4-hexyl resorcinol
a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections. Food additive for prevention of enzymic browning in shrimp and fruits
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    • R C Treatt and Co Ltd
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      4-Hexylresorcinol, Experimental
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
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      H0139 4-Hexylresorcinol >98.0%(GC)
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4-hexylbenzene-1,3-diol (Click)
CAS Number: 136-77-6Picture of molecule
ECHA EINECS - REACH Pre-Reg: 205-257-4
Nikkaji Web: J2.020F
Beilstein Number: 2048312
MDL: MFCD00002284
XlogP3: 3.50 (est)
Molecular Weight: 194.27386000
Formula: C12 H18 O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents: Search
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JECFA Food Additive: 4-Hexylresorcinol
DG SANTE Food Additives: 4-hexylresorcinol
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Physical Properties:
Appearance: white powder (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 68.00 °C. @ 760.00 mm Hg
Boiling Point: 334.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.000092 mm/Hg @ 25.00 °C. (est)
Flash Point: 311.00 °F. TCC ( 155.20 °C. ) (est)
logP (o/w): 3.450
Soluble in:
 water, 500 mg/L @ 18C (exp)
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Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
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BOC Sciences
For experimental / research use only.
4-Hexylresorcinol 98%
Odor: characteristic
Use: 4-Hexylresorcinol, a phenol derivative, could be commonly used as antioxidant, vermifuge and food additives. 4-Hexylresorcinol could be commonly used as antioxidant, vermifuge and food additives.
For experimental / research use only.
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
4-Hexylresorcinol 99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-Hexylresorcinol 98%
For experimental / research use only.
4-Hexylresorcinol >98.0%(GC)
4-Hexylresorcinol, Experimental
Universal Preserv-A-Chem Inc.
Odor: characteristic
Use: 4-Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties.
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  550 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 53, Pg. 198, 1935.

oral-mouse LD50  1040 mg/kg
Pharmazie. Vol. 30, Pg. 147, 1975.

intraperitoneal-mouse LD50  335 mg/kg
Japanese Kokai Tokyo Koho Patents. Vol. #90-292213

oral-guinea pig LDLo  400 mg/kg
Proceedings of the Society for Experimental Biology and Medicine. Vol. 28, Pg. 609, 1931.

unreported-mouse LDLo  100 mg/kg
Annals of Tropical Medicine and Parasitology. Vol. 32, Pg. 177, 1938.

