
PubMed:Prediction of Listeria spp. growth as affected by various levels of chemicals, pH, temperature and storage time in a model broth.
PubMed:Evaluation of preservative effectiveness in pharmaceutical products: the use of a wild strain of Pseudomonas cepacia.
PubMed:A method for preserving saliva samples at ambient temperatures.
PubMed:Synthesis and characterization of pH-sensitive poly(organophosphazene) hydrogels.
PubMed:Evaluation of sodium 4-hydroxybenzoate as an hydroxyl radical trap using gas chromatography-mass spectrometry and high-performance liquid chromatography with electrochemical detection.
PubMed:Na(+)-translocating cytochrome bo terminal oxidase from Vitreoscilla: some parameters of its Na+ pumping and orientation in synthetic vesicles.
PubMed:Purification and characterization of an oxygen-sensitive, reversible 3,4-dihydroxybenzoate decarboxylase from Clostridium hydroxybenzoicum.
PubMed:Use-dependent inhibition of Na+ currents by benzocaine homologs.
PubMed:Determination of dexamethasone sodium phosphate in the vitreous by high performance liquid chromatography.
PubMed:[Aspirin-induced asthma as an important type of bronchial asthma].
PubMed:Demonstration of synergy with fluconazole and either ibuprofen, sodium salicylate, or propylparaben against Candida albicans in vitro.
PubMed:[Preservation and stability of corn tortillas at room temperature].
PubMed:Evaluation of predictable irritative power of surfactant mixtures by human fibroblast culture and its correlation to physico-chemical parameters.
PubMed:Experimental design for the rapid selection of separation conditions for methyl and propyl parahydroxybenzoate, phenylephrine hydrochloride and chlorphenamine maleate by ion-pair liquid chromatography.
PubMed:The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test.
PubMed:Clostridium hydroxybenzoicum sp. nov., an amino acid-utilizing, hydroxybenzoate-decarboxylating bacterium isolated from methanogenic freshwater pond sediment.
PubMed:Evaluation of phototoxic properties of some food additives: sulfites exhibit prominent phototoxicity.
PubMed:Complete oxidation of benzoate and 4-hydroxybenzoate by a new sulfate-reducing bacterium resembling Desulfoarculus.
PubMed:DNA cleavage by metabolites of butylated hydroxytoluene.
PubMed:[A case of asthma relieved by aspirin--the first case in Japan and investigation of its mechanism].
PubMed:Subconjunctival gentamicin induction of extraocular toxic muscle myopathy.
PubMed:Stability of succinylcholine chloride injection.
PubMed:The use of a new laser particle sizer and shape analyser to detect and evaluate gelatinous microparticles suspended in reconstituted anthracycline infusion solutions.
PubMed:Liquid chromatographic determination of clobetasone-17-butyrate in ointments.
PubMed:The coenzyme analogue adenosine 5-diphosphoribose displaces FAD in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation.
PubMed:Separation of water-soluble vitamins by micellar electrokinetic chromatography.
PubMed:Assessment of salicylate derivatives for potential use in ulcerative colitis: proposal for a new action of 5-aminosalicylic acid?
PubMed:Stabilization of meat lipids with nitrite-free curing mixtures.
PubMed:The elucidation of the microheterogeneity of highly purified p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens by various biochemical techniques.
PubMed:Difference spectrophotometric assay of 5-hydroxymethylfurfuraldehyde in hydrolysed pharmaceutical syrups--I. Sodium borohydride reagent.
PubMed:Adverse reactions to food additives.
PubMed:Measurement of the distribution parameter in solubilized systems. Application of the derivative spectrum method to alkylparabens solubilized with sodium dodecyl sulfate.
PubMed:Colorimetric determination of carboxypeptidase A activity in serum.
PubMed:[Adverse reactions to food preservatives].
PubMed:Inhibition by antimicrobial food additives of ochratoxin A production by Aspergillus sulphureus and Penicillium viridicatum.
PubMed:[Influence of salicylaldehyde and its analogs on the antispermatogenic effect of gossypol].
PubMed:[Eczema of the lower leg and contact allergy].
PubMed:Optimal conditions for 4-hydroxybenzoyl- and 2-furoylhydrazine as reagents for the determination of carbohydrates, including ketosamines.
PubMed:Effects of preservatives, steroids, and ethylenediaminetetraacetate on the antimicrobial activity of sulfacetamide.
PubMed:Dyes, preservatives and salicylates in the induction of food intolerance and/or hypersensitivity in children.
PubMed:Paraben-associated autoanti-Jka antibodies. Three examples detected using commercially prepared low-ionic strength saline containing parabens.
PubMed:Nitrite, nitrite alternatives, and the control of Clostridium botulinum in cured meats.
PubMed:[Allergy to preservatives].
PubMed:High-performance liquid chromatographic determination of metaraminol bitartrate in the presence of parabens.
PubMed:A study of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Improved purification, relative molecular mass, and amino acid composition.
PubMed:Quantitative dexamethasone and dexamethasone sodium phosphate determinations in pharmaceutical dosage forms by high-pressure liquid chromatography.
PubMed:[Gel filtration of solubilized systems. II. Studies on the complexes of sodium lauryl sulfate and alkyl paraben by the gel filtration on Bio Gel P-4 (author's transl)].
PubMed:Column chromatographic analysis of barbiturates in their dosage forms. IV. Combinations with parabens.
PubMed:Quantitative determination of four antihistamines in combination by high-pressure liquid chromatography.
PubMed:Effects of detergents on the properties of 4-hydroxybenzoate. Polyprenyl transferase and the specificity of the polyprenyl pyrophosphate synthetic system in mitochondria.
PubMed:Comparison of compounds used for intradermal anesthesia.
PubMed:On the solubilization properties of surfactant-polymer complexes.
PubMed:Reduction of activity of cyanocobalamin in the presence of methylparaben sodium at autoclave temperature.
PubMed:Effect of sodium butyrate on mammalian cells in culture: a review.
PubMed:[Chronic urticaria. Provocation test].
PubMed:Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias.
PubMed:Effect of flavoring oils on preservative concentrations in oral liquid dosage forms.
PubMed:Neutral amino acid transport in cultivated human skin fibrovlasts (38521).
PubMed:Pharmaceutics of cephapirin sodium (Cefadyl) a new semisynthetic cephalosporin - part III.
PubMed:The effect of urea on the solubility of methyl p-hydroxybenzoate in aqueous sodium chloride solutions.
PubMed:Effect of different anions on 22Na permeability of liposomes.
PubMed:Influence of polysorbate 20 and sodium cholate on uptake of p-hydroxybenzoates by the frog, Nana pipiens.
PubMed:The tolerance and safety of intravenously administered benzyl alcohol in methylprednisolone sodium succinate formulations in normal human subjects.
PubMed:Allergic contact dermatitis due to ingredients of vehicles. A "vehicle tray" for patch testing.
PubMed:Some biochemical and anatomic effects of sodium salicylate on the chick embryo heart.
PubMed:Penetration through the blood-brain barriers of cats after intracarotid injections of 125-I sodium diatrizoate, methylglucamine diatrizoate, or methylglucamine diatrizoate plus parabens and the retention of 131-I methylglucamine diatrizoate in the blood of rats.
None found
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