Dermal Toxicity:
subcutaneous-mouse LDLo 750 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidants
Recommendation for 4-hexyl resorcinol usage levels up to:
 not for fragrance use.
Recommendation for 4-hexyl resorcinol flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the re-evaluation of 4-hexylresorcinol (E 586) as a food additive
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 136-77-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3610
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0000136776
EPA/NOAA CAMEO: hazardous materials
RTECS: VH1575000 for cas# 136-77-6
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 136-77-6
Pubchem (cid): 3610
Pubchem (sid): 134973215
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): D04441
HMDB (The Human Metabolome Database): HMDB32567
FooDB: FDB010499
Export Tariff Code: 2907.29.9000
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
•st 37, caprokol, crystoids, sucrets. •official hexylresorcinol pills are coated by patented process, gelatin coating being so tough that it cannot be readily broken even though chewed. •dosage forms-- pills nf: 100 & 200 mg. •formulation: sorunex
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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 benzenediol, 4-hexyl-
1,3-benzenediol, 4-hexyl-
1,3-dihydroxy-4-hexyl benzene
 hexyl resorcinol
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PubMed: Silk fibroin and 4-hexylresorcinol incorporation membrane for guided bone regeneration.
PubMed: 4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers.
PubMed: Cisplatin and 4-hexylresorcinol synergise to decrease metastasis and increase survival rate in an oral mucosal melanoma xenograft model: a preliminary study.
PubMed: 4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation.
PubMed: 4-hexylresorcinol stimulates the differentiation of SCC-9 cells through the suppression of E2F2, E2F3 and Sp3 expression and the promotion of Sp1 expression.
PubMed: Comparison of the simple cyclic voltammetry (CV) and DPPH assays for the determination of antioxidant capacity of active principles.
PubMed: 4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells.
PubMed: Aerosol deposition of hydroxyapatite and 4-hexylresorcinol coatings on titanium alloys for dental implants.
PubMed: Differential tissue distribution and specificity of phenoloxidases from the Pacific oyster Crassostrea gigas.
PubMed: A measurement of the unstirred aqueous boundary layer in a Franz diffusion cell.
PubMed: Edible mushroom (Flammulina velutipes) extract inhibits melanosis in Kuruma shrimp (Marsupenaeus japonicus).
PubMed: [Effect of chemical chaperones on properties of lysozyme and the reaction center protein from Rhodobacter sphaeroides].
PubMed: 4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells.
PubMed: First evidence of laccase activity in the Pacific oyster Crassostrea gigas.
PubMed: Variations in IC(50) values with purity of mushroom tyrosinase.
PubMed: Effect of natural antibrowning agents on color and related enzymes in fresh-cut Fuji apples as an alternative to the use of ascorbic acid.
PubMed: Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach.
PubMed: Effect of pyrophosphate and 4-hexylresorcinol pretreatment on quality of refrigerated white shrimp (Litopenaeus vannamei) kept under modified atmosphere packaging.
PubMed: Solvent effects on the spectroscopic properties of 4-hexylresorcinol.
PubMed: Browning prevention by ascorbic acid and 4-hexylresorcinol: different mechanisms of action on polyphenol oxidase in the presence and in the absence of substrates.
PubMed: Ascorbic acid and 4-hexylresorcinol effects on pear PPO and PPO catalyzed browning reaction.
PubMed: Oxyresveratrol as an antibrowning agent for cloudy apple juices and fresh-cut apples.
PubMed: Use of experimental design methodology to prepare Maillard reaction products from glucose and cysteine inhibitors of polyphenol oxidase from eggplant (Solanum melongena).
PubMed: [Determination of 4-hexylresorcinol residues in prawns and crabs].
PubMed: Role of sulfites and 4-hexylresorcinol in microbial growth and melanosis prevention of deepwater pink shrimp (Parapenaeus longirostris) using a controlled atmosphere.
PubMed: Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes.
PubMed: Polyphenol oxidases from latex of Hevea brasiliensis: purification and characterization.
PubMed: Maintaining quality of fresh-cut mangoes using antibrowning agents and modified atmosphere packaging.
PubMed: Cytokine release and cytotoxicity in human keratinocytes and fibroblasts induced by phenols and sodium dodecyl sulfate.
PubMed: Characterization of catecholase and cresolase activities of eggplant polyphenol oxidase.
PubMed: Determination of 4-hexylresorcinol in shrimp by liquid chromatography with fluorescence detection.
PubMed: Influence of pH, benzoic acid, glutathione, EDTA, 4-hexylresorcinol, and sodium chloride on the pressure inactivation kinetics of mushroom polyphenol oxidase.
PubMed: Oxidation of the flavonol quercetin by polyphenol oxidase.
PubMed: Extending storage life of fresh-cut apples using natural products and their derivatives.
PubMed: Oxidation of the flavonol fisetin by polyphenol oxidase.
PubMed: 4-Hexylresorcinol as inhibitor of shrimp melanosis: efficacy and residues studies; evaluation of possible toxic effect in a human intestinal in vitro model (Caco-2); preliminary safety assessment.
PubMed: Determination of 4-hexylresorcinol in crab meat.
PubMed: Liquid chromatographic determination of the processing aid 4-hexylresorcinol in shrimp.
PubMed: Generally recognized as safe (GRAS) evaluation of 4-hexylresorcinol for use as a processing aid for prevention of melanosis in shrimp.
PubMed: Does everything "cause" cancer: an alternative interpretation of the "carcinogenesis" bioassay.
PubMed: Development and validation of a cellular transplant model for leukemia in Fischer rats: a short-term assay for potential anti-leukemic chemicals.
PubMed: Inhibition of some spontaneous tumors by 4-hexylresorcinol in F344/N rats and B6C3F1 mice.
PubMed: NTP Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CAS No. 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed: Genotoxicity of amebicide and anthelmintic drugs in Escherichia coli pol A+/pol A-.
PubMed: Prediction of solubility in nonideal multicomponent systems using the UNIFAC group contribution model.
PubMed: Mutagenicity of antiamebic and anthelmintic drugs in the Salmonella typhimurium microsomal test system.
PubMed: Solubility behavior of phenolic compounds in hexane-ethyl acetate, hexane-ethyl myristate, and hexane-ethyl pivalate cosolvent systems.
PubMed: Effect of complex formation between 4-hexylresorcinol and ethyl myristate on release rate of 4-hexylresorcinol from petrolatum base.
PubMed: Review of the 4-hexylresorcinol procedure for acrolein analysis.
PubMed: [Determination of acrolein in the air by means of its reaction with 4-hexylresorcinol].
PubMed: The use of acid dissociation constants in selecting buffers to effect the electrophoretic separation of bithionol, fenticlor, hexachlorophene, bromchlorophene, dichlorophene, tetrachlorophene and 4-hexylresorcinol.
PubMed: [Experimental anticancer studies. II. On the anti-tumor effect of 6-(2'-hydroxy-3', 5'-dihalophenylazo)-4-hexylresorcinol and related compounds on Yoshida sarcoma and Ehrlich ascites carcinoma in vivo].
PubMed: Experimental anticancer studies. I. The preparation of 6-(2'-hydroxy-3', 5'-dibromophenylazo)-4-hexylresorcinol and related compounds, with brief reference to their anticancer activity.
